메뉴 건너뛰기




Volumn 64, Issue 3, 2011, Pages 207-212

Antibody drug conjugates - Trojan horses in the war on cancer

Author keywords

Antibody toxin conjugates; Cancer therapy; Cytotoxin delivery; Targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; BIIB 015; BRENTUXIMAB VEDOTIN; BT 062; CYTOTOXIC AGENT; CYTOTOXIN; DOXORUBICIN; GEMTUZUMAB OZOGAMICIN; IMGN 242; IMGN 388; INOTUZUMAB OZOGAMICIN; LORVOTUZUMAB MERTANSINE; MAYTANSINE; MONOCLONAL ANTIBODY; SAR 3419; SGN 75; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

EID: 81955160713     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2011.07.005     Document Type: Review
Times cited : (58)

References (62)
  • 1
    • 77953151053 scopus 로고    scopus 로고
    • American Cancer Society, A.C.S.
    • A.C.S. Cancer facts & figures 2010 2010, American Cancer Society.
    • (2010) Cancer facts & figures 2010
  • 2
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag D.M., McQueney P.A., Zhu J., Hensens O., Koupal L., Liesch J., et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Research 1995, 55:2325-2333.
    • (1995) Cancer Research , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3    Hensens, O.4    Koupal, L.5    Liesch, J.6
  • 3
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • Carter P.J. Potent antibody therapeutics by design. Nature Reviews Immunology 2006, 6:343-357.
    • (2006) Nature Reviews Immunology , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 6
    • 0023715265 scopus 로고
    • DNA binding by epipodophyllotoxins and N-acyl anthracyclines: Implications for mechanism of topoisomerase II inhibition
    • Chow K.C., Macdonald T.L., Ross W.E. DNA binding by epipodophyllotoxins and N-acyl anthracyclines: Implications for mechanism of topoisomerase II inhibition. Molecular Pharmacology 1988, 34:467-473.
    • (1988) Molecular Pharmacology , vol.34 , pp. 467-473
    • Chow, K.C.1    Macdonald, T.L.2    Ross, W.E.3
  • 7
    • 9444260479 scopus 로고    scopus 로고
    • Biological impediments to monoclonal antibody-based cancer immunotherapy
    • Christiansen J., Rajasekaran A.K. Biological impediments to monoclonal antibody-based cancer immunotherapy. Molecular Cancer Therapeutics 2004, 3:1493-1501.
    • (2004) Molecular Cancer Therapeutics , vol.3 , pp. 1493-1501
    • Christiansen, J.1    Rajasekaran, A.K.2
  • 8
    • 31544455876 scopus 로고    scopus 로고
    • Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against Non-Hodgkin's B-Cell lymphoma
    • Dijoseph J.F., Dougher M.M., Kalyandrug L.B., Armellino D.C., Boghaert E.R., Hamann P.R., et al. Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against Non-Hodgkin's B-Cell lymphoma. Clinical Cancer Research 2006, 12:242-249.
    • (2006) Clinical Cancer Research , vol.12 , pp. 242-249
    • Dijoseph, J.F.1    Dougher, M.M.2    Kalyandrug, L.B.3    Armellino, D.C.4    Boghaert, E.R.5    Hamann, P.R.6
  • 10
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nature Reviews Cancer 2003, 3:11-22.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 11
    • 74949107560 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
    • Ducry L., Stump B. Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies. Bioconjugate Chemistry 2010, 21:5-13.
    • (2010) Bioconjugate Chemistry , vol.21 , pp. 5-13
    • Ducry, L.1    Stump, B.2
  • 12
    • 33645500289 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
    • Erickson H.K., Park P.U., Widdison W.C., Kovtun Y.V., Garrett L.M., Hoffman K., et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Research 2006, 66:4426-4433.
    • (2006) Cancer Research , vol.66 , pp. 4426-4433
    • Erickson, H.K.1    Park, P.U.2    Widdison, W.C.3    Kovtun, Y.V.4    Garrett, L.M.5    Hoffman, K.6
  • 13
    • 33847613926 scopus 로고    scopus 로고
    • Process economics of industrial monoclonal antibody manufacture
    • Farid S.S. Process economics of industrial monoclonal antibody manufacture. Journal of Chromatography B 2007, 848:8-18.
    • (2007) Journal of Chromatography B , vol.848 , pp. 8-18
    • Farid, S.S.1
  • 18
    • 0141725730 scopus 로고    scopus 로고
    • Mode of action of docetaxel - a basis for combination with novel anticancer agents
    • Herbst R.S., Khuri F.R. Mode of action of docetaxel - a basis for combination with novel anticancer agents. Cancer Treatment Reviews 2003, 29:407-415.
    • (2003) Cancer Treatment Reviews , vol.29 , pp. 407-415
    • Herbst, R.S.1    Khuri, F.R.2
  • 19
    • 0027194197 scopus 로고
    • Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: A novel and potent family of antitumor antibiotics
    • Hinman L.M., Hamann P.R., Wallace R., Menendez A.T., Durr F.E., Upeslacis J. Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: A novel and potent family of antitumor antibiotics. Cancer Research 1993, 53:3336-3342.
    • (1993) Cancer Research , vol.53 , pp. 3336-3342
    • Hinman, L.M.1    Hamann, P.R.2    Wallace, R.3    Menendez, A.T.4    Durr, F.E.5    Upeslacis, J.6
  • 20
    • 1242352458 scopus 로고    scopus 로고
    • Internalization and cell cycle-dependent killing of leukemic cells by gemtuzumab ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity
    • Jedema I., Barge R.M.Y., Van Der Velden V.H.J., Nijmeijer B.A., Van Dongen J.J.M., Willemze R., et al. Internalization and cell cycle-dependent killing of leukemic cells by gemtuzumab ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity. Leukemia 2004, 18:316-325.
    • (2004) Leukemia , vol.18 , pp. 316-325
    • Jedema, I.1    Barge, R.M.Y.2    Van Der Velden, V.H.J.3    Nijmeijer, B.A.4    Van Dongen, J.J.M.5    Willemze, R.6
  • 21
    • 0032006059 scopus 로고    scopus 로고
    • Microtubules and actin filaments: dynamic targets for cancer chemotherapy
    • Jordan M.A., Wilson L. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Current Opinion in Cell Biology 1998, 10:123-130.
    • (1998) Current Opinion in Cell Biology , vol.10 , pp. 123-130
    • Jordan, M.A.1    Wilson, L.2
  • 22
    • 49449087300 scopus 로고    scopus 로고
    • Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
    • Junutula J.R., Raab H., Clark S., Bhakta S., Leipold D.D., Weir S., et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nature Biotechonology 2008, 26:925-932.
    • (2008) Nature Biotechonology , vol.26 , pp. 925-932
    • Junutula, J.R.1    Raab, H.2    Clark, S.3    Bhakta, S.4    Leipold, D.D.5    Weir, S.6
  • 23
    • 0027464742 scopus 로고
    • Uses and limitations of monoclonal antibodies (MoAbs) in the treatment of malignant disease: A review
    • Kemshead J.T., Hopkins K. Uses and limitations of monoclonal antibodies (MoAbs) in the treatment of malignant disease: A review. Journal of the Royal Society of Medicine 1993, 86:219-224.
    • (1993) Journal of the Royal Society of Medicine , vol.86 , pp. 219-224
    • Kemshead, J.T.1    Hopkins, K.2
  • 25
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975, 256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 27
    • 33644787435 scopus 로고    scopus 로고
    • Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen
    • Kovtun Y.V., Audette C.A., Ye Y., Xie H., Ruberti M.F., Phinney S.J. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Research 2006, 66:3214-3221.
    • (2006) Cancer Research , vol.66 , pp. 3214-3221
    • Kovtun, Y.V.1    Audette, C.A.2    Ye, Y.3    Xie, H.4    Ruberti, M.F.5    Phinney, S.J.6
  • 29
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-Positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
    • Lewis Phillips G.D., Li G., Dugger D.L., Crocker L.M., Parsons K.L., Mai E., et al. Targeting HER2-Positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Research 2008, 68:9280-9290.
    • (2008) Cancer Research , vol.68 , pp. 9280-9290
    • Lewis Phillips, G.D.1    Li, G.2    Dugger, D.L.3    Crocker, L.M.4    Parsons, K.L.5    Mai, E.6
  • 31
    • 0038446696 scopus 로고    scopus 로고
    • Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance
    • Manshouri T., Do K.-A., Wang X., Giles F.J., O'brien S.M., Saffer H., et al. Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance. Blood 2003, 101:2507-2513.
    • (2003) Blood , vol.101 , pp. 2507-2513
    • Manshouri, T.1    Do, K.-A.2    Wang, X.3    Giles, F.J.4    O'brien, S.M.5    Saffer, H.6
  • 32
    • 0038206660 scopus 로고    scopus 로고
    • Managing taxane toxicities
    • Markman M. Managing taxane toxicities. Supportive Care in Cancer 2003, 11:144-147.
    • (2003) Supportive Care in Cancer , vol.11 , pp. 144-147
    • Markman, M.1
  • 33
    • 18444411317 scopus 로고    scopus 로고
    • Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers
    • Matsui H.T.A., Naito K., Shinjo K., Shigeno K., Maekawa M., Yamakawa Y., et al. Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers. Leukemia 2002, 16:813-819.
    • (2002) Leukemia , vol.16 , pp. 813-819
    • Matsui, H.T.A.1    Naito, K.2    Shinjo, K.3    Shigeno, K.4    Maekawa, M.5    Yamakawa, Y.6
  • 35
    • 0030923296 scopus 로고    scopus 로고
    • Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248)
    • Mosure K.W., Henderson A.J., Klunk L.J., Knipe J.O. Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248). Cancer Chemotherapy and Pharmacology 1997, 40:251-258.
    • (1997) Cancer Chemotherapy and Pharmacology , vol.40 , pp. 251-258
    • Mosure, K.W.1    Henderson, A.J.2    Klunk, L.J.3    Knipe, J.O.4
  • 36
    • 0001055380 scopus 로고
    • Molecular design, chemical synthesis, and biological action of enediynes
    • Nicolaou K.C., Smith A.L. Molecular design, chemical synthesis, and biological action of enediynes. Accounts of Chemical Research 1992, 25:497-503.
    • (1992) Accounts of Chemical Research , vol.25 , pp. 497-503
    • Nicolaou, K.C.1    Smith, A.L.2
  • 37
    • 3543092021 scopus 로고    scopus 로고
    • Pathways of apoptotic and non-apoptotic death in tumour cells
    • Okada H., Mak T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nature Reviews. Cancer 2004, 4:592-603.
    • (2004) Nature Reviews. Cancer , vol.4 , pp. 592-603
    • Okada, H.1    Mak, T.W.2
  • 39
    • 0032008099 scopus 로고    scopus 로고
    • Novel therapeutic strategies to selectively kill cancer cells
    • Panchal R.G. Novel therapeutic strategies to selectively kill cancer cells. Biochemical Pharmacology 1998, 55:247-252.
    • (1998) Biochemical Pharmacology , vol.55 , pp. 247-252
    • Panchal, R.G.1
  • 41
    • 77956437053 scopus 로고    scopus 로고
    • Anti-CD22-MCC-DM1: An antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma
    • Polson A.G., Williams M., Gray A.M., Fuji R.N., Poon K.A., McBride J. Anti-CD22-MCC-DM1: An antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia 2010, 24:1566-1573.
    • (2010) Leukemia , vol.24 , pp. 1566-1573
    • Polson, A.G.1    Williams, M.2    Gray, A.M.3    Fuji, R.N.4    Poon, K.A.5    McBride, J.6
  • 42
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert J.M. Antibody-based therapeutics to watch in 2011. MAbs 2010, 3:76-98.
    • (2010) MAbs , vol.3 , pp. 76-98
    • Reichert, J.M.1
  • 44
    • 50049134725 scopus 로고    scopus 로고
    • Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
    • Riechelmann H., Sauter A., Golze W., Hanft G., Schroen C., Hoermann K., et al. Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. Oral Oncology 2008, 44:823-829.
    • (2008) Oral Oncology , vol.44 , pp. 823-829
    • Riechelmann, H.1    Sauter, A.2    Golze, W.3    Hanft, G.4    Schroen, C.5    Hoermann, K.6
  • 45
    • 77955983472 scopus 로고    scopus 로고
    • Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody-drug conjugate SGN-75
    • Ryan M.C., Kostner H., Gordon K.A., Duniho S., Sutherland M.K., Yu C., et al. Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody-drug conjugate SGN-75. British Journal of Cancer 2010, 103:676-684.
    • (2010) British Journal of Cancer , vol.103 , pp. 676-684
    • Ryan, M.C.1    Kostner, H.2    Gordon, K.A.3    Duniho, S.4    Sutherland, M.K.5    Yu, C.6
  • 46
    • 0034077405 scopus 로고    scopus 로고
    • Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with Lewis Y - Expressing epithelial tumors
    • Saleh M.N., Sugarman S., Murray J., Ostroff J.B., Healey D., Jones D., et al. Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with Lewis Y - Expressing epithelial tumors. Journal of Clinical Oncology 2000, 18:2282-2292.
    • (2000) Journal of Clinical Oncology , vol.18 , pp. 2282-2292
    • Saleh, M.N.1    Sugarman, S.2    Murray, J.3    Ostroff, J.B.4    Healey, D.5    Jones, D.6
  • 47
    • 67649851892 scopus 로고    scopus 로고
    • MAbs: A business perspective
    • Scolnik P.A. mAbs: A business perspective. MAbs 2009, 2:179-184.
    • (2009) MAbs , vol.2 , pp. 179-184
    • Scolnik, P.A.1
  • 48
    • 27144447076 scopus 로고    scopus 로고
    • The problem with potency
    • Scott C.T. The problem with potency. Nature Biotechonology 2005, 23:1037-1039.
    • (2005) Nature Biotechonology , vol.23 , pp. 1037-1039
    • Scott, C.T.1
  • 50
    • 67649886201 scopus 로고    scopus 로고
    • Potent antibody drug conjugates for cancer therapy
    • Senter P.D. Potent antibody drug conjugates for cancer therapy. Current Opinion in Chemical Biology 2009, 13:235-244.
    • (2009) Current Opinion in Chemical Biology , vol.13 , pp. 235-244
    • Senter, P.D.1
  • 51
    • 85086810627 scopus 로고    scopus 로고
    • Antibody-cytotoxic agent conjugates: preparation and characterization
    • SpringerLink
    • Singh R., Erickson H.K. Antibody-cytotoxic agent conjugates: preparation and characterization. Methods in Molecular Biology 2009, 525:1-23. SpringerLink.
    • (2009) Methods in Molecular Biology , vol.525 , pp. 1-23
    • Singh, R.1    Erickson, H.K.2
  • 52
    • 1842369073 scopus 로고    scopus 로고
    • Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats
    • Sjogren H.O., Isaksson M., Willner D., Hellstrom I., Hellstram K.E., Trail P.A. Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats. Cancer Research 1997, 57:4530-4536.
    • (1997) Cancer Research , vol.57 , pp. 4530-4536
    • Sjogren, H.O.1    Isaksson, M.2    Willner, D.3    Hellstrom, I.4    Hellstram, K.E.5    Trail, P.A.6
  • 53
    • 33744537358 scopus 로고    scopus 로고
    • Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates
    • Sutherland M.S., Sanderson R.J., Gordon K.A., Andreyka J., Cerveny C.G., Yu C., et al. Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. Journal of Biological Chemistry 2006, 281:10540-10547.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 10540-10547
    • Sutherland, M.S.1    Sanderson, R.J.2    Gordon, K.A.3    Andreyka, J.4    Cerveny, C.G.5    Yu, C.6
  • 54
    • 66949176946 scopus 로고    scopus 로고
    • CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma
    • Takeshita A., Shinjo K., Yamakage N., Ono T., Hirano I., Matsui H., et al. CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma. British Journal of Haematology 2009, 146:34-43.
    • (2009) British Journal of Haematology , vol.146 , pp. 34-43
    • Takeshita, A.1    Shinjo, K.2    Yamakage, N.3    Ono, T.4    Hirano, I.5    Matsui, H.6
  • 55
    • 0023554984 scopus 로고
    • New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo
    • Thorpe P.E., Wallace P.M., Knowles P.P., Relf M.G., Brown A.N.F., Watson, et al. New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo. Cancer Research 1987, 47:5924-5931.
    • (1987) Cancer Research , vol.47 , pp. 5924-5931
    • Thorpe, P.E.1    Wallace, P.M.2    Knowles, P.P.3    Relf, M.G.4    Brown, A.N.F.5    Watson6
  • 57
    • 2342572260 scopus 로고    scopus 로고
    • High CD33-antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg[reg]) treatment in acute myeloid leukemia patients
    • Van Der Velden V.H.J., Boeckx N., Jedema I., Te Marvelde J.G., Hoogeveen P.G., Boogaerts M., et al. High CD33-antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg[reg]) treatment in acute myeloid leukemia patients. Leukemia 2004, 18:983-988.
    • (2004) Leukemia , vol.18 , pp. 983-988
    • Van Der Velden, V.H.J.1    Boeckx, N.2    Jedema, I.3    Te Marvelde, J.G.4    Hoogeveen, P.G.5    Boogaerts, M.6
  • 58
    • 33746047673 scopus 로고    scopus 로고
    • Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity
    • Van Meerten T., Van Rijn R.S., Hol S., Hagenbeek A., Ebeling S.B. Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity. Clinical Cancer Research 2006, 12:4027-4035.
    • (2006) Clinical Cancer Research , vol.12 , pp. 4027-4035
    • Van Meerten, T.1    Van Rijn, R.S.2    Hol, S.3    Hagenbeek, A.4    Ebeling, S.B.5
  • 60
    • 12844257365 scopus 로고    scopus 로고
    • Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity
    • Walter R.B., Raden B.W., Kamikura D.M., Cooper J.A., Bernstein I.D. Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity. Blood 2005, 105:1295-1302.
    • (2005) Blood , vol.105 , pp. 1295-1302
    • Walter, R.B.1    Raden, B.W.2    Kamikura, D.M.3    Cooper, J.A.4    Bernstein, I.D.5
  • 61
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • Weiner L.M., Surana R., Wang S. Monoclonal antibodies: Versatile platforms for cancer immunotherapy. Nature Reviews Immunology 2010, 10:317-327.
    • (2010) Nature Reviews Immunology , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 62
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • Wu A.M., Senter P.D. Arming antibodies: Prospects and challenges for immunoconjugates. Nature Biotechonology 2005, 23:1137-1146.
    • (2005) Nature Biotechonology , vol.23 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.