A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep

Journal of Dairy Science

Volumn 89, Issue 5, 2006, Pages 1525-1532

  Lock, A L ^a   Teles, B M ^b   Perfield II, J W ^a   Bauman, D E ^a   Sinclair, L A ^b  

^a Department of Obstetrics Gynecology   (United States)

^b HARPER ADAMS UNIVERSITY   (United Kingdom)

Author keywords

Conjugated linoleic acid; Lactation; Milk fat depression; Sheep

Indexed keywords

BOS TAURUS; BOVIDAE; OVIS; OVIS ARIES;

CONJUGATED LINOLEIC ACID; FAT; FATTY ACID; LIPID; TRANS 10,CIS 12 CONJUGATED LINOLEIC ACID; TRANS-10,CIS-12-CONJUGATED LINOLEIC ACID;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; DIET; DIET SUPPLEMENTATION; DIETARY FIBER; DRUG EFFECT; FEMALE; LACTATION; METABOLISM; MILK; SHEEP;

ANIMALS; DIET; DIETARY FIBER; DIETARY SUPPLEMENTS; FATS; FATTY ACIDS; FEMALE; LACTATION; LINOLEIC ACIDS, CONJUGATED; LIPIDS; MILK; SHEEP;

EID: 33745876551     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(06)72220-2     Document Type: Article

References (47)

1. AOAC. 2000. Official Methods of Analysis. 17th ed. Association of Official Analytical Chemists, International, Arlington, VA.
2. Bauman, D. E., B. A. Corl, and D. G. Peterson. 2003. The biology of conjugated linoleic acids in ruminants. Pages 146-173 in Advances in Conjugated Linoleic Acid Research. Volume 2. J.-L. Sebedio, W. W. Christie, and R. O. Adlof, ed. AOCS Press, Champaign, IL.
3. Bauman, D. E., and J. M. Griinari. 2003. Nutritional regulation of milk fat synthesis. Annu. Rev. Nutr. 23:203-227.
4. Baumgard, L. H., B. A. Corl, D. A. Dwyer, and D. E. Bauman. 2002. Effects of conjugated linoleic acids (CLA) on tissue response to homeostatic signals and plasma variables associated with lipid metabolism in lactating dairy cows. J. Anim. Sci. 80:1285-1293.
5. Baumgard, L. H., B. A. Corl, D. A. Dwyer, A. Saebo, and D. E. Bauman. 2000. Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. Am. J. Physiol. 278:R179-R184.
6. Baumgard, L. H., J. K. Sangster, and D. E. Bauman. 2001. Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). J. Nutr. 131:1764-1769.
7. Bernal-Santos, G., J. W. Perfield, II, D. M. Barbano, D. E. Bauman, and T. R. Overton. 2003. Production responses of dairy cows to dietary supplementation with conjugated linoleic acid (CLA) during the transition period and early lactation. J. Dairy Sci. 86:3218-3228.
8. Bernard, L., J. Rouel, C. Leroux, A. Ferlay, Y. Faulconnier, P. Legrand, and Y. Chilliard. 2005. Mammary lipid metabolism and fatty acid secretion in Alpine goats fed vegetable lipids. J. Dairy Sci. 88:1478-1489.
9. Blaxter, K. 1989. Energy Metabolism in Animals and Man. Cambridge Univ. Press, Cambridge, UK.
10. Castañeda-Gutiérrez, E., T. R. Overton, W. R. Butler, and D. E. Bauman. 2005. Dietary supplements of two doses of calcium salts of conjugated linoleic acid during the transition period and early lactation. J. Dairy Sci. 88:1078-1089.
11. Chilliard, Y., A. Ferlay, J. Rouel, and G. Lamberet. 2003. A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis. J. Dairy Sci. 86:1751-1770.
12. Chouinard, P. Y., L. Corneau, D. M. Barbano, L. E. Metzger, and D. E. Bauman. 1999. Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. J. Nutr. 129:1579-1584.
13. Christie, W. W. 1982. A simple procedure for the rapid transmethylation of glycerolipids and cholesteryl esters. J. Lipid Res. 23:1072-1075.
14. de Veth, M. J., E. Castañeda-Gutiérrez, D. A. Dwyer, A. M. Pfeiffer, D. Putnam, and D. E. Bauman. 2004b. Nutrient status influences the effect of conjugated linoleic acid on milk synthesis. J. Dairy Sci. 87(Suppl. 1):94. (Abstr.)
15. de Veth, M. J., J. M. Griinari, A. M. Pfeiffer, and D. E. Bauman. 2004a. Effect of CLA on milk fat synthesis in dairy cows: Comparison of inhibition by methyl esters and free fatty acids, and relationships among studies. Lipids 39:365-372.
16. Dowman, M. G., and F. C. Collins. 1982. The use of enzymes to predict the digestibility of animal feeds. J. Sci. Food Agric. 33:689-696.
17. Erasmus, L. J., Z. Bester, T. Fourie, R. J. Coertze, and L. Hall. 2004. Effect of level of rumen protected CLA supplementation on milk yield and composition in Saanen goats. S. Afr. J. Anim. Sci. 34(Suppl. 1):42-45.
18. Grevais, R., R. Spratt, M. Léonard, and P. Y. Chouinard. 2005. Lactation response of cows to different levels of ruminally inert conjugated linoleic acids under commercial conditions. Can. J. Anim. Sci. 85:231-242.
19. Griinari, J. M., and D. E. Bauman. 2006. Regulation of milk fat production. Pages 483-411 in Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress. K. Sejrsen, T. Hvelplund, and M. O. Nielson. Wageningen Acad. Publ., Wageningen, The Netherlands.
20. Hara, A., and N. S. Radin. 1978. Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem. 90:420-426.
21. Kelsey, J. A., B. A. Corl, R. J. Collier, and D. E. Bauman. 2003. The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows. J. Dairy Sci. 86:2588-2597.
22. Kleiber, M. 1961. The Fire of Life. John Wiley & Sons, Inc., New York, NY.
23. Kramer, J. K. G., C. Cruz-Hernandez, Z. Deng, J. Zhou, G. Jahreis, and E. R. Dugan. 2004. Analysis of conjugated linoleic acid and trans-18:1 isomers in synthetic and animal products. Am. J. Clin. Nutr. 79:1137S-1145S.
24. Lock, A. L., and D. E. Bauman. 2004. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids 39:1197-1206.
25. Lock, A. L., D. E. Bauman, and P. C. Garnsworthy. 2005. Effect of production variables on the cis-9, trans-11 conjugated linoleic acid content of cows' milk. J. Dairy Sci. 88:2714-2717.
26. 9-desaturase in rats. J. Nutr. 134:2698-2704.
27. Lock, A. L., J. W. Perfield, II, D. Putnam, and D. E. Bauman. 2004b. Evaluation of the degree of rumen inertness and bioavailability of trans-10, cis-12 CLA in a lipid encapsulated supplement. J. Dairy Sci. 87(Suppl. 1):335. (Abstr.)
28. Loor, J. J., and J. H. Herbein. 2003. Reduced fatty acid synthesis and desaturation due to exogenous trans-10, cis-12-CLA in cows fed oleic or linoleic oil. J. Dairy Sci. 86:1354-1369.
29. Luna, P., J. Fontecha, M. Juárez, and M. A. de la Fuente. 2005. Changes in the milk and cheese fat composition of ewes fed commercial supplements containing linseed with special reference to the CLA content and isomer composition. Lipids 40:445-454.
30. Mackle, T. R., J. K. Kay, M. J. Auldist, A. K. H. McGibbon, B. A. Philpott, L. H. Baumgard, and D. E. Bauman. 2003. Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. J. Dairy Sci. 86:644-652.
31. Ministry of Agriculture, Fisheries and Food. 1993. Prediction of the Energy Values of Compound Feeding Stuffs for Farm Animals. HMSO, London, UK.
32. Moss, A. R., and D. I. Givens. 1990. Chemical composition and in vitro digestion to predict digestibility of field-cured and barn-dried grass hays. Anim. Feed Sci. Technol. 31:125-138.
33. Nudda, A., M. A. McGuire, G. Battacone, and G. Pulina. 2005. Seasonal variation in conjugated linoleic acid and vaccenic acid in milk fat of sheep and its transfer to cheese and ricotta. J. Dairy Sci. 88:1311-1319.
34. Perfield, J. W., II, G. Bernal-Santos, T. R. Overton, and D. E. Bauman. 2002. Effects of dietary supplementation of rumen-protected conjugated linoleic acid in dairy cows during established lactation. J. Dairy Sci. 85:2609-2617.
35. Perfield, J. W., II, A. L. Lock, A. M. Pfeiffer, and D. E. Bauman. 2004. Effects of amide-protected and lipid-encapsulated conjugated linoleic acid (CLA) supplements on milk fat synthesis. J. Dairy Sci. 87:3010-3016.
36. Pulina, G., and A. Nudda. 2005. Milk production. Pages 1-12 in Dairy Sheep Nutrition. G. Pulina, ed. CABI Publishing, New York, NY.
37. Rotunno, T., A. Sevi, R. Di Caterina, and A. Muscio. 1998. Effects of graded levels of dietary rumen-protected fat on milk characteristics of Comisana ewes. Small Rumin. Res. 30:137-145.
38. Russell, A. J. F., J. M. Doney, and R. G. Gunn. 1969. Subjective assessment of body fat in live sheep. J. Agric. Sci. (Camb.) 72:351-358.
39. Schauff, D. M., J. H. Clark, and J. K. Drackley. 1992. Effects of feeding lactating dairy cows diets containing extruded soybeans and calcium salts of long-chain fatty acids. J. Dairy Sci. 75:3003-3019.
40. Schmidely, P., and P. Morand-Fehr. 2004. Effects of intravenous infusion of trans-10, cis-12 or cis-9, trans-11 conjugated linoleic acid (CLA) on milk fat synthesis and composition in dairy goats during mid-lactation. S. Afr. J. Anim. Sci. 34(Suppl. 1):195-197.
41. Selberg, K. T., A. C. Lowe, C. R. Staples, N. D. Luchini, and L. Badinga. 2004. Production and metabolic responses of periparturient Holstein cows to dietary conjugated linoleic acid and trans-octadecenoic acids. J. Dairy Sci. 87:158-168.
42. Sevi, A., T. Rotunno, R. Di Caterina, and A. Muscio. 2002. Fatty acid composition of ewe milk as affected by solar radiation and high ambient temperature. J. Dairy Res. 69:181-194.
43. Singh, K., D. G. Hartley, T. B. McFadden, and D. D. S. Mackenzie. 2004. Dietary fat regulates mammary stearoyl CoA desaturase expression and activity in lactating mice. J. Dairy Res. 71:1-6.
44. Terpstra, A. H. M. 2001. Differences between humans and mice in efficiency of the body fat lowering effect of conjugated linoleic acid: Role of metabolic rate. J. Nutr. 131:2067-2068.
45. Van Soest, P. J., J. B. Robertson, and B. A. Lewis. 1991. Methods for dietary fiber, neutral detergent fiber and nonstarch polysacharides in relation to animal nutrition. J. Dairy Sci. 74:3583-3597.
46. Wang, Y. W., and P. J. H. Jones. 2004. Conjugated linoleic acid and obesity control: Efficiency and mechanisms. Int. J. Obes. 28:941-955.
47. Wu, Z., and A. Papas. 1997. Rumen-stable delivery systems. Adv. Drug Deliv. Rev. 28:323-334.