The effect of excess cobalt on milk fatty acid profiles and transcriptional regulation of SCD, FASN, DGAT1 and DGAT2 in the mammary gland of lactating dairy cows

Journal of Animal Physiology and Animal Nutrition

Volumn 96, Issue 6, 2012, Pages 1065-1073

  Karlengen, I J ^a   Harstad, O M ^a   Taugbol O ^a   Berget, I ^a   Aastveit, A H ^a   Vage D I ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

9 desaturase; Cobalt; Dairy cow; DGAT1; DGAT2; FASN; SCD; Stearoyl CoA desaturase

Indexed keywords

ACYL COENZYME A DESATURASE; COBALT; DIACYLGLYCEROL ACYLTRANSFERASE; FATTY ACID; FATTY ACID SYNTHASE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; CATTLE; CHEMISTRY; CLASSIFICATION; DIET; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENETICS; LACTATION; METABOLISM; MILK; PHYSIOLOGY; UDDER;

ANIMAL FEED; ANIMALS; CATTLE; COBALT; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; LACTATION; MAMMARY GLANDS, ANIMAL; MILK; STEAROYL-COA DESATURASE;

BOS;

EID: 84869082877     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2011.01221.x     Document Type: Article

References (44)

1. Bionaz, M.; Loor, J. J., 2008: Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 9, 366-387.
2. Cases, S.; Smith, S. J.; Zheng, Y. W.; Myers, H. M.; Lear, S. R.; Sande, E.; Novak, S.; Collins, C.; Welch, C. B.; Lusis, A. J.; Erickson, S. K.; Farese, R. V., 1998: Identification of a gene encoding an acyl CoA: diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proceedings of the National Academy of Sciences of the United States of America 95, 13018-13023.
3. Clejan, S.; Maddaiah, V. T.; Castromagana, M.; Collipp, P. J., 1981: Zinc deficiency-induced changes in the composition of microsomal-membranes and in the enzymatic regulation of glycerolipid synthesis. Lipids 16, 454-460.
4. Corrier, D. E.; Rowe, L. D.; Clark, D. E.; Hare, M. F., 1986: Tolerance and effect of chronic dietary cobalt on sheep. Veterinary and Human Toxicology 28, 216-219.
5. Cunnane, S. C., 1982: Differential regulation of essential fatty-acid metabolism to the prostaglandins - possible basis for the interaction of zinc and copper in biological-systems. Progress in Lipid Research 21, 73-90.
6. Cunnane, S. C.; Wahle, K. W. J., 1981: Zinc-deficiency increases the rate of delta-6 desaturation of linoleic-acid in rat mammary tissue. Lipids 16, 771-774.
7. Dailey, H. A.; Strittmatter, P., 1980: Characterization of the interaction of amphipathic cytochrome-b5 with stearoyl coenzyme-A desaturase and NADPH - cytochrome-P-450 reductase. The Journal of Biological Chemistry 255, 5184-5189.
8. Elliot, J. I.; Bowland, J. P., 1968: Effects of dietary copper sulfate on fatty acid composition of porcine depot fats. Journal of Animal Science 27, 956-960.
9. Ely, R. E.; Dunn, K. M.; Huffman, C. F., 1948: Cobalt toxicity in calves resulting from high oral administration. Journal of Animal Science 7, 238-246.
10. Ho, S. K.; Elliot, J. I., 1973: Supplemental dietary copper and desaturation of 1-C-14-stearoyl-coenzyme-A by porcine hepatic and adipose microsomes. Canadian Journal of Animal Science 53, 537-545.
11. Karlengen, I. J.; Harstad, O. M.; Kjos, N. P.; Salbu, B.; Aastveit, A. H.; Taugbol, O., In press: Cobalt reduces the delta-9 desaturase index of sow milk. Journal of Animal Physiology and Animal Nutrition, DOI:10.1111/j.1439-0396.2010.01099.x.
12. Keener, H. A.; Percival, G. P.; Morrow, K. S.; Ellis, G. H., 1949: Cobalt tolerance in young dairy cattle. Journal of Dairy Science 32, 527-533.
13. Kelsey, J. A.; Corl, B. A.; Collier, R. J.; Bauman, D. E., 2003: The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows. Journal of Dairy Science 86, 2588-2597.
14. Kramer, J. K. C.; Fellner, V.; Dugan, M. E. R.; Sauer, F. D.; Mossoba, M. M.; Yurawecz, M. P., 1997: Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids. Lipids 32, 1219-1228.
15. Kudo, N.; Nakagawa, Y.; Waku, K.; Kawashima, Y.; Kozuka, H., 1991: Prevention by zinc of cadmium inhibition of stearoyl-CoA desaturase in rat-liver. Toxicology 68, 133-142.
16. Maines, M. D.; Kappas, A., 1974: Cobalt induction of hepatic heme oxygenase with evidence that cytochrome-P-450 is not essential for this enzyme-activity. Proceedings of the National Academy of Sciences of the United States of America 71, 4293-4297.
17. Maines, M. D.; Kappas, A., 1975: Cobalt stimulation of heme degradation in liver - dissociation of microsomal oxidation of heme from cytochrome-P-450. The Journal of Biological Chemistry 250, 4171-4177.
18. Maines, M. D.; Kappas, A., 1976a: The induction of heme oxidation in various tissues by trace-metals - evidence for catabolism of endogenous heme by hepatic heme oxygenase. Annals of Clinical Research 8, 39-46.
19. Maines, M. D.; Kappas, A., 1976b: Studies on mechanism of induction of heme oxygenase by cobalt and other metal-ions. Biochemical Journal 154, 125-131.
20. Man, W. C.; Miyazaki, M.; Chu, K.; Ntambi, J., 2006: Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Journal of Lipid Research 47, 1928-1939.
21. Mitchell, A. G.; Martin, C. E., 1995: A novel cytochrome b(5)-like domain is linked to the carboxyl-terminus of the saccharomyces-cerevisiae delta-9 fatty-acid desaturase. The Journal of Biological Chemistry 270, 29766-29772.
22. Nakamura, M. T.; Nara, T. Y., 2004: Structure, function, and dietary regulation of delta 6, delta 5, and delta 9 desaturases. Annual Review of Nutrition 24, 345-376.
23. Naylor, G. P. L.; Harrison, J. D., 1995: Gastrointestinal iron and cobalt absorption and iron status in young rats and guinea pigs. Human & Experimental Toxicology 14, 949-954.
24. NRC, 2005: Mineral Tolerance of Animals, 2nd rev. edn. National Academies Press, Washington, DC.
25. Ntambi, J. M., 1995: The regulation of stearoyl-Coa desaturase (SCD). Progress in Lipid Research 34, 139-150.
26. Ntambi, J. M.; Miyazaki, M., 2004: Regulation of stearoyl-CoA desaturases and role in metabolism. Progress in Lipid Research 43, 91-104.
27. Paton, C. M.; Ntambi, J. M., 2009: Biochemical and physiological function of stearoyl-CoA desaturase. American Journal of Physiology. Endocrinology and Metabolism 297, E28-E37.
28. Pigeon, C.; Legrand, P.; Leroyer, P.; Bouriel, M.; Turlin, B.; Brissot, P.; Loreal, O., 2001: Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload. Biochimica Et Biophysica Acta. Molecular Basis of Disease 1535, 275-284.
29. Rao, G. A.; Manix, M.; Larkin, E. C., 1980: Reduction of essential fatty-acid deficiency in rats fed a low iron fat free diet. Lipids 15, 55-60.
30. Rao, G. A.; Crane, R. T.; Larkin, E. C., 1983: Reduction of hepatic stearoyl-CoA desaturase activity in rats fed iron-deficient diets. Lipids 18, 573-575.
31. Shingfield, K. J.; Ahvenjarvi, S.; Toivonen, V.; Arola, A.; Nurmela, K. V. V.; Huhtanen, P.; Griinari, J. M., 2003: Effect of dietary fish oil on biohydrogenation of fatty acids and milk fatty acid content in cows. Animal Science 77, 165-179.
32. Shingfield, K. J.; Toivonen, V.; Vanhatalo, A.; Huhtanen, P.; Griinari, J. M., 2006: Short communication: indigestible markers reduce the mammary Delta(9)-desaturase index and alter the milk fatty acid composition in cows. Journal of Dairy Science 89, 3006-3010.
33. Shingfield, K. J.; Arola, A.; Ahvenjarvi, S.; Vanhatalo, A.; Toivonen, V.; Griinari, J. M.; Huhtanen, P., 2008: Ruminal infusions of cobalt-EDTA reduce mammary delta 9-desaturase index and alter milk fatty acid composition in lactating cows. Journal of Nutrition 138, 710-717.
34. Sreekrishna, K.; Joshi, V. C., 1980: Inhibition of the microsomal stearoyl coenzyme-A desaturation by divalent copper and its chelates. Biochimica Et Biophysica Acta 619, 267-273.
35. Stevnebø, A., 2009: Barley varieties (Hordeum Vulgare L.) with different proportions of amylose - effect on starch degradation characteristics and performance of monogastrics and ruminants. PhD thesis, Norwegian university of life sciences, Ås, Norway.
36. Sun, J. Y.; Wang, J. F.; Zi, N. T.; Jing, M. Y.; Weng, X. Y., 2007: Gene expression profiles analysis of the growing rat liver in response to different zinc status by cDNA microarray analysis. Biological Trace Element Research 115, 169-185.
37. Taugbøl, O.; Karlengen, I. J.; Bolstad, T.; Aastveit, A. H.; Harstad, O. M., 2008: Cobalt supplied per os reduces the mammary Delta(9)-desaturase index of bovine milk. Journal of Animal Science 86, 3062-3068.
38. Taugbøl, O.; Karlengen, I. J.; Salbu, B.; Aastveit, A. H.; Harstad, O. M., 2010: Intravenous injections of cobalt reduce fatty acid desaturation products in milk and blood of lactating cows. Journal of Animal Physiology and Animal Nutrition 94, 635-640.
39. Tocher, D. R.; Leaver, M. J.; Hodgson, P. A., 1998: Recent advances in the biochemistry and molecular biology of fatty acyl desaturases. Progress in Lipid Research 37, 73-117.
40. Volden, H., 1999: Effects of level of feeding and ruminally undegraded protein on ruminal bacterial protein synthesis, escape of dietary protein, intestinal amino acid profile, and performance of dairy cows. Journal of Animal Science 77, 1905-1918.
41. Wahle, K. W. J.; Davies, N. T., 1974: Effect of dietary copper deficiency on desaturation of stearic acid by rat-liver microsomal fractions. Biochemical Society Transactions 2, 1283-1285.
42. Wahle, K. W. J.; Davies, N. T., 1975: Effect of dietary copper deficiency in rat on fatty-acid composition of adipose-tissue and desaturase activity of liver-microsomes. British Journal of Nutrition 34, 105-112.
43. Wakil, S. J., 1989: Fatty-acid synthase, a proficient multifunctional enzyme. Biochemistry 28, 4523-4530.
44. Wolfinger, R. D., 1996: Heterogeneous variance-covariance structures for repeated measures. Journal of Agricultural, Biological and Environmental Statistics 1, 205-230.