Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

Oncogene

Volumn 25, Issue 7, 2006, Pages 1070-1080

  Ying, J ^a   Li, H ^a   Seng, T J ^b   Langford, C ^c   Srivastava, G ^d   Tsao, S W ^d   Putti, T ^e   Murray, P ^f   Chan, A T C ^a   Tao, Q ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Johns Hopkins Singapore   (Singapore)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^f UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Carcinoma; Epigenetic; Methylation; Promoter; Protocadherin; Tumor suppressor gene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CADHERIN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; PROTOCADHERIN PCDH10; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULTHOOD; ALLELE; ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA; CARCINOMA CELL; CELL GROWTH; CELL IMMORTALIZATION; CELL INVASION; CELL MIGRATION; COLONY FORMATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; EPITHELIUM; EPITHELIUM CELL; ESOPHAGUS CARCINOMA; FEMALE; FETUS (ANATOMY); GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCATION; GENE SEQUENCE; GENE SILENCING; HEMIZYGOTE; HUMAN; HUMAN CELL; KNOCKOUT GENE; LIVER CELL CARCINOMA; LUNG CARCINOMA; MULTIPLE CANCER; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA;

AZACITIDINE; CADHERINS; CARCINOMA; CELL MOVEMENT; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; ESOPHAGEAL NEOPLASMS; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; NASOPHARYNGEAL NEOPLASMS; PROMOTER REGIONS (GENETICS); SEQUENCE DELETION; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 33244483580     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209154     Document Type: Article

References (52)

1. Angst BD, Marcozzi C, Magee AI. (2001). J Cell Sci 114: 629-641.
2. Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C et al. (1995). EMBO J 14: 6107-6115.
3. Bolz H, von BB, Ramirez A, Bryda EC, Kutsche K, Nothwang HG et al. (2001). Nat Genet 27: 108-112.
4. Chan AT, Tao Q, Robertson KD, Flinn IW, Mann RB, Klencke B et al. (2004). J Clin Oncol 22: 1373-1381.
5. Di PF, Holme RH, Bryda EC, Belyantseva IA, Pellegrino R, Kachar B et al. (2001). Nat Genet 27: 103-107.
6. Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG et al. (1995). Genomics 30: 207-223.
7. Fanto M, Clayton L, Meredith J, Hardiman K, Charroux B, Kerridge S et al. (2003). Development 130: 763-774.
8. Fiegler H, Carr P, Douglas EJ, Burford DC, Hunt S, Scott CE et al. (2003). Genes Chromosomes Cancer 36: 361-374.
9. Frank M, Kemler R. (2002). Curr Opin Cell Biol 14: 557-562.
10. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF et al. (1995). Cancer Res 55: 5195-5199.
11. Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P et al. (1998). Nature 392: 402-405.
12. Gumbiner BM, Yamada KM. (1995). Curr Opin Cell Biol 7: 615-618.
13. Hirano S, Yan Q, Suzuki ST. (1999). J Neurosci 19: 995-1005.
14. Hukku B, Thraves P, Dritschilo A, Rhim JS. (1997). Cancer Genet Cytogenet 93: 125-139.
15. Hurst CD, Fiegler H, Carr P, Williams S, Carter NP, Knowles MA. (2004). Oncogene 23: 2250-2263.
16. Jones PA, Baylin SB. (2002). Nat Rev Genet 3: 415-428.
17. Kaneda A, Takai D, Kaminishi M, Okochi E, Ushijima T. (2003). Ann N Y Acad Sci 983: 131-141.
18. Knudson AG. (2001). Nat Rev Cancer 1: 157-162.
19. Lee SW. (1996). Nat Med 2: 776-782.
20. Mahoney PA, Weber U, Onofrechuk P, Biessmann H, Bryant PJ, Goodman CS. (1991). Cell 67: 853-868.
21. Matthews JM, Kowalski K, Liew CK, Sharpe BK, Fox AH, Crossley M et al. (2000). Eur J Biochem 267: 1030-1038.
22. Miotto E, Sabbioni S, Veronese A, Calin GA, Gullini S, Liboni A et al. (2004). Cancer Res 64: 8156-8159.
23. Nakao S, Uemura M, Aoki E, Suzuki ST, Takeichi M, Hirano S. (2005). Brain Res Mol Brain Res 134: 294-308.
24. Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H. (2002). Carcinogenesis 23: 1139-1148.
25. Paz MF, Wei S, Cigudosa JC, Rodriguez-Perales S, Peinado MA, Huang TH et al. (2003). Hum Mol Genet 12: 2209-2219.
26. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. (1998). Nature 392: 190-193.
27. Qiu GH, Tan LK, Loh KS, Lim CY, Srivastava G, Tsai ST et al. (2004). Oncogene 23: 4793-4806.
28. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE et al. (2002). Nature 416: 552-556.
29. Risinger JI, Berchuck A, Kohler MF, Boyd J. (1994). Nat Genet 7: 98-102.
30. Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP. (2000). Nat Genet 25: 338-342.
31. Rountree MR, Bachman KE, Baylin SB. (2000). Nat Genet 25: 269-277.
32. Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grubel G et al. (1995). Nature 374: 327-337.
33. Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Muller U. (2002). Proc Natl Acad Sci USA 99: 14946-14951.
34. Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG et al. (2004). Nature 428: 950-955.
35. Sollner C, Rauch GJ, Siemens J, Geisler R, Schuster SC, Muller U et al. (2004). Nature 428: 955-959.
36. Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van EM, Weijenberg MP et al. (2002). Nat Genet 31: 141-149.
37. Suzuki ST. (2000). Exp Cell Res 261: 13-18.
38. Szyf M, Pakneshan P, Rabbani SA. (2004). Cancer Lett 211: 133-143.
39. Tao Q, Huang H, Geiman TM, Lim CY, Fu L, Qiu GH et al. (2002). Hum Mol Genet 11: 2091-2102.
40. Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF. (1998). J Virol 72: 7075-7083.
41. Tao Q, Swinnen LJ, Yang J, Srivastava G, Robertson KD, Ambinder RF. (1999). Am J Pathol 155: 619-625.
42. Toyooka KO, Toyooka S, Virmani AK, Sathyanarayana UG, Euhus DM, Gilcrease M et al. (2001). Cancer Res 61: 4556-4560.
43. Tsao SW, Wang X, Liu Y, Cheung YC, Feng H, Zheng Z et al. (2002). Biochim Biophys Acta 1590: 150-158.
44. Ushijima T, Morimura K, Hosoya Y, Okonogi H, Tatematsu M, Sugimura T et al. (1997). Proc Natl Acad Sci USA 94: 2284-2289.
45. Waha A, Guntner S, Huang TH, Yan PS, Arslan B, Pietsch T et al. (2005). Neoplasia 7: 193-199.
46. Wolverton T, Lalande M. (2001). Genomics 76: 66-72.
47. Wu Q, Maniatis T. (2000). Proc Natl Acad Sci USA 97: 3124-3129.
48. Yagi T, Takeichi M. (2000). Genes Dev 14: 1169-1180.
49. Ying J, Srivastava G, Gao Z, Zhang X, Murray P, Ambinder R et al. (2004). Blood 103: 743-746.
50. Ying J, Srivastava G, Hsieh W-S, Gao Z, Murray P, Liao S-K et al. (2005). Clin Cancer Res, in press.
51. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S. (1995). Proc Natl Acad Sci USA 92: 7416-7419.
52. Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu YZ et al. (2005). Nat Genet 37: 265-274.