Trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows

Journal of Dairy Science

Volumn 85, Issue 9, 2002, Pages 2155-2163

  Baumgard, L H ^a,b   Matitashvili, E ^a   Corl, B A ^a   Dwyer, D A ^a   Bauman, D E ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Conjugated linoleic acid; Lactation; Milk fat; Milk fat depression

Indexed keywords

BOS TAURUS;

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; CARRIER PROTEIN; FATTY ACID; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; LINOLEIC ACID; LIPID; LIPOPROTEIN LIPASE; MESSENGER RNA; TRIACYLGLYCEROL; TUMOR PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CATTLE; CHEMISTRY; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETICS; METABOLISM; MILK; RUMINANT STOMACH; UDDER;

ABOMASUM; ACETYL-COA CARBOXYLASE; ANIMALS; CARRIER PROTEINS; CATTLE; FATTY ACID SYNTHETASE COMPLEX; FATTY ACID-BINDING PROTEINS; FATTY ACIDS; FEMALE; GENE EXPRESSION; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; LINOLEIC ACID; LIPIDS; LIPOPROTEIN LIPASE; MAMMARY GLANDS, ANIMAL; MILK; NEOPLASM PROTEINS; RNA, MESSENGER; STEAROYL-COA DESATURASE; TRIGLYCERIDES;

EID: 0036728338     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(02)74294-X     Document Type: Article

References (44)

1. Auwrex, J. 1999. PPARγ, the ultimate thrifty gene. Diabetologia 42:1033-1049.
2. Azain, M. J., D. B. Hausman, M. B. Sisk, W. P. Flatt, and D. E. Jewell. 2000. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J. Nutr. 130:1548-1554.
3. Bauman, D. E., L. H. Baumgard, B. A. Corl, and J. M. Griinari. 2000. Biosynthesis of CLA in ruminants. Proc. Am. Soc. Anim. Sci. 1999. Available at: http://www.asas.org/jas/symposia/proceedings/0937.pdf.
4. Bauman, D. E., B. A. Corl, L. H. Baumgard, and J. M. Griinari. 2001. Conjugated linoleic acid (CLA) and the dairy cow. Pages 221-250 in Recent Advances in Animal Nutrition. P. C. Garnsworthy and J. Wiseman, eds. Nottingham University Press, Nottingham, UK.
5. Bauman, D. E., and C. L. Davis. 1974. Biosynthesis of milk fat. Pages 31-75 in Lactation: A Comprehensive Treatise. Vol. 2. B. L. Larson and V. R. Smith, eds. Academic Press, New York.
6. Bauman, D. E., and J. M. Griinari. 2001. Regulation and nutritional manipulation of milk fat: Low-fat milk syndrome. Livest. Prod. Sci. 70:15-29.
7. Bauman, D. E., D. L. Ingle, R. W. Mellenberger, and C. L. Davis. 1973. Factors affecting in vitro lipogenesis by bovine mammary tissue slices. J. Dairy Sci. 56:1520-1525.
8. Baumgard, L. H., B. A. Corl, and D. E. Bauman. 2000a. Effect of CLA isomers on fat synthesis during growth and lactation. Pages 180-190 in Proc. Cornell Nutr. Conf. Cornell Univ., Ithaca, NY.
9. Baumgard, L. H., B. A. Corl, D. A. Dwyer, A. Saebo, and D. E. Bauman. 2000b. Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. Am. J. Physiol. 278:R179-R184.
10. Baumgard, L. H., J. K. Sangster, and D. E. Bauman. 2001. Milk fat synthesis in dairy cows is progressively reduced by increasing amounts of trans-10, cis-12 CLA conjugated linoleic acid (CLA). J. Nutr. 131:1764-1769.
11. Bee, G. 2000. Dietary conjugated linoleic acid consumption during pregnancy and lactation influences on growth and tissue composition in weaned pigs. J. Nutr. 130:2981-2989.
12. Bernlohr, D. A., N. R. Coe, and V. J. LiCata. 1999. Fatty acid trafficking in the adipocyte. Cell Develop. Biol. 10:43-49.
13. Bretillon, L., J. M. Chardigny, S. Gregoire, O. Berdeaux, and J. L. Sebedio. 1999. Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. Lipids 34:965-969.
14. Choi, Y. J., Y. C. Kim, Y. B. Han, Y. Park, M. W. Pariza, and J. M. Ntambi. 2000. The trans-10, cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 130:1920-1924.
15. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
16. Chouinard, P. Y., L. Corneau, D. M. Barbano, L. E. Metzger, and D. E. Bauman. 1999a. Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. J. Nutr. 129:1579-1584.
17. Chouinard, P. Y., L. Corneau, A. Saebo, and D. E. Bauman. 1999b. Milk yield and composition during abomasal infusion of conjugated linoleic acids in dairy cows. J. Dairy Sci. 82:2737-2745.
18. Christie, W. W. 1982. A simple procedure for rapid transmethylation of glycerolipids and cholesterol esters. J. Lipid Res. 23:1072-1075.
19. Clark, S. D. 2001. Polyunsaturated fatty acid regulation of gene transcription: A molecular mechanism to improve the metabolic syndrome. J. Nutr. 131:1129-1132.
20. Farr, V. C., K. Stelwagen, L. R. Cate, A. J. Molenaar, T. B. McFadden, and S. R. Davis. 1996. An improved method for the routine biopsy of bovine mammary tissue. J. Dairy Sci. 79:543-549.
21. Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
22. Fox, D. G., C. J. Sniffen, J. D. O'Connor, J. B. Russell, and P. J. Van Soest. 1992. A net carbohydrate and protein system for evaluating cattle diets: III. Cattle requirements and diet adequacy. J. Anim. Sci. 70:3578-3596.
23. Hara, A., and N. S. Radin. 1978. Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem. 90:420-426.
24. Harrell, R. J., O. Phillips, D. L. Jerome, R. D. Boyd, D. A. Dwyer, and D. E. Bauman. 2000. Effects of conjugated linoleic acid on milk composition and baby pig growth in lactating sows. J. Anim. Sci. 78(Suppl. 1):137-138 (Abstr.).
25. Horton, J. D., and I. Shimomura. 1999. Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis. Curr. Opin. Lipid. 10:143-150.
26. Lehner, R., and A. Kuksis. 1996. Biosynthesis of triacylglycerols. Prog. Lipid Res. 35:169-201.
27. Loor, J. J., and J. H. Herbein. 1998. Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis. J. Nutr. 128:2411-2419.
28. Masters, N., M. A. McGuire, K. A. Beerman, N. Dasguoia, and M. K. McGuire. 2002. Maternal supplementation with CLA decreases milk fat in humans, Lipids. 37:133-138.
29. Moore, J. H., and W. W. Christie. 1979. Lipid metabolism in the mammary gland of ruminant animals. Prog. Lipid Res. 17:347-395.
30. Moya-Camarena, S. Y., and M. A. Belury. 1999. Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid. Nutr. Rev. 57:336-340.
31. National Research Council. 1989. Nutrient Requirements of Dairy Cattle, 6th rev. ed. National Academy of Sciences, Washington, DC.
32. Pariza, M. W., Y. Park, and M. E. Cook. 2000. Mechanisms of action of conjugated linoleic acid: Evidence and speculation. Proc. Soc. Exp. Biol. Med. 223:8-13.
33. Park, Y., K. J. Albright, W. Liu, J. M. Storkson, M. E. Cook, and M. W. Pariza. 1997. Effect of conjugated linoleic acid on body composition in mice. Lipids 32:853-858.
34. Park, Y., J. M. Storkson, K. J. Albright, W. Liu, and M. W. Pariza. 1999. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34:235-241.
35. Park, Y., J. M. Storkson, J. M. Ntambi, M. E. Cook, C. J. Sih, and M. W. Pariza. 2000. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486:285-292.
36. Parodi, P. 1982. Positional distribution of fatty acids in the triglyceride classes of milk fat. J. Dairy Res. 49:73-80.
37. Piperova, L. S., B. B. Teter, I. Bruckental, J. Sampugna, S. E. Mills, M. P. Yurawecz, J. Fritsche, K. Ku, and R. A. Erdman. 2000. Mammary lipogenic enzyme activity, trans fatty acids and conjugated linoleic acids are altered in lactating dairy cows fed a milk fat-depressing diet. J. Nutr. 130:2568-2574.
38. Poulos, S. P., M. J. Azain, and G. J. Hausman. 2000. In utero dietary conjugated linoleic acid (CLA) alters body composition and growth rate in newborn pigs. J. Anim. Sci. 78(Suppl. 1):137.(Abstr.)
39. Roche, H. M., E. Noone, A. Nugent, and M. J. Gibney. 2001. Conjugated linoleic acid: A novel therapeutic nutrient? Nutr. Res. Rev. 14:173-187.
40. SAS Institute, Inc. 1992 SAS Technical Report P-229, SAS/STAT Software: Changes, and Enhancements, Release 6.07. SAS Institute, Cary, NC.
41. Spires, H. R., J. H. Clark, R. G. Derrig, and C. L. Davis. 1975. Milk production and nitrogen utilization in response to postruminal infusion of sodium caseinate in lactating cows. J. Nutr. 105:1111-1121.
42. Sunvold, H., A. Brzozowska, and S. Lein. 1997. Characterization of bovine peroxisomse proliferator-activated receptorsγ1 and γ2: Genetic mapping differential expression of the two isoforms. Biochem. Biophys. Res. Commun. 239:857-861.
43. Tsuboyama-Kasaoka, N., M. Takahashi, K. Tanemura, H. J. Kim, T. Tange, H. Okuyama, M. Kasai, S. Ikemoto, and O. Ezaki. 2000. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49:1534-1542.
44. West, D. B., J. P. DeLany, P. M. Carnet, F. Blohm, A. A. Truett, and J. Scimeca. 1998. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. 275:R667-R672.