Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

Journal of the American Chemical Society

Volumn 135, Issue 27, 2013, Pages 10164-10171

  Martín, María Jesús ^a   Coello, Laura ^a   Fernández, Rogelio ^a   Reyes, Fernando ^a,b   Rodríguez, Alberto ^a   Murcia, Carmen ^a   Garranzo, María ^a   Mateo, Cristina ^a   Sánchez Sancho, Francisco ^a,c   Bueno, Santiago ^a   De Eguilior, Carlos ^a   Francesch, Andrés ^a   Munt, Simon ^a   Cuevas, Carmen ^a  

^a Research and Development Director RD PharmaMar   (Spain)

^b Health Sciences Technology Park   (Spain)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER COMPOUNDS; ANTICANCER DRUG; HUMAN TUMOR CELLS; INHIBITION MECHANISMS; NATURALLY OCCURRING; PHARMACEUTICAL DEVELOPMENT; STRUCTURAL ELUCIDATION; SYNTHETIC PROCEDURES;

MOLECULES;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; PM 050489; PM 060184; POLYKETIDE; TUBULIN; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; DRUG ISOLATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; LITHOPLOCAMIA LITHISTOIDES; MADAGASCAR; MARINE SPECIES; MICROTUBULE; MITOSIS INHIBITION; SPONGE (PORIFERA);

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; MOLECULAR CONFORMATION; POLYKETIDES; PORIFERA; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880014851     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja404578u     Document Type: Article

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