Expression and nutritional regulation of stearoyl-CoA desaturase genes in the ruminant mammary gland: Relationship with milk fatty acid composition

Stearoyl-CoA Desaturase Genes in Lipid Metabolism

Volumn , Issue , 2013, Pages 161-193

  Bernard, L ^a,b   Leroux, C ^a,b   Chilliard, Y ^a,b  

^a CEMAGREF   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84892680481     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-7969-7_13     Document Type: Chapter

References (135)

1. Ahnadi CE, Beswick N, Delbecchi L, Kennelly JJ, Lacasse P (2002) Addition of fish oil to diets for dairy cows. II. Effects on milk fat and gene expression of mammary lipogenic enzymes. J Dairy Res 69(4):521-531
2. Alim MA, Fan YP, Wu XP, Xie Y, Zhang Y, Zhang SL, Sun DX, Zhang Y, Zhang Q, Liu L et al (2012) Genetic effects of stearoyl-coenzyme A desaturase (SCD) polymorphism on milk production traits in the Chinese dairy population. Mol Biol Rep 39(9):8733-8740
3. Andrade PVD, Schmidely P (2006) Effect of duodenal infusion of trans10, cis12-CLA on milk performance and milk fatty acid profi le in dairy goats fed high or low concentrate diet in combination with rolled canola seed. Reprod Nutr Dev 46(1):31-48
4. Angulo J, Mahecha L, Nuernberg K, Nuernberg G, Dannenberger D, Olivera M, Boutinaud M, Leroux C, Albrecht E, Bernard L (2012) Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression. Animal 6:1-12
5. Annison EF, Bickerstaffe R, Linzell JL (1974) Glucose and fatty acid metabolism in cows producing milk of low fat content. J Agric Sci 82:87-95
6. Barber MC, Clegg RA, Travers MT, Vernon RG (1997) Lipid metabolism in the lactating mammary gland. Biochim Biophys Acta 1347(2-3):101-126
7. Bauman DE, Corl BA, Baumgard LH, Griinari JM (2001) Conjugated linoleic acid (CLA) and the dairy cow. In: Recent advances in animal nutrition, Garnsworthy PC, Wiseman J (eds), Nottingham university press, Nottingham, p 221-250
8. Bauman DE, Griinari JM (2001) Regulation and nutritional manipulation of milk fat: low-fat milk syndrome. Livest Prod Sci 70(1-2):15-29
9. Bauman DE, Griinari JM (2003) Nutritional regulation of milk fat synthesis. Annu Rev Nutr 23:203-227
10. Baumgard LH, Corl BA, Dwyer DA, Sæbø A, Bauman DE (2000) Identifi cation of the conjugated linoleic acid isomer that inhibits milk fat synthesis. Am J Physiol Regul Integr Comp Physiol 278(1):R179-R184
11. Baumgard LH, Matitashvili E, Corl BA, Dwyer DA, Bauman DE (2002) Trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows. J Dairy Sci 85(9):2155-2163
12. Bernard L, Bonnet M, Leroux C, Shingfield KJ, Chilliard Y (2009a) Effect of sunfl ower-seed oil and linseed oil on tissue lipid metabolism, gene expression, and milk fatty acid secretion in Alpine goats fed maize silage-based diets. J Dairy Sci 92(12):6083-6094
13. Bernard L, Leroux C, Bonnet M, Rouel J, Martin P, Chilliard Y (2005a) Expression and nutritional regulation of lipogenic genes in mammary gland and adipose tissues of lactating goats. J Dairy Res 72(2):250-255
14. Bernard L, Leroux C, Chilliard Y (2008) Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Adv Exp Med Biol 606:67-108
15. Bernard L, Leroux C, Faulconnier Y, Durand D, Shingfield KJ, Chilliard Y (2009b) Effect of sunfl ower-seed oil or linseed oil on milk fatty acid secretion and lipogenic gene expression in goats fed hay-based diets. J Dairy Res 76(241-248)
16. Bernard L, Leroux C, Hayes H, Gautier M, Chilliard Y, Martin P (2001) Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3?-UTR sequence arising from a single exon. Gene 281(1-2):53-61
17. Bernard L, Montazer Torbati MB, Graulet B, Leroux C, Chilliard Y (2012) Long-chain fatty acids differentially alter lipogenesis in bovine and caprine mammary slices. J Dairy Res 80(89-95)
18. Bernard L, Mouriot J, Rouel J, Glasser F, Capitan P, Pujos-Guillot E, Chardigny JM, Chilliard Y (2010) Effects of fish oil and starch added to a diet containing sunfl ower-seed oil on dairy goat performance, milk fatty acid composition and in vivo delta 9-desaturation of [C-13]vaccenic acid. Br J Nutr 104(3):346-354
19. Bernard L, Rouel J, Leroux C, Ferlay A, Faulconnier Y, Legrand P, Chilliard Y (2005b) Mammary lipid metabolism and milk fatty acid secretion in alpine goats fed vegetable lipids. J Dairy Sci 88(4):1478-1489
20. Bernard L, Shingfield KJ, Rouel J, Ferlay A, Chilliard Y (2009c) Effect of plant oils in the diet on performance and milk fatty acid composition in goats fed diets based on grass hay or maize silage. Br J Nutr 101(2):213-224
21. Bichi E, Toral PG, Hervás G, Frutos P, Gómez-Cortés P, Juárez M, de la Fuente MA (2012) Inhibition of ?9-desaturase activity with sterculic acid: effect on the endogenous synthesis of cis-9 18:1 and cis-9, trans-11 18:2 in dairy sheep. J Dairy Sci 95(9):5242-5252
22. Bickerstaffe R, Annison EF (1970) The desaturase activity of goat and sow mammary tissue. Comp Biochem Physiol 35:653-665
23. Bionaz M, Loor JJ (2008) Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 9:366
24. Brown MS, Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89(3):331-340
25. Carta A, Casu S, Usai MG, Addis M, Fiori M, Fraghi A, Miari S, Mura L, Piredda G, Schibler L et al (2008) Investigating the genetic component of fatty acid content in sheep milk. Small Ruminant Res 79(1):22-28
26. Chilliard Y, Ferlay A, Mansbridge RM, Doreau M (2000) Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Ann Zootechnol 49(3):181-205
27. Chilliard Y, Glasser F, Ferlay A, Bernard L, Rouel J, Doreau M (2007) Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat. Eur J Lipid Sci Technol 109(8):828-855
28. Chilliard Y, Rouel J, Leroux C (2006) Goat's alpha-s1 casein genotype infl uences its milk fatty acid composition and delta-9 desaturation ratios. Anim Feed Sci Technol 131(3-4):474-487
29. Christie WW (1981) The composition, structure and function of lipids in the tissues of ruminant animals. In: Christie WW (ed) Lipid metabolism in ruminant animals. Pergamon press, Oxford, pp 95-192
30. Chung M, Ha S, Jeong S, Bok J, Cho K, Baik M, Choi Y (2000) Cloning and characterization of bovine stearoyl CoA desaturasel cDNA from adipose tissues. Biosci Biotechnol Biochem 64(7):1526-1530
31. Clarke SD (2001) Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J Nutr 131(4):1129-1132
32. Conte G, Mele M, Chessa S, Castiglioni B, Serra A, Pagnacco G, Secchiari P (2010) Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1gene polymorphisms and milk fatty acid composition in Italian Brown cattle. J Dairy Sci 93(2):753-763
33. Corl BA, Baumgard LH, Dwyer DA, Griinari JM, Phillips BS, Bauman DE (2001) The role of delta(9)-desaturase in the production of cis-9, trans-11 CLA. J Nutr Biochem 12(11):622-630
34. Corl BA, Baumgard LH, Griinari JM, Delmonte P, Morehouse KM, Yuraweczc MP, Bauman DE (2002) Trans-7, cis-9 CLA is synthesized endogenously by delta(9)-desaturase in dairy cows. Lipids 37(7):681-688
35. Delbecchi L, Ahnadi CE, Kennelly JJ, Lacasse P (2001) Milk fatty acid composition and mammary lipid metabolism in Holstein cows fed protected or unprotected canola seeds. J Dairy Sci 84(6):1375-1381
36. Dewhurst RJ, Shingfield KJ, Lee MRF, Scollan ND (2006) Increasing the concentrations of benefi-cial polyunsaturated fatty acids in milk produced by dairy cows in high-forage systems. Anim Feed Sci Technol 131(3-4):168-206
37. Eberlé D, Hegarty B, Bossard P, Ferre P, Foufelle F (2004) SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86(11):839-848
38. Enjalbert F, Nicot MC, Bayourthe C, Moncoulon R (1998) Duodenal infusions of palmitic, stearic or oleic acids differently affect mammary gland metabolism of fatty acids in lactating dairy cows. J Nutr 128(9):1525-1532
39. Gama MAS, Garnsworthy PC, Griinari JM, Leme PR, Rodrigues PHM, Souza LWO, Lanna DPD (2008) Diet-induced milk fat depression: association with changes in milk fatty acid composition and fl uidity of milk fat. Livest Sci 115(2-3):319-331
40. Garcia-Fernandez M, Gutierrez-Gill B, Garcia-Gamez E, Arranz JJ (2009) Genetic variability of the stearoyl-CoA desaturase gene in sheep. Mol Cell Probes 23(2):107-111
41. Garcia-Fernandez M, Gutierrez-Gil B, Garcia-Gamez E, Sanchez JP, Arranz JJ (2010) Detection of quantitative trait loci affecting the milk fatty acid profi le on sheep chromosome 22: role of the stearoyl-CoA desaturase gene in Spanish Churra sheep. J Dairy Sci 93(1):348-357
42. Gervais R, McFadden JW, Lengi AJ, Corl BA, Chouinard PY (2009) Effects of intravenous infusion of trans-10, cis-12 18: 2 on mammary lipid metabolism in lactating dairy cows. J Dairy Sci 92(10):5167-5177
43. Glasser F, Ferlay A, Doreau M, Schmidely P, Sauvant D, Chilliard Y (2008) Long-chain fatty acid metabolism in dairy cows: a meta-analysis of milk fatty acid yield in relation to duodenal fl ows and de novo synthesis. J Dairy Sci 91(7):2771-2785
44. Griinari JM, Corl BA, Lacy SH, Chouinard PY, Nurmela KVV, Bauman DE (2000) Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by delta(9)-desaturase. J Nutr 130(9):2285-2291
45. Griinari JM, Dwyer DA, McGuire MA, Bauman DE, Palmquist DL, Nurmela KV (1998) Transoctadecenoic acids and milk fat depression in lactating dairy cows. J Dairy Sci 81(5):1251-1261
46. Hansen HO, Knudsen J (1987) Effect of exogenous long-chain fatty acids on lipid biosynthesis in dispersed ruminant mammary gland epithelial cells: esterifi cation of long-chain exogenous fatty acids. J Dairy Sci 70(7):1344-1349
47. Hansen HO, Tornehave D, Knudsen J (1986) Synthesis of milk specifi c fatty acids and proteins by dispersed goat mammary-gland epithelial cells. Biochem J 238(1):167-172
48. Harvatine KJ, Bauman DE (2006) SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA. J Nutr 136(10):2468-2474
49. Horton JD (2002) Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans 30:1091-1095
50. Invernizzi G, Thering BJ, McGuire MA, Savoini G, Loor JJ (2010) Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. Funct Integr Genomics 10(4):561-575
51. Jacobs AAA, van Baal J, Smits MA, Taweel HZH, Hendriks WH, van Vuuren AM, Dijkstra J (2011) Effects of feeding rapeseed oil, soybean oil, or linseed oil on stearoyl-CoA desaturase expression in the mammary gland of dairy cows. J Dairy Sci 94(2):874-887
52. Jayan GC, Herbein JH (2000) "Healthier" dairy fat using trans-vaccenic acid. Nutr Food Sci 30(6):304-309
53. Jensen RG (2002) The composition of bovine milk lipids: January 1995 to December 2000. J Dairy Sci 85(2):295-350
54. Jin YC, Li ZH, Hong ZS, Xu CX, Han JA, Choi SH, Yin JL, Zhang QK, Lee KB, Kang SK et al (2012) Conjugated linoleic acid synthesis-related protein proteasome subunit ? 5 (PSMA5) is increased by vaccenic acid treatment in goat mammary tissue. J Dairy Sci 95(8):4286-4297
55. Kadegowda AKG, Bionaz M, Piperova LS, Erdman RA, Loor JJ (2009) Peroxisome proliferatoractivated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents. J Dairy Sci 92(9):4276-4289
56. Kaestner KH, Ntambi JM, Kelly TJJ, Lane MD (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 264(25):14755-14761
57. Karlengen IJ, Harstad OM, Taugbol O, Berget I, Aastveit AH, Vage DI (2012) The effect of excess cobalt on milk fatty acid profi les and transcriptional regulation of SCD, FASN, DGAT1 and DGAT2 in the mammary gland of lactating dairy cows. J Anim Physiol Anim Nutr 96(6):1065-1073
58. Kay JK, Mackle TR, Auldist MJ, Thomson NA, Bauman DE (2004) Endogenous synthesis of cis-9, trans-11 conjugated linoleic acid in dairy cows fed fresh pasture. J Dairy Sci 87(2):369-378
59. Keating AF, Kennelly JJ, Zhao FQ (2006) Characterization and regulation of the bovine stearoyl-CoA desaturase gene promoter. Biochem Biophys Res Commun 344(1):233-240
60. Keating AF, Stanton C, Murphy JJ, Smith TJ, Ross RP, Cairns MT (2005) Isolation and characterization of the bovine stearoyl-CoA desaturase promoter and analysis of polymorphisms in the promoter region in dairy cows. Mamm Genome 16(3):184-193
61. Kgwatalala PM, Ibeagha-Awemu EM, Hayes JF, Zhao X (2007) Single nucleotide polymorphisms in the open reading frame of the stearoyl-CoA desaturase gene and resulting genetic variants in Canadian Holstein and Jersey cows. DNA Seq 18(5):357-362
62. Kgwatalala PM, Ibeagha-Awemu EM, Hayes JF, Zhao X (2009a) Stearoyl-CoA desaturase 1 3?UTR SNPs and their infl uence on milk fatty acid composition of Canadian Holstein cows. J Anim Breed Genet 126(5):394-403
63. Kgwatalala PM, Ibeagha-Awemu EM, Mustafa AF, Zhao X (2009b) Stearoyl-CoA desaturase 1 genotype and stage of lactation infl uences milk fatty acid composition of Canadian Holstein cows. Anim Genet 40(5):609-615
64. Kinsella JE (1970) Stearic acid metabolism by mammary cells. J Dairy Sci 53(12):1757-1765
65. Legrand P, Catheline D, Fichot MC, Lemarchal P (1997) Inhibiting delta9-desaturase activity impairs triacylglycerol secretion in cultured chicken hepatocytes. J Nutr 127(2):249-256
66. Lengi AJ, Corl BA (2007) Identifi cation and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. Lipids 42(6):499-508
67. Lengi AJ, Corl BA (2008) Comparison of pig, sheep and chicken SCD5 homologs: evidence for an early gene duplication event. Comp Biochem Physiol B Biochem Mol Biol 150(4):440-446
68. Lengi AJ, Corl BA (2010) Short communication: identifi cation of the bovine sterol regulatory element binding protein-1c promoter and its activation by liver X receptor1. J Dairy Sci 93(12):5831-5836
69. Lengi AJ, Corl BA (2012) Regulation of the bovine SCD5 promoter by EGR2 and SREBP1. Biochem Biophys Res Commun 421(2):375-379
70. Lerch S, Shingfield KJ, Ferlay A, Vanhatalo A, Chilliard Y (2012) Rapeseed or linseed in grassbased diets: effects on conjugated linoleic and conjugated linolenic acid isomers in milk fat from Holstein cows over 2 consecutive lactations. J Dairy Sci 95(12):7269-7287
71. Li XZ, Yan CG, Lee HG, Choi CW, Song MK (2012) Infl uence of dietary plant oils on mammary lipogenic enzymes and the conjugated linoleic acid content of plasma and milk fat of lactating goats. Anim Feed Sci Technol 174(1-2):26-35
72. Liu W, Degner SC, Romagnolo DF (2006) Trans-10, cis-12 conjugated linoleic acid inhibits prolactin-induced cytosolic NADP + ?dependent isocitrate dehydrogenase expression in bovine mammary epithelial cells. J Nutr 136(11):2743-2747
73. Lock AL, Teles BM, Perfield JW, Bauman DE, Sinclair LA (2006) A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep. J Dairy Sci 89(5):1525-1532
74. Loor JJ, Doreau M, Chardigny JM, Ollier A, Sébédio JL, Chilliard Y (2005a) Effects of ruminal or duodenal supply of fish oil on milk fat secretion and profi les of trans-fatty acids and conjugated linoleic acid isomers in dairy cows fed maize silage. Anim Feed Sci Technol 119(3-4):227-246
75. Loor JJ, Ferlay A, Ollier A, Chilliard Y (2005b) Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil. J Dairy Sci 88(2):726-740
76. Ma L, Corl BA (2012) Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1. J Dairy Sci 95(7):3743-3755
77. Matitashvili E, Bauman DE (2000) Effect of different isomers of C18:1 and C18:2 fatty acids on lipogenesis in bovine mammary epithelial cells. J Anim Sci 78(Supplement 1):165
78. Matitashvili E, Baumgard LH, Bauman DE (2001) The effect of trans-10, cis-12 conjugated linoleic acid (CLA) infusion on milk fat synthesis and expression of lipogenic enzymes in the mammary gland of lactating cows. J Anim Sci 79(Suppl 1):310
79. Mauvoisin D, Mounier C (2011) Hormonal and nutritional regulation of SCD1 gene expression. Biochimie 93(1):78-86
80. McDonald TM, Kinsella JE (1973) Stearyl-CoA desaturase of bovine mammary microsomes. Arch Biochem Biophys 156(1):223-231
81. McFadden JW, Corl BA (2010) Activation of liver X receptor (LXR) enhances de novo fatty acid synthesis in bovine mammary epithelial cells. J Dairy Sci 93(10):4651-4658
82. McFadden JW, Mullarky IK, Corl BA (2008) Inhibitory effect of unsaturated fatty acids on de novo fatty acid synthesis in bovine mammary epithelial cells. J Anim Sci 86(E-Suppl 2):566
83. Mele M, Conte G, Castiglioni B, Chessa S, Macciotta NPP, Serra A, Buccioni A, Pagnacco G, Secchiari P (2007) Stearoyl-Coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins. J Dairy Sci 90(9):4458-4465
84. Mihara K (1990) Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. J Biochem 108(6):1022-1029
85. Miyazaki M, Bruggink SM, Ntambi JM (2006) Identifi cation of mouse palmitoyl-coenzyme A Delta 9-desaturase. J Lipid Res 47(4):700-704
86. Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, Ntambi JM (2003) Identifi cation and characterization of murine SCD4, a novel heart-specifi c stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem 278(36):33904-33911
87. Moioli B, Contarini G, Avalli A, Catillo G, Orru L, De Matteis G, Masoero G, Napolitano F (2007) Short communication: effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk. J Dairy Sci 90(7):3553-3558
88. Mosley EE, McGuire MA (2007) Methodology for the in vivo measurement of the delta(9)-desaturation of myristic, palmitic, and stearic acids in lactating dairy cattle. Lipids 42:939-945
89. Mosley EE, Shafii B, Moate PJ, McGuire MA (2006) Cis-9, trans-11 conjugated linoleic acid is synthesized directly from vaccenic acid in lactating dairy cattle. J Nutr 136(3):570-575
90. Murrieta CM, Hess BW, Scholljegerdes EJ, Engle TE, Hossner KL, Moss GE, Rule DC (2006) Evaluation of milk somatic cells as a source of mRNA for study of lipogenesis in the mammary gland of lactating beef cows supplemented with dietary high-linoleate saffl ower seeds. J Anim Sci 84(9):2399-2405
91. Nakamura MT, Nara TY (2004) Structure, function, and dietary regulation of delta 6, delta 5, and delta 9 desaturases. Annu Rev Nutr 24:345-376
92. Ntambi JM (1999) Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 40(9):1549-1558
93. Ntambi JM, Buhrow SA, Kaestner KH, Christy RJ, Sibley E, Kelly TJJ, Lane MD (1988) Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 263(33):17291-17300
94. Ntambi JM, Miyazaki M, Dobrzyn A (2004) Regulation of stearoyl-CoA desaturase expression. Lipids 39(11):1061-1065
95. Ollier S, Leroux C, de la Foye A, Bernard L, Rouel J, Chilliard Y (2009) Whole intact rapeseeds or sunfl ower oil in high-forage or high-concentrate diets affects milk yield, milk composition, and mammary gene expression profi le in goats. J Dairy Sci 92(11):5544-5560
96. Oshino N, Sato R (1972) The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver. Arch Biochem Biophys 149(2):369-377
97. Palmquist DL, Lock AL, Shingfield KJ, Bauman DE (2005) Biosynthesis of conjugated linoleic acid in ruminants and humans. In: Taylor SL (ed) Advances in food and nutrition research. Elsevier, San Diego, CA, pp 179-217
98. Parodi PW (1982) Positional distribution of fatty acids in the triglyceride classes of milk fat. J Dairy Res 49(1):73-80
99. Parodi PW (2005) Dairy product consumption and the risk of breast cancer. J Am Coll Nutr 24(6 Suppl):556S-568S
100. Pauciullo A, Cosenza G, Steri R, Coletta A, La Battaglia A, Di Berardino D, Macciotta NPP, Ramunno L (2012) A single nucleotide polymorphism in the promoter region of river buffalo stearoyl CoA desaturase gene (SCD) is associated with milk yield. J Dairy Res 79(04):429-435
101. Perfield JW, Delmonte P, Lock AL, Yurawecz MP, Bauman DE (2006) Trans-10, trans-12 conjugated linoleic acid does not affect milk fat yield but reduces delta9-desaturase index in dairy cows. J Dairy Sci 89(7):2559-2566
102. Perfield JW, Lock AL, Griinari JM, Sæbø A, Delmonte P, Dwyer DA, Bauman DE (2007) Trans-9, cis-11 conjugated linoleic acid reduces milk fat synthesis in lactating dairy cows. J Dairy Sci 90(5):2211-2218
103. Peterson DG, Matitashvili EA, Bauman DE (2003) Diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 CLA in milk fat and coordinate suppression of mRNA abundance for mammary enzymes involved in milk fat synthesis. J Nutr 133(10):3098-3102
104. Peterson DG, Matitashvili EA, Bauman DE (2004) The inhibitory effect of trans-10, cis-12 CLA on lipid synthesis in bovine mammary epithelial cells involves reduced proteolytic activation of the transcription factor SREBP-1. J Nutr 134(10):2523-2527
105. Piperova LS, Teter BB, Bruckental I, Sampugna J, Mills SE, Yurawecz MP, Fritsche J, Ku K, Erdman RA (2000) Mammary lipogenic enzyme activity, trans fatty acids and conjugated linoleic acids are altered in lactating dairy cows fed a milk fat-depressing diet. J Nutr 130(10):2568-2574
106. Qiu X, Eastridge ML, Firkins JL (2004) Effects of dry matter intake, addition of buffer, and source of fat on duodenal fl ow and concentration of conjugated linoleic acid and trans-11 C18:1 in milk. J Dairy Sci 87(12):4278-4286
107. Rincon G, Islas-Trejo A, Castillo AR, Bauman DE, German BJ, Medrano JF (2012) Polymorphisms in genes in the SREBP1 signalling pathway and SCD are associated with milk fatty acid composition in Holstein cattle. J Dairy Res 79(01):66-75
108. Roy A, Ferlay A, Shingfield KJ, Chilliard Y (2006) Examination of the persistency of milk fatty acid composition responses to plant oils in cows given different basal diets, with particular emphasis on trans-C18:1 fatty acids and isomers of conjugated linoleic acid. Anim Sci 82:479-492
109. Sæbø A, Sæbø PC, Griinari JM, Shingfield KJ (2005) Effect of abomasal infusions of geometric isomers of 10, 12 conjugated synthesis linoleic acid on milk fat in dairy cows. Lipids 40(8): 823-832
110. Sampath H, Ntambi JM (2005) Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr 25:317-340
111. Sessler AM, Kaur N, Palta JP, Ntambi JM (1996) Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes. J Biol Chem 271(47): 29854-29858
112. Schennink A, Heck JML, Bovenhuis H, Visker MHPW, van Valenberg HJF, van Arendonk JAM (2008) Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1). J Dairy Sci 91(5): 2135-2143
113. Shingfield KJ, Ahvenjarvi S, Toivonen V, Vanhatalo A, Huhtanen P (2007) Transfer of absorbed cis-9, trans-11 conjugated linoleic acid into milk is biologically more effi cient than endogenous synthesis from absorbed vaccenic acid in lactating cows. J Nutr 137(5):1154-1160
114. Shingfield KJ, Arola A, Ahvenjarvi S, Vanhatalo A, Toivonen V, Griinari JM, Huhtanen P (2008a) Ruminal infusions of cobalt-EDTA reduce mammary delta 9-desaturase index and alter milk fatty acid composition in lactating cows. J Nutr 138(4):710-717
115. Shingfield KJ, Chilliard Y, Toivonen V, Kairenius P, Givens DI (2008b) Trans fatty acids and bioactive lipids in ruminant milk. Adv Exp Med Biol 606:3-65
116. Shingfield KJ, Bernard L, Leroux C, Chilliard Y (2010) Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants. Animal 4(7):1140-1166
117. Shingfield KJ, Bonnet M, Scollan ND ( 2013) Recent developments in altering the fatty acid composition of ruminant-derived foods. Animal 7(Supplements 1)132-162
118. Shingfield KJ, Rouel J, Chilliard Y (2009) Effect of calcium salts of a mixture of conjugated linoleic acids containing trans-10, cis-12 in the diet on milk fat synthesis in goats. Br J Nutr 101(7):1006-1019
119. Shingfield KJ, Toivonen V, Vanhatalo A, Huhtanen P, Griinari JM (2006) Short communication: indigestible markers reduce the mammary delta9-desaturase index and alter the milk fatty acid composition in cows. J Dairy Sci 89(8):3006-3010
120. Stoop WM, Bovenhuis H, Heck JML, van Arendonk JAM (2009) Effect of lactation stage and energy status on milk fat composition of Holstein-Friesian cows. J Dairy Sci 92(4):1469-1478
121. Taugbøl O, Karlengen IJ, Bolstad T, Aastveit AH, Harstad OM (2008) Cobalt supplied per os reduces the mammary {delta}9-desaturase index of bovine milk. J Anim Sci 86(11):3062-3068
122. Taugbøl O, Karlengen IJ, Salbu B, Aastveit AH, Harstad OM (2010) Intravenous injections of cobalt reduce fatty acid desaturation products in milk and blood of lactating cows. J Anim Physiol Anim Nutr 94(5):635-640
123. Thiede MA, Strittmatter P (1985) The induction and characterization of rat liver stearyl-CoA desaturase mRNA. J Biol Chem 260(27):14459-14463
124. Timmen H, Patton S (1988) Milk fat globules: fatty acid composition, size and in vivo regulation of fat liquidity. Lipids 23(7):685-689
125. Toral PG, Bernard L, Chilliard Y, Glasser F (2013a) Diet-induced variations in milk fatty acid composition have minor effects on the estimated melting point of milk fat in cows, goats, and ewes: insights from a meta-analysis. J Dairy Sci 96:1232-1236
126. Toral PG, Bernard L, Delavaud C, Gruffat D, Leroux C, Chilliard Y (2013b) Effects of fish oil and additional starch on tissue fatty acid profi le and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunfl ower-seed oil. Animal 7(6):948-956
127. Vakalopoulou E, Schaack J, Shenk T (1991) A 32-kilodalton protein binds to AU-rich domains in the 3? untranslated regions of rapidly degraded mRNAs. Mol Cell Biol 11(6):3355-3364
128. Wahle KWJ, Heys SD, Rotondo D (2004) Conjugated linoleic acids: are they benefi cial or detrimental to health? Prog Lipid Res 43(6):553-587
129. Wang W, Luo J, Zhong Y, Lin XZ, Shi HB, Zhu JJ, Li J, Sun YT, Zhao WS (2012) Goat liver X receptor alpha, molecular cloning, functional characterization and regulating fatty acid synthesis in epithelial cells of goat mammary glands. Gene 505(1):114-120
130. Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G (2005) Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun 332(3):735-742
131. Ward RJ, Travers MT, Richards SE, Vernon RG, Salter AM, Buttery PJ, Barber MC (1998) Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome. Biochim Biophys Acta 1391(2):145-156
132. Yonezawa T, Haga S, Kobayashi Y, Katoh K, Obara Y (2008) Regulation of hormone-sensitive lipase expression by saturated fatty acids and hormones in bovine mammary epithelial cells. Biochem Biophys Res Commun 376(1):36-39
133. Zhang L, Ge L, Parimoo S, Stenn K, Prouty SM (1999) Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 340(Pt 1):255-264
134. Zheng Y, Prouty SM, Harmon A, Sundberg JP, Stenn KS, Parimoo S (2001) Scd3-a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Genomics 71(2): 182-191
135. Zidi A, Fernández-Cabanás VM, Urrutia B, Carrizosa J, Polvillo O, González-Redondo P, Jordana J, Gallardo D, Amills M, Serradilla JM (2010) Association between the polymorphism of the goat stearoyl-CoA desaturase 1 (SCD1) gene and milk fatty acid composition in Murciano-Granadina goats. J Dairy Sci 93(9):4332-4339