New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism

ACS Chemical Biology

Volumn 8, Issue 9, 2013, Pages 2084-2094

  Pera, Benet ^a,c   Barasoain, Isabel ^a   Pantazopoulou, Areti ^a   Canales, Angeles ^a   Matesanz, Ruth ^a   Rodriguez Salarichs, Javier ^a   García Fernandez, Luis F ^b   Moneo, Victoria ^b   Jiménez Barbero, Jesús ^a   Galmarini, Carlos M ^b   Cuevas, Carmen ^b   Peñalva, Miguel A ^a   Díaz, J Fernando ^a   Andreu, José M ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b PHARMAMAR S A   (Spain)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; ERIBULIN; HALICHONDRIN B; MICROTUBULE PROTEIN; PM 050489; PM 060184; PM 060327; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS NIDULANS; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; MITOSIS; MODELS, MOLECULAR; NEOPLASMS; POLYKETIDES; PORIFERA; PYRONES; TUBULIN; TUBULIN MODULATORS;

EID: 84880000244     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400461j     Document Type: Article

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