Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes

Cancer Research

Volumn 69, Issue 19, 2009, Pages 7518-7523

  Steensma, David P ^a   Neiger, Jessemy D ^a   Porcher, Julie C ^a   Keats, J Jonathan ^b   Bergsagel, P Leif ^b   Dennis, Thomas R ^c   Knudson, Ryan A ^a   Jenkins, Robert B ^a   Santana Davila, Rafael ^a   Kumar, Rajiv ^a   Ketterling, Rhett P ^a  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN 3; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION 6; CLINICAL ARTICLE; CLONING; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENE SEQUENCE; GENE TRANSLOCATION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; KARYOTYPE; MALE; MICROARRAY ANALYSIS; MOUSE; MYELODYSPLASTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REFRACTORY ANEMIA WITH EXCESS BLASTS; REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA; REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA AND RINGED SIDEROBLASTS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC MUTATION;

AGED; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 9; COMPARATIVE GENOMIC HYBRIDIZATION; GENE AMPLIFICATION; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MYELODYSPLASTIC SYNDROMES; POINT MUTATION; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 70350238389     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1428     Document Type: Article

References (20)

1. Kondratyev AD, Chung KN, Jung MO. Identification and characterization of a radiation-inducible glycosylated human early-response gene. Cancer Res 1996;56:1498-1502 (Pubitemid 26104009)
2. Feldmann KA, Pittelkow MR, Roche PC, Kumar R, Grande JP. Expression of an immediate early gene, IEX-1, in human tissues. Histochem Cell Biol 2001;115:489-497 (Pubitemid 32662424)
3. Wu MX. Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. Apoptosis 2003;8:11-18
4. Kumar R, Pittelkow MR, Salisbury JL, et al. A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis. Recent Results Cancer Res 2003;164:123-134
5. Huang YH, Wu JY, Zhang Y, Wu MX. Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-κB/rel complexes. Oncogene 2002;21:6819-6828 (Pubitemid 35221924)
6. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science (New York, NY) 1998;281:998-1001. (Pubitemid 28399251)
7. Im HJ, Pittelkow MR, Kumar R. Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. J Biol Chem 2002;277:14612-14621 (Pubitemid 34952528)
8. Shen L, Guo J, Santos-Berrios C, Wu MX. Distinct domains for anti- and pro-apoptotic activities of IEX-1. J Biol Chem 2006;281:15304-15311 (Pubitemid 43855120)
9. Zhang Y, Schlossman SF, Edwards RA, Ou CN, Gu J, Wu MX. Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. Proc Natl Acad Sci U S A 2002;99:878-883 (Pubitemid 34106604)
10. Zhang Y, Finegold MJ, Porteu F, Kanteti P, Wu MX. Development of T-cell lymphomas in Emu-IEX-1 mice. Oncogene 2003;22:6845-6851 (Pubitemid 37386683)
11. Sommer SL, Berndt TJ, Frank E, et al. Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol 2006;100:707-716 (Pubitemid 43671629)
12. Dilley WG, Kalyanaraman S, Verma S, Cobb JP, Laramie JM, Lairmore TC. Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome. Mol Cancer 2005;4:9. (Pubitemid 40230557)
13. Sasada T, Azuma K, Hirai T, et al. Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer. Ann Surg Oncol 2008;15:609-617
14. Hofmann WK, de Vos S, Komor M, Hoelzer D, Wachsman W, Koeffler HP. Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood 2002;100:3553-3560 (Pubitemid 35303923)
15. Prall WC, Czibere A, Grall F, et al. Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome. Int J Hematol 2009;89:173-187
16. Sebens Muerkoster S, Rausch AV, Isberner A, et al. The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-κ B inhibition. Oncogene 2008;27:1122-1134 (Pubitemid 351253191)
17. Semlali A, Oliva J, Badia E, Pons M, Duchesne MJ. Immediate early gene X-1 (IEX-1), a hydroxytamoxifen regulated gene with increased stimulation in MCF-7 derived resistant breast cancer cells. J Steroid Biochem Mol Biol 2004;88:247-259 (Pubitemid 38553756)
18. Highsmith WE, Jr., Meyer KJ, Marley VM, Jenkins RB. Conversion Technology for the separation of maternal and paternal copies of any autosomal chromosome in somatic cell hybrids. Curr Protoc Hum Genet 2007; Chapter 3:Unit 3.6.
19. Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89:2079-2088 (Pubitemid 27132124)
20. Hamelin V, Letourneux C, Romeo PH, Porteu F, Gaudry M. Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation. Blood 2006;107:3106-3113