Design of a long-term antipsychotic in situ forming implant and its release control method and mechanism

International Journal of Pharmaceutics

Volumn 427, Issue 2, 2012, Pages 284-292

  Wang, Lexi ^a   Wang, Aiping ^a   Zhao, Xiaolei ^a   Liu, Ximing ^a   Wang, Dan ^a   Sun, Fengying ^a   Li, Youxin ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Antipsychotic; Burst release control; In situ forming; In vivo; Pharmacologic effect; Phase inversion dynamics

Indexed keywords

1 METHYL 2 PYRROLIDINONE; DIMETHYL SULFOXIDE; DIZOCILPINE; ORGANIC SOLVENT; PALIPERIDONE; POLYGLACTIN; RISPERIDONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG RETENTION; EXPERIMENTAL DOG; IN SITU FORMING IMPLANT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SCHIZOPHRENIA; SUSTAINED DRUG RELEASE;

ANIMALS; ANTIPSYCHOTIC AGENTS; DELAYED-ACTION PREPARATIONS; DIMETHYL SULFOXIDE; DIZOCILPINE MALEATE; DOGS; DRUG IMPLANTS; EXCIPIENTS; EXCITATORY AMINO ACID ANTAGONISTS; GELS; ISOXAZOLES; KINETICS; LACTIC ACID; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYGLYCOLIC ACID; PYRIMIDINES; PYRROLIDINONES; SOLUBILITY; SOLUTIONS; SOLVENTS; STEREOTYPED BEHAVIOR;

EID: 84862826623     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.02.015     Document Type: Article

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