-
1
-
-
10744222473
-
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
-
DOI 10.1038/nbt832
-
Doronina, S.O., Toki, B.E., Torgov, M.Y. et al. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol 2003, 21(7): 778-84. (Pubitemid 36791396)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.7
, pp. 778-784
-
-
Doronina, S.O.1
Toki, B.E.2
Torgov, M.Y.3
Mendelsohn, B.A.4
Cerveny, C.G.5
Chace, D.F.6
DeBlanc, R.L.7
Gearing, R.P.8
Bovee, T.D.9
Siegall, C.B.10
Francisco, J.A.11
Wahl, A.F.12
Meyer, D.L.13
Senter, P.D.14
-
2
-
-
67650874081
-
Cancer Statistics, 2009
-
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Thun, M.J. Cancer Statistics, 2009. CA Cancer J Clin 2009, 59(4): 225-49.
-
(2009)
CA Cancer J Clin
, vol.59
, Issue.4
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
3
-
-
47049084821
-
ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: Report from the International Peripheral T-Cell Lymphoma Project
-
Savage, K.J., Harris, N.L., Vose, J.M. et al. ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: Report from the International Peripheral T-Cell Lymphoma Project. Blood 2008, 111(12): 5496-504.
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5496-5504
-
-
Savage, K.J.1
Harris, N.L.2
Vose, J.M.3
-
4
-
-
77953175143
-
-
National Cancer Institute. Bethesda, MD, based on November 2009 SEER data submission, posted to the SEER web site, 2010
-
Altekruse, S.F., Kosary, C.L., Krapcho, M. et al. (Eds). SEER Cancer Statistics Review, 1975-2007, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975-2007/, based on November 2009 SEER data submission, posted to the SEER web site, 2010.
-
SEER Cancer Statistics Review, 1975-2007
-
-
Altekruse, S.F.1
Kosary, C.L.2
Krapcho, M.3
-
5
-
-
59449100987
-
Defining a population of Hodgkin lymphoma patients for novel therapeutics: An international effort
-
Horning, S.J., Fanale, M., De Vos, S. Defining a population of Hodgkin lymphoma patients for novel therapeutics: An international effort. Ann Oncol 2008, 20: 118.
-
(2008)
Ann Oncol
, vol.20
, pp. 118
-
-
Horning, S.J.1
Fanale, M.2
De Vos, S.3
-
6
-
-
0029867276
-
CD30 ligand, a member of the TNF ligand superfamily, with growth and activation control for CD30+ lymphoid and lymphoma cells
-
Gruss, H.J., Herrmann, F. CD30 ligand, a member of the TNF ligand superfamily, with growth and activation control CD30+ lymphoid and lymphoma cells. Leuk Lymphoma 1996, 20(5-6): 397-409. (Pubitemid 26096045)
-
(1996)
Leukemia and Lymphoma
, vol.20
, Issue.5-6
, pp. 397-409
-
-
Gruss, H.-J.1
Herrmann, F.2
-
7
-
-
0028228915
-
High serum level of the soluble form of CD30 molecule in the early phase of HIV-1 infection as an independent predictor of progression to AIDS
-
Pizzolo, G., Vinante, F., Morosato, L. et al. High serum level of the soluble form of CD30 molecule in the early phase of HIV-1 infection as an independent predictor of progression to AIDS. AIDS 1994, 8(6): 741-5. (Pubitemid 24163414)
-
(1994)
AIDS
, vol.8
, Issue.6
, pp. 741-745
-
-
Pizzolo, G.1
Vinante, F.2
Morosato, L.3
Nadali, G.4
Chilosi, M.5
Gandinit, G.6
Sinicco, A.7
Raiteri, R.8
Semenzato, G.9
Stein, H.10
Perona, G.11
-
8
-
-
0030051014
-
Serum levels of soluble CD30 in chronic hepatitis B virus infection
-
Fattovich, G., Vinante, F., Giustina, G., Morosato, L., Alberti, A., Ruol, A., Pizzolo, G. Serum levels of soluble CD30 in chronic hepatitis B virus infection. Clin Exp Immunol 1996, 103(1): 105-10. (Pubitemid 26027380)
-
(1996)
Clinical and Experimental Immunology
, vol.103
, Issue.1
, pp. 105-110
-
-
Fattovich, G.1
Vinante, F.2
Giustina, G.3
Morosato, L.4
Alberti, A.5
Ruol, A.6
Pizzolo, G.7
-
9
-
-
0030981805
-
Circulating levels of soluble CD30 are increased in patients with systemic sclerosis (SSc) and correlate with serological and clinical features of the disease
-
Giacomelli, R., Cipriani, P., Lattanzio, R. et al. Circulating levels of soluble CD30 are increased in patients with systemic sclerosis (SSc) and correlate with serological and clinical features of the disease. Clin Exp Immunol 1997, 108(1): 42-6. (Pubitemid 27140328)
-
(1997)
Clinical and Experimental Immunology
, vol.108
, Issue.1
, pp. 42-46
-
-
Giacomelli, R.1
Cipriani, P.2
Lattanzio, R.3
Di, F.M.4
Locanto, M.5
Parzanese, I.6
Passacantando, A.7
Ciocci, A.8
Tonietti, G.9
-
10
-
-
0033931464
-
Autocrine growth regulation of CD30 ligand in CD30-expressing Reed-Sternberg cells: Distinction between Hodgkin's disease and anaplastic large cell lymphoma
-
Hsu, P.L., Hsu, S.M. Autocrine growth regulation of CD30 ligand in CD30-expressing Reed-Sternberg cells: Distinction between Hodgkin's disease and anaplastic large cell lymphoma. Lab Invest 2000, 80(7): 1111-9.
-
(2000)
Lab Invest
, vol.80
, Issue.7
, pp. 1111-1119
-
-
Hsu, P.L.1
Hsu, S.M.2
-
11
-
-
0036645267
-
The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in Vitro and affects antitumor activity in models of Hodgkin's disease
-
Wahl, A.F., Klussman, K., Thompson, J.D. et al. The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease. Cancer Res 2002, 62(13): 3736-42. (Pubitemid 34728855)
-
(2002)
Cancer Research
, vol.62
, Issue.13
, pp. 3736-3742
-
-
Wahl, A.F.1
Klussman, K.2
Thompson, J.D.3
Chen, J.H.4
Francisco, L.V.5
Risdon, G.6
Chace, D.F.7
Siegall, C.B.8
Francisco, J.A.9
-
12
-
-
41349086204
-
+ hematologic malignancies
-
DOI 10.1182/blood-2007-07-099317
-
Bartlett, N.L., Younes, A., Carabasi, M.H. et al. A phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignancies. Blood 2008, 111(4): 1848-54. (Pubitemid 351451492)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 1848-1854
-
-
Bartlett, N.L.1
Younes, A.2
Carabasi, M.H.3
Forero, A.4
Rosenblatt, J.D.5
Leonard, J.P.6
Bernstein, S.H.7
Bociek, R.G.8
Lorenz, J.M.9
Hart, B.W.10
Barton, J.11
-
13
-
-
67649908324
-
A phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma
-
Forero-Torres, A., Leonard, J.P., Younes, A. et al. A phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma. Br J Haematol 2009, 146(2): 171-9.
-
(2009)
Br J Haematol
, vol.146
, Issue.2
, pp. 171-179
-
-
Forero-Torres, A.1
Leonard, J.P.2
Younes, A.3
-
14
-
-
77958490178
-
Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcγRIIIa-158 V/F polymorphism
-
Epub ahead of print
-
Blum, K.A., Jung, S.H., Johnson, J.L. et al. Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcγRIIIa-158 V/F polymorphism. Ann Oncol 2010, Epub ahead of print.
-
(2010)
Ann Oncol
-
-
Blum, K.A.1
Jung, S.H.2
Johnson, J.L.3
-
15
-
-
71849105156
-
Susceptibility of human T-cell leukemia virus type I-infected cells to humanized anti-CD30 monoclonal antibodies in vitro and in vivo
-
Maeda, N., Muta, H., Oflazoglu, E., Yoshikai, Y. Susceptibility of human T-cell leukemia virus type I-infected cells to humanized anti-CD30 monoclonal antibodies in vitro and in vivo. Cancer Sci 2010, 101(1): 224-30.
-
(2010)
Cancer Sci
, vol.101
, Issue.1
, pp. 224-230
-
-
Maeda, N.1
Muta, H.2
Oflazoglu, E.3
Yoshikai, Y.4
-
16
-
-
33748098678
-
A humanized anti-CD30 monoclonal antibody, XmAb(TM)2513, with enhanced in vitro potency against CD30-positive lymphomas mediated by high affinity Fc-receptor binding
-
th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005 Abst 1470
-
th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 1470.
-
(2005)
Blood
, vol.106
, Issue.11
-
-
Hammond, P.W.1
Vafa, O.2
Jacinto, J.3
-
17
-
-
76049122850
-
Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate
-
Okeley, N.M., Miyamoto, J.B., Zhang, X. et al. Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res 2010, 16(3): 888-97.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.3
, pp. 888-897
-
-
Okeley, N.M.1
Miyamoto, J.B.2
Zhang, X.3
-
18
-
-
33744537358
-
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates
-
DOI 10.1074/jbc.M510026200
-
Sutherland, M.S.K., Sanderson, R.J., Gordon, K.A. et al. Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. J Biol Chem 2006, 281(15): 10540-7. (Pubitemid 43864594)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.15
, pp. 10540-10547
-
-
Kung, S.M.S.1
Sanderson, R.J.2
Gordon, K.A.3
Andreyka, J.4
Cerveny, C.G.5
Yu, C.6
Lewis, T.S.7
Meyer, D.L.8
Zabinski, R.F.9
Doronina, S.O.10
Senter, P.D.11
Law, C.-L.12
Wahl, A.F.13
-
19
-
-
0042738861
-
CAC10-vcMMAE, an anti-CD30-monomethyl auristatin e conjugate with potent and selective antitumor activity
-
DOI 10.1182/blood-2003-01-0039
-
Francisco, J.A., Cerveny, C.G., Meyer, D.L. et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 2003, 102(4): 1458-65. (Pubitemid 36988057)
-
(2003)
Blood
, vol.102
, Issue.4
, pp. 1458-1465
-
-
Francisco, J.A.1
Cerveny, C.G.2
Meyer, D.L.3
Mixan, B.J.4
Klussman, K.5
Chace, D.F.6
Rejniak, S.X.7
Gordon, K.A.8
DeBlanc, R.9
Toki, B.E.10
Law, C.-L.11
Doronina, S.O.12
Siegall, C.B.13
Senter, P.D.14
Wahl, A.F.15
-
20
-
-
44649184200
-
Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma
-
DOI 10.1111/j.1365-2141.2008.07146.x
-
Oflazoglu, E., Kissler, K.M., Sievers, E.L., Grewal, I.S., Gerber, H.-P. Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma. Br J Haematol 2008, 142(1): 69-73. (Pubitemid 351783148)
-
(2008)
British Journal of Haematology
, vol.142
, Issue.1
, pp. 69-73
-
-
Oflazoglu, E.1
Kissler, K.M.2
Sievers, E.L.3
Grewal, I.S.4
Gerber, H.-P.5
-
21
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
DOI 10.1158/1078-0432.CCR-04-0789
-
Hamblett, K.J., Senter, P.D., Chace, D.F. et al. Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin Cancer Res 2004, 10(20): 7063-70. (Pubitemid 39383058)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.20
, pp. 7063-7070
-
-
Hamblett, K.J.1
Senter, P.D.2
Chace, D.F.3
Sun, M.M.C.4
Lenox, J.5
Cerveny, C.G.6
Kissler, K.M.7
Bernhardt, S.X.8
Kopcha, A.K.9
Zabinski, R.F.10
Meyer, D.L.11
Francisco, J.A.12
-
22
-
-
66249142404
-
Multiple complete responses in a phase 1 dose-escalation study of the antibody-drug conjugate SGN-35 in patients with relapsed or refractory CD30-positive lymphomas
-
th Annu Meet Am Soc Hematol (Dec 6-9, San Francisco) 2008 Abst 1006
-
th Annu Meet Am Soc Hematol (Dec 6-9, San Francisco) 2008] 2008, 112(11): Abst 1006.
-
(2008)
Blood
, vol.112
, Issue.11
-
-
Younes, A.1
Forero-Torres, A.2
Bartlett, N.L.3
-
23
-
-
77955311034
-
The antibody-drug conjugate brentuximab vedotin (SGN-35) induced multiple objective responses in patients with relapsed or refractory CD30-positive lymphomas in a phase 1 weekly dosing study
-
st Annu Meet Am Soc Hematol (Dec 5-8, New Orleans) 2009 Abst 2731
-
st Annu Meet Am Soc Hematol (Dec 5-8, New Orleans) 2009] 2009, 114(22): Abst 2731.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Fanale, M.1
Bartlett, N.L.2
Forero-Torres, A.3
-
24
-
-
78650275149
-
Objective responses with brentuximab vedotin (SGN-35) retreatment in CD30-positive hematologic malignancies: A case series
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010 Abst 8062
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 8062.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Bartlett, N.1
Grove, L.E.2
Kennedy, D.A.3
Sievers, E.L.4
Forero-Torres, A.5
-
25
-
-
59149091564
-
Increased doses of an anti-CD30 antibody, MDX-060, results in prolonged progression free survival in subjects with CD30 positive lymphoma
-
Abst 5525
-
Ansell, S., Horwitz, S., Engert, A. et al. Increased doses of an anti-CD30 antibody, MDX-060, results in prolonged progression free survival in subjects with CD30 positive lymphoma. Proc Am Assoc Cancer Res (AACR) 2008, 49: Abst 5525.
-
Proc Am Assoc Cancer Res (AACR) 2008
, vol.49
-
-
Ansell, S.1
Horwitz, S.2
Engert, A.3
-
26
-
-
79956225348
-
A phase I, open-label, dose-escalation, multidose study of MDX-1401 (defucosylated human antiCD30 monoclonal antibody) in patients with CD30-positive refractory/relapsed Hodgkin's lymphoma
-
Abst 1227
-
Thertulien, R., Frankel, A., Evens, A. A phase I, open-label, dose-escalation, multidose study of MDX-1401 (defucosylated human antiCD30 monoclonal antibody) in patients with CD30-positive refractory/relapsed Hodgkin's lymphoma. Proc Am Assoc Cancer Res (AACR) 2009, 50: Abst 1227.
-
Proc Am Assoc Cancer Res (AACR) 2009
, vol.50
-
-
Thertulien, R.1
Frankel, A.2
Evens, A.3
-
27
-
-
79956202280
-
Evaluation of the pharmacokinetics, immunogenicity, and safety of XmAb(R)2513 in the ongoing study XmAb2513-01: A phase 1 study of every other week XmAb2513 to evaluate the safety, tolerability, and pharmacokinetics in patients with Hodgkin lymphoma or anaplastic large cell lymphoma
-
th Annu Meet Am Soc Hematol (Dec 6-9, San Francisco) 2008 Abst 5012
-
th Annu Meet Am Soc Hematol (Dec 6-9, San Francisco) 2008] 2008, 112(11): Abst 5012.
-
(2008)
Blood
, vol.112
, Issue.11
-
-
Younes, A.1
Zalevsky, J.2
Blum, K.A.3
|