Gamma irradiation effects on poly(DL-lactictide-co-glycolide) microspheres

Journal of Controlled Release

Volumn 56, Issue 1-3, 1998, Pages 219-229

  Montanari, Luisa ^a   Costantini, Monica ^a   Signoretti, Elena Ciranni ^b   Valvo, Luisa ^b   Santucci, Mara ^b   Bartolomei, Monica ^b   Fattibene, Paola ^b   Onori, Sandro ^b   Faucitano, Antonio ^c   Conti, Bice ^c   Genta, Ida ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

Irradiation; Biodegradable polymers; Microspheres; Polylactide co glycolide

Indexed keywords

COPOLYMER; MICROSPHERE; POLYGLACTIN;

ARTICLE; DRUG STABILITY; DRUG STERILITY; ELECTRON SPIN RESONANCE; GAMMA IRRADIATION; IN VITRO STUDY; MOLECULAR WEIGHT; PRIORITY JOURNAL;

BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; GAMMA RAYS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; OXYGEN; POLYGLYCOLIC ACID; POLYMERS; STERILIZATION;

EID: 0032484048     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00082-0     Document Type: Article

References (11)

1. Okada H., Toguchi H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Systems. 12(1):1995;1-99.
2. Skiens W.E. Sterilizing radiations effects on selected polymers. Radiat. Phys. Chem. 15:1980;47-57.
3. Mitomo H., Watanabe Y., Yoshii F., Makuuchi K. Radiation effect on polyesters. Radiat. Phys. Chem. 46:1995;233-242.
4. Hausberger A.G., Kenley R.A., DeLuca P.P. Gamma irradiation effects on molecular weight and in vitro degradation of poly(DL-lactide-co-glycolide) microparticles. Pharm. Res. 12:1995;851-856.
5. Collett J.H., Lim L.Y., Booth C. Drug release from irradiated poly(L-lactic-co-glycolic acid) microspheres. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. Contr. Rel. Soc. 17:1990;285-286.
6. Hartas S.R., Collett J.H., Booth C. The influence of gamma irradiation on the release of melatonin from poly(lactide-co-glycolide) microspheres. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. Contr. Rel. Soc. 19:1992;321-322.
7. Sintzel M.B., Merkli A., Tabatabay C., Gurny R. Influence of irradiation sterilization on polymers used as drug carriers. Drug Dev. Ind. Pharm. 23:1997;857-878.
8. Van Dijk J.A.P.P., Smit J.A.M. Characterization of poly(DL-lactic acid) by gel permeation chromatography. J. Polym. Sci. 21:1983;197-208.
9. Hausberg A.G., DeLuca P.P. Characterization of biodegradable poly(DL-lactide-co-glycolide) polymers and microspheres. J. Pharm. Biomed. Anal. 13:1995;747-760.
10. D. Benedix. Some problems in the molecular weight determination of resorbable polymers by GPC and viscosimetry. Symposium on Characterization of macromolecules used as Pharmaceutical excipient. Gothenburg, Sweden, March 7-9 (1990).
11. C.Y. Wen, A.F. Galli. Dilute phase systems, in: J.F. Davidson, D. Harrison (Eds.), Fluidization, Chpt. 16, 1971, pp. 677-710.