-
1
-
-
0036162009
-
Mitogen-activated protein kinases
-
Ababi, S., Maier, R.V., 2002. Mitogen-activated protein kinases. Crit. Care Med. 30, S74-S79.
-
(2002)
Crit. Care Med.
, vol.30
-
-
Ababi, S.1
Maier, R.V.2
-
2
-
-
0033027608
-
Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug induced apoptosis in salivary gland acinar cells
-
Anderson, S.M., Reyland, M.E., Hunter, S., Deisher, L.M., Barzen, K.A., Quissell, D.Q., 1999. Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug induced apoptosis in salivary gland acinar cells. Cell Death Differ. 6, 454-462.
-
(1999)
Cell Death Differ.
, vol.6
, pp. 454-462
-
-
Anderson, S.M.1
Reyland, M.E.2
Hunter, S.3
Deisher, L.M.4
Barzen, K.A.5
Quissell, D.Q.6
-
3
-
-
0037155837
-
Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
-
Aoki, H., Kang, P.M., Hampe, J., Yoshimura, K., Noma, T., Matsuzaki, M., Izumo, S., 2002. Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J. Biol. Chem. 277, 10244-10250.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10244-10250
-
-
Aoki, H.1
Kang, P.M.2
Hampe, J.3
Yoshimura, K.4
Noma, T.5
Matsuzaki, M.6
Izumo, S.7
-
4
-
-
0034806972
-
Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress
-
Benhar, M., Dalyot, I., Engalberg, D., Levitzki, A., 2001. Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress. Mol. Cell. Biol. 21, 6913-6926.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 6913-6926
-
-
Benhar, M.1
Dalyot, I.2
Engalberg, D.3
Levitzki, A.4
-
5
-
-
0034930391
-
Signaling pathways and effector mechanisms pre-programmed cell death
-
Blatt, N.B., Glick, G.D., 2001. Signaling pathways and effector mechanisms pre-programmed cell death. Bioorg. Med. Chem. 9, 1371-1384.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 1371-1384
-
-
Blatt, N.B.1
Glick, G.D.2
-
6
-
-
0036848491
-
The role of MAPK pathways in the action of chemotherapeutic drugs
-
Boldt, S., Weidle, U.H., Kolh, W., 2002. The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis 23, 1831-1838.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1831-1838
-
-
Boldt, S.1
Weidle, U.H.2
Kolh, W.3
-
7
-
-
0036618858
-
Molecular aspects of resistance to antitumor platinum drugs
-
Brabec, V., Kasparkova, J., 2002. Molecular aspects of resistance to antitumor platinum drugs. Drug Resist. Update 5, 147-161.
-
(2002)
Drug Resist. Update
, vol.5
, pp. 147-161
-
-
Brabec, V.1
Kasparkova, J.2
-
8
-
-
0034745050
-
2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
-
2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell. Biol. 21, 2743-2754.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2743-2754
-
-
Buschmann, T.1
Potapova, O.2
Bar-Shira, A.3
-
9
-
-
0035282334
-
Mammalian MAP kinase signaling cascades
-
Chang, L., Karin, M., 2001. Mammalian MAP kinase signaling cascades. Nature 410, 37-40.
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
10
-
-
0033531240
-
ASK1 mediates apoptotic cell death induced by genotoxic stress
-
Chen, Z., Seimiya, H., Naito, M., et al., 1999. ASK1 mediates apoptotic cell death induced by genotoxic stress. Oncogene 18, 173-180.
-
(1999)
Oncogene
, vol.18
, pp. 173-180
-
-
Chen, Z.1
Seimiya, H.2
Naito, M.3
-
11
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell, J.E., 2002. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2, 740-749.
-
(2002)
Nat. Rev. Cancer.
, vol.2
, pp. 740-749
-
-
Darnell, J.E.1
-
12
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis, R., 2000. Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.1
-
13
-
-
0037174934
-
JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery
-
Donovan, N., Becker, E.B.E., Konishi, Y., Bonni, A., 2002. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J. Biol. Chem. 277, 40944-40949.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40944-40949
-
-
Donovan, N.1
Becker, E.B.E.2
Konishi, Y.3
Bonni, A.4
-
14
-
-
0033796587
-
A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs
-
Eichhorst, S.T., Muller, M., Li-Weber, M., Schulze-Bergkamen, H., Angel, P., Krammer, P.H., 2000. A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol. Cell. Biol. 20, 7826-7837.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 7826-7837
-
-
Eichhorst, S.T.1
Muller, M.2
Li-Weber, M.3
Schulze-Bergkamen, H.4
Angel, P.5
Krammer, P.H.6
-
15
-
-
0035735754
-
Role of niitogen-activated protein kinases in the response of tumor cells to chemotherapy
-
Fan, M., Chambers, T.C., 2001. Role of niitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist. Update 5, 253-267.
-
(2001)
Drug Resist. Update
, vol.5
, pp. 253-267
-
-
Fan, M.1
Chambers, T.C.2
-
17
-
-
0035361599
-
2-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine
-
2-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine. Cancer Res. 61, 4450-4458.
-
(2001)
Cancer Res.
, vol.61
, pp. 4450-4458
-
-
Fan, M.1
Goodwin, M.E.2
Birrer, M.J.3
Chambers, T.C.4
-
18
-
-
0031883140
-
The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression
-
Faris, M., Kokot, N., Latinis, K., Kasibhatla, S., Green, D.R., Koretzky, G.A., Nel, A., 1998. The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J. Immunol. 160, 134-144.
-
(1998)
J. Immunol.
, vol.160
, pp. 134-144
-
-
Faris, M.1
Kokot, N.2
Latinis, K.3
Kasibhatla, S.4
Green, D.R.5
Koretzky, G.A.6
Nel, A.7
-
19
-
-
0036731701
-
Mixed-lineage kinase control of JNK and p38 MAPK pathways
-
Gallo, K.A., Johnson, G.L., 2002. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat. Rev. Mol. Cell. Biol. 3, 663-672.
-
(2002)
Nat. Rev. Mol. Cell. Biol.
, vol.3
, pp. 663-672
-
-
Gallo, K.A.1
Johnson, G.L.2
-
20
-
-
0033574434
-
Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents
-
Gibson, S., Widmann, C., Johnson, G.L., 1999. Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. J. Biol. Chem. 274, 10916-10922.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10916-10922
-
-
Gibson, S.1
Widmann, C.2
Johnson, G.L.3
-
21
-
-
0032771826
-
Inhibition of Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification
-
Gjerset, R.A., Lebedeva, S., Haghigni, A., Turia, S.T., Mercola, D., 1999. Inhibition of Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification. Cell Growth Differ. 10, 545-554.
-
(1999)
Cell Growth Differ.
, vol.10
, pp. 545-554
-
-
Gjerset, R.A.1
Lebedeva, S.2
Haghigni, A.3
Turia, S.T.4
Mercola, D.5
-
22
-
-
0033615657
-
Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitized human ovarian cancer cell line
-
Hayakawa, J., Ohmich, M., Kurachi, H., et al., 1999. Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitized human ovarian cancer cell line. J. Biol. Chem. 274, 31648-31654.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31648-31654
-
-
Hayakawa, J.1
Ohmich, M.2
Kurachi, H.3
-
23
-
-
0038757747
-
2-terminal Jun kinase (JNK) by DNA-damaging agents serves to promote drug resistance via phospho-ATF2-dependent enhanced DNA repair
-
10.1074/jbc.M210992200
-
2-terminal Jun kinase (JNK) by DNA-damaging agents serves to promote drug resistance via phospho-ATF2-dependent enhanced DNA repair. J. Biol. Chem. 10.1074/jbc.M210992200.
-
(2003)
J. Biol. Chem.
-
-
Hayakawa, J.1
Depatie, C.2
Ohmichi, M.3
Mercola, D.4
-
24
-
-
0036358038
-
MAPK-regulated transcription: A continuously variable gene switch?
-
Hazzalin, C.A., Mahadevan, L.C., 2001. MAPK-regulated transcription: a continuously variable gene switch? Nat. Rev. Mol. Cell. Biol. 3, 30-40.
-
(2001)
Nat. Rev. Mol. Cell. Biol.
, vol.3
, pp. 30-40
-
-
Hazzalin, C.A.1
Mahadevan, L.C.2
-
25
-
-
0035525733
-
Cellular stress response and apoptosis in cancer therapy
-
Herr, I., Debafin, K.-M., 2001. Cellular stress response and apoptosis in cancer therapy. Blood 98, 2603-2614.
-
(2001)
Blood
, vol.98
, pp. 2603-2614
-
-
Herr, I.1
Debafin, K.-M.2
-
26
-
-
0033231020
-
From receptors to stress-activated MAP kinases
-
Ichijo, H., 1999. From receptors to stress-activated MAP kinases. Oncogene 18, 6087-6093.
-
(1999)
Oncogene
, vol.18
, pp. 6087-6093
-
-
Ichijo, H.1
-
27
-
-
0032541633
-
Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death
-
Jarpe, M.B., Widmann, C., Knall, C., et al., 1998. Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death. Oncogene 17, 1475-1482.
-
(1998)
Oncogene
, vol.17
, pp. 1475-1482
-
-
Jarpe, M.B.1
Widmann, C.2
Knall, C.3
-
28
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases
-
Johnson, G.L., Lapadat, R., 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases. Science 298, 1911-1912.
-
(2002)
Science
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
29
-
-
0030606319
-
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
-
Kallunki, T., Deng, T., Hibi, M., Karin, M., 1996. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87, 929-939.
-
(1996)
Cell
, vol.87
, pp. 929-939
-
-
Kallunki, T.1
Deng, T.2
Hibi, M.3
Karin, M.4
-
30
-
-
0033935649
-
Activation of MEK kinase by the c-Abl protein tyrosine kinase in response to DNA damage
-
Kharbanda, S., Pandey, P., Yamauchi, T., et al., 2000a. Activation of MEK kinase by the c-Abl protein tyrosine kinase in response to DNA damage. Mol. Cell. Biol. 20, 4979-4989.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4979-4989
-
-
Kharbanda, S.1
Pandey, P.2
Yamauchi, T.3
-
32
-
-
0034126231
-
Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun N-terminal kinase 1 and caspase 3 (CPP32) in bax-transfected gastric cancer cells
-
Kim, R., Ohi, Y., Inoue, H., Toge, T., 2000. Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun N-terminal kinase 1 and caspase 3 (CPP32) in bax-transfected gastric cancer cells. Anticancer Res. 20, 439-444.
-
(2000)
Anticancer Res.
, vol.20
, pp. 439-444
-
-
Kim, R.1
Ohi, Y.2
Inoue, H.3
Toge, T.4
-
33
-
-
0035736492
-
The role of caspase-8 in resistance to cancer chemotherapy
-
Kim, P.K.M., Mahidhara, R., Seol, D.-W., 2001. The role of caspase-8 in resistance to cancer chemotherapy. Drug Resist. Update 4, 293-296.
-
(2001)
Drug Resist. Update
, vol.4
, pp. 293-296
-
-
Kim, P.K.M.1
Mahidhara, R.2
Seol, D.-W.3
-
34
-
-
0035958630
-
Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21 (WAF1/CIP1) preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin
-
Kobayashi, K., Tsukamoto, I., 2001. Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21 (WAF1/CIP1) preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin. Biochim. Biophys. Acta 1537, 79-88.
-
(2001)
Biochim. Biophys. Acta
, vol.1537
, pp. 79-88
-
-
Kobayashi, K.1
Tsukamoto, I.2
-
35
-
-
0033961711
-
c-Jun dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents
-
Kolbus, A., Herr, I., Schreiber, M., Debatin, K.M., Wagner, E.F., Angel, P., 2000. c-Jun dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol. Cell. Biol. 20, 575-582.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 575-582
-
-
Kolbus, A.1
Herr, I.2
Schreiber, M.3
Debatin, K.M.4
Wagner, E.F.5
Angel, P.6
-
36
-
-
0037085048
-
Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer lines as a response to docetaxel
-
Kolfschoten, G.M., Hulscher, T.M., Duyndam, M.C., Pinedo, H.M., Boven, E., 2002. Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer lines as a response to docetaxel. Biochem. Pharmacol. 63, 733-743.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 733-743
-
-
Kolfschoten, G.M.1
Hulscher, T.M.2
Duyndam, M.C.3
Pinedo, H.M.4
Boven, E.5
-
37
-
-
0037198169
-
Signaling and function of caspase and c-Jun N-terminal kinase in cisplatin-induced apoptosis
-
Kyriakis, J.M., Avruch, J., 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869
-
Koo, M.S., Kwo, Y.G., Park, J.H., Choi, W.J., Billiar, T.R., Kim, Y.M., 2002. Signaling and function of caspase and c-Jun N-terminal kinase in cisplatin-induced apoptosis. Mol. Cells 13, 194-201. Kyriakis, J.M., Avruch, J., 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869.
-
(2002)
Mol. Cells
, vol.13
, pp. 194-201
-
-
Koo, M.S.1
Kwo, Y.G.2
Park, J.H.3
Choi, W.J.4
Billiar, T.R.5
Kim, Y.M.6
-
39
-
-
0032482752
-
MEKK1 activates both IkB kinase alpha and IkB kinase beta
-
Lee, F.S., Peters, R.T., Dang, L.C., Maniatis, T., 1998b. MEKK1 activates both IkB kinase alpha and IkB kinase beta. Proc. Natl. Acad. Sci. U.S.A. 95, 9319-9324.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 9319-9324
-
-
Lee, F.S.1
Peters, R.T.2
Dang, L.C.3
Maniatis, T.4
-
40
-
-
0036269755
-
2-terminal kinase
-
2-terminal kinase. Mol. Cell. Biol. 22, 4929-4942.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4929-4942
-
-
Lei, K.1
Ninmual, A.2
Zong, W.-X.3
Kennedy, N.J.4
Flavell, R.A.5
Thompson, C.B.6
Bar-Sagi, D.7
Davis, R.J.8
-
41
-
-
0032937879
-
Withdrawal of survival factors results in activation of JNK pathway in neuronal cells leading to Fas ligand induction and cell death
-
Le-Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F.-X., Green, D.R., Karin, M., 1999. Withdrawal of survival factors results in activation of JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell. Biol. 19, 751-763.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 751-763
-
-
Le-Niculescu, H.1
Bonfoco, E.2
Kasuya, Y.3
Claret, F.-X.4
Green, D.R.5
Karin, M.6
-
42
-
-
0008290616
-
Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
-
Leppa, S., Bohmann, D., 1999. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 18, 6158-6162.
-
(1999)
Oncogene
, vol.18
, pp. 6158-6162
-
-
Leppa, S.1
Bohmann, D.2
-
43
-
-
0036765750
-
Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells
-
Levresse, V., Marek, L., Blumberg, D., Heasley, L.E., 2002. Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. Mol. Pharmacol. 62, 689-697.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 689-697
-
-
Levresse, V.1
Marek, L.2
Blumberg, D.3
Heasley, L.E.4
-
44
-
-
0032483379
-
Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells
-
Li, Q., Gardner, K., Zhang, L., Tsang, B., Bostick-Bruton, F., Reed, E., 1998. Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells. J. Biol. Chem. 273, 23419-23425.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 23419-23425
-
-
Li, Q.1
Gardner, K.2
Zhang, L.3
Tsang, B.4
Bostick-Bruton, F.5
Reed, E.6
-
45
-
-
0032946612
-
Modulation of excision repair cross complementation group 1 (ERCC-1) mRNA expression by pharmacological agents in human ovarian carcinoma cells
-
Li, Q., Tsang, B., Bostick-Bruton, F., Reed, E., 1999. Modulation of excision repair cross complementation group 1 (ERCC-1) mRNA expression by pharmacological agents in human ovarian carcinoma cells. Biochem. Pharmacol. 15, 347-353.
-
(1999)
Biochem. Pharmacol.
, vol.15
, pp. 347-353
-
-
Li, Q.1
Tsang, B.2
Bostick-Bruton, F.3
Reed, E.4
-
46
-
-
0036371753
-
Integration of signals from receptor tyrosin kinases and G protein-coupled receptors
-
Lowes, V.L., Ip, N.Y., Wong, Y.H., 2002. Integration of signals from receptor tyrosin kinases and G protein-coupled receptors. Neurosignals 11, 5-19.
-
(2002)
Neurosignals
, vol.11
, pp. 5-19
-
-
Lowes, V.L.1
Ip, N.Y.2
Wong, Y.H.3
-
47
-
-
0038482086
-
Sustained activation of JNK-p38 MAP kinase pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
-
M208134200
-
Mansouri, A., Ridgway, L.D., Korapati, A.L., Zhang, Q., Tian, L., Wang, Y., Siddik, Z.H., Mills, G.B., Claret, F.X., 2003. Sustained activation of JNK-p38 MAP kinase pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J. Biol. Chem. M208134200.
-
(2003)
J. Biol. Chem.
-
-
Mansouri, A.1
Ridgway, L.D.2
Korapati, A.L.3
Zhang, Q.4
Tian, L.5
Wang, Y.6
Siddik, Z.H.7
Mills, G.B.8
Claret, F.X.9
-
48
-
-
0032703216
-
Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase
-
Noguchi, K., Kitanaka, C., Yamana, H., Kokubu, A., Mochuzuki, T., Kuchino, Y., 1999. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. J. Biol. Chem. 274, 32580-32587.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32580-32587
-
-
Noguchi, K.1
Kitanaka, C.2
Yamana, H.3
Kokubu, A.4
Mochuzuki, T.5
Kuchino, Y.6
-
49
-
-
0034821254
-
Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents
-
Onoda, N., Nehmi, A., Weiner, D., Mujumdar, S., Christen, R., Los, G., 2001. Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents. Head Neck 23, 860-870.
-
(2001)
Head Neck
, vol.23
, pp. 860-870
-
-
Onoda, N.1
Nehmi, A.2
Weiner, D.3
Mujumdar, S.4
Christen, R.5
Los, G.6
-
50
-
-
0036569631
-
Reversal of cisplatin resistance by a c-jun antisense oligodeoxynucleotide (ISIS 10582): Evidence for the role of transcription factor overexpression in determining resistant phenotype
-
Pan, B., Yao, K.-S., Monia, B.P., Dean, N.M., McKay, R.A., Hamilton, T.C., O'Dwyer, P.J., 2002. Reversal of cisplatin resistance by a c-jun antisense oligodeoxynucleotide (ISIS 10582): evidence for the role of transcription factor overexpression in determining resistant phenotype. Biochem. Pharmacol. 63, 1699-1707.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 1699-1707
-
-
Pan, B.1
Yao, K.-S.2
Monia, B.P.3
Dean, N.M.4
McKay, R.A.5
Hamilton, T.C.6
O'Dwyer, P.J.7
-
51
-
-
0030857126
-
Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of bcl-2
-
Park, J., Kim, I., Young, J.O., Lee, K.-W., Han, P.-L., Choi, E.J., 1997. Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of bcl-2. J. Biol. Chem. 272, 16725-16728.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16725-16728
-
-
Park, J.1
Kim, I.2
Young, J.O.3
Lee, K.-W.4
Han, P.-L.5
Choi, E.J.6
-
52
-
-
0037436155
-
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms
-
Park, S.-H., Zarrinpar, A., Lim, W.A., 2003. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299, 1061-1064.
-
(2003)
Science
, vol.299
, pp. 1061-1064
-
-
Park, S.-H.1
Zarrinpar, A.2
Lim, W.A.3
-
53
-
-
0030920914
-
The JNK/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
-
Potapova, O., Haghighi, A., Bost, F., Liu, C., Birrer, M.J., Gjerset, R., Mercola, D., 1997. The JNK/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J. Biol. Chem. 272, 14041-14044.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14041-14044
-
-
Potapova, O.1
Haghighi, A.2
Bost, F.3
Liu, C.4
Birrer, M.J.5
Gjerset, R.6
Mercola, D.7
-
54
-
-
0035958870
-
Protective role for c-Jun in the cellular response to DNA damage
-
Potapova, O., Basu, S., Mercola, D., Holbrook, N.J., 2001. Protective role for c-Jun in the cellular response to DNA damage. J. Biol. Chem. 267, 28546-28553.
-
(2001)
J. Biol. Chem.
, vol.267
, pp. 28546-28553
-
-
Potapova, O.1
Basu, S.2
Mercola, D.3
Holbrook, N.J.4
-
55
-
-
0037436144
-
Imposing specificity on kinases
-
Ptashne, M., Gann, A., 2003. Imposing specificity on kinases. Science 299, 1025-1027.
-
(2003)
Science
, vol.299
, pp. 1025-1027
-
-
Ptashne, M.1
Gann, A.2
-
56
-
-
0036570081
-
Partial depletion of intracellular ATP mediates stress survival function of the PCPH oncoprotein
-
Recio, J.A., Paez, J.G., Sanders, S., Kawakami, T., Notario, V., 2002. Partial depletion of intracellular ATP mediates stress survival function of the PCPH oncoprotein. Cancer Res. 62, 2690-2694.
-
(2002)
Cancer Res.
, vol.62
, pp. 2690-2694
-
-
Recio, J.A.1
Paez, J.G.2
Sanders, S.3
Kawakami, T.4
Notario, V.5
-
57
-
-
0344258124
-
Lack of c-Jun activity increases survival to cisplatin
-
Sanchez-Perez, I., Perona, R., 1999. Lack of c-Jun activity increases survival to cisplatin. FEBS Lett. 453, 151-158.
-
(1999)
FEBS Lett.
, vol.453
, pp. 151-158
-
-
Sanchez-Perez, I.1
Perona, R.2
-
58
-
-
0032576868
-
Cisplatin induces a persistent activation of JNK that is related to cell death
-
Sanchez-Perez, I., Murguia, J.R., Perona, R., 1998. Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene 16, 533-540.
-
(1998)
Oncogene
, vol.16
, pp. 533-540
-
-
Sanchez-Perez, I.1
Murguia, J.R.2
Perona, R.3
-
59
-
-
0034718760
-
CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin
-
Sanchez-Perez, I., Martinez-Gomariz, M., Williams, D., Keyse, S.M., Perona, R., 2000. CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin. Oncogene 19, 5142-5152.
-
(2000)
Oncogene
, vol.19
, pp. 5142-5152
-
-
Sanchez-Perez, I.1
Martinez-Gomariz, M.2
Williams, D.3
Keyse, S.M.4
Perona, R.5
-
60
-
-
0036679169
-
Cell stress and MEKK1-mediated c-Jun activation modulate NFkB activity and cell viability
-
Sanchez-Perez, I., Benitah, S.A., Martinez-Gomariz, M., Lacal, J.C., Perona, R., 2002. Cell stress and MEKK1-mediated c-Jun activation modulate NFkB activity and cell viability. Mol. Biol. Cell 13, 2933-2945.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 2933-2945
-
-
Sanchez-Perez, I.1
Benitah, S.A.2
Martinez-Gomariz, M.3
Lacal, J.C.4
Perona, R.5
-
61
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger, J., 2000. Cell signaling by receptor tyrosine kinases. Cell 103, 211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
62
-
-
0030614914
-
2-terminal kinase-mediated activation of interleukin-lbeta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis
-
2-terminal kinase-mediated activation of interleukin-lbeta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis. J. Biol. Chem. 272, 4631-4636.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4631-4636
-
-
Seimiya, H.1
Mashima, T.2
Toho, M.3
Tsuruo, T.4
-
63
-
-
0035136965
-
Involvement of Asp-GluVal-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells
-
Shiah, S.-G., Chuang, S.-E., Kuo, M.-L., 2001. Involvement of Asp-GluVal-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells. Mol. Pharmacol. 59, 254-262.
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 254-262
-
-
Shiah, S.-G.1
Chuang, S.-E.2
Kuo, M.-L.3
-
64
-
-
0001554639
-
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
-
Shtil, A.A., Mandlekar, S., Yu, R., Walter, R.J., Hagen, K., Tan, T.H., Roninson, I.B., Kong, A.N., 1999. Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. Oncogene 18, 377-384.
-
(1999)
Oncogene
, vol.18
, pp. 377-384
-
-
Shtil, A.A.1
Mandlekar, S.2
Yu, R.3
Walter, R.J.4
Hagen, K.5
Tan, T.H.6
Roninson, I.B.7
Kong, A.N.8
-
65
-
-
0033616709
-
Deletion of the loop region of bcl-2 completely blocks paclitaxel-induced apoptosis
-
Srivastava, R.K., Mi, Q.S., Hardwick, J.M., Longo, D.L., 1999. Deletion of the loop region of bcl-2 completely blocks paclitaxel-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 96, 3775-3780.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 3775-3780
-
-
Srivastava, R.K.1
Mi, Q.S.2
Hardwick, J.M.3
Longo, D.L.4
-
66
-
-
0034627879
-
Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells
-
Stone, A.A., Chambers, T.C., 2000. Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells. Exp. Cell Res. 254, 110-119.
-
(2000)
Exp. Cell Res.
, vol.254
, pp. 110-119
-
-
Stone, A.A.1
Chambers, T.C.2
-
67
-
-
0037422858
-
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway
-
Takaesu, G., Surabhi, R.M., Park, K.J., Ninomiya-Tsuji, J., Matsumoto, K., Gaynor, R.B., 2003. TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J. Mol. Biol. 326, 105-115.
-
(2003)
J. Mol. Biol.
, vol.326
, pp. 105-115
-
-
Takaesu, G.1
Surabhi, R.M.2
Park, K.J.3
Ninomiya-Tsuji, J.4
Matsumoto, K.5
Gaynor, R.B.6
-
68
-
-
0034607702
-
Requirement of JNK for stress-induced activation of cytochrome c-mediated death pathway
-
Tournier, C., Hess, P., Yang, D.D., Xu, J., et al., 2000. Requirement of JNK for stress-induced activation of cytochrome c-mediated death pathway. Science 288, 870-874.
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
-
69
-
-
0032570594
-
Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated kinase through both Ras and apoptosis signal-regulating kinase pathways
-
Wang, T.-H., Wang, H.-S., Ichijo, H., Giannakakou, P., Foster, J.S., Fojo, T., Wimalasena, J., 1998. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated kinase through both Ras and apoptosis signal-regulating kinase pathways. J. Biol. Chem. 273, 4928-4936.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4928-4936
-
-
Wang, T.-H.1
Wang, H.-S.2
Ichijo, H.3
Giannakakou, P.4
Foster, J.S.5
Fojo, T.6
Wimalasena, J.7
-
70
-
-
0033583321
-
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal (JNK)-dependent and -independent pathways in ovarian cancer cells
-
Wang, T.-H., Popp, D.M., Wang, H.-S., Saitoh, M., Mural, J.G., Henley, D.C., Ichijo, H., Wimalasena, J., 1999. Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal (JNK)-dependent and -independent pathways in ovarian cancer cells. J. Biol. Chem. 274, 8208-8216.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8208-8216
-
-
Wang, T.-H.1
Popp, D.M.2
Wang, H.-S.3
Saitoh, M.4
Mural, J.G.5
Henley, D.C.6
Ichijo, H.7
Wimalasena, J.8
-
71
-
-
0034212385
-
Paclitaxel-induced cell death
-
Wang, T.-H., Wang, H.-S., Soong, Y.-K., 2000. Paclitaxel-induced cell death. Cancer 88, 2619-2628.
-
(2000)
Cancer
, vol.88
, pp. 2619-2628
-
-
Wang, T.-H.1
Wang, H.-S.2
Soong, Y.-K.3
-
72
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West, K.A., Castillo, S.S., Dennis, P.A., 2002. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist. Update 5, 234-248.
-
(2002)
Drug Resist. Update
, vol.5
, pp. 234-248
-
-
West, K.A.1
Castillo, S.S.2
Dennis, P.A.3
-
74
-
-
0032508714
-
A mammalian scaffold complex that selectively mediates MAP kinase activation
-
Whitmarsh, A.J., Cavanagh, J., Tournier, C., Yasuda, J., Davis, R.J., 1999. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281, 1671-1674.
-
(1999)
Science
, vol.281
, pp. 1671-1674
-
-
Whitmarsh, A.J.1
Cavanagh, J.2
Tournier, C.3
Yasuda, J.4
Davis, R.J.5
-
75
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J., Greenberg, M.E., 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
76
-
-
0034625170
-
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
-
Xia, Y., Makris, C., Su, B., Li, E., Yang, J., Nemerow, G.R., Karin, M., 2000. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc. Natl. Acad. Sci. U.S.A. 97, 5243-5248.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 5243-5248
-
-
Xia, Y.1
Makris, C.2
Su, B.3
Li, E.4
Yang, J.5
Nemerow, G.R.6
Karin, M.7
-
77
-
-
0037439170
-
POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis
-
Xu, Z., Kukekov, N.V., Greene, L.A., 2003. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22, 252-261.
-
(2003)
EMBO J.
, vol.22
, pp. 252-261
-
-
Xu, Z.1
Kukekov, N.V.2
Greene, L.A.3
-
79
-
-
0034922161
-
The essential role of MEKK3 in TNF-induced NF-kappaB activation
-
Yang, J., Lin, Y., Guo, Z., et al., 2001. The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat. Immunol. 2, 620-624.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 620-624
-
-
Yang, J.1
Lin, Y.2
Guo, Z.3
-
80
-
-
0036053357
-
An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation
-
Yoshida, S., Kawaguchi, H., Sato, S., Ueda, R., Furukawa, K., 2002. An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. Jpn. J. Cancer Res. 93, 816-824.
-
(2002)
Jpn. J. Cancer Res.
, vol.93
, pp. 816-824
-
-
Yoshida, S.1
Kawaguchi, H.2
Sato, S.3
Ueda, R.4
Furukawa, K.5
-
81
-
-
0038342509
-
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASKI: Implication of AKT2 in chemoresistance
-
10.1074/jbc M302674200
-
Yuan, Z.-Q., Feldman, R.I., Sussman, G.E., Coppola, D., Nicosia, S.V., Cheng, J.Q., 2003. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASKI: implication of AKT2 in chemoresistance. J. Biol. Chem. 10.1074/jbc M302674200.
-
(2003)
J. Biol. Chem.
-
-
Yuan, Z.-Q.1
Feldman, R.I.2
Sussman, G.E.3
Coppola, D.4
Nicosia, S.V.5
Cheng, J.Q.6
-
82
-
-
0031895658
-
Tumor necrosis alpha gene regulation: Enhancement of C/EBPb-induced activation by c-Jun
-
Zagariya, A., Mungre, S., Lovis, R., Birrer, M., Ness, S., Thimmapaya, B., Pope, R., 2000. Tumor necrosis alpha gene regulation: enhancement of C/EBPb-induced activation by c-Jun. Mol. Cell. Biol. 18, 2815-2824.
-
(2000)
Mol. Cell. Biol.
, vol.18
, pp. 2815-2824
-
-
Zagariya, A.1
Mungre, S.2
Lovis, R.3
Birrer, M.4
Ness, S.5
Thimmapaya, B.6
Pope, R.7
-
83
-
-
0030134173
-
The stress-activated protein kinase pathway mediates cell death following injury by cis-platinum, UV irradiation or heat
-
Zanke, B.W., Boudreau, K., Rubie, E., et al., 1996. The stress-activated protein kinase pathway mediates cell death following injury by cis-platinum, UV irradiation or heat. Curr. Biol. 6, 606-613.
-
(1996)
Curr. Biol.
, vol.6
, pp. 606-613
-
-
Zanke, B.W.1
Boudreau, K.2
Rubie, E.3
-
84
-
-
0033605575
-
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta
-
Zhao, Q., Lee, F.S., 1999. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. J. Biol. Chem. 274, 8355-8358.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8355-8358
-
-
Zhao, Q.1
Lee, F.S.2
-
85
-
-
0029055761
-
Components of a new human protein kinase signal transduction pathway
-
Zhou, G., Bao, Z.Q., Dixon, J.E., 1995. Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270, 12665-12669.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12665-12669
-
-
Zhou, G.1
Bao, Z.Q.2
Dixon, J.E.3
|