Solvent induced phase inversion-based in situ forming controlled release drug delivery implants

Journal of Controlled Release

Volumn 176, Issue 1, 2014, Pages 8-23

  Thakur, Raghu Raj Singh ^a   McMillan, Hannah L ^a   Jones, David S ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Controlled release; Drug delivery; In situ forming implants; Solvent induced phase inversion implants; Sustained release

Indexed keywords

BIOCOMPATIBLE SOLVENTS; BIOMEDICAL APPLICATIONS; CONTROLLED RELEASE; CONTROLLED RELEASE DRUGS; IN-SITU FORMING; PHASE INVERSION; SUSTAINED RELEASE; THERAPEUTIC APPLICATION;

BIOCOMPATIBILITY; BIODEGRADATION; DRUG DELIVERY; DRUG PRODUCTS; MEDICAL APPLICATIONS; TISSUE ENGINEERING;

SOLVENTS;

ATRISORB; ATRISORB D; BENZYL ALCOHOL; BENZYL BENZOATE; DIMETHYL SULFOXIDE; DOXYCYCLINE HYCLATE; DRUG ADDITIVE; DRUG CARRIER; ETHYL BENZOATE; FREEFLOW; FUMARIC ACID; LEUPRORELIN; MACROGOL; MONOMER; OCTREOTIDE; PAPAVERINE; POSIDUR; PROPYLENE GLYCOL; RELDAY; SOLVENT; SUCROMATE; TRIACETIN; UNCLASSIFIED DRUG;

BIOCOMPATIBILITY; CHEMICAL PROCEDURES; CLINICAL TRIAL (TOPIC); CONTROLLED RELEASE FORMULATION; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRUG HYDROLYSIS; DRUG IMPLANT; DRUG SOLUBILITY; DRUG STABILITY; HUMAN; IN SITU IMPLANT FORMATION; IN VITRO STUDY; INSTRUMENT STERILIZATION; MOLECULAR WEIGHT; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REVIEW; SLOW RELEASE FORMULATION; SOLVENT INDUCED PHASE INVERSION TECHNIQUE; SUSTAINED DRUG RELEASE;

CONTROLLED RELEASE; DRUG DELIVERY; IN SITU FORMING IMPLANTS; SOLVENT INDUCED PHASE INVERSION IMPLANTS; SUSTAINED RELEASE;

ANIMALS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; HUMANS; POLYMERS; SOLVENTS; STERILIZATION;

EID: 84892642192     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.12.020     Document Type: Review

References (150)

1. A. Lendlein, and V.P. Shastri Stimuli-sensitive polymers Adv. Mater. 22 2010 3344 3347
2. Hatefi, and B. Amsden Biodegradable injectable in situ forming drug delivery systems J. Control. Release 80 2002 9 28 (Pubitemid 34273745)
3. D. Chitkara, A. Shikanov, N. Kumar, and A.J. Domb Biodegradable injectable in situ depot-forming drug delivery systems Macromol. Biosci. 6 2006 977 990 (Pubitemid 46032935)
4. S. Abashzadeh, R. Dinarvand, M. Sharifzadeh, G. Hassanzadeh, M. Amini, and F. Atyabi Formulation and evaluation of an in situ gel forming system for controlled delivery of triptorelin acetate Eur. J. Pharm. Sci. 4 2011 514 521
5. E. Gil, and S. Hudson Stimuli-reponsive polymers and their bioconjugates Prog. Polym. Sci. 29 2004 1173 1222
6. P.D.D. Graham, K.J.J. Brodbeck, and A.J.J. McHugh Phase inversion dynamics of PLGA solutions related to drug delivery J. Control. Release 58 1999 233 245
7. L. Wang, S. Venkatraman, and L. Kleiner Drug release from injectable depots: two different in vitro mechanisms J. Control. Release 99 2004 207 216 (Pubitemid 39222107)
8. E. Ruel-Gariépy, and J.-C. Leroux In situ-forming hydrogels - review of temperature-sensitive systems Eur. J. Pharmacol. Biopharm. 58 2004 409 426 (Pubitemid 39037244)
9. K.J. Brodbeck, S. Pushpala, and A.J. McHugh Sustained release of human growth hormone from PLGA solution depots Pharm. Res. 16 1999 1825 1829 (Pubitemid 30040697)
10. H. Kranz, and R. Bodmeier Structure formation and characterization of injectable drug loaded biodegradable devices: in situ implants versus in situ microparticles Eur. J. Pharm. Sci. 34 2008 164 172
11. M. Körber, and R. Bodmeier Development of an in situ forming PLGA drug delivery system I. Characterization of a non-aqueous protein precipitation Eur. J. Pharm. Sci. 35 2008 283 292
12. C.B. Packhaeuser, J. Schnieders, C.G. Oster, and T. Kissel In situ forming parenteral drug delivery systems: an overview Eur. J. Pharm. Biopharm. 58 2004 445 455 (Pubitemid 39037247)
13. R.L. Dunn, J.P. English, D.R. Cowsar, D.P. Vanderbilt, Biodegradable in-situ forming implants and methods of producing the same, US Patents 4,938,763, 1990.
14. R.L. Dunn, A.J. Tipton, R.J. Harkrader, J.A. Rogers, Intragingival delivery systems for treatment of periodontal disease, US Patent 5,324,520, 1994.
15. R.L. Dunn, J.P. English, D.R. Cowsar, D.P. Vanderbilt, Biodegradable in-situ forming implants and methods of producing the same, US Patent 4,938,763, 1995.
16. K.J. Brodbeck, A.T. Gaynor-Duarte, T. Shen, Gel Composition and Methods, US Patent 6,130,200, 2000.
17. C. Matschke, U. Isele, P. Van Hoogevest, and A. Fahr Sustained-release injectables formed in situ and their potential use for veterinary products J. Control. Release 85 2002 1 15 (Pubitemid 35449450)
18. R. Astaneh, M. Erfan, H. Moghimi, and H. Mobedi Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behavior J. Pharm. Sci. 98 2009 135 145
19. X. Luan, and R. Bodmeier Influence of the poly(lactide-co-glycolide) type on the leuprolide release from in situ forming microparticle systems J. Control. Release 110 2006 266 272 (Pubitemid 41827479)
20. K.J.J. Brodbeck, J.R.R. Desnoyer, and A.J.J. McHugh Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer. J. Control. Release 62 1999 333 344
21. Y. Liu, A. Kemmer, K. Keim, C. Curdy, H. Petersen, and T. Kissel Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study Eur. J. Pharm. Biopharm. 76 2010 222 229
22. S.S. Lee, P. Hughes, A.D. Ross, and M.R. Robinson Biodegradable implants for sustained drug release in the eye Pharm. Res. 27 2010 2043 2053
23. J.R. DesNoyer, and A.J. McHugh Role of crystallization in the phase inversion dynamics and protein release kinetics of injectable drug delivery systems J. Control. Release 70 2001 285 294 (Pubitemid 32155452)
24. D.F. Kiernan, and W.F. Mieler The use of intraocular corticosteroids Expert Opin. Pharmacother. 10 2009 2511 2525
25. T. Yasukawa, H. Kimura, Y. Tabata, and Y. Ogura Biodegradable scleral plugs for vitreoretinal drug delivery Adv. Drug Deliv. Rev. 52 2001 25 36 (Pubitemid 32973636)
26. D.A. Mohammad, B.V. Sweet, and S.G. Elner Retisert: is the new advance in treatment of uveitis a good one? Ann. Pharmacother. 41 2007 449 454
27. K. Schoenhammer, J. Boisclair, H. Schuetz, H. Petersen, and A. Goepferich Biocompatibility of an injectable in situ forming depot for peptide delivery J. Pharm. Sci. 99 2010 4390 4399
28. L. Brannon-Peppas Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery Int. J. Pharm. 116 1995 1 9
29. S.J. Bae, M.K. Joo, Y. Jeong, S.W. Kim, W.-K. Lee, and Y.S. Sohn et al. Gelation behavior of poly(ethylene glycol) and polycaprolactone triblock and multiblock copolymer aqueous solutions Macromolecular 39 2006 4873 4879 (Pubitemid 44106225)
30. B.O. Haglund, R. Joshi, and K.J. Himmelstein An in situ gelling system for parenteral delivery J. Control. Release 41 1996 229 235 (Pubitemid 26284478)
31. F.A. Ismail, J. Napaporn, J.A. Hughes, and G.A. Brazeau In situ gel formulations for gene delivery: release and myotoxicity studies Pharm. Dev. Technol. 5 2000 391 397 (Pubitemid 30602847)
32. S. Fredenberg, M. Wahlgren, M. Reslow, and A. Axelsson The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems - a review Int. J. Pharm. 415 2011 34 55
33. R.E. Eliaz, and J. Kost Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins J. Biomed. Mater. Res. 50 2000 388 396 (Pubitemid 30180731)
34. A. Merkli, C. Tabatabay, R. Gurny, and J. Heller Biodegradable polymers for the controlled release of ocular drugs Prog. Polym. Sci. 23 1998 563 580 (Pubitemid 128676066)
35. K. Jamshidi, S.-H. Hyon, and Y. Ikada Thermal characterization of polylactides Polymer 29 1988 2229 2234
36. H. Kranz, and R. Bodmeier A novel in situ forming drug delivery system for controlled parenteral drug delivery Int. J. Pharmacol. 332 2007 107 114 (Pubitemid 46227772)
37. M. Zare, H. Mobedi, J. Barzin, H. Mivehchi, A. Jamshidi, and R. Mashayekhi Effect of additives on release profile of leuprolide acetate in an in situ forming controlled-release system: in vitro study J. App. Polym. Sci. 107 2008 3781 3787 (Pubitemid 351388247)
38. Y. Tang, and J. Singh Controlled delivery of aspirin: effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems Int. J. Pharmacol. 357 2008 119 125
39. R. Bakhshi, E. Vasheghani-farahani, H. Mobedi, A. Jamshidi, and M. Khakpour The effect of additives on naltrexone hydrochloride release and solvent removal rate from an injectable in situ forming PLGA implant Release profiles Polym. Adv. Technol. 17 2006 354 359 (Pubitemid 44044486)
40. C. Wischke, Y. Zhang, S. Mittal, and S.P. Schwendeman Development of PLGA-based injectable delivery systems for hydrophobic fenretinide Pharm. Res. 27 2010 2063 2074
41. S. Dong, S. Wang, C. Zheng, W. Liang, and Y. Huang An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics Soft Matter 7 2011 5873
42. J.C. Middleton, and A.J. Tipton Synthetic biodegradable polymers as orthopedic devices Biomaterialia 21 2000 2335 2346
43. P. a Gunatillake, and R. Adhikari Biodegradable synthetic polymers for tissue engineering Eur. Cell. Mater. 5 2003 1 16 (discussion 16) (Pubitemid 38957397)
44. H. Ueda, M.C. Hacker, a Haesslein, S. Jo, D.M. Ammon, and R.N. Borazjan et al. Injectable, in situ forming poly(propylene fumarate)-based ocular drug delivery systems J. Biomed. Mater. Res. A 83 2007 656 666 (Pubitemid 350086291)
45. Y. Liu, A. Kemmer, K. Keim, C. Curdy, H. Petersen, and T. Kissel Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study Eur. J. Pharm. Biopharm. 76 2 2010 222 229
46. L.A. Cornacchione, B. Qi, J. Bianco, Z. Zhou, and B.G. Amsden Photo-cross-linked poly(ethylene carbonate) elastomers: synthesis, in vivo degradation, and determination of in vivo degradation mechanism Biomacromolecules 13 10 2012 3099 3107
47. T. Renette, D. Librizzi, T. Endres, O. Merkel, M. Beck-Broichsitter, N. Bege, H. Petersen, C. Curdy, and T. Kissel Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy Macromol. Biosci. 12 7 2012 970 978
48. N. Nasongkla, A. Boongird, S. Hongeng, C. Manaspon, and N. Larbcharoensub Preparation and biocompatibility study of in situ forming polymer implants in rat brains J. Mater. Sci. Mater. Med. 23 2012 497 505
49. J. Lee, G.I. Jallo, M.B. Penno, K.L. Gabrielson, G.D. Young, and R.M. Johnson et al. Intracranial drug-delivery scaffolds: biocompatibility evaluation of sucrose acetate isobutyrate gels Toxicol. Appl. Pharmacol. 215 2006 64 70 (Pubitemid 44137378)
50. X. Lin, S. Yang, G. Jingxin, M. Zhao, Y. Zhang, and N. Qi et al. A novel risperidone-loaded SAIB-PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviours in vitro/in vivo J. Mater. Sci. Mater. Med. 23 2012 443 455
51. R.L. Dunn, J.P. English, D.R. Cowsar, D.D. Vanderbilt, Biodegradable in-situ forming implants and methods of producing the same, US Patent 5,278,202, 2004.
52. D.N. Kapoor, O.P. Katare, and S. Dhawan In situ forming implant for controlled delivery of an anti-HIV fusion inhibitor Int. J. Pharmacol. 426 2012 132 143
53. K. Malik, I. Singh, M. Nagpal, and S. Arora Atrigel: a potential parenteral controlled drug delivery system Der Pharm. Sin. 1 2010 74 81
54. L. Wang, A. Wang, X. Zhao, X. Liu, D. Wang, and F. Sun et al. Design of a long-term antipsychotic in situ forming implant and its release control method and mechanism Int. J. Pharmacol. 427 2012 284 292
55. A.J. McHugh The role of polymer membrane formation in sustained release drug delivery systems J. Control. Release 109 2005 211 221 (Pubitemid 41737265)
56. http://www.sigmaaldrich.com/united-kingdom.html (Accessed on 09 September 2013)
57. R. Eliaz, D. Wallach, and J. Kost Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants: in-vivo Pharm. Res. 17 2000 1546 1550 (Pubitemid 32217565)
58. F. Kang, and J. Singh In vitro release of insulin and biocompatibility of in situ forming gel systems Int. J. Pharm. 304 2005 83 90 (Pubitemid 41427652)
59. R.L. Dunn, A.J. Tipton, G.L. Southard, J.A. Rogers, Biodegradable polymer composition, US Patent 5,599,552, 1997.
60. K. Schoenhammer, H. Petersen, F. Guethlein, and A. Goepferich Poly(ethyleneglycol) 500 dimethylether as novel solvent for injectable in situ forming depots Pharm. Res. 26 2009 2568 2577
61. K. Schoenhammer, H. Petersen, F. Guethlein, and A. Goepferich Injectable in situ forming depot systems: PEG-DAE as novel solvent for improved PLGA storage stability Int. J. Pharmacol. 371 2009 33 39
62. B. Bleiberg, T. Beers, M. Persson, and J. Miles Metabolism of triacetin-derived acetate in dogs Am. J. Clin. Nutr. 58 1993 908 911 (Pubitemid 23353601)
63. R.T. Chern, J.R. Zingerman, Liquid polymeric compositions for controlled release of bioactive substances, US Patent 10/753,724, 2004.
64. C. Raman, and A.J. McHugh A model for drug release from fast phase inverting injectable solutions J. Control. Release 102 2005 145 157 (Pubitemid 40093781)
65. A. Mashak, H. Mobedi, F. Ziaee, and M. Nekoomanesh The effect of aliphatic esters on the formation and degredation behavior of PLGA-based in situ forming system Polym. Bull. 66 2011 1063 1073
66. S. Kempe, H. Metz, P.G.C. Pereira, and K. Mäder Non-invasive in vivo evaluation of in situ forming PLGA implants by benchtop magnetic resonance imaging (BT-MRI) and EPR spectroscopy Eur. J. Pharm. Biopharm. 74 2010 102 108
67. D.J. Lurie, and K. Mäder Monitoring drug delivery processes by EPR and related techniques - principles and applications Adv. Drug Deliv. Rev. 57 2005 1171 1190 (Pubitemid 40797573)
68. L. Wang, L. Kleiner, and S. Venkatraman Structure formation in injectable poly(lactide-co-glycolide) depots J. Control. Release 90 2003 345 354 (Pubitemid 36859965)
69. M. Rafienia, H. Mirzadeh, H. Mobedi, and a. Jamshidi In vitro evaluation of drug solubility and gamma irradiation on the release of betamethasone under simulated in vivo conditions J. Bioact. Compat. Polym. 22 2007 443 459 (Pubitemid 47366788)
70. L. Solorio, B.M. Babin, R.B. Patel, J. Mach, N. Azar, and A.A. Exner Noninvasive characterization of in situ forming implants using diagnostic ultrasound J. Control. Release 143 2010 183 190
71. M. a Royals, S.M. Fujita, G.L. Yewey, J. Rodriguez, P.C. Schultheiss, and R.L. Dunn Biocompatibility of a biodegradable in situ forming implant system in rhesus monkeys J. Biomed. Mater. Res. 45 1999 231 239 (Pubitemid 29165939)
72. R. Astaneh, M. Erfan, J. Barzin, and H. Mobedi Effects of ethyl benzoate on performance, morphology, and erosion of PLGA implants formed in situ Adv. Polym. Technol. 27 2008 17 26
73. T. Ahmed, H. Ibrahim, F. Ibrahim, A.M. Samy, A. Kaseem, M.T. Nutan, and M.D. Hussain Development of biodegradable in situ implant and microparticle injectable formulations for sustained delivery of haloperidol J. Pharm. Sci. 101 2012 3753 3762
74. X. Huang, and C.S. Brazel On the importance and mechanisms of burst release in matrix-controlled drug delivery systems J. Control. Release 73 2001 121 136 (Pubitemid 32539245)
75. M.L. Shively, B.A. Coonts, W.D. Renner, J.L. Southard, and A.T. Bennett Physico-chemical characterization of a polymeric injectable implant delivery system J. Control. Release 33 1995 237 243
76. R.B. Patel, L. Solorio, H. Wu, T. Krupka, and A.A. Exner Effect of injection site on in situ implant formation and drug release in vivo J. Control. Release 147 2010 350 358
77. J. Setterstrom, T. Tice, W. Meyers, and J. Vincent Development of encapsulated antibiotics for topical administration to wounds Second World Congress on Biomaterials 10th Annual Meeting of the Society for Biomaterials, Washington 1984 4 (Pubitemid 16543733)
78. R.B. Patel, A.N. Carlson, L. Solorio, and A. a Exner Characterization of formulation parameters affecting low molecular weight drug release from in situ forming drug delivery systems J. Biomed. Mater. Res. A 94 2010 476 484
79. L.P. Tan, S.S. Venkatraman, P.F. Sung, and X.T. Wang Effect of plasticization on heparin release from biodegradable matrices Int. J. Pharmacol. 283 2004 89 96 (Pubitemid 39200930)
80. J. DesNoyer, and A. McHugh The effect of Pluronic on the protein release kinetics of an injectable drug delivery system J. Control. Release 86 2003 15 24 (Pubitemid 35461971)
81. C.S. Yong, Y.-K. Oh, Y.-I. Kim, J.O. Kim, B.-K. Yoo, and J.-D. Rhee et al. Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats Int. J. Pharmacol. 301 2005 54 61 (Pubitemid 41206590)
82. K. Edsman, J. Carlfors, and R. Petersson Rheological evaluation of poloxamer as an in situ gel for ophthalmic use Eur. J. Pharm. Sci. 6 1998 105 112 (Pubitemid 28164280)
83. R. Henry, and I. Schmolka Burn wound coverings and the use of poloxamer preparations Crit. Rev. Biocompat. 5 1989 207 220
84. A. Paavola, J. Yliruusi, Y. Kajimoto, E. Kalso, T. Wahlström, and P. Rosenberg Controlled release of lidocaine from injectable gels and efficacy in rat sciatic nerve block Pharm. Res. 12 1995 1997 2002 (Pubitemid 26032298)
85. M.O. Omelczuk, and J.W. McGinity The influence of polymer glass transition temperature and molecular weight on drug release from tablets containing poly(dl-lactic acid) Pharm. Res. 9 1992 26 32
86. Q. Liu, H. Zhang, G. Zhou, S. Xie, H. Zou, and Y. Yu et al. In vitro and in vivo study of thymosin alpha1 biodegradable in situ forming poly(lactide-co-glycolide) implants Int. J. Pharmacol. 397 2010 122 129
87. W.J. Lambert, and K.D. Peck Development of an in situ forming biodegradable poly-lactide-coglycolide system for the controlled release of proteins J. Control. Release 33 1995 189 195
88. X. Wang, S.S. Venkatraman, F.Y.C. Boey, J.S.C. Loo, and L.P. Tan Controlled release of sirolimus from a multilayered PLGA stent matrix Biomaterialia 27 2006 5588 5595 (Pubitemid 44176151)
89. S. Chhabra, V. Sachdeva, and S. Singh Influence of end groups on in vitro release and biological activity of lysozyme from a phase-sensitive smart polymer-based in situ gel forming controlled release drug delivery system Int. J. Pharm. 342 2007 72 77 (Pubitemid 47259328)
90. A. Göpferich Polymer degradation and erosion: mechanisms and applications Eur. J. Pharm. Biopharm. 42 1996 1 11 (Pubitemid 26092502)
91. M. Miyajima, A. Koshika, J. Okada, M. Ikeda, and K. Nishimura Effect of polymer crystallinity on papaverine release from poly (l-lactic acid) matrix J. Control. Release 49 1997 207 215 (Pubitemid 28020274)
92. W.Y. Dong, M. Körber, V. López Esguerra, and R. Bodmeier Stability of poly(d,l-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems J. Control. Release 115 2006 158 167 (Pubitemid 44537494)
93. H.B. Ravivarapu, K.L. Moyer, and R.L. Dunn Sustained activity and release of leuprolide acetate from an in situ forming polymeric implant AAPS PharmSciTech 1 2000 E1
94. H.B. Ravivarapu, K.L. Moyer, and R.L. Dunn Parameters affecting the efficacy of a sustained release polymeric implant of leuprolide Int. J. Pharm. 194 2000 181 191 (Pubitemid 30110680)
95. A. Göpferich Mechanisms of polymer degradation and erosion Biomaterialia 17 1996 103 114 (Pubitemid 26031366)
96. M. Acemoglu Chemistry of polymer biodegradation and implications on parenteral drug delivery Int. J. Pharmacol. 277 2004 133 139 (Pubitemid 38670428)
97. S. Wang, L. Lu, and M.J. Yaszemski Bone-tissue-engineering material poly(propylene fumarate): correlation between molecular weight, chain dimensions, and physical properties Biomacromolecules 7 2006 1976 1982 (Pubitemid 43994852)
98. T. St. Pierre, and E. Chiellini Review: biodegradability of synthetic polymers used for medical and pharmaceutical applications: part 1 - principles of hydrolysis mechanisms J. Bioact. Compat. Polym. 1 1986 467 497
99. S. Li, and S. McCarthy Further investigations on the hydrolytic degradation of poly (dl-lactide) Biomaterialia 20 1999 35 44 (Pubitemid 29002543)
100. X. Chen, C.P. Ooi, and T.H. Lim Effect of ganciclovir on the hydrolytic degradation of poly(lactide-co-glycolide) microspheres J. Biomater. Appl. 20 2006 287 302 (Pubitemid 43168998)
101. S. Li, H. Garreau, and M. Vert Structure-property relationships in the case of the degradation of massive poly(?-hydroxy acids) in aqueous media J. Mater. Sci. Mater. Med. 1 1990 198 206
102. M.L. Houchin, and E.M. Topp Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms J. Pharm. Sci. 97 7 2008 2395 2404
103. N. Bege, S.O. Steinmüller, M. Kalinowski, R. Reul, S. Klaus, H. Petersen, C. Curdy, J. Janek, and T. Kissel Drug eluting stents based on poly(ethylene carbonate): optimization of the stent coating process Eur. J. Pharm. Biopharm. 80 3 2012 562 570
104. M. Acemoglu, F. Nimmerfall, S. Bantle, and H. Stoll Poly(ethylene carbonate)s part I: syntheses and structural effects on biodegradation J. Control. Release 49 1997 263 276 (Pubitemid 28020279)
105. S.J. Siegel, J.B. Kahn, K. Metzger, K.I. Winey, K. Werner, and N. Dan Effect of drug type on the degradation rate of PLGA matrices Eur. J. Pharm. Biopharm. 64 3 2006 287 293 (Pubitemid 44585214)
106. J.W. Streilein Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation J. Leukocyte Biol. 74 2003 179 185 (Pubitemid 38040414)
107. R.E. Holmes, S.R. Cohen, G.B. Cornwall, K.A. Thomas, K.K. Kleinhenz, and M.Z. Beckett MacroPore resorbable devices in craniofacial surgery Clin. Plast. Surg. 31 2004 393 406 v (Pubitemid 38829237)
108. G.G. Giordano, P. Chevez-Barrios, M.F. Refojo, and C.A. Garcia Biodegradation and tissue reaction to intravitreous biodegradable poly(d,l-lactic-co-glycolic)acid microspheres Curr. Eye Res. 14 1995 761 768
109. S. Dhawan, R. Kapil, and D.N. Kapoor Development and evaluation of in situ gel-forming system for sustained delivery of insulin J. Biomater. Appl. 25 2011 699 720
110. J.S. Temeno, A.G. Mikos, and J.S. Temenoff Injectable biodegradable materials for orthopedic tissue engineering Biomaterialia 21 2000 2405 2412
111. S.J. Peter, S.T. Miller, G. Zhu, A.W. Yasko, and A.G. Mikos In vivo degradation of a poly(propylene fumarate)/beta-tricalcium phosphate injectable composite scaffold J. Biomed. Mater. Res. 41 1998 1 7 (Pubitemid 28255888)
112. M.C. Serrano, R. Pagani, M. Vallet-Regí, J. Peña, A. Rámila, and I. Izquierdo et al. In vitro biocompatibility assessment of poly(epsilon-caprolactone) films using L929 mouse fibroblasts Biomaterialia 25 2004 5603 5611 (Pubitemid 38680488)
113. C.X.F. Lam, D.W. Hutmacher, J.-T. Schantz, M.A. Woodruff, and S.H. Teoh Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo J. Biomed. Mater. Res. A 90 2009 906 919
114. N.A. David The pharmacology of dimethyl sulfoxide Ann. Rev. Pharmacol. 12 1972 353 374
115. K.P. Lee, N.C. Chromey, R. Culik, J.R. Barnes, and P.W. Schneider Toxicity of N-methyl-2-pyrrolidone (NMP): teratogenic, subchronic, and two-year inhalation studies Toxicol. Sci. 9 1987 222 235 (Pubitemid 18043754)
116. A. Jouyban, M.A. Fakhree, and A. Shayanfar Review of pharmaceutical applications of N-methyl-2-pyrrolidone J. Pharm. Pharm. Sci. 13 2010 524 535
117. Scientific Committee on Consumer Safety, Opinion on N-Methyl-2- pyrrolidone (NMP) SCCS/1413/11, Brussels 2011
118. N.J. Medlicott, K.A. Foster, K.L. Audus, S. Gupta, and V.J. Stella Comparison of the effects of potential parenteral vehicles for poorly water soluble anticancer drugs (organic cosolvents and cyclodextrin solutions) on cultured endothelial cells (HUV-EC) J. Pharm. Sci. 87 1998 1138 1143 (Pubitemid 28452116)
119. M. Shive, and J. Anderson Biodegradation and biocompatibility of PLA and PLGA microspheres Adv. Drug Deliv. Rev. 28 1997 5 24 (Pubitemid 27497671)
120. S. Singh, and J. Singh Phase-sensitive polymer-based controlled delivery systems of leuprolide acetate: in vitro release, biocompatibility, and in vivo absorption in rabbits Int. J. Pharm. 328 2007 42 48 (Pubitemid 44827559)
121. S. Yoshioka, Y. Aso, T. Otsuka, and S. Kojima The effect of gamma-irradiation on drug release from poly(lactide) microspheres Radiat. Phys. Chem. 46 1995 281 285
122. L. Montanari, M. Costantini, E.C. Signoretti, L. Valvo, M. Santucci, and M. Bartolomei et al. Gamma irradiation effects on poly(dl-lactictide-co- glycolide) microspheres J. Control. Release 56 1998 219 229 (Pubitemid 28511142)
123. L. Montanari, F. Cilurzo, L. Valvo, A. Faucitano, A. Buttafava, and A. Groppo et al. Gamma irradiation effects on stability of poly(lactide-co- glycolide) microspheres containing clonazepam J. Control. Release 75 2001 317 330 (Pubitemid 32727262)
124. L. Montanari, F. Cilurzo, B. Conti, I. Genta, A. Groppo, and L. Valvo et al. Gamma irradiation effects and EPR investigation on poly(lactide-co- glycolide) microspheres containing bupivacaine Il. Farmacol. 57 2002 427 433 (Pubitemid 34603774)
125. http://www.zila.com/atrisorb/ (Accessed on 09 September 2013)
126. MHRA Granted marketing authorisations (MAs) published in March/April 2003 2003
127. N.H. Stoller, L.R. Johnson, S. Trapnell, C.Q. Harrold, and S. Garrett The pharmacokinetic profile of a biodegradable controlled-release delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum J. Periodontal 69 1998 1085 1091 (Pubitemid 28487237)
128. S. Garrett, L. Johnson, C.H. Drisko, D.F. Adams, C. Bandt, and B. Beiswanger et al. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planning in the treatment of periodontitis J. Periodontal 70 1999 490 503 (Pubitemid 29269661)
129. US Food and Drug Administration, Devices@FDA 2012
130. B.A. Coonts, S.L. Whitman, M. O'Donnell, A.M. Polson, G. Bogle, and S. Garrett et al. Biodegradation and biocompatibility of a guided tissue regeneration barrier membrane formed from a liquid polymer material J. Biomed. Mater. Res. 42 1998 303 311 (Pubitemid 28446973)
131. O. Sartor Eligard: leuprolide acetate in a novel sustained-release delivery system Urology 61 2003 25 31 (Pubitemid 36349539)
132. F.M. Chu, M. Jayson, M.K. Dineen, R. Perez, R. Harkaway, and R.C. Tyler A clinical study of 22.5 mg. La-2550: a new subcutaneous depot delivery system for leuprolide acetate for the treatment of prostate cancer J. Urology 168 2002 1199 1203
133. US Food and Drug Administration FDA Drug Safety Communication: Ongoing Safety Review of GnRH Agonists and Possible Increased Risk of Diabetes and Certain Cardiovascular Diseases 2011
134. US Food and Drug Adminsitration Highlights of Prescribing Information 2011
135. http://www.abbvie.com/products/home.html (Accessed on 09 September 2013)
136. US Food and Drug Administration Drug Approval Package 2005
137. http://www.medicines.org.uk/emc/medicine/1321/SPC#ORIGINAL (Accessed on 09 September 2013)
138. Novartis Pharmaceuticals UK Ltd, Summary of Product Characteristics of Sandostatin LAR 2011
139. I.M. Modlin, M. Pavel, M. Kidd, and B.I. Gustafsson Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours Aliment. Pharmacol. Therapeut. 31 2010 169 188
140. R.A. James, M.M.C. Connell, G.A. Roberts, M.F. Scanlon, P.M. Stewart, and E. Teasdale et al. Primary medical therapy for acromegaly: An open, prospective, multicenter study of the effects of subcutaneous and intramuscular slow-release octreotide on growth hormone, insulin-like growth factor-I, and tumor size J. Clin. Endocrinol. Metab. 87 2002 4554 4563
141. A. Hadj, D. Nicholson, J. Moodie, R. Turner, R. Watts, and N. Abrouk et al. SABER-Bupivacaine, a novel extended-release formulation of bupivacaine for postoperative pain control demonstrates dose-response, safety and no impact on surgical wound healing following inguinal herniorrhaphy American College of Surgeons 95th Annual Clinical Congress 2009 (Chicago)
142. http://www.durect.com (Accessed on 09 September 2013)
143. Y. Lu, Y. Yu, and X. Tang Sucrose acetate isobutyrate as an in situ forming system for sustained risperidone release J. Pharm. Sci. 96 2007 3252 3262
144. H. Kranz, G.A. Brazeau, J. Napaporn, R.L. Martin, W. Millard, and R. Bodmeier Myotoxicity studies of injectable biodegradable in-situ forming drug delivery systems Int. J. Pharm. 212 2001 11 18 (Pubitemid 32121946)
145. Bausch & Lomb Inc. US2006/0018949 A1 injectable biodegradable drug delivery system.
146. K. Schönhammer Pharmaceutical Compositions, WO2010/018159A1 2010
147. S. Dongling, A. Paul, and C. Jianbing In Situ Gelling Drug Delivery System US2011/0165242A1 2011
148. F. Dumont, R.L. Dunn, S.A. Jeffers, R.W. Korsmeyer, M. Li, V.M. Paralkar, and M. Zhou Controlled Release Polymeric Compositions of Bone Growth Promoting Compounds US2009/0169595 2009
149. A. Luk, G. Junnarkar, and G. Chen Sustained Release Small Molecule Drug Formulation US 2007/0077304 A1 2007
150. R.T. Chern, and J.R. Zingerman Liquid Polymeric Compositions for Controlled Release of Bioactive Substances US6733767 B2 2004