Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats

International Journal of Pharmaceutics

Volumn 301, Issue 1-2, 2005, Pages 54-61

  Yong, Chul Soon ^a   Oh, Yu Kyoung ^b   Kim, Yong Il ^a   Jong, Oh Kim ^a   Yoo, Bong Kyu ^a   Rhee, Jong Dal ^a   Lee, Kang Choon ^c   Kim, Dae Duk ^d   Park, Young Joon ^d   Kim, Chong Kook ^d   Choi, Han Gon ^a  

^a Yeungnam University   (South Korea)

^b CHA University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Diclofenac sodium; Mucoadhesive; Pharmacokinetics; Poloxamer 124; Poloxamer 188; Poloxamer based solid suppository

Indexed keywords

DICLOFENAC; MACROGOL; MACROGOL 4000; POLOXAMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG EFFICACY; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG SAFETY; DRUG SCREENING; DRUG SOLUBILITY; IN VIVO STUDY; MALE; MELTING POINT; MORPHOLOGY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RECTUM MUCOSA; RECUMBENCY; ROOM TEMPERATURE; SKIN IRRITATION; SOLID; SUPPOSITORY;

ADHESIVES; ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHYSICAL; DICLOFENAC; DRUG COMPOUNDING; EXCIPIENTS; MALE; MUCOUS MEMBRANE; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; RECTUM; SOLUBILITY; SUPPOSITORIES; SURFACE-ACTIVE AGENTS;

EID: 23944477398     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.05.037     Document Type: Article

References (22)

1. Abhaham, C., 1994. Poloxamer gel systems with gelling temperatures higher than room temperature. Canadian Patent 1,072,413.
2. A.H. Burstein, K.M. Fisher, M.L. McPherson, and C.A. Roby Absorption of phenytoin from rectal suppositories formulated with a polyethylene glycol base Pharmacotherapy 20 2000 562 567
3. H.G. Choi, J.H. Jung, C.S. Yong, J.D. Rhee, M.K. Lee, J.H. Han, K.M. Park, and C.K. Kim Formulation and in vivo evaluation of omeprazole buccal adhesive tablet J. Control. Release 68 2000 405 412
4. H.G. Choi, B.J. Lee, C. Yong, J.D. Rhee, J.H. Han, M.K. Lee, K.M. Park, and C.K. Kim Terfenadine-β-cyclodextrin inclusion complex with the anti-histaminic activity enhancement Drug Dev. Ind. Pharm. 27 2001 1259 1263
5. H.G. Choi, Y.K. Oh, and C.K. Kim In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability Int. J. Pharm. 165 1998 23 32
6. G. Dumortier, M. Zumer, G. Courarraze, J.C. Chaumeil, and J.L. Grossiord Rheological study of a thermoreversible morphine gel Drug Dev. Ind. Pharm. 17 1991 1255 1265
7. C.J. Eboka, R.S. Okor, J.O. Akerele, and S.O. Aigbavboa Kinetics of absorption and elimination of ofloxacin in humans after oral and rectal administrations J. Clin. Pharm. Ther. 22 1997 217 220
8. M.S. Garcia, M.I. Albero, C. Sanchez-Pedreno, and J. Molina Flow-injection spectrophotometric determination of diclofenac sodium in pharmaceuticals and urine samples J. Pharm. Biomed. Anal. 17 1998 267 273
9. C.H. Huang, T. Tokumura, Y. Machida, and T. Nagai Formulation of double-layered suppository for prolonged stay in lower rectum Yakuzaigaku 47 1987 42 48
10. N.M. Idkaidek, G.L. Amidon, D.E. Smith, N.M. Najib, and M.M. Hassan Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM Biopharm. Drug Dispos. 19 1998 169 174
11. M. Iwata, K. Takayama, Y. Takahashi, Y. Obata, Y. Machida, T. Nagai, and S. Shirotake Effect of temperature on drug release and drug absorption in mixed type diclofenac sodium suppositories Yakugaku Zasshi (Japan) 119 1999 170 177
12. C.K. Kim, S.W. Lee, H.G. Choi, M.K. Lee, Z.G. Gao, I.S. Kim, and K.M. Park Trials of in situ gelling and mucoadhesive acetaminophen liquid suppository in human subjects Int. J. Pharm. 174 1998 201 207
13. S. Miyazaki, T. Nakamura, C. Yokouchi, and M. Tanaka Effect of pluronic gels on the rectal absorption of indomethacin in rabbits Chem. Pharm. Bull. 35 1987 1243 1248
14. A. Nagatomi, M. Mishima, O. Tsuzuki, S. Ohdo, and S. Higuchi Utility of a rectal suppository containing the antiepileptic drug zonisamide Biol. Pharm. Bull. 20 1997 892 896
15. K. Nakanishi, T. Masukawa, M. Masada, and T. Nadai Improvement of the rectal bioavailability of latamoxef sodium by adjuvants following administration of a suppository Biol. Pharm. Bull. 17 1994 1496 1500
16. N.A. Peppas Analysis of fickian and non-fickian drug release polymers Pharm. Acta Helv. 60 1985 110 111
17. L.M. Pinto Pereira, D. Chen, Y. Clement, and D. Simeon Analgesic effects of diclofenac suppository and injection after preoperative administration Int. J. Clin. Pharmacol. Res. 19 1999 47 51
18. S. Ramakrishna, N.W. Fadnavis, and P.V. Diwan Comparative pharmacokinetic evaluation of compressed suppositories of diclofenac sodium in humans Arzneimittelforschung 46 1996 175 177
19. A. Schneeweis, and C.C. Muller-Goymann In vivo and in vitro diclofenac sodium evaluation after rectal application of soft gelatine capsules enabling application induced transformation (AIT) into a semisolid system of liquid crystals (SSLC) for controlled release Pharm. Res. 14 1997 1726 1729
20. K. Watanabe, S. Yakou, K. Takayama, Y. Machida, and K. Isowa Investigation on rectal absorption of indomethacin from sustained-release hydrogel suppositories prepared with water-soluble dietary fibers, xanthan gum and locust bean gum Bio. Pharm. Bull. 16 1993 391 394
21. C.S. Yong, J.S. Choi, Q.Z. Quan, J.D. Rhee, C.K. Kim, S.J. Lim, K.M. Kim, and H.G. Choi Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium Int. J. Pharm. 226 2001 195 205
22. M.O. Yun, H.G. Choi, J.H. Jung, and C.K. Kim Development of thermoreversible insulin liquid suppository with sodium salicylate Int. J. Pharm. 189 1999 137 145