The WAVE regulatory complex links diverse receptors to the actin cytoskeleton

Cell

Volumn 156, Issue 1-2, 2014, Pages 195-207

  Chen, Baoyu ^a   Brinkmann, Klaus ^b   Chen, Zhucheng ^a   Pak, Chi W ^a   Liao, Yuxing ^a   Shi, Shuoyong ^a   Henry, Lisa ^a   Grishin, Nick V ^a   Bogdan, Sven ^b   Rosen, Michael K ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; LIGAND; MEMBRANE PROTEIN; PEPTIDE; UNCLASSIFIED DRUG; WASP FAMILY VERPROLIN HOMOLOGOUS PROTEIN; WAVE REGULATORY COMPLEX; WISKOTT ALDRICH SYNDROME PROTEIN; ACTIN RELATED PROTEIN 2-3 COMPLEX; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; NETRIN RECEPTOR; NEUROLIGIN 1; PROTOCADHERIN 10; PROTOCADHERIN 19; ROUNDABOUT RECEPTOR;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOSKELETON; DROSOPHILA; EVOLUTION; HUMAN; NONHUMAN; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; TRANSGENE; ACTIN FILAMENT; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CYTOPLASM; FEMALE STERILITY; HYDROGEN BOND; LIGAND BINDING; POINT MUTATION; SEQUENCE ALIGNMENT;

METAZOA;

ACTIN CYTOSKELETON; ACTIN-RELATED PROTEIN 2-3 COMPLEX; AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; OOGENESIS; SEQUENCE ALIGNMENT; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY;

EID: 84892740941     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.11.048     Document Type: Article

References (265)

1. P.D. Adams, P.V. Afonine, G. Bunkóczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, and R.W. Grosse-Kunstleve et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D Biol. Crystallogr. 66 2010 213 221
2. R.A. Alegado, L.W. Brown, S. Cao, R.K. Dermenjian, R. Zuzow, S.R. Fairclough, J. Clardy, and N. King A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals Elife 1 2012 e00013
3. H. Ashkenazy, E. Erez, E. Martz, T. Pupko, and N. Ben-Tal ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids Nucleic Acids Res. 38 Web Server issue 2010 W529 W533
4. R. Bastock, and D. St Johnston Drosophila oogenesis Curr. Biol. 18 2008 R1082 R1087
5. Y.Y. Bernadskaya, A. Wallace, J. Nguyen, W.A. Mohler, and M.C. Soto UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complex PLoS Genet. 8 2012 e1002863
6. D. Bilder, and S.L. Haigo Expanding the morphogenetic repertoire: perspectives from the Drosophila egg Dev. Cell 22 2012 12 23
7. J. Bischof, R.K. Maeda, M. Hediger, F. Karch, and K. Basler An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases Proc. Natl. Acad. Sci. USA 104 2007 3312 3317
8. S. Bogdan, R. Stephan, C. Löbke, A. Mertens, and C. Klämbt Abi activates WASP to promote sensory organ development Nat. Cell Biol. 7 2005 977 984
9. M. Buck, W. Xu, and M.K. Rosen A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting J. Mol. Biol. 338 2004 271 285
10. P. Burkhardt, C.M. Stegmann, B. Cooper, T.H. Kloepper, C. Imig, F. Varoqueaux, M.C. Wahl, and D. Fasshauer Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis Proc. Natl. Acad. Sci. USA 108 2011 15264 15269
11. K.G. Campellone, and M.D. Welch A nucleator arms race: cellular control of actin assembly Nat. Rev. Mol. Cell Biol. 11 2010 237 251
12. P.-H. Chia, B. Chen, P. Li, M.K. Rosen, and K. Shen Local F-actin network links synapse formation and axon branching Cell 156 2014 208 220 this issue
13. Z. Chen, D. Borek, S.B. Padrick, T.S. Gomez, Z. Metlagel, A.M. Ismail, J. Umetani, D.D. Billadeau, Z. Otwinowski, and M.K. Rosen Structure and control of the actin regulatory WAVE complex Nature 468 2010 533 538
14. C. Depienne, M. Cincotta, S. Billot, D. Bouteiller, S. Groppa, V. Brochard, C. Flamand, C. Hubsch, S. Meunier, and F. Giovannelli et al. A novel DCC mutation and genetic heterogeneity in congenital mirror movements Neurology 76 2011 260 264
15. L.M. Dibbens, P.S. Tarpey, K. Hynes, M.A. Bayly, I.E. Scheffer, R. Smith, J. Bomar, E. Sutton, L. Vandeleur, and C. Shoubridge et al. X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment Nat. Genet. 40 2008 776 781
16. P.S. Dimova, A. Kirov, A. Todorova, T. Todorov, and V. Mitev A novel PCDH19 mutation inherited from an unaffected mother Pediatr. Neurol. 46 2012 397 400
17. S. Eden, R. Rohatgi, A.V. Podtelejnikov, M. Mann, and M.W. Kirschner Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck Nature 418 2002 790 793
18. M.R. Emond, S. Biswas, and J.D. Jontes Protocadherin-19 is essential for early steps in brain morphogenesis Dev. Biol. 334 2009 72 83
19. P. Emsley, B. Lohkamp, W.G. Scott, and K. Cowtan Features and development of Coot Acta Crystallogr. D Biol. Crystallogr. 66 2010 486 501
20. H.O. Gutzeit, W. Eberhardt, and E. Gratwohl Laminin and basement membrane-associated microfilaments in wild-type and mutant Drosophila ovarian follicles J. Cell Sci. 100 1991 781 788
21. N.C. Hartman, and J.T. Groves Signaling clusters in the cell membrane Curr. Opin. Cell Biol. 23 2011 370 376
22. A.H. Hawasli, D.R. Benavides, C. Nguyen, J.W. Kansy, K. Hayashi, P. Chambon, P. Greengard, C.M. Powell, D.C. Cooper, and J.A. Bibb Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation Nat. Neurosci. 10 2007 880 886
23. H.Y. Ho, R. Rohatgi, A.M. Lebensohn, Le Ma, J. Li, S.P. Gygi, and M.W. Kirschner Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex Cell 118 2004 203 216
24. P.V. Hornbeck, J.M. Kornhauser, S. Tkachev, B. Zhang, E. Skrzypek, B. Murray, V. Latham, and M. Sullivan PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse Nucleic Acids Res. 40 Database issue 2012 D261 D270
25. A.M. Hudson, and L. Cooley A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex J. Cell Biol. 156 2002 677 687
26. A.M. Hudson, and L. Cooley Understanding the function of actin-binding proteins through genetic analysis of Drosophila oogenesis Annu. Rev. Genet. 36 2002 455 488
27. A.M. Ismail, S.B. Padrick, B. Chen, J. Umetani, and M.K. Rosen The WAVE regulatory complex is inhibited Nat. Struct. Mol. Biol. 16 2009 561 563
28. A.V. Karpushev, V. Levchenko, D.V. Ilatovskaya, T.S. Pavlov, and A. Staruschenko Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel Hypertension 57 2011 996 1002
29. Y. Kim, J.Y. Sung, I. Ceglia, K.W. Lee, J.H. Ahn, J.M. Halford, A.M. Kim, S.P. Kwak, J.B. Park, and S. Ho Ryu et al. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology Nature 442 2006 814 817
30. N. King, M.J. Westbrook, S.L. Young, A. Kuo, M. Abedin, J. Chapman, S. Fairclough, U. Hellsten, Y. Isogai, and I. Letunic et al. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans Nature 451 2008 783 788
31. W. Kolanus, C. Romeo, and B. Seed T cell activation by clustered tyrosine kinases Cell 74 1993 171 183
32. V. Koronakis, P.J. Hume, D. Humphreys, T. Liu, O. Hørning, O.N. Jensen, and E.J. McGhie WAVE regulatory complex activation by cooperating GTPases Arf and Rac1 Proc. Natl. Acad. Sci. USA 108 2011 14449 14454
33. L. Lane, G. Argoud-Puy, A. Britan, I. Cusin, P.D. Duek, O. Evalet, A. Gateau, P. Gaudet, A. Gleizes, and A. Masselot et al. neXtProt: a knowledge platform for human proteins Nucleic Acids Res. 40 Database issue 2012 D76 D83
34. A.M. Lebensohn, and M.W. Kirschner Activation of the WAVE complex by coincident signals controls actin assembly Mol. Cell 36 2009 512 524
35. E.M. Morrow, S.Y. Yoo, S.W. Flavell, T.K. Kim, Y. Lin, R.S. Hill, N.M. Mukaddes, S. Balkhy, G. Gascon, and A. Hashmi et al. Identifying autism loci and genes by tracing recent shared ancestry Science 321 2008 218 223
36. S. Nakao, A. Platek, S. Hirano, and M. Takeichi Contact-dependent promotion of cell migration by the OL-protocadherin-Nap1 interaction J. Cell Biol. 182 2008 395 410
37. I. Napoli, V. Mercaldo, P.P. Boyl, B. Eleuteri, F. Zalfa, S. De Rubeis, D. Di Marino, E. Mohr, M. Massimi, and M. Falconi et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP Cell 134 2008 1042 1054
38. H. Oda, Y. Imai, Y. Nakatsuru, J. Hata, and T. Ishikawa Somatic mutations of the APC gene in sporadic hepatoblastomas Cancer Res. 56 1996 3320 3323
39. T. Oikawa, H. Yamaguchi, T. Itoh, M. Kato, T. Ijuin, D. Yamazaki, S. Suetsugu, and T. Takenawa PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia Nat. Cell Biol. 6 2004 420 426
40. S.B. Padrick, and M.K. Rosen Physical mechanisms of signal integration by WASP family proteins Annu. Rev. Biochem. 79 2010 707 735
41. S.B. Padrick, H.C. Cheng, A.M. Ismail, S.C. Panchal, L.K. Doolittle, S. Kim, B.M. Skehan, J. Umetani, C.A. Brautigam, J.M. Leong, and M.K. Rosen Hierarchical regulation of WASP/WAVE proteins Mol. Cell 32 2008 426 438
42. S. Pathirana, D. Zhao, and M. Bownes The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping Mech. Dev. 109 2001 137 150
43. A.Y. Pollitt, and R.H. Insall WASP and SCAR/WAVE proteins: the drivers of actin assembly J. Cell Sci. 122 2009 2575 2578
44. P. Rørth Gal4 in the Drosophila female germline Mech. Dev. 78 1998 113 118
45. E.M. Roulier, S. Panzer, and S.K. Beckendorf The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development Mol. Cell 1 1998 819 829
46. J.R. Ryu, A. Echarri, R. Li, and A.M. Pendergast Regulation of cell-cell adhesion by Abi/Diaphanous complexes Mol. Cell. Biol. 29 2009 1735 1748
47. T. Schwabe, R.J. Bainton, R.D. Fetter, U. Heberlein, and U. Gaul GPCR signaling is required for blood-brain barrier formation in drosophila Cell 123 2005 133 144
48. M. Srivastava, E. Begovic, J. Chapman, N.H. Putnam, U. Hellsten, T. Kawashima, A. Kuo, T. Mitros, A. Salamov, and M.L. Carpenter et al. The Trichoplax genome and the nature of placozoans Nature 454 2008 955 960
49. A.K. Stavoe, J.C. Nelson, L.A. Martínez-Velázquez, M. Klein, A.D. Samuel, and D.A. Colón-Ramos Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin Genes Dev. 26 2012 2206 2221
50. R. Stephan, C. Gohl, A. Fleige, C. Klämbt, and S. Bogdan Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila Mol. Biol. Cell 22 2011 4079 4092
51. S. Suetsugu, S. Kurisu, T. Oikawa, D. Yamazaki, A. Oda, and T. Takenawa Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac J. Cell Biol. 173 2006 571 585
52. K. Tai, M. Kubota, K. Shiono, H. Tokutsu, and S.T. Suzuki Adhesion properties and retinofugal expression of chicken protocadherin-19 Brain Res. 1344 2010 13 24
53. T. Takenawa, and S. Suetsugu The WASP-WAVE protein network: connecting the membrane to the cytoskeleton Nat. Rev. Mol. Cell Biol. 8 2007 37 48
54. M. Uemura, S. Nakao, S.T. Suzuki, M. Takeichi, and S. Hirano OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections Nat. Neurosci. 10 2007 1151 1159
55. I. Viktorinová, T. König, K. Schlichting, and C. Dahmann The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary Development 136 2009 4123 4132
56. O.D. Weiner, M.C. Rentel, A. Ott, G.E. Brown, M. Jedrychowski, M.B. Yaffe, S.P. Gygi, L.C. Cantley, H.R. Bourne, and M.W. Kirschner Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis PLoS Biol. 4 2006 e38
57. N. Wittenmayer, C. Körber, H. Liu, T. Kremer, F. Varoqueaux, E.R. Chapman, N. Brose, T. Kuner, and T. Dresbach Postsynaptic Neuroligin1 regulates presynaptic maturation Proc. Natl. Acad. Sci. USA 106 2009 13564 13569
58. J. Ying, H. Li, T.J. Seng, C. Langford, G. Srivastava, S.W. Tsao, T. Putti, P. Murray, A.T. Chan, and Q. Tao Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation Oncogene 25 2006 1070 1080
59. J.A. Zallen, Y. Cohen, A.M. Hudson, L. Cooley, E. Wieschaus, and E.D. Schejter SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila J. Cell Biol. 156 2002 689 701
60. T. Zobel, and S. Bogdan A high resolution view of the fly actin cytoskeleton lacking a functional WAVE complex J. Microsc. 251 2013 224 231
61. C. Adrain, M. Zettl, Y. Christova, N. Taylor, and M. Freeman Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE Science 335 2012 225 228
62. N. Al Tassan, D. Khalil, J. Shinwari, L. Al Sharif, P. Bavi, Z. Abduljaleel, N. Abu Dhaim, A. Magrashi, S. Bobis, and H. Ahmed et al. A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia Hum. Mutat. 33 2012 351 354
63. N. Anastasio, T. Ben-Omran, A. Teebi, K.C. Ha, E. Lalonde, R. Ali, M. Almureikhi, V.M. Der Kaloustian, J. Liu, and D.S. Rosenblatt et al. Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome Am. J. Hum. Genet. 87 2010 553 559
64. A. Anitha, K. Nakamura, K. Yamada, S. Suda, I. Thanseem, M. Tsujii, Y. Iwayama, E. Hattori, T. Toyota, and T. Miyachi et al. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism Am. J. Med. Genet. B. Neuropsychiatr. Genet. 147B 2008 1019 1027
65. J. Aruga, N. Yokota, and K. Mikoshiba Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue Gene 315 2003 87 94
66. H. Asao, Y. Sasaki, T. Arita, N. Tanaka, K. Endo, H. Kasai, T. Takeshita, Y. Endo, T. Fujita, and K. Sugamura Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth J. Biol. Chem. 272 1997 32785 32791
67. M. Ashburner, C.A. Ball, J.A. Blake, D. Botstein, H. Butler, J.M. Cherry, A.P. Davis, K. Dolinski, S.S. Dwight, J.T. Eppig The Gene Ontology Consortium Gene ontology: tool for the unification of biology Nat. Genet. 25 2000 25 29
68. L. Backx, B. Ceulemans, J.R. Vermeesch, K. Devriendt, and H. Van Esch Early myoclonic encephalopathy caused by a disruption of the neuregulin-1 receptor ErbB4 Eur. J. Hum. Genet. 17 2009 378 382
69. W.F. Bahou, A.D. Campbell, and M.S. Wicha cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression J. Biol. Chem. 267 1992 13986 13992
70. S.M. Baig, A. Koschak, A. Lieb, M. Gebhart, C. Dafinger, G. Nürnberg, A. Ali, I. Ahmad, M.J. Sinnegger-Brauns, and N. Brandt et al. Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness Nat. Neurosci. 14 2011 77 84
71. S. Begni, M. Popoli, S. Moraschi, S. Bignotti, G.B. Tura, and M. Gennarelli Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia Mol. Psychiatry 7 2002 416 418
72. S. Berkel, C.R. Marshall, B. Weiss, J. Howe, R. Roeth, U. Moog, V. Endris, W. Roberts, P. Szatmari, and D. Pinto et al. Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation Nat. Genet. 42 2010 489 491
73. B. Bettler, J. Egebjerg, G. Sharma, G. Pecht, I. Hermans-Borgmeyer, C. Moll, C.F. Stevens, and S. Heinemann Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit Neuron 8 1992 257 265
74. I.M. Blasutig, L.A. New, A. Thanabalasuriar, T.K. Dayarathna, M. Goudreault, S.E. Quaggin, S.S. Li, S. Gruenheid, N. Jones, and T. Pawson Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization Mol. Cell. Biol. 28 2008 2035 2046
75. D.C. Blaydon, S.L. Etheridge, J.M. Risk, H.C. Hennies, L.J. Gay, R. Carroll, V. Plagnol, F.E. McRonald, H.P. Stevens, and N.K. Spurr et al. RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome Am. J. Hum. Genet. 90 2012 340 346
76. H.P. Bogerd, R.A. Fridell, S. Madore, and B.R. Cullen Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins Cell 82 1995 485 494
77. M.F. Bolliger, J. Pei, S. Maxeiner, A.A. Boucard, N.V. Grishin, and T.C. Südhof Unusually rapid evolution of Neuroligin-4 in mice Proc. Natl. Acad. Sci. USA 105 2008 6421 6426
78. M.F. Bolliger, D.C. Martinelli, and T.C. Südhof The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins Proc. Natl. Acad. Sci. USA 108 2011 2534 2539
79. E. Bonora, J.A. Lamb, G. Barnby, N. Sykes, T. Moberly, K.S. Beyer, S.M. Klauck, F. Poustka, E. Bacchelli, F. Blasi International Molecular Genetic Study of Austism Consortium Mutation screening and association analysis of six candidate genes for autism on chromosome 7q Eur. J. Hum. Genet. 13 2005 198 207
80. R. Brugada, K. Hong, R. Dumaine, J. Cordeiro, F. Gaita, M. Borggrefe, T.M. Menendez, J. Brugada, G.D. Pollevick, and C. Wolpert et al. Sudden death associated with short-QT syndrome linked to mutations in HERG Circulation 109 2004 30 35
81. P.D. Burbelo, D.M. Snow, W. Bahou, and S. Spiegel MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts Proc. Natl. Acad. Sci. USA 96 1999 9083 9088
82. C.J. Büsst, L.D. Bloomer, K.J. Scurrah, J.A. Ellis, T.A. Barnes, F.J. Charchar, P. Braund, P.N. Hopkins, N.J. Samani, and S.C. Hunt et al. The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses Hypertension 58 2011 1073 1078
83. D. Castermans, V. Wilquet, E. Parthoens, C. Huysmans, J. Steyaert, L. Swinnen, J.P. Fryns, W. Van de Ven, and K. Devriendt The neurobeachin gene is disrupted by a translocation in a patient with idiopathic autism J. Med. Genet. 40 2003 352 356
84. P.L. Channavajhala, L. Wu, J.W. Cuozzo, J.P. Hall, W. Liu, L.L. Lin, and Y. Zhang Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling J. Biol. Chem. 278 2003 47089 47097
85. L.P. Cid, C. Montrose-Rafizadeh, D.I. Smith, W.B. Guggino, and G.R. Cutting Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues Hum. Mol. Genet. 4 1995 407 413
86. G.L. Costa, J.M. Benson, C.M. Seroogy, P. Achacoso, C.G. Fathman, and G.P. Nolan Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease J. Immunol. 164 2000 3581 3590
87. M.E. Curran, I. Splawski, K.W. Timothy, G.M. Vincent, E.D. Green, and M.T. Keating A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome Cell 80 1995 795 803
88. A. Dallol, E. Forgacs, A. Martinez, Y. Sekido, R. Walker, T. Kishida, P. Rabbitts, E.R. Maher, J.D. Minna, and F. Latif Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers Oncogene 21 2002 3020 3028
89. A.R. Dallosso, A.L. Hancock, M. Szemes, K. Moorwood, L. Chilukamarri, H.H. Tsai, A. Sarkar, J. Barasch, R. Vuononvirta, and C. Jones et al. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor PLoS Genet. 5 2009 e1000745
90. A.T. De Souza, G.R. Hankins, M.K. Washington, T.C. Orton, and R.L. Jirtle M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity Nat. Genet. 11 1995 447 449
91. M. Deguchi, Y. Hata, M. Takeuchi, N. Ide, K. Hirao, I. Yao, M. Irie, A. Toyoda, and Y. Takai BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein J. Biol. Chem. 273 1998 26269 26272
92. C. Depienne, D. Bouteiller, B. Keren, E. Cheuret, K. Poirier, O. Trouillard, B. Benyahia, C. Quelin, W. Carpentier, and S. Julia et al. Sporadic infantile epileptic encephalopathy caused by mutations in PCDH19 resembles Dravet syndrome but mainly affects females PLoS Genet. 5 2009 e1000381
93. C. Depienne, O. Trouillard, D. Bouteiller, I. Gourfinkel-An, K. Poirier, F. Rivier, P. Berquin, R. Nabbout, D. Chaigne, and D. Steschenko et al. Mutations and deletions in PCDH19 account for various familial or isolated epilepsies in females Hum. Mutat. 32 2011 E1959 E1975
94. E. Derivery, C. Sousa, J.J. Gautier, B. Lombard, D. Loew, and A. Gautreau The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex Dev. Cell 17 2009 712 723
95. P. Devarajan, D.A. Scaramuzzino, and J.S. Morrow Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase alpha subunit Proc. Natl. Acad. Sci. USA 91 1994 2965 2969
96. M.L. Dietz, T.M. Bernaciak, F. Vendetti, J.M. Kielec, and J.D. Hildebrand Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins J. Biol. Chem. 281 2006 20542 20554
97. L. Ding, G. Getz, D.A. Wheeler, E.R. Mardis, M.D. McLellan, K. Cibulskis, C. Sougnez, H. Greulich, D.M. Muzny, and M.B. Morgan et al. Somatic mutations affect key pathways in lung adenocarcinoma Nature 455 2008 1069 1075
98. H. Doi, K. Yoshida, T. Yasuda, M. Fukuda, Y. Fukuda, H. Morita, S. Ikeda, R. Kato, Y. Tsurusaki, and N. Miyake et al. Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation Am. J. Hum. Genet. 89 2011 320 327
99. D.B. Donoviel, D.D. Freed, H. Vogel, D.G. Potter, E. Hawkins, J.P. Barrish, B.N. Mathur, C.A. Turner, R. Geske, and C.A. Montgomery et al. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN Mol. Cell. Biol. 21 2001 4829 4836
100. Y. Du, S.A. Weed, W.C. Xiong, T.D. Marshall, and J.T. Parsons Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons Mol. Cell. Biol. 18 1998 5838 5851
101. M.G. Dunlop, S.E. Dobbins, S.M. Farrington, A.M. Jones, C. Palles, N. Whiffin, A. Tenesa, S. Spain, P. Broderick, L.Y. Ooi Colorectal Tumour Gene Identification (CORGI) Consortium Swedish Low-Risk Colorectal Cancer Study Group COIN Collaborative Group Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk Nat. Genet. 44 2012 770 776
102. V.G. Dyomin, S.R. Chaganti, K. Dyomina, N. Palanisamy, V.V. Murty, R. Dalla-Favera, and R.S. Chaganti BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function Genomics 80 2002 158 165
103. S. Endele, G. Rosenberger, K. Geider, B. Popp, C. Tamer, I. Stefanova, M. Milh, F. Kortüm, A. Fritsch, and F.K. Pientka et al. Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes Nat. Genet. 42 2010 1021 1026
104. A. Erhardt, L. Czibere, D. Roeske, S. Lucae, P.G. Unschuld, S. Ripke, M. Specht, M.A. Kohli, S. Kloiber, and M. Ising et al. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies Mol. Psychiatry 16 2011 647 663
105. R. Etournay, I. Zwaenepoel, I. Perfettini, P. Legrain, C. Petit, and A. El-Amraoui Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions J. Cell Sci. 120 2007 2838 2850
106. C. Faivre-Sarrailh, J. Falk, E. Pollerberg, M. Schachner, and G. Rougon NrCAM, cerebellar granule cell receptor for the neuronal adhesion molecule F3, displays an actin-dependent mobility in growth cones J. Cell Sci. 112 1999 3015 3027
107. E.R. Fearon, K.R. Cho, J.M. Nigro, S.E. Kern, J.W. Simons, J.M. Ruppert, S.R. Hamilton, A.C. Preisinger, G. Thomas, and K.W. Kinzler et al. Identification of a chromosome 18q gene that is altered in colorectal cancers Science 247 1990 49 56
108. K.A. Feldmann, M.R. Pittelkow, P.C. Roche, R. Kumar, and J.P. Grande Expression of an immediate early gene, IEX-1, in human tissues Histochem. Cell Biol. 115 2001 489 497
109. R.E. Ferrell, K.L. Levinson, J.H. Esman, M.A. Kimak, E.C. Lawrence, M.M. Barmada, and D.N. Finegold Hereditary lymphedema: evidence for linkage and genetic heterogeneity Hum. Mol. Genet. 7 1998 2073 2078
110. M. Franco, P.J. Peters, J. Boretto, E. van Donselaar, A. Neri, C. D'Souza-Schorey, and P. Chavrier EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization EMBO J. 18 1999 1480 1491
111. G. Gamba, A. Miyanoshita, M. Lombardi, J. Lytton, W.S. Lee, M.A. Hediger, and S.C. Hebert Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney J. Biol. Chem. 269 1994 17713 17722
112. P. Garg, R. Verma, D. Nihalani, D.B. Johnstone, and L.B. Holzman Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization Mol. Cell. Biol. 27 2007 8698 8712
113. D.S. Geller, J. Rodriguez-Soriano, A. Vallo Boado, S. Schifter, M. Bayer, S.S. Chang, and R.P. Lifton Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I Nat. Genet. 19 1998 279 281
114. D.S. Geller, A. Farhi, N. Pinkerton, M. Fradley, M. Moritz, A. Spitzer, G. Meinke, F.T. Tsai, P.B. Sigler, and R.P. Lifton Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy Science 289 2000 119 123
115. J. Giza, M.J. Urbanski, F. Prestori, B. Bandyopadhyay, A. Yam, V. Friedrich, K. Kelley, E. D'Angelo, and M. Goldfarb Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2 J. Neurosci. 30 2010 14805 14816
116. J.T. Glessner, K. Wang, G. Cai, O. Korvatska, C.E. Kim, S. Wood, H. Zhang, A. Estes, C.W. Brune, and J.P. Bradfield et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes Nature 459 2009 569 573
117. T. GrandPré, F. Nakamura, T. Vartanian, and S.M. Strittmatter Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein Nature 403 2000 439 444
118. S.P. Gregório, P.C. Sallet, K.A. Do, E. Lin, W.F. Gattaz, and E. Dias-Neto Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence Psychiatry Res. 165 2009 1 9
119. C. Grimm, R. Kraft, S. Sauerbruch, G. Schultz, and C. Harteneck Molecular and functional characterization of the melastatin-related cation channel TRPM3 J. Biol. Chem. 278 2003 21493 21501
120. M. Grumet, V. Mauro, M.P. Burgoon, G.M. Edelman, and B.A. Cunningham Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules J. Cell Biol. 113 1991 1399 1412
121. J. Gudmundsson, P. Sulem, D.F. Gudbjartsson, J.G. Jonasson, G. Masson, H. He, A. Jonasdottir, A. Sigurdsson, S.N. Stacey, and H. Johannsdottir et al. Discovery of common variants associated with low TSH levels and thyroid cancer risk Nat. Genet. 44 2012 319 322
122. D. Guo, C. Holmlund, R. Henriksson, and H. Hedman The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea Genomics 84 2004 157 165
123. K. Håberg, R. Lundmark, and S.R. Carlsson SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking J. Cell Sci. 121 2008 1495 1505
124. O. Hagens, A. Dubos, F. Abidi, G. Barbi, L. Van Zutven, M. Hoeltzenbein, N. Tommerup, C. Moraine, J.P. Fryns, and J. Chelly et al. Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation Hum. Genet. 118 2006 578 590
125. K. Hannula-Jouppi, N. Kaminen-Ahola, M. Taipale, R. Eklund, J. Nopola-Hemmi, H. Kääriäinen, and J. Kere The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia PLoS Genet. 1 2005 e50
126. J.H. Hansson, C. Nelson-Williams, H. Suzuki, L. Schild, R. Shimkets, Y. Lu, C. Canessa, T. Iwasaki, B. Rossier, and R.P. Lifton Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome Nat. Genet. 11 1995 76 82
127. S. Haruki, I. Imoto, K. Kozaki, T. Matsui, H. Kawachi, S. Komatsu, T. Muramatsu, Y. Shimada, T. Kawano, and J. Inazawa Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma Carcinogenesis 31 2010 1027 1036
128. M.M. Hijazi, E.W. Thompson, C. Tang, P. Coopman, J.A. Torri, D. Yang, S.C. Mueller, and R. Lupu Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines Int. J. Oncol. 17 2000 629 641
129. J.D. Hildebrand, and P. Soriano Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice Cell 99 1999 485 497
130. S. Hirano, Q. Yan, and S.T. Suzuki Expression of a novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain J. Neurosci. 19 1999 995 1005
131. S.E. Holmes, E. O'Hearn, A. Rosenblatt, C. Callahan, H.S. Hwang, R.G. Ingersoll-Ashworth, A. Fleisher, G. Stevanin, A. Brice, and N.T. Potter et al. A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2 Nat. Genet. 29 2001 377 378
132. T. Hummel, K. Leifker, and C. Klämbt The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization Genes Dev. 14 2000 863 873
133. P.M. Hwang, C.E. Glatt, D.S. Bredt, G. Yellen, and S.H. Snyder A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization Neuron 8 1992 473 481
134. K. Ichtchenko, Y. Hata, T. Nguyen, B. Ullrich, M. Missler, C. Moomaw, and T.C. Südhof Neuroligin 1: a splice site-specific ligand for beta-neurexins Cell 81 1995 435 443
135. Y. Imai, M. Soda, H. Inoue, N. Hattori, Y. Mizuno, and R. Takahashi An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Cell 105 2001 891 902
136. A. Irrthum, M.J. Karkkainen, K. Devriendt, K. Alitalo, and M. Vikkula Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase Am. J. Hum. Genet. 67 2000 295 301
137. H. Ishiguro, Q.R. Liu, J.P. Gong, F.S. Hall, H. Ujike, M. Morales, T. Sakurai, M. Grumet, and G.R. Uhl NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice Neuropsychopharmacology 31 2006 572 584
138. J. Ishii, H. Adachi, J. Aoki, H. Koizumi, S. Tomita, T. Suzuki, M. Tsujimoto, K. Inoue, and H. Arai SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain J. Biol. Chem. 277 2002 39696 39702
139. B. Isidor, M. Le Merrer, G.U. Exner, O. Pichon, G. Thierry, A. Guiochon-Mantel, A. David, V. Cormier-Daire, and C. Le Caignec Serpentine fibula-polycystic kidney syndrome caused by truncating mutations in NOTCH2 Hum. Mutat. 32 2011 1239 1242
140. B. Isidor, P. Lindenbaum, O. Pichon, S. Bézieau, C. Dina, S. Jacquemont, D. Martin-Coignard, C. Thauvin-Robinet, M. Le Merrer, and J.L. Mandel et al. Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis Nat. Genet. 43 2011 306 308
141. S. Jamain, H. Quach, C. Betancur, M. Råstam, C. Colineaux, I.C. Gillberg, H. Soderstrom, B. Giros, M. Leboyer, C. Gillberg, T. Bourgeron Paris Autism Research International Sibpair Study Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism Nat. Genet. 34 2003 27 29
142. S.M. Jamal, R.K. Basran, S. Newton, Z. Wang, and J.M. Milunsky Novel de novo PCDH19 mutations in three unrelated females with epilepsy female restricted mental retardation syndrome Am. J. Med. Genet. A. 152A 2010 2475 2481
143. J.C. Jen, W.M. Chan, T.M. Bosley, J. Wan, J.R. Carr, U. Rüb, D. Shattuck, G. Salamon, L.C. Kudo, and J. Ou et al. Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis Science 304 2004 1509 1513
144. Z.A. Jenkins, M. van Kogelenberg, T. Morgan, A. Jeffs, R. Fukuzawa, E. Pearl, C. Thaller, A.V. Hing, M.E. Porteous, and S. Garcia-Miñaur et al. Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis Nat. Genet. 41 2009 95 100
145. G. Jun, M. Nicolaou, M.A. Morrison, J. Buros, D.J. Morgan, M.J. Radeke, Y. Yonekawa, E.E. Tsironi, M.G. Kotoula, and F. Zacharaki et al. Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology PLoS ONE 6 2011 e25775
146. E. Kaiser, R. Förster, I. Wolf, C. Ebensperger, W.M. Kuehl, and M. Lipp The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues Eur. J. Immunol. 23 1993 2532 2539
147. P.A. Kanetsky, N. Mitra, S. Vardhanabhuti, M. Li, D.J. Vaughn, R. Letrero, S.L. Ciosek, D.R. Doody, L.M. Smith, and J. Weaver et al. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer Nat. Genet. 41 2009 811 815
148. H. Kariyazono, T. Ohno, V. Khajoee, K. Ihara, K. Kusuhara, N. Kinukawa, Y. Mizuno, and T. Hara Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease Pediatr. Res. 56 2004 953 959
149. M.J. Karkkainen, R.E. Ferrell, E.C. Lawrence, M.A. Kimak, K.L. Levinson, M.A. McTigue, K. Alitalo, and D.N. Finegold Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema Nat. Genet. 25 2000 153 159
150. J. Kasnauskiene, Z. Ciuladaite, E. Preiksaitiene, A. Matulevič iene, A. Alexandrou, G. Koumbaris, C. Sismani, I. Pepalyte, P.C. Patsalis, and V. Kučinskas A single gene deletion on 4q28.3: PCDH18 - a new candidate gene for intellectual disability? Eur. J. Med. Genet. 55 2012 274 277
151. L. Kaufman, K. Hayashi, M.J. Ross, M.D. Ross, and P.E. Klotman Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy J. Am. Soc. Nephrol. 15 2004 1721 1730
152. L. Kaufman, G. Yang, K. Hayashi, J.R. Ashby, L. Huang, M.J. Ross, M.E. Klotman, and P.E. Klotman The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy FASEB J. 21 2007 1367 1375
153. J.H. Kim, M. Park, S.Y. Yang, B.S. Jeong, H.J. Yoo, J.W. Kim, J.H. Chung, and S.A. Kim Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism Neurosci. Res. 56 2006 220 223
154. J. Klingensmith, Y. Yang, J.D. Axelrod, D.R. Beier, N. Perrimon, and D.J. Sussman Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2 Mech. Dev. 58 1996 15 26
155. N. Kohmura, K. Senzaki, S. Hamada, N. Kai, R. Yasuda, M. Watanabe, H. Ishii, M. Yasuda, M. Mishina, and T. Yagi Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex Neuron 20 1998 1137 1151
156. A. Köttgen, N.L. Glazer, A. Dehghan, S.J. Hwang, R. Katz, M. Li, Q. Yang, V. Gudnason, L.J. Launer, and T.B. Harris et al. Multiple loci associated with indices of renal function and chronic kidney disease Nat. Genet. 41 2009 712 717
157. S. Krugmann, K.E. Anderson, S.H. Ridley, N. Risso, A. McGregor, J. Coadwell, K. Davidson, A. Eguinoa, C.D. Ellson, and P. Lipp et al. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices Mol. Cell 9 2002 95 108
158. H. Kuniba, K. Yoshiura, T. Kondoh, H. Ohashi, K. Kurosawa, H. Tonoki, T. Nagai, N. Okamoto, M. Kato, and Y. Fukushima et al. Molecular karyotyping in 17 patients and mutation screening in 41 patients with Kabuki syndrome J. Hum. Genet. 54 2009 304 309
159. S. Kupershmidt, T. Yang, S. Chanthaphaychith, Z. Wang, J.A. Towbin, and D.M. Roden Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus J. Biol. Chem. 277 2002 27442 27448
160. F. Laumonnier, F. Bonnet-Brilhault, M. Gomot, R. Blanc, A. David, M.P. Moizard, M. Raynaud, N. Ronce, E. Lemonnier, and P. Calvas et al. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family Am. J. Hum. Genet. 74 2004 552 557
161. A.J. Law, J.E. Kleinman, D.R. Weinberger, and C.S. Weickert Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia Hum. Mol. Genet. 16 2007 129 141
162. A. Lawson-Yuen, J.S. Saldivar, S. Sommer, and J. Picker Familial deletion within NLGN4 associated with autism and Tourette syndrome Eur. J. Hum. Genet. 16 2008 614 618
163. N. Lee, J. Chen, L. Sun, S. Wu, K.R. Gray, A. Rich, M. Huang, J.H. Lin, J.N. Feder, and E.B. Janovitz et al. Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3) J. Biol. Chem. 278 2003 20890 20897
164. M.Z. Li, and S.J. Elledge Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC Nat. Methods 4 2007 251 256
165. S. Lim, S. Naisbitt, J. Yoon, J.I. Hwang, P.G. Suh, M. Sheng, and E. Kim Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development J. Biol. Chem. 274 1999 29510 29518
166. E.V. Linardopoulou, S.S. Parghi, C. Friedman, G.E. Osborn, S.M. Parkhurst, and B.J. Trask Human subtelomeric WASH genes encode a new subclass of the WASP family PLoS Genet. 3 2007 e237
167. D. Ludwig, J. Lorenz, E. Dejana, P. Bohlen, D.J. Hicklin, L. Witte, and B. Pytowski cDNA cloning, chromosomal mapping, and expression analysis of human VE-Cadherin-2 Mamm. Genome 11 2000 1030 1033
168. D. Marazziti, E. Golini, A. Gallo, M.S. Lombardi, R. Matteoni, and G.P. Tocchini-Valentini Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library Genomics 45 1997 68 77
169. C. Marini, D. Mei, L. Parmeggiani, V. Norci, E. Calado, A. Ferrari, A. Moreira, T. Pisano, N. Specchio, and F. Vigevano et al. Protocadherin 19 mutations in girls with infantile-onset epilepsy Neurology 75 2010 646 653
170. C.R. Marshall, A. Noor, J.B. Vincent, A.C. Lionel, L. Feuk, J. Skaug, M. Shago, R. Moessner, D. Pinto, and Y. Ren et al. Structural variation of chromosomes in autism spectrum disorder Am. J. Hum. Genet. 82 2008 477 488
171. N. Martens, M. Wery, P. Wang, F. Braet, A. Gertler, R. Hooghe, J. Vandenhaute, and E.L. Hooghe-Peters The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin Exp. Cell Res. 298 2004 239 248
172. K. Matuoka, H. Miki, K. Takahashi, and T. Takenawa A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs Biochem. Biophys. Res. Commun. 239 1997 488 492
173. R. McDaniell, D.M. Warthen, P.A. Sanchez-Lara, A. Pai, I.D. Krantz, D.A. Piccoli, and N.B. Spinner NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway Am. J. Hum. Genet. 79 2006 169 173
174. S.O. Meakin, J.I. MacDonald, E.A. Gryz, C.J. Kubu, and J.M. Verdi The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation J. Biol. Chem. 274 1999 9861 9870
175. S.A. Meda, B. Narayanan, J. Liu, N.I. Perrone-Bizzozero, M.C. Stevens, V.D. Calhoun, D.C. Glahn, L. Shen, S.L. Risacher, A.J. Saykin, and G.D. Pearlson A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort Neuroimage 60 2012 1608 1621
176. G.F. Mells, J.A. Floyd, K.I. Morley, H.J. Cordell, C.S. Franklin, S.Y. Shin, M.A. Heneghan, J.M. Neuberger, P.T. Donaldson, D.B. Day UK PBC Consortium Wellcome Trust Case Control Consortium 3 Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis Nat. Genet. 43 2011 329 332
177. J.A. Meyerhardt, A.T. Look, S.H. Bigner, and E.R. Fearon Identification and characterization of neogenin, a DCC-related gene Oncogene 14 1997 1129 1136
178. W. Minor, M. Cymborowski, Z. Otwinowski, and M. Chruszcz HKL-3000: the integration of data reduction and structure solution - from diffraction images to an initial model in minutes Acta Crystallogr. D Biol. Crystallogr. 62 2006 859 866
179. A. Miyake, S. Mochizuki, H. Yokoi, M. Kohda, and K. Furuichi New ether-à-go-go K(+) channel family members localized in human telencephalon J. Biol. Chem. 274 1999 25018 25025
180. P.J. Mohler, J.J. Schott, A.O. Gramolini, K.W. Dilly, S. Guatimosim, W.H. duBell, L.S. Song, K. Haurogné, F. Kyndt, and M.E. Ali et al. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death Nature 421 2003 634 639
181. L. Mutesa, A.K. Azad, C. Verhaeghe, K. Segers, J.F. Vanbellinghen, L. Ngendahayo, E.K. Rusingiza, P.R. Mutwa, S. Rulisa, and L. Koulischer et al. Genetic analysis of Rwandan patients with cystic fibrosis-like symptoms: identification of novel cystic fibrosis transmembrane conductance regulator and epithelial sodium channel gene variants Chest 135 2009 1233 1242
182. R. Nabbout, C. Depienne, C. Chiron, and O. Dulac Protocadherin 19 mutations in girls with infantile-onset epilepsy Neurology 76 2011 1193 1194 author reply 1194
183. S. Nagae, T. Tanoue, and M. Takeichi Temporal and spatial expression profiles of the Fat3 protein, a giant cadherin molecule, during mouse development Dev. Dyn. 236 2007 534 543
184. S. Naisbitt, E. Kim, J.C. Tu, B. Xiao, C. Sala, J. Valtschanoff, R.J. Weinberg, P.F. Worley, and M. Sheng Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin Neuron 23 1999 569 582
185. T. Nakamura, M. Komiya, K. Sone, E. Hirose, N. Gotoh, H. Morii, Y. Ohta, and N. Mori Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules Mol. Cell. Biol. 22 2002 8721 8734
186. T. Nakazawa, A.M. Watabe, T. Tezuka, Y. Yoshida, K. Yokoyama, H. Umemori, A. Inoue, S. Okabe, T. Manabe, and T. Yamamoto p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling Mol. Biol. Cell 14 2003 2921 2934
187. Y. Nasu-Nishimura, H. Jaffe, J.T. Isaac, and K.W. Roche Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6 J. Biol. Chem. 285 2010 2847 2856
188. S. Negri, A. Oberson, M. Steinmann, C. Sauser, P. Nicod, G. Waeber, D.F. Schorderet, and C. Bonny cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein Genomics 64 2000 324 330
189. A.W. Nguyen, and P.S. Daugherty Evolutionary optimization of fluorescent proteins for intracellular FRET Nat. Biotechnol. 23 2005 355 360
190. M. Nishi, A. Mizushima, Ki. Nakagawara, and H. Takeshima Characterization of human junctophilin subtype genes Biochem. Biophys. Res. Commun. 273 2000 920 927
191. K. Nishimura, F. Yoshihara, T. Tojima, N. Ooashi, W. Yoon, K. Mikoshiba, V. Bennett, and H. Kamiguchi L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow J. Cell Biol. 163 2003 1077 1088
192. Y. Nishimura, M. Shimojima, Y. Tano, T. Miyamura, T. Wakita, and H. Shimizu Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71 Nat. Med. 15 2009 794 797
193. I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, and P. Hedge Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients Science 253 1991 665 669
194. H. Nomoto, T. Yonezawa, K. Itoh, K. Ono, K. Yamamoto, T. Oohashi, F. Shiraga, H. Ohtsuki, and Y. Ninomiya Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes J. Biochem. 134 2003 231 238
195. B.J. O'Roak, P. Deriziotis, C. Lee, L. Vives, J.J. Schwartz, S. Girirajan, E. Karakoc, A.P. Mackenzie, S.B. Ng, and C. Baker et al. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations Nat. Genet. 43 2011 585 589
196. M. Oguri, K. Kato, K. Yokoi, T. Yoshida, S. Watanabe, N. Metoki, H. Yoshida, K. Satoh, Y. Aoyagi, Y. Nozawa, and Y. Yamada Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals Am. J. Hypertens. 23 2010 70 77
197. K. Oh-hashi, Y. Naruse, F. Amaya, G. Shimosato, and M. Tanaka Cloning and characterization of a novel GRP78-binding protein in the rat brain J. Biol. Chem. 278 2003 10531 10537
198. K. Ohi, R. Hashimoto, T. Nakazawa, T. Okada, Y. Yasuda, H. Yamamori, M. Fukumoto, S. Umeda-Yano, M. Iwase, and H. Kazui et al. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits PLoS ONE 7 2012 e35696
199. P.K. Olszewski, J. Rozman, J.A. Jacobsson, B. Rathkolb, S. Strömberg, W. Hans, A. Klockars, J. Alsiö, U. Risérus, and L. Becker et al. Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans PLoS Genet. 8 2012 e1002568
200. K. Pajusola, O. Aprelikova, J. Korhonen, A. Kaipainen, L. Pertovaara, R. Alitalo, and K. Alitalo FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines Cancer Res. 52 1992 5738 5743
201. H.K. Park, H.W. Park, S.G. Jeon, E.S. Shin, Y.S. Gho, S.H. Cho, Y.Y. Kim, and Y.K. Kim Distinct association of genetic variations of vascular endothelial growth factor, transforming growth factor-beta, and fibroblast growth factor receptors with atopy and airway hyperresponsiveness Allergy 63 2008 447 453
202. A. Parnis, M. Rawet, L. Regev, B. Barkan, M. Rotman, M. Gaitner, and D. Cassel Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 isoforms J. Biol. Chem. 281 2006 3785 3792
203. J.A. Payne, J.C. Xu, M. Haas, C.Y. Lytle, D. Ward, and B. Forbush 3rd Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon J. Biol. Chem. 270 1995 17977 17985
204. E. Pedrosa, R. Stefanescu, B. Margolis, O. Petruolo, Y. Lo, K. Nolan, T. Novak, P. Stopkova, and H.M. Lachman Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia Schizophr. Res. 102 2008 210 219
205. L. Perletti, D. Talarico, D. Trecca, D. Ronchetti, N.S. Fracchiolla, A.T. Maiolo, and A. Neri Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains Genomics 46 1997 251 259
206. L.L. Peters, K.M. John, F.M. Lu, E.M. Eicher, A. Higgins, M. Yialamas, L.C. Turtzo, A.J. Otsuka, and S.E. Lux Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain J. Cell Biol. 130 1995 313 330
207. R.S. Petralia, Y.X. Wang, and R.J. Wenthold The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1 J. Neurosci. 14 1994 6102 6120
208. R.A. Philibert, S.L. Winfield, H.K. Sandhu, B.M. Martin, and E.I. Ginns The structure and expression of the human neuroligin-3 gene Gene 246 2000 303 310
209. D. Pinto, A.T. Pagnamenta, L. Klei, R. Anney, D. Merico, R. Regan, J. Conroy, T.R. Magalhaes, C. Correia, and B.S. Abrahams et al. Functional impact of global rare copy number variation in autism spectrum disorders Nature 466 2010 368 372
210. G.D. Plowman, J.M. Culouscou, G.S. Whitney, J.M. Green, G.W. Carlton, L. Foy, M.G. Neubauer, and M. Shoyab Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family Proc. Natl. Acad. Sci. USA 90 1993 1746 1750
211. S.G. Potkin, J.A. Turner, G. Guffanti, A. Lakatos, J.H. Fallon, D.D. Nguyen, D. Mathalon, J. Ford, J. Lauriello, F. Macciardi FBIRN A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype Schizophr. Bull. 35 2009 96 108
212. E. Prigmore, S. Ahmed, A. Best, R. Kozma, E. Manser, A.W. Segal, and L. Lim A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils J. Biol. Chem. 270 1995 10717 10722
213. S. Qin, X. Zhao, Y. Pan, J. Liu, G. Feng, J. Fu, J. Bao, Z. Zhang, and L. He An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray Eur. J. Hum. Genet. 13 2005 807 814
214. F. Quintero-Rivera, A. Chan, D.J. Donovan, J.F. Gusella, and A.H. Ligon Disruption of a synaptotagmin (SYT14) associated with neurodevelopmental abnormalities Am. J. Med. Genet. A. 143 2007 558 563
215. F.K. Rae, J.D. Hooper, H.J. Eyre, G.R. Sutherland, D.L. Nicol, and J.A. Clements TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma Genomics 77 2001 200 207
216. E.M. Reiman, J.A. Webster, A.J. Myers, J. Hardy, T. Dunckley, V.L. Zismann, K.D. Joshipura, J.V. Pearson, D. Hu-Lince, and M.J. Huentelman et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers Neuron 54 2007 713 720
217. M.N. Rivera, W.J. Kim, J. Wells, D.R. Driscoll, B.W. Brannigan, M. Han, J.C. Kim, A.P. Feinberg, W.L. Gerald, and S.O. Vargas et al. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor Science 315 2007 642 645
218. M.N. Rivera, W.J. Kim, J. Wells, A. Stone, A. Burger, E.J. Coffman, J. Zhang, and D.A. Haber The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity Proc. Natl. Acad. Sci. USA 106 2009 8338 8343
219. P. Rodrigues, J. Furriol, E. Tormo, S. Ballester, A. Lluch, and P. Eroles The single-nucleotide polymorphisms +936 C/T VEGF and -710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population Breast Cancer Res. Treat. 133 2012 769 778
220. J.A. Ronesi, K.A. Collins, S.A. Hays, N.P. Tsai, W. Guo, S.G. Birnbaum, J.H. Hu, P.F. Worley, J.R. Gibson, and K.M. Huber Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome Nat Neurosci. 15 2012 431 440 S431
221. S. Rot, H. Taubert, M. Bache, T. Greither, P. Würl, A.W. Eckert, J. Schubert, D. Vordermark, and M. Kappler A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients BMC Cancer 11 2011 429
222. J. Sáez de Guinoa, L. Barrio, M. Mellado, and Y.R. Carrasco CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics Blood 118 2011 1560 1569
223. H. Sakuma, A. Ikeda, S. Oka, Y. Kozutsumi, J.P. Zanetta, and T. Kawasaki Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain J. Biol. Chem. 272 1997 28622 28629
224. D. Sato, A.C. Lionel, C.S. Leblond, A. Prasad, D. Pinto, S. Walker, I. O'Connor, C. Russell, I.E. Drmic, and F.F. Hamdan et al. SHANK1 Deletions in Males with Autism Spectrum Disorder Am. J. Hum. Genet. 90 2012 879 887
225. M.V. Schiaffino, M.T. Bassi, E.I. Rugarli, A. Renieri, L. Galli, and A. Ballabio Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region Hum. Mol. Genet. 4 1995 373 382
226. H.H. Schiffer, and S.F. Heinemann Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder Am. J. Med. Genet. B. Neuropsychiatr. Genet. 144B 2007 20 26
227. M. Shekarabi, and T.E. Kennedy The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1 Mol. Cell. Neurosci. 19 2002 1 17
228. T. Shiratsuchi, H. Nishimori, H. Ichise, Y. Nakamura, and T. Tokino Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) Cytogenet. Cell Genet. 79 1997 103 108
229. D.B. Simon, F.E. Karet, J.M. Hamdan, A. DiPietro, S.A. Sanjad, and R.P. Lifton Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2 Nat. Genet. 13 1996 183 188
230. M.A. Simpson, M.D. Irving, E. Asilmaz, M.J. Gray, D. Dafou, F.V. Elmslie, S. Mansour, S.E. Holder, C.E. Brain, and B.K. Burton et al. Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss Nat. Genet. 43 2011 303 305
231. K.Y. Siu, M.K. Yu, X. Wu, M. Zong, M.G. Roth, H.C. Chan, and S. Yu The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1 PLoS ONE 6 2011 e18458
232. K.R. Snapp, C.E. Heitzig, and G.S. Kansas Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin Blood 99 2002 4494 4502
233. H. Song, D. Tong, Z. Cha, and J. Bai C-X-C chemokine receptor type 5 gene polymorphisms are associated with non-Hodgkin lymphoma Mol. Biol. Rep. 39 2012 8629 8635
234. I. Splawski, J. Shen, K.W. Timothy, M.H. Lehmann, S. Priori, J.L. Robinson, A.J. Moss, P.J. Schwartz, J.A. Towbin, G.M. Vincent, and M.T. Keating Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2 Circulation 102 2000 1178 1185
235. M. Srour, J.B. Rivière, J.M. Pham, M.P. Dubé, S. Girard, S. Morin, P.A. Dion, G. Asselin, D. Rochefort, and P. Hince et al. Mutations in DCC cause congenital mirror movements Science 328 2010 592
236. D.P. Steensma, J.D. Neiger, J.C. Porcher, J.J. Keats, P.L. Bergsagel, T.R. Dennis, R.A. Knudson, R.B. Jenkins, R. Santana-Davila, R. Kumar, and R.P. Ketterling Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes Cancer Res. 69 2009 7518 7523
237. H. Stefansson, E. Sigurdsson, V. Steinthorsdottir, S. Bjornsdottir, T. Sigmundsson, S. Ghosh, J. Brynjolfsson, S. Gunnarsdottir, O. Ivarsson, and T.T. Chou et al. Neuregulin 1 and susceptibility to schizophrenia Am. J. Hum. Genet. 71 2002 877 892
238. S.S. Strautnieks, R.J. Thompson, R.M. Gardiner, and E. Chung A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families Nat. Genet. 13 1996 248 250
239. S. Strehl, K. Glatt, Q.M. Liu, H. Glatt, and M. Lalande Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14 Genomics 53 1998 81 89
240. V. Sundaresan, I. Roberts, A. Bateman, A. Bankier, M. Sheppard, C. Hobbs, J. Xiong, J. Minna, F. Latif, M. Lerman, and P. Rabbitts The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression Mol. Cell. Neurosci. 11 1998 29 35
241. M.E. Talkowski, J.A. Rosenfeld, I. Blumenthal, V. Pillalamarri, C. Chiang, A. Heilbut, C. Ernst, C. Hanscom, E. Rossin, and A.M. Lindgren et al. Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries Cell 149 2012 525 537
242. M. Tariq, J.W. Belmont, S. Lalani, T. Smolarek, and S.M. Ware SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing Genome Biol. 12 2011 R91
243. T.D. Tayler, and P.A. Garrity Axon targeting in the Drosophila visual system Curr. Opin. Neurobiol. 13 2003 90 95
244. G.B. Triana-Baltzer, and M. Blank Cytoplasmic domain of protocadherin-alpha enhances homophilic interactions and recognizes cytoskeletal elements J. Neurobiol. 66 2006 393 407
245. M. Uhlen, P. Oksvold, L. Fagerberg, E. Lundberg, K. Jonasson, M. Forsberg, M. Zwahlen, C. Kampf, K. Wester, and S. Hober et al. Towards a knowledge-based Human Protein Atlas Nat. Biotechnol. 28 2010 1248 1250
246. UniProt Consortium Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40 Database issue 2012 D71 D75
247. J.W. Walter, P.E. North, M. Waner, A. Mizeracki, F. Blei, J.W. Walker, J.F. Reinisch, and D.A. Marchuk Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma Genes Chromosomes Cancer 33 2002 295 303
248. Z.X. Wang An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule FEBS Lett. 360 1995 111 114
249. J.F. Wang, X.F. Zhang, and J.E. Groopman Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration J. Biol. Chem. 276 2001 41950 41957
250. Y. Wang, J.A. Kelber, H.S. Tran Cao, G.T. Cantin, R. Lin, W. Wang, S. Kaushal, J.M. Bristow, T.S. Edgington, and R.M. Hoffman et al. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected] Proc. Natl. Acad. Sci. USA 107 2010 10920 10925
251. N.J. Wang, Z. Sanborn, K.L. Arnett, L.J. Bayston, W. Liao, C.M. Proby, I.M. Leigh, E.A. Collisson, P.B. Gordon, and L. Jakkula et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma Proc. Natl. Acad. Sci. USA 108 2011 17761 17766
252. T. Watanabe, S. Wang, J. Noritake, K. Sato, M. Fukata, M. Takefuji, M. Nakagawa, N. Izumi, T. Akiyama, and K. Kaibuchi Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration Dev. Cell 7 2004 871 883
253. A.R. Wechezak, and D.E. Coan Dvl2 silencing in postdevelopmental cells results in aberrant cell membrane activity and actin disorganization J. Cell. Physiol. 202 2005 867 873
254. G. Weinmaster, V.J. Roberts, and G. Lemke Notch2: a second mammalian Notch gene Development 116 1992 931 941
255. H.J. Williams, N. Craddock, G. Russo, M.L. Hamshere, V. Moskvina, S. Dwyer, R.L. Smith, E. Green, D. Grozeva, and P. Holmans et al. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries Hum. Mol. Genet. 20 2011 387 391
256. T. Wolverton, and M. Lalande Identification and characterization of three members of a novel subclass of protocadherins Genomics 76 2001 66 72
257. K. Wong, X.R. Ren, Y.Z. Huang, Y. Xie, G. Liu, H. Saito, H. Tang, L. Wen, S.M. Brady-Kalnay, and L. Mei et al. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway Cell 107 2001 209 221
258. R.S. Wymore, G.A. Gintant, R.T. Wymore, J.E. Dixon, D. McKinnon, and I.S. Cohen Tissue and species distribution of mRNA for the IKr-like K+ channel, erg Circ. Res. 80 1997 261 268
259. M. Wyszynski, J. Lin, A. Rao, E. Nigh, A.H. Beggs, A.M. Craig, and M. Sheng Competitive binding of alpha-actinin and calmodulin to the NMDA receptor Nature 385 1997 439 442
260. A. Yamaguchi, T. Urano, T. Goi, and L.A. Feig An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1 J. Biol. Chem. 272 1997 31230 31234
261. J.S. Yu, S. Koujak, S. Nagase, C.M. Li, T. Su, X. Wang, M. Keniry, L. Memeo, A. Rojtman, and M. Mansukhani et al. PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer Oncogene 27 2008 4657 4665
262. J.J. Zamorano-Leon, R. Yanez, G. Jaime, P. Rodriguez-Sierra, L. Calatrava-Ledrado, R.R. Alvarez-Granada, P.J. Mateos-Caceres, C. Macaya, and A.J. Lopez-Farre KCNH2 gene mutation: a potential link between epilepsy and long QT-2 syndrome J. Neurogenet. 26 2012 382 386
263. E. Zeggini, L.J. Scott, R. Saxena, B.F. Voight, J.L. Marchini, T. Hu, P.I. de Bakker, G.R. Abecasis, P. Almgren, G. Andersen Wellcome Trust Case Control Consortium Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat. Genet. 40 2008 638 645
264. H. Zhang, A. Maximov, Y. Fu, F. Xu, T.S. Tang, T. Tkatch, D.J. Surmeier, and I. Bezprozvanny Association of CaV1.3 L-type calcium channels with Shank J. Neurosci. 25 2005 1037 1049
265. C. Zhao, D.H. Yu, R. Shen, and G.S. Feng Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1 J. Biol. Chem. 274 1999 19649 19654