Structure formation in injectable poly(lactide-co-glycolide) depots

Journal of Controlled Release

Volumn 90, Issue 3, 2003, Pages 345-354

  Wang, Liwei ^a   Kleiner, Lothar ^b   Venkatraman, Subbu ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b ALZA CORPORATION   (United States)

Author keywords

Benzyl benzoate (BB); Drug delivery; Gelation; Poly(lactide co glycolide) (PLGA); Thermoeversible

Indexed keywords

CONTROLLED DRUG DELIVERY; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; ESTERS; GEL PERMEATION CHROMATOGRAPHY; GELATION; MOLECULAR WEIGHT; ORGANIC SOLVENTS; POLYMERS; RHEOLOGY;

CONTROLLED STRESS RHEOMETRY;

POLYETHYLENE GLYCOLS;

POLYGLACTIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; FLOW MEASUREMENT; GEL PERMEATION CHROMATOGRAPHY; GELATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; TEMPERATURE; TIME;

EID: 0038783265     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00198-6     Document Type: Article

References (23)

1. Wright J.C., Leonard S.T., Stevenson C.L., Beck J.C., Chen G., Jao R.M., et al. An in vivo/in vitro comparison with a leuprolide osmotic implant for the treatment of prostate cancer. J. Control. Release. 75:2001;1-10.
2. R.L. Dunn, J.P. English, D.R. Cowsar, D.P. Vanderbilt, Biodegradable in-situ forming implants and methods of producing the same, US Pat. 4,938,763, 3 July 1990.
3. R.L. Dunn, A.J. Tipton, Polymeric compositions used as controlled release implants, US Pat. 5,702,716, 30 December 1997.
4. R.E. Eliaz, J. Kost, Composition and method for forming biodegradable implants in situ and uses of these implants, US Pat. 6,206,920, 27 March 2001.
5. Dunn R.L., Yewey G.L., Fujita S.M., Josephs K.R., Whitman S.L., Southard G.L. Sustained release of cisplatin in dogs from an injectable implant delivery system. J. Bioact. Compat. Polym. 11:1996;286-300.
6. Graham P.D., Brodbeck K.J., McHugh A.J. Phase inversion dynamics of PLGA solutions related to drug delivery. J. Control. Release. 58:1999;233-245.
7. Brodbeck K.J., Desnoyer J.R., McHugh A.J. Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer. J. Control. Release. 62:1999;333-344.
8. Eliaz R.E., Kost J. Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins. J. Biomed. Mater. Res. 50:2000;388-396.
9. Eliaz R.E., Wallach D., Kost J. Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants in-vivo. Pharm. Res. 17:2000;1546-1550.
10. Singh U.V., Bisht K.S., Rao S., Uma Devi P., Udupa N. Reduced toxicity and enhanced antitumor efficacy of plambagin using poly(lactic-co-glycolic) biodegradable injectable implant. Indian J. Pharmacol. 29:1997;168-172.
11. Shively M.L., Coonts B.A., Renner W.D., Southard J.L., Bennett A.T. Physico-chemical characterization of a polymeric injectable implant delivery system. J. Control. Release. 33:1995;237-243.
12. DesNoyer J.R., McHugh A.J. Role of crystallization in the phase inversion dynamics and protein release kinetics of injectable drug delivery systems. J. Control. Release. 70:2001;285-294.
13. Dunn R.L., English J.P., Strobel J.D., Cowser D.R., Tice T.R. Preparation and evaluation of lactide/glycolide copolymers for drug delivery. Polym. Med. 3C:1988;149-160.
14. Ravivarapu H.B., Moyer K.L., Dunn R.L. Sustained activity and release of leuprolide acetate from an in situ forming polymeric implant. AAPS PharmSciTech. 1:2000.
15. Brodbeck K.J., Pushpala S., McHugh A.J. Sustained release of human growth hormone from PLGA solution depots. Pharm. Res. 16:1999;1825-1829.
16. DesNoyer J.R., McHugh A.J. Role of crystallization in the phase inversion dynamics and protein release kinetics of injectable drug delivery systems. J. Control. Release. 70:2001;285-294.
17. Lambert W.J., Peck K.D. Development of an in situ forming biodegradable poly-lactide-co-glycolide system for the controlled release of proteins. J. Control. Release. 33:1995;189-195.
18. Jain R.A., Rhodes C.T., Railkar A.M., Malick A.W., Shah N.H. Comparison of various injectable protein-loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices: in-situ-formed implant versus in-situ-formed microspheres versus isolated microspheres. Pharm. Dev. Technol. 5:2000;201-207.
19. Dikshit A.K., Nandi A.K. Thermoreversible gelation of poly(vinylidene flouride) in diethyl adipate: a concerted mechanism. Macromolecules. 31:1998;8886-8892.
20. Huang W.Y., Matsuoka S., Kwei T.K., Okamoto Y. Aggregation and gelation of fully conjugated rigid-rod polymers. Poly(2,5-dialkyl-1,4-phenyleneethynylene)s. Macromolecules. 34:2001;7166-7171.
21. Saiani A., Spevacek J., Guenet J.M. Phase behavior and polymer/solvent interactions in thermoreversible gels of syndiotactic poly(methyl methacrylate). Macromolecules. 31:1998;703-710.
22. Jeong B., Bae Y.H., Kim S.W. Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions. Macromolecules. 32:1999;7064-7069.
23. Larson R.G. The Structure and Rheology of Complex Fluids. 1999;Oxford University Press, New York.