메뉴 건너뛰기




Volumn 13, Issue 1, 2014, Pages

GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli

Author keywords

Acquired chemoresistance; Gli; GPCR; JNK; Smoothened

Indexed keywords

DOXORUBICIN; ETOPOSIDE; G PROTEIN COUPLED RECEPTOR; IMATINIB; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; VINCRISTINE;

EID: 84892171530     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-4     Document Type: Article
Times cited : (15)

References (60)
  • 1
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: paradigms and principles
    • 10.1101/gad.938601, 11731473
    • Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001, 15:3059-3087. 10.1101/gad.938601, 11731473.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 2
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: functions and mechanisms
    • 10.1101/gad.1693608, 18794343
    • Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008, 22:2454-2472. 10.1101/gad.1693608, 18794343.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 3
    • 67650289584 scopus 로고    scopus 로고
    • Mechanisms of hedgehog pathway activation in cancer and implications for therapy
    • 10.1016/j.tips.2009.03.007, 19443052
    • Scales SJ, de Sauvage FJ. Mechanisms of hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009, 30:303-312. 10.1016/j.tips.2009.03.007, 19443052.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 303-312
    • Scales, S.J.1    de Sauvage, F.J.2
  • 4
    • 84859321979 scopus 로고    scopus 로고
    • Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential
    • 10.1038/nrd3714, 22460111
    • Guha M. Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential. Nat Rev Drug Discov 2012, 11:257-258. 10.1038/nrd3714, 22460111.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 257-258
    • Guha, M.1
  • 5
    • 0032519906 scopus 로고    scopus 로고
    • The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling
    • 10.1006/dbio.1997.8796, 9501021
    • Hammerschmidt M, McMahon AP. The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling. Dev Biol 1998, 194:166-171. 10.1006/dbio.1997.8796, 9501021.
    • (1998) Dev Biol , vol.194 , pp. 166-171
    • Hammerschmidt, M.1    McMahon, A.P.2
  • 6
    • 0034713934 scopus 로고    scopus 로고
    • Smoothened activates Galphai-mediated signaling in frog melanophores
    • 10.1074/jbc.M004055200, 10835429
    • DeCamp DL, Thompson TM, de Sauvage FJ, Lerner MR. Smoothened activates Galphai-mediated signaling in frog melanophores. J Biol Chem 2000, 275:26322-26327. 10.1074/jbc.M004055200, 10835429.
    • (2000) J Biol Chem , vol.275 , pp. 26322-26327
    • DeCamp, D.L.1    Thompson, T.M.2    de Sauvage, F.J.3    Lerner, M.R.4
  • 8
    • 57049085407 scopus 로고    scopus 로고
    • G protein galphai functions immediately downstream of smoothened in hedgehog signalling
    • 10.1038/nature07459, 2744466, 18987629
    • Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ. G protein galphai functions immediately downstream of smoothened in hedgehog signalling. Nature 2008, 456:967-970. 10.1038/nature07459, 2744466, 18987629.
    • (2008) Nature , vol.456 , pp. 967-970
    • Ogden, S.K.1    Fei, D.L.2    Schilling, N.S.3    Ahmed, Y.F.4    Hwa, J.5    Robbins, D.J.6
  • 9
    • 33747614580 scopus 로고    scopus 로고
    • Activation of heterotrimeric G proteins by smoothened
    • 10.1073/pnas.0600880103, 1567926, 16885213
    • Riobo NA, Saucy B, Dilizio C, Manning DR. Activation of heterotrimeric G proteins by smoothened. Proc Natl Acad Sci USA 2006, 103:12607-12612. 10.1073/pnas.0600880103, 1567926, 16885213.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12607-12612
    • Riobo, N.A.1    Saucy, B.2    Dilizio, C.3    Manning, D.R.4
  • 10
    • 49049108307 scopus 로고    scopus 로고
    • The decoupling of smoothened from galphai proteins has little effect on Gli3 protein processing and hedgehog-regulated chick neural tube patterning
    • 10.1016/j.ydbio.2008.06.014, 2597282, 18590719
    • Low WC, Wang C, Pan Y, Huang XY, Chen JK, Wang B. The decoupling of smoothened from galphai proteins has little effect on Gli3 protein processing and hedgehog-regulated chick neural tube patterning. Dev Biol 2008, 321:188-196. 10.1016/j.ydbio.2008.06.014, 2597282, 18590719.
    • (2008) Dev Biol , vol.321 , pp. 188-196
    • Low, W.C.1    Wang, C.2    Pan, Y.3    Huang, X.Y.4    Chen, J.K.5    Wang, B.6
  • 11
    • 79957613017 scopus 로고    scopus 로고
    • Heterotrimeric Gi proteins link hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
    • 10.1074/jbc.M110.197111, 3103338, 21474452
    • Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR, Riobo NA. Heterotrimeric Gi proteins link hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem 2011, 286:19589-19596. 10.1074/jbc.M110.197111, 3103338, 21474452.
    • (2011) J Biol Chem , vol.286 , pp. 19589-19596
    • Polizio, A.H.1    Chinchilla, P.2    Chen, X.3    Kim, S.4    Manning, D.R.5    Riobo, N.A.6
  • 12
    • 77951932085 scopus 로고    scopus 로고
    • Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
    • 10.4161/cc.9.3.10591, 20081366
    • Chinchilla P, Xiao L, Kazanietz MG, Riobo NA. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle 2010, 9:570-579. 10.4161/cc.9.3.10591, 20081366.
    • (2010) Cell Cycle , vol.9 , pp. 570-579
    • Chinchilla, P.1    Xiao, L.2    Kazanietz, M.G.3    Riobo, N.A.4
  • 13
    • 79952733097 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
    • 10.1073/pnas.1018217108, 3060219, 21368195
    • Belgacem YH, Borodinsky LN. Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc Natl Acad Sci USA 2011, 108:4482-4487. 10.1073/pnas.1018217108, 3060219, 21368195.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4482-4487
    • Belgacem, Y.H.1    Borodinsky, L.N.2
  • 14
    • 84881082520 scopus 로고    scopus 로고
    • Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-kappaB activation in diffuse large B-cell lymphoma
    • 10.1182/blood-2012-12-470153, 23632891
    • Qu C, Liu Y, Kunkalla K, Singh RR, Blonska M, Lin X, Agarwal NK, Vega F. Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-kappaB activation in diffuse large B-cell lymphoma. Blood 2013, 121:4718-4728. 10.1182/blood-2012-12-470153, 23632891.
    • (2013) Blood , vol.121 , pp. 4718-4728
    • Qu, C.1    Liu, Y.2    Kunkalla, K.3    Singh, R.R.4    Blonska, M.5    Lin, X.6    Agarwal, N.K.7    Vega, F.8
  • 17
    • 34249878632 scopus 로고    scopus 로고
    • Sonic hedgehog promotes multiple drug resistance by regulation of drug transport
    • 10.1038/sj.onc.1210356, 17353904
    • Sims-Mourtada J, Izzo JG, Ajani J, Chao KS. Sonic hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007, 26:5674-5679. 10.1038/sj.onc.1210356, 17353904.
    • (2007) Oncogene , vol.26 , pp. 5674-5679
    • Sims-Mourtada, J.1    Izzo, J.G.2    Ajani, J.3    Chao, K.S.4
  • 18
    • 58249116119 scopus 로고    scopus 로고
    • Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp
    • 2606123, 19107236
    • Zhang Y, Laterra J, Pomper MG. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia 2009, 11:96-101. 2606123, 19107236.
    • (2009) Neoplasia , vol.11 , pp. 96-101
    • Zhang, Y.1    Laterra, J.2    Pomper, M.G.3
  • 20
    • 82955237344 scopus 로고    scopus 로고
    • ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma
    • 10.1038/onc.2011.195, 3165099, 21625222
    • Singh RR, Kunkalla K, Qu C, Schlette E, Neelapu SS, Samaniego F, Vega F. ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene 2011, 30:4874-4886. 10.1038/onc.2011.195, 3165099, 21625222.
    • (2011) Oncogene , vol.30 , pp. 4874-4886
    • Singh, R.R.1    Kunkalla, K.2    Qu, C.3    Schlette, E.4    Neelapu, S.S.5    Samaniego, F.6    Vega, F.7
  • 22
    • 73649145223 scopus 로고    scopus 로고
    • Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
    • 10.1002/emmm.200900039, 3378144, 20049737
    • Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009, 1:338-351. 10.1002/emmm.200900039, 3378144, 20049737.
    • (2009) EMBO Mol Med , vol.1 , pp. 338-351
    • Varnat, F.1    Duquet, A.2    Malerba, M.3    Zbinden, M.4    Mas, C.5    Gervaz, P.6    Ruiz i Altaba, A.7
  • 23
    • 84869203655 scopus 로고    scopus 로고
    • The Hedgehog receptor patched functions in multidrug transport and chemotherapy resistance
    • 10.1158/1541-7786.MCR-11-0578, 22752092
    • Bidet M, Tomico A, Martin P, Guizouarn H, Mollat P, Mus-Veteau I. The Hedgehog receptor patched functions in multidrug transport and chemotherapy resistance. Mol Cancer Res 2012, 10:1496-1508. 10.1158/1541-7786.MCR-11-0578, 22752092.
    • (2012) Mol Cancer Res , vol.10 , pp. 1496-1508
    • Bidet, M.1    Tomico, A.2    Martin, P.3    Guizouarn, H.4    Mollat, P.5    Mus-Veteau, I.6
  • 24
    • 0027176558 scopus 로고
    • Establishment of the multidrug-resistant cell line K562/A02 and its drug-resistant properties
    • Luan FJ. Establishment of the multidrug-resistant cell line K562/A02 and its drug-resistant properties. Zhonghua Zhong Liu Za Zhi 1993, 15:101-103.
    • (1993) Zhonghua Zhong Liu Za Zhi , vol.15 , pp. 101-103
    • Luan, F.J.1
  • 25
    • 1642611239 scopus 로고
    • [Vincristine-resistant human KB cell line and mechanism of multidrug resistance]
    • Zhang XH, Zhang FY, Ji XJ, Li ZY. [Vincristine-resistant human KB cell line and mechanism of multidrug resistance]. Yao Xue Xue Bao 1994, 29:246-251.
    • (1994) Yao Xue Xue Bao , vol.29 , pp. 246-251
    • Zhang, X.H.1    Zhang, F.Y.2    Ji, X.J.3    Li, Z.Y.4
  • 26
    • 33846003866 scopus 로고    scopus 로고
    • The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4
    • 10.1074/jbc.M609062200, 17056591
    • Tan W, Martin D, Gutkind JS. The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. J Biol Chem 2006, 281:39542-39549. 10.1074/jbc.M609062200, 17056591.
    • (2006) J Biol Chem , vol.281 , pp. 39542-39549
    • Tan, W.1    Martin, D.2    Gutkind, J.S.3
  • 27
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • 10.1016/0022-1759(83)90303-4, 6606682
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63. 10.1016/0022-1759(83)90303-4, 6606682.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 29
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened
    • 10.1101/gad.1025302, 187469, 12414725
    • Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev 2002, 16:2743-2748. 10.1101/gad.1025302, 187469, 12414725.
    • (2002) Genes Dev , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 30
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • 10.1038/nature01493, 12629553
    • Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003, 422:313-317. 10.1038/nature01493, 12629553.
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3    Wang, B.4    Beachy, P.A.5    Baylin, S.B.6
  • 31
    • 0021111692 scopus 로고
    • Identification of the predominant substrate for ADP-ribosylation by islet activating protein
    • Bokoch GM, Katada T, Northup JK, Hewlett EL, Gilman AG. Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem 1983, 258:2072-2075.
    • (1983) J Biol Chem , vol.258 , pp. 2072-2075
    • Bokoch, G.M.1    Katada, T.2    Northup, J.K.3    Hewlett, E.L.4    Gilman, A.G.5
  • 32
    • 0026562725 scopus 로고
    • Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits
    • 10.1038/356159a0, 1312225
    • Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature 1992, 356:159-161. 10.1038/356159a0, 1312225.
    • (1992) Nature , vol.356 , pp. 159-161
    • Federman, A.D.1    Conklin, B.R.2    Schrader, K.A.3    Reed, R.R.4    Bourne, H.R.5
  • 33
    • 0037195074 scopus 로고    scopus 로고
    • Small molecule modulation of smoothened activity
    • 10.1073/pnas.182542899, 137838, 12391318
    • Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of smoothened activity. Proc Natl Acad Sci USA 2002, 99:14071-14076. 10.1073/pnas.182542899, 137838, 12391318.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14071-14076
    • Chen, J.K.1    Taipale, J.2    Young, K.E.3    Maiti, T.4    Beachy, P.A.5
  • 35
    • 0034636685 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors
    • Gutkind JS. Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE 2000, 2000:re1.
    • (2000) Sci STKE , vol.2000
    • Gutkind, J.S.1
  • 36
    • 0035152487 scopus 로고    scopus 로고
    • Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death
    • 10.2337/diabetes.50.1.77, 11147798
    • Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 2001, 50:77-82. 10.2337/diabetes.50.1.77, 11147798.
    • (2001) Diabetes , vol.50 , pp. 77-82
    • Bonny, C.1    Oberson, A.2    Negri, S.3    Sauser, C.4    Schorderet, D.F.5
  • 38
    • 0028329953 scopus 로고
    • JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • 10.1016/0092-8674(94)90380-8, 8137421
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037. 10.1016/0092-8674(94)90380-8, 8137421.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 39
    • 0036269755 scopus 로고    scopus 로고
    • The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase
    • 10.1128/MCB.22.13.4929-4942.2002, 133923, 12052897
    • Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 2002, 22:4929-4942. 10.1128/MCB.22.13.4929-4942.2002, 133923, 12052897.
    • (2002) Mol Cell Biol , vol.22 , pp. 4929-4942
    • Lei, K.1    Nimnual, A.2    Zong, W.X.3    Kennedy, N.J.4    Flavell, R.A.5    Thompson, C.B.6    Bar-Sagi, D.7    Davis, R.J.8
  • 40
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • 10.1073/pnas.0609699104, 1866313, 17494766
    • Lauth M, Bergstrom A, Shimokawa T, Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007, 104:8455-8460. 10.1073/pnas.0609699104, 1866313, 17494766.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3    Toftgard, R.4
  • 41
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • 10.1016/j.devcel.2008.11.010, 19081070
    • Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008, 15:801-812. 10.1016/j.devcel.2008.11.010, 19081070.
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 42
    • 77952546990 scopus 로고    scopus 로고
    • Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
    • 10.1016/j.tcb.2010.02.002, 20207148
    • Ayers KL, Therond PP. Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling. Trends Cell Biol 2010, 20:287-298. 10.1016/j.tcb.2010.02.002, 20207148.
    • (2010) Trends Cell Biol , vol.20 , pp. 287-298
    • Ayers, K.L.1    Therond, P.P.2
  • 44
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the Hedgehog pathway in cancer
    • 10.1038/nm.3389, 24202394
    • Amakye D, Jagani Z, Dorsch M. Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med 2013, 19:1410-1422. 10.1038/nm.3389, 24202394.
    • (2013) Nat Med , vol.19 , pp. 1410-1422
    • Amakye, D.1    Jagani, Z.2    Dorsch, M.3
  • 45
    • 77649337790 scopus 로고
    • Hedgehog beyond medulloblastoma and basal cell carcinoma
    • Teglund S, Toftgard R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 1805, 2010:181-208.
    • (1805) Biochim Biophys Acta , vol.2010 , pp. 181-208
    • Teglund, S.1    Toftgard, R.2
  • 46
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • 10.1073/pnas.0813203106, 2647977, 19246386
    • Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 2009, 106:4254-4259. 10.1073/pnas.0813203106, 2647977, 19246386.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    DuPree, K.J.3    Darbonne, W.C.4    Ahn, C.P.5    Scales, S.J.6    de Sauvage, F.J.7
  • 48
    • 33646231995 scopus 로고    scopus 로고
    • Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
    • 10.1158/0008-5472.CAN-05-4505, 16618744
    • Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, Curran T. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 2006, 66:4215-4222. 10.1158/0008-5472.CAN-05-4505, 16618744.
    • (2006) Cancer Res , vol.66 , pp. 4215-4222
    • Sasai, K.1    Romer, J.T.2    Lee, Y.3    Finkelstein, D.4    Fuller, C.5    McKinnon, P.J.6    Curran, T.7
  • 50
    • 80054949733 scopus 로고    scopus 로고
    • Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
    • 10.1242/dev.070805, 3201661, 22007132
    • Tuson M, He M, Anderson KV. Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development 2011, 138:4921-4930. 10.1242/dev.070805, 3201661, 22007132.
    • (2011) Development , vol.138 , pp. 4921-4930
    • Tuson, M.1    He, M.2    Anderson, K.V.3
  • 51
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • 10.1016/S0092-8674(00)80678-9, 10693759
    • Wang B, Fallon JF, Beachy PA. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 2000, 100:423-434. 10.1016/S0092-8674(00)80678-9, 10693759.
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 52
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for sonic hedgehog signaling
    • 10.1073/pnas.0504337103, 1450201, 16537363
    • Riobo NA, Lu K, Ai X, Haines GM, Emerson CP. Phosphoinositide 3-kinase and Akt are essential for sonic hedgehog signaling. Proc Natl Acad Sci USA 2006, 103:4505-4510. 10.1073/pnas.0504337103, 1450201, 16537363.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4505-4510
    • Riobo, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson, C.P.5
  • 53
    • 31544461492 scopus 로고    scopus 로고
    • Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
    • 10.1158/0008-5472.CAN-05-2539, 16424016
    • Riobo NA, Haines GM, Emerson CP. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res 2006, 66:839-845. 10.1158/0008-5472.CAN-05-2539, 16424016.
    • (2006) Cancer Res , vol.66 , pp. 839-845
    • Riobo, N.A.1    Haines, G.M.2    Emerson, C.P.3
  • 54
    • 84874359079 scopus 로고    scopus 로고
    • GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas
    • 10.1038/nature11889, 3761364, 23446420
    • Atwood SX, Li M, Lee A, Tang JY, Oro AE. GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. Nature 2013, 494:484-488. 10.1038/nature11889, 3761364, 23446420.
    • (2013) Nature , vol.494 , pp. 484-488
    • Atwood, S.X.1    Li, M.2    Lee, A.3    Tang, J.Y.4    Oro, A.E.5
  • 56
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • 10.1038/nrc2694, 19629069
    • Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009, 9:537-549. 10.1038/nrc2694, 19629069.
    • (2009) Nat Rev Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 57
    • 0038037108 scopus 로고    scopus 로고
    • Role of Jun and Jun kinase in resistance of cancer cells to therapy
    • 10.1016/S1368-7646(03)00043-8, 12860462
    • Vasilevskaya I, O'Dwyer PJ. Role of Jun and Jun kinase in resistance of cancer cells to therapy. Drug Resist Updat 2003, 6:147-156. 10.1016/S1368-7646(03)00043-8, 12860462.
    • (2003) Drug Resist Updat , vol.6 , pp. 147-156
    • Vasilevskaya, I.1    O'Dwyer, P.J.2
  • 58
    • 79953163484 scopus 로고    scopus 로고
    • MAPK signaling in inflammation-associated cancer development
    • 10.1007/s13238-010-0019-9, 21203968
    • Huang P, Han J, Hui L. MAPK signaling in inflammation-associated cancer development. Protein Cell 2010, 1:218-226. 10.1007/s13238-010-0019-9, 21203968.
    • (2010) Protein Cell , vol.1 , pp. 218-226
    • Huang, P.1    Han, J.2    Hui, L.3
  • 59
    • 77949916262 scopus 로고    scopus 로고
    • AP-1-the Jun proteins: oncogenes or tumor suppressors in disguise?
    • 10.1016/j.cellsig.2009.12.008, 20060892
    • Shaulian E. AP-1-the Jun proteins: oncogenes or tumor suppressors in disguise?. Cell Signal 2010, 22:894-899. 10.1016/j.cellsig.2009.12.008, 20060892.
    • (2010) Cell Signal , vol.22 , pp. 894-899
    • Shaulian, E.1
  • 60
    • 78751520029 scopus 로고    scopus 로고
    • Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
    • 10.1158/0008-5472.CAN-10-2876, 21123452
    • Dijkgraaf GJ, Alicke B, Weinmann L, Januario T, West K, Modrusan Z, Burdick D, Goldsmith R, Robarge K, Sutherlin D, et al. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res 2011, 71:435-444. 10.1158/0008-5472.CAN-10-2876, 21123452.
    • (2011) Cancer Res , vol.71 , pp. 435-444
    • Dijkgraaf, G.J.1    Alicke, B.2    Weinmann, L.3    Januario, T.4    West, K.5    Modrusan, Z.6    Burdick, D.7    Goldsmith, R.8    Robarge, K.9    Sutherlin, D.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.