GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers

Neuron

Volumn 54, Issue 5, 2007, Pages 713-720

  Reiman, Eric M ^a,b,c,q   Webster, Jennifer A ^a,q   Myers, Amanda J ^d,e   Hardy, John ^e,f   Dunckley, Travis ^a,q   Zismann, Victoria L ^a,q   Joshipura, Keta D ^a,q   Pearson, John V ^a,q   Hu Lince, Diane ^a,q   Huentelman, Matthew J ^a,q   Craig, David W ^a,q   Coon, Keith D ^a,g,q   Liang, Winnie S ^a,q   Herbert, RiLee H ^a,q   Beach, Thomas ^h,q   Rohrer, Kristen C ^e   Zhao, Alice S ^e   Leung, Doris ^e   Bryden, Leslie ^e   Marlowe, Lauren ^e   Kaleem, Mona ^e   Mastroeni, Diego ^h   Grover, Andrew ^h,q   Heward, Christopher B ⁱ   Ravid, Rivka ^j   Rogers, Joseph ^h,q   Hutton, Michael L ^k   Melquist, Stacey ^k   Petersen, Ron C ^l   Alexander, Gene E ^m,q   Caselli, Richard J ^n,q   Kukull, Walter ^p   Papassotiropoulos, Andreas ^a,o   Stephan, Dietrich A ^a,b,q   more..

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^b BANNER ALZHEIMER S INSTITUTE   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

^h SUN HEALTH RESEARCH INSTITUTE   (United States)

ⁱ Kronos Science Laboratories   (United States)

^j NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^k MAYO GRADUATE SCHOOL   (United States)

^l MAYO CLINIC   (United States)

^m ARIZONA STATE UNIVERSITY   (United States)

ⁿ MAYO CLINIC   (United States)

^o UNIVERSITY OF BASEL   (Switzerland)

^p UNIVERSITY OF WASHINGTON   (United States)

^q ARIZONA ALZHEIMER S CONSORTIUM   (United States)

more..

Author keywords

HUMDISEASE; MOLNEURO

Indexed keywords

APOLIPOPROTEIN E; BINDING PROTEIN; GRB ASSOCIATED BINDING PROTEIN 2; SMALL INTERFERING RNA; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; NEURITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; BRAIN; BRAIN CHEMISTRY; CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HAPLOTYPES; HUMANS; MUTATION; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TAU PROTEINS;

EID: 34249745769     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2007.05.022     Document Type: Article

References (32)

1. Ahmadian A., Gharizadeh B., Gustafsson A.C., Sterky F., Nyren P., Uhlen M., and Lundeberg J. Single-nucleotide polymorphism analysis by pyrosequencing. Anal. Biochem. 280 (2000) 103-110
2. Baki L., Shioi J., Wen P., Shao Z., Schwarzman A., Gama-Sosa M., Neve R., and Robakis N.K. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 (2004) 2586-2596
3. Bertram L., McQueen M.B., Mullin K., Blacker D., and Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39 (2007) 17-23
4. Bobinski M., de Leon M.J., Wegiel J., Desanti S., Convit A., Saint Louis L.A., Rusinek H., and Wisniewski H.M. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience 95 (2000) 721-725
5. Braak H., and Braak E. Neuropathological staging of Alzheimer's-related changes. Acta Neuropathol. (Berl.) 82 (1991) 239-259
6. Buckner R., Snyder A.Z., Shannon B.J., LaRossa G., Sachs R., Fotenos A.F., Sheline Y.I., Klunk W.E., Mathis C.A., Morris J.C., and Mintun M.A. Molecular, structural and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid and memory. J. Neurosci. 25 (2005) 7709-7717
7. Coon K.D., Myers A.J., Craig D.W., Webster J.A., Pearson J.V., Hu-Lince D., Zismann V.L., Beach T., Leung D., Bryden L., et al. A high density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J. Clin. Psychiatry 68 (2007) 613-618
8. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., and Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 (1993) 921-923
9. Corder E.H., Saunders A.M., Risch N.J., Strittmatter W.J., Schemchel D.E., Gaskell Jr. P.C., Rimmler J.B., Locke P.A., Conneally P.M., Schmader K.E., et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7 (1994) 180-184
10. Evans D.A., Funkenstein H.H., Albert M.S., Scherr P.A., Cook N.R., Chown M.J., Hebert L.E., Hennekens C.H., and Taylor J.O. Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported. JAMA 262 (1989) 2551-2556
11. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., and van Duijn C.M. Effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278 (1997) 1349-1356
12. Gatz M., Reynolds C.A., Fratiglioni L., Johansson B., Mortimer J.A., Berg S., Fiske A., and Pedersen N.L. Role of genes and environments for explaining Alzheimer disease. Arch. Gen. Psychiatry 63 (2006) 168-174
13. Gu H., Saito K., Klaman L.D., Shen J., Fleming T., Wang Y., Pratt J.C., Lin G., Lim B., Kinet J.P., and Neel B.G. Essential role for Gab2 in the allergic response. Nature 412 (2001) 186-190
14. Hua J., Craig D.W., Brun M., Webster J., Zismann V., Tembe W., Joshipura K., Huentelman M.J., Dougherty E.R., and Stephan D.A. SNiPer-HD: Improved genotype calling accuracy by an expectation-maximization algorithm for high-density SNP arrays. Bioinformatics 23 (2007) 57-63
15. Jack Jr. C.R., Petersen R.C., Xu Y.C., O'Brien P.C., Smith G.E., Ivnik R.J., Boeve B.F., Waring S.C., Tangalos E.G., and Kokmen E. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 52 (1999) 1397-1403
16. Johnson S.C., Schmitz T.W., Moritz C.H., Meyerand M.E., Rowley H.A., Alexander A.L., Hansen K.W., Gleason C.E., Carlsson C.M., Ries M.L., et al. Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment. Neurobiol. Aging 27 (2006) 1604-1612
17. Kang D.E., Yoon I.S., Repetto E., Busse T., Yermian N., Ie L., and Koo E.H. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J. Biol. Chem. 208 (2005) 31537-31547
18. Koncz G., Bodor C., Kovesdi D., Gati R., and Sarmay G. BCR mediated signal transduction in immature and mature B cells. Immunol. Lett. 82 (2002) 41-49
19. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat. Genet. 22 (1999) 139-144
20. Lai E., Riley J., Purvis I., and Roses A. A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Genomics 54 (1998) 31-38
21. Lein E.S., Hawrylycz M.J., Ao N., Ayres M., Bensinger A., Bernard A., Boe A.F., Boguski M.S., Brockway K.S., Byrnes E.J., et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445 (2007) 160-161
22. Li K., Liu C., Sun W., Yuan S., and Yu T. A system for enhancing genome-wide coexpression dynamic study. Proc. Natl. Acad. Sci. USA 101 (2004) 15561-15566
23. Li R., Strohmeyer R., Liang Z., Lue L.-F., and Rogers J. CCAAT/Enhancer binding protein δ (C/EBP-δ) expression and elevation in Alzheimer's disease. Neurobiol. Aging 25 (2004) 991-999
24. Liang W.S., Dunckley T., Beach T.G., Grover A., Mastroeni D., Walker D.G., Caselli R.J., Kukull W.A., McKeel D., Morris J.C., et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol. Genomics 28 (2007) 311-322
25. Mintun M.A., Larossa G.N., Sheline Y.I., Dence C.S., Lee S.Y., Mach R.H., Klunk W.E., Mathis C.A., DeKosky S.T., and Morris J.C. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 67 (2006) 446-452
26. Papassotiropoulos A., Fountoulakis M., Dunckley T., Stephan D.A., and Reiman E.M. Genetics, transcriptomics and proteomics of Alzheimer's disease. J. Clin. Psychiatry 67 (2006) 652-670
27. Pratt J.C., Igras V.E., Maeda H., Baksh S., Gelfand E.W., Burakoff S.J., Neel B.G., and Gu H. Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling. J. Immunol. 165 (2001) 4158-4163
28. Pritchard J.K., Stephens M., and Donnelly P. Inference of population structure using multilocus genotype data. Genetics 155 (2000) 945-959
29. Reiman E.M., Caselli R.J., Yun L.S., Chen K., Bandy D., Minoshima S., Thibodeau S.N., and Osborne D. Preclinical evidence for Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N. Engl. J. Med. 334 (1996) 752-758
30. Reiman E.M., Chen K., Alexander G.E., Caselli R.J., Bandy D., Osborne D., Saunders A.M., and Hardy J. Correlations between apolipoprotein E ε4 gene dose and brain-imaging measurements of regional hypometabolism. Proc. Natl. Acad. Sci. USA 102 (2005) 8299-8302
31. The International HapMap Consortium. A haplotype map of the human genome. Nature 437 (2005) 1299-1320
32. Zompi S., Gu H., and Colucci F. The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions. J. Leukoc. Biol. 76 (2004) 896-903