Preparation and biocompatibility study of in situ forming polymer implants in rat brains

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 2, 2012, Pages 497-505

  Nasongkla, Norased ^a   Boongird, Atthaporn ^b   Hongeng, Suradej ^b   Manaspon, Chawan ^a   Larbcharoensub, Noppadol ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; BLOOD-BRAIN BARRIER; BODY WEIGHT; CAPROLACTONE; D , L-LACTIDE; DRUG DELIVERY SYSTEM; IMPLANT SURFACE; IN-SITU FORMING; INJECTION VOLUME; POLYMER IMPLANTS; RAT BRAIN; SEM ANALYSIS;

ANTHROPOMETRY; BIOCOMPATIBILITY; COPOLYMERS; DEGRADATION; DRUG DELIVERY; GEL PERMEATION CHROMATOGRAPHY; POLYETHYLENE GLYCOLS; SCANNING ELECTRON MICROSCOPY; TISSUE;

RATS;

POLYMER;

ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BODY WEIGHT; BRAIN; GEL PERMEATION CHROMATOGRAPHY; HISTOPATHOLOGY; IMPLANT; MALE; NONHUMAN; POROSITY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY;

ANIMALS; BIOCOMPATIBLE MATERIALS; BRAIN; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY, GEL; HEXANOIC ACIDS; LACTIC ACID; LACTONES; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; POROSITY; RATS; TIME FACTORS;

RATTUS;

EID: 84863482050     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-011-4520-3     Document Type: Article

References (30)

1. Gabathuler R. Blood-brain barrier transport of drugs for the treatment of brain diseases. CNS Neurol Disord Drug Targ. 2009;8(3):195-204.
2. Huynh GH, Deen DF, Szoka FC. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release. 2006; 110(2):236-59.
3. Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, et al. Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res. 1992;52(7):1993-5.
4. Jain RK. The next frontier of molecular medicine: delivery of therapeutics. Nat Med. 1998;4(6):655-7.
5. Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, et al. Interstitial fluid pressure in solid tumors following hyper-thermia: possible correlation with therapeutic response. Cancer Res. 1992;52(2):487-90.
6. Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, et al. Angiogenesis, microvascular architecture, microhemo-dynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 1992;52(23):6553-60.
7. Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol. 2000;20(2): 131-47.
8. Bart J, Groen HJ, Hendrikse NH, van der Graaf WTA, Vaalburg W, de Vries EGE. The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat Rev. 2000;26(6):449-62.
9. Steiniger S, Kreuter J, Khalansky AS, Skidan IN, Bobruskin AI, Smirnova ZS, et al. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int J Cancer. 2004;109(5): 759-67.
10. Wu D, Pardridge WM. Blood-brain barrier transport of reduced folic acid. Pharm Res. 1999;16(3):415-9.
11. Laske DW, Youle RJ, Oldfield EH. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med. 1997;3(12):1362-8.
12. Guerin C, Olivi A, Weingart JD, Lawson HC, Brem H. Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Investig New Drugs. 2004;22(1):27-37.
13. Brem H, Langer R. Polymer-based drug delivery to the brain. Sci Med. 1996;3:9.
14. Gallego JM, Barcia JA, Barcia-Marino C. Fatal outcome related to carmustine implants in glioblastoma multiforme. Acta Neu-rochir. 2007;149(3):261-5. discussion 5.
15. Boongird A, Nasongkla N, Hongeng S, Sukdawong N, Sa-Nguanruang W, Larbcharoensub N. Biocompatibility study of glycofurol in rat brains. Exp Biol Med. 2011;236(1):77-83.
16. Weinberg BD, Patel RB, Wu H, Blanco E, Barnett CC, Exner AA, et al. Model simulation and experimental validation of in-tratumoral chemotherapy using multiple polymer implants. Med Bio Eng Comput. 2008;46(10):1039-49.
17. Ivaturi VD, Riss JR, Kriel RL, Siegel RA, Cloyd JC. Bioavail-ability and tolerability of intranasal diazepam in healthy adult volunteers. Epilepsy Res. 2009;84(2-3):120-6.
18. Eliaz RE, Szoka FC. Robust and prolonged gene expression from injectable polymeric implants. Gene Ther. 2002;9(18):1230-7.
19. Bagger MA, Nielsen HW, Bechgaard E. Nasal bioavailability of peptide T in rabbits: absorption enhancement by sodium glyco-cholate and glycofurol. Eur J Pharm Sci. 2001;14(1):69-74.
20. Hu Y, Jiang X, Ding Y, Zhang L, Yang C, Zhang J, et al. Preparation and drug release behaviors of nimodipine-loaded poly(caprolactone)-poly(ethylene oxide)-polylactide amphi-philic copolymer nanoparticles. Biomaterials. 2003;24(13): 2395-404.
21. Tsai CY, Chow NH, Ho TS, Lei HY. Intracerebral injection of myelin basic protein (MBP) induces inflammation in brain and causes paraplegia in MBP-sensitized B6 mice. Clin Exp Immu-nol. 1997;109(1):127-33.
22. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 5th ed. Burlington: Elsevier Academic Press; 2005.
23. Siparsky GL, Voorhees KJ, Miao F. Hydrolysis ofpolylactic acid (PLA) and polycaprolactone (PCL) in aqueous acetonitrile solu-tions: autocatalysis. J Environ Polym Degrad. 1998;6(1):31-41.
24. Gallego JM, Barcia JA, Barcia-Mariño C. Fatal outcome related to carmustine implants in glioblastoma multiforme. Acta Neu-rochir (Wien). 2007;149(3):261-5.
25. Patel RB, Solorio L, Wu H, Krupka TM, Exner AA. Effect of injection site on in situ implant formation and drug release in vivo. J Control Release. 2010;147:350-8.
26. Krupka TM, Weinberg BD, Ziats NP, Haaga JR, Exner AA. Injectable polymer depot combined with radiofrequency ablation for treatment of experimental carcinoma in rat. Investiga Radiol. 2006;41(12):890-7.
27. Bjugstad KB, Lampe K, Kern DS, Mahoney M. Biocompatibility ofpoly(ethylene glycol)-based hydrogels in the brain: an analysis of the glial response across space and time. J Biomed Mater Res Part A. 2010;95A(1):79-91.
28. Vertenten G, Vlaminck L, Gorski T, Schreurs E, Van Den Broeck W, Duchateau L, et al. Evaluation of an injectable, photopoly-merizable three-dimensional scaffold based on D:L: -lactide and epsilon-caprolactone in a tibial goat model. J Mater Sci. 2008; 19(7):2761-9.
29. Murakami H, Kobayashi M, Takeuchi H, Kawashima Y. Utili-zation of poly(DL-lactide-co-glycolide) nanoparticles for prepa-ration of mini-depot tablets by direct compression. J Control Release. 2000;67(1):29-36.
30. Ekholm M, Hietanen J, Tulamo RM, Muhonen J, Lindqvist C, Kellomaki M, et al. Tissue reactions of subcutaneously implanted mixture of epsilon- caprolactone-lactide copolymer and trical-cium phosphate. An electron microscopic evaluation in sheep. J Mater Sci. 2003;14(10):913-8.