Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel

Hypertension

Volumn 57, Issue 5, 2011, Pages 996-1002

  Karpushev, Alexey V ^a   Levchenko, Vladislav ^a   Ilatovskaya, Daria V ^a,b   Pavlov, Tengis S ^a   Staruschenko, Alexander ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

actin cytoskeleton; aldosterone; aldosterone sensitive distal nephron; epithelial transport; Wiskott Aldrich syndrome protein

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ACTIN; ALDOSTERONE; EPITHELIAL SODIUM CHANNEL; ISOPROTEIN; PROTEIN CDC42; RAC1 PROTEIN; WISKOTT ALDRICH SYNDROME PROTEIN;

ALDOSTERONE URINE LEVEL; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VOLUME; CELL TRANSPORT; CHO CELL; CORTICAL COLLECTING DUCT; CYTOSKELETON; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; EPITHELIUM CELL; HYPERTENSION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; SODIUM ABSORPTION; WESTERN BLOTTING;

AMINOQUINOLINES; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; ELECTROPHYSIOLOGY; EPITHELIAL SODIUM CHANNEL; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES, COLLECTING; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SODIUM; WISKOTT-ALDRICH SYNDROME PROTEIN; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY;

EID: 79955480132     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.157784     Document Type: Article

References (39)

1. Bhalla V, Hallows KR. Mechanisms of ENaC regulation and clinical implications. JAm Soc Nephrol. 2008;19:1845-1854.
2. Rossier BC, Pradervand S, Schild L, Hummler E. Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol. 2002;64:877-897. (Pubitemid 34259252)
3. Rossier BC, Schild L. Epithelial sodium channel: mendelian versus essential hypertension. Hypertension. 2008;52:595-600.
4. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001;104:545-556. (Pubitemid 32201949)
5. Pochynyuk O, Stockand JD, Staruschenko A. Ion channel regulation by Ras, Rho, and Rab small GTPases. Exp Biol Med (Maywood). 2007;232: 1258-1265. (Pubitemid 350014415)
6. Brown JH, Del Re DP, Sussman MA. The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res. 2006;98:730-742.
7. Hordijk PL. Regulation of NADPH oxidases: the role of Rac proteins. Circ Res. 2006;98:453-462.
8. Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med. 2008;14:1370-1376.
9. Silva GB, Garvin JL. Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb. Am J Physiol Renal Physiol. 2009;298: F421-F425.
10. Takemura Y, Goodson P, Bao HF, Jain L, Helms MN. Rac1-mediated NADPH oxidase release of O2-regulates epithelial sodium channel activity in the alveolar epithelium. Am J Physiol Lung Cell Mol Physiol. 2010;298:L509-L520.
11. Takenawa T, Miki H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci. 2001;114:1801-1809. (Pubitemid 32530035)
12. Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A. Endothelin-1 inhibits the epithelial Na+ channel through/?Pix/14-3-3/Nedd4-2. J Am Soc Nephrol. 2010;21:833-843.
13. Bens M, Vallet V, Cluzeaud F, Pascual-Letallec L, Kahn A, Rafestin-Oblin ME, Rossier BC, Vandewalle A. Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line. JAm Soc Nephrol. 1999;10:923-934. (Pubitemid 29203078)
14. Staruschenko A, Pochynyuk O, Vandewalle A, Bugaj V, Stockand JD. Acute regulation of the epithelial Na + channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells. JAm Soc Nephrol. 2007;18:1652-1661. (Pubitemid 46870302)
15. Staruschenko A, Nichols A, Medina JL, Camacho P, Zheleznova NN, Stockand JD. Rho small GTPases activate the epithelial Na(+) channel. J Biol Chem. 2004;279:49989-49994. (Pubitemid 39577808)
16. Staruschenko A, Patel P, Tong Q, Medina JL, Stockand JD. Ras activates the epithelial Na(+) channel through phosphoinositide 3-OH kinase sig-naling. J Biol Chem. 2004;279:37771-37778. (Pubitemid 39195491)
17. Wei Y, Sun P, Wang Z, Yang B, Carroll MA, Wang WH. Adenosine inhibits ENaC via cytochrome P-450 epoxygenase-dependent metabolites of arachidonic acid. Am J Physiol Renal Physiol. 2006;290:F1163-F1168. (Pubitemid 43724916)
18. Levchenko V, Zheleznova NN, Pavlov TS, Vandewalle A, Wilson PD, Staruschenko A. EGF and its related growth factors mediate sodium transport in mpkCCD(c14) cells via ErbB2 (neu/HER-2) receptor. J Cell Physiol. 2010;223:252-259.
19. Pavlov TS, Levchenko V, Karpushev AV, Vandewalle A, Staruschenko A. Peroxisome proliferator-activated receptor gamma antagonists decrease Na+ transport via the epithelial Na+ channel. Mol Pharmacol. 2009;76:1333-1340.
20. Karpushev AV, Levchenko V, Pavlov TS, Lam VY, Vinnakota KC, Vandewalle A, Wakatsuki T, Staruschenko A. Regulation of ENaC expression at the cell surface by Rab11. Biochem Biophys Res Commun. 2008;377:521-525.
21. Saxena SK, Kaur S. Regulation of epithelial ion channels by Rab GTPases. Biochem Biophys Res Commun. 2006;351:582-587. (Pubitemid 44708867)
22. Staruschenko A, Pochynyuk OM, Tong Q, Stockand JD. Ras couples phosphoinositide 3-OH kinase to the epithelial Na+ channel. Biochim Biophys Acta. 2005;1669:108-115. (Pubitemid 40704728)
23. Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA. 2004;101:7618-7623. (Pubitemid 38658078)
24. Naray-Fejes-Toth A, Helms MN, Stokes JB, Fejes-Toth G. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. Mol Cell Endocrinol. 2004;217:197-202. (Pubitemid 38596644)
25. Naray-Fejes-Toth A, Boyd C, Fejes-Toth G. Regulation of epithelial sodium transport by promyelocytic leukemia zinc finger protein. Am J Physiol Renal Physiol. 2008;295:F18-F26.
26. Raikwar NS, Thomas CP. Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. Am J Physiol Renal Physiol. 2008;294:F1157- F1165.
27. Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical in-hibitor of N-WASP reveals a new mechanism for targeting protein inter-actions. Proc Natl Acad Sci USA. 2001;98:10624-10629. (Pubitemid 32878671)
28. Pochynyuk O, Medina J, Gamper N, Genth H, Stockand JD, Staruschenko A. Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling. J Biol Chem. 2006;281:26520-26527. (Pubitemid 44401861)
29. Karpushev AV, Ilatovskaya DV, Pavlov TS, Negulyaev YA, Star-uschenko A. Intact cytoskeleton is required for small g protein dependent activation of the epithelial na channel. PLoS ONE. 2010;5:e8827.
30. Mazzochi C, Benos DJ, Smith PR. Interaction of epithelial ion channels with the actin-based cytoskeleton. Am J Physiol Renal Physiol. 2006;291: F1113-F1122. (Pubitemid 44887223)
31. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004;6:709-720. (Pubitemid 39144476)
32. Thebault S, Alexander RT, Tiel Groenestege WM, Hoenderop JG, Bindels RJ. EGF increases TRPM6 activity and surface expression. JAm SocNephrol. 2009;20:78-85.
33. Loirand G, Pacaud P. The role of Rho protein signaling in hypertension. Nat Rev Cardiol. 2010;7:637-647.
34. Yamazaki D, Oikawa T, Takenawa T. Rac-WAVE-mediated actin reor-ganization is required for organization and maintenance of cell-cell adhesion. J Cell Sci. 2007;120:86-100. (Pubitemid 46206652)
35. Ganeshan R, Nowotarski K, Di A, Nelson DJ, Kirk KL. CFTR surface expression and chloride currents are decreased by inhibitors of N-WASP and actin polymerization. Biochim Biophys Acta. 2007;1773:192-200. (Pubitemid 46123614)
36. Guerriero CJ, Weisz OA. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am J Physiol Cell Physiol. 2007;292:C1562-C1566. (Pubitemid 46631741)
37. Miki H, Suetsugu S, Takenawa T. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac EMBO J. 1998;17: 6932-6941. (Pubitemid 28550287)
38. Miki H, Yamaguchi H, Suetsugu S, Takenawa T. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature. 2000;408:732-735. (Pubitemid 32015990)
39. Pollitt AY, Insall RH. WASP and SCAR/WAVE proteins: the drivers of actin assembly. J Cell Sci. 2009;122:2575-2578.