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The proper localization of glial cells in the eye disc is shown to be important in orienting the initial stages of R-cell axon outgrowth.
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The Runt transcription factor is found to be a potentially key regulatory target of Brakeless. The misregulation of Runt expression in Brakeless mutants and the effects of misexpressing Runt protein on R1-R6 axon targeting are consistent with Runt regulating the expression of genes that determine R-cell axon target-layer selection.
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••], demonstrates that the receptor protein tyrosine phosphatase Lar is required for R7 axon targeting. In addition, the detailed time course of R7 axon target-layer selection is followed, demonstrating the multistep nature of target selection in this system.
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