메뉴 건너뛰기




Volumn 4, Issue DEC, 2013, Pages

Immature, semi-mature, and fully mature dendritic cells: Toward a DC-cancer cells interface that augments anticancer immunity

Author keywords

Antigen; Cancer; Cell death; Chemotherapy; Cytokine; Immunogenic cell death; Immunosurveillance; Phenotypic DC maturation

Indexed keywords


EID: 84892150886     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00438     Document Type: Review
Times cited : (305)

References (138)
  • 1
    • 0036212849 scopus 로고    scopus 로고
    • Innate immune recognition
    • doi: 10.1146/annurev.immunol.20.083001.084359
    • Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol (2002) 20:197-216. doi: 10.1146/annurev.immunol.20.083001.084359.
    • (2002) Annu Rev Immunol , vol.20 , pp. 197-216
    • Janeway Jr., C.A.1    Medzhitov, R.2
  • 2
    • 77349101042 scopus 로고    scopus 로고
    • Features of the dendritic cell lineage
    • doi:10.1111/j.0105-2896.2009.00888.x
    • Steinman RM, Idoyaga J. Features of the dendritic cell lineage. Immunol Rev (2010) 234:5-17. doi:10.1111/j.0105-2896.2009.00888.x.
    • (2010) Immunol Rev , vol.234 , pp. 5-17
    • Steinman, R.M.1    Idoyaga, J.2
  • 3
    • 79953059789 scopus 로고    scopus 로고
    • Natural innate and adaptive immunity to cancer
    • doi:10.1146/annurev-immunol-031210-101324
    • Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ. Natural innate and adaptive immunity to cancer. Annu Rev Immunol (2011) 29:235-71. doi:10.1146/annurev-immunol-031210-101324.
    • (2011) Annu Rev Immunol , vol.29 , pp. 235-271
    • Vesely, M.D.1    Kershaw, M.H.2    Schreiber, R.D.3    Smyth, M.J.4
  • 4
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • doi:10.1126/science.1071059
    • Matzinger P. The danger model: a renewed sense of self. Science (2002) 296:301-5. doi:10.1126/science.1071059.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 5
    • 84861435630 scopus 로고    scopus 로고
    • A perspective on mammalian caspases as positive and negative regulators of inflammation
    • doi:10.1016/j.molcel.2012.04.026
    • Martin SJ, Henry CM, Cullen SP. A perspective on mammalian caspases as positive and negative regulators of inflammation. Mol Cell (2012) 46:387-97. doi:10.1016/j.molcel.2012.04.026.
    • (2012) Mol Cell , vol.46 , pp. 387-397
    • Martin, S.J.1    Henry, C.M.2    Cullen, S.P.3
  • 7
    • 84881668150 scopus 로고    scopus 로고
    • Cancer immunogenicity, danger signals, and DAMPs: what, when, and how?
    • doi:10.1002/biof.1125
    • Garg AD, Dudek AM, Agostinis P. Cancer immunogenicity, danger signals, and DAMPs: what, when, and how? Biofactors (2013) 39:355-67. doi:10.1002/biof.1125.
    • (2013) Biofactors , vol.39 , pp. 355-367
    • Garg, A.D.1    Dudek, A.M.2    Agostinis, P.3
  • 8
    • 75349083568 scopus 로고    scopus 로고
    • Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation
    • doi:10.1016/j.bbcan.2009.08.003
    • Garg AD, Nowis D, Golab J, Vandenabeele P, Krysko DV, Agostinis P. Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. Biochim Biophys Acta (2010) 1805:53-71. doi:10.1016/j.bbcan.2009.08.003.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 53-71
    • Garg, A.D.1    Nowis, D.2    Golab, J.3    Vandenabeele, P.4    Krysko, D.V.5    Agostinis, P.6
  • 9
    • 33745712871 scopus 로고    scopus 로고
    • Dendritic cells in a mature age
    • doi:10.1038/nri1845
    • Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol (2006) 6:476-83. doi:10.1038/nri1845.
    • (2006) Nat Rev Immunol , vol.6 , pp. 476-483
    • Reis e Sousa, C.1
  • 10
    • 0036715411 scopus 로고    scopus 로고
    • Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?
    • doi:10.1016/S1471-4906(02)02281-0
    • Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol (2002) 23:445-9. doi:10.1016/S1471-4906(02)02281-0.
    • (2002) Trends Immunol , vol.23 , pp. 445-449
    • Lutz, M.B.1    Schuler, G.2
  • 11
    • 84890034987 scopus 로고    scopus 로고
    • Danger signalling during cancer cell death: origins, plasticity and regulation
    • doi: 10.1038/cdd.2013.48
    • Garg AD, Martin S, Golab J, Agostinis P. Danger signalling during cancer cell death: origins, plasticity and regulation. Cell Death Differ (2013). doi:10.1038/cdd.2013.48.
    • (2013) Cell Death Differ
    • Garg, A.D.1    Martin, S.2    Golab, J.3    Agostinis, P.4
  • 12
    • 84892173445 scopus 로고    scopus 로고
    • Dendritic cells: master regulators of the immune response
    • doi:10.1158/2326-6066.CIR-13-0102
    • Mellman I. Dendritic cells: master regulators of the immune response. Cancer Immunol Res (2013) 1:145. doi:10.1158/2326-6066.CIR-13-0102.
    • (2013) Cancer Immunol Res , vol.1 , pp. 145
    • Mellman, I.1
  • 13
    • 84859417315 scopus 로고    scopus 로고
    • Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing
    • doi:10.4049/jimmunol.1101313
    • Simmons DP, Wearsch PA, Canaday DH, Meyerson HJ, Liu YC, Wang Y, et al. Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing. J Immunol (2012) 188:3116-26. doi:10.4049/jimmunol.1101313.
    • (2012) J Immunol , vol.188 , pp. 3116-3126
    • Simmons, D.P.1    Wearsch, P.A.2    Canaday, D.H.3    Meyerson, H.J.4    Liu, Y.C.5    Wang, Y.6
  • 14
    • 0742272509 scopus 로고    scopus 로고
    • Toll-like receptors and dendritic cells: for whom the bug tolls
    • doi:10.1016/j.smim.2003.10.004
    • Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol (2004) 16:27-34. doi:10.1016/j.smim.2003.10.004.
    • (2004) Semin Immunol , vol.16 , pp. 27-34
    • Reis e Sousa, C.1
  • 15
    • 84884820907 scopus 로고    scopus 로고
    • Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system
    • doi:10.1016/j.semcancer.2013.03.001
    • Romao S, Gannage M, Munz C. Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system. Semin Cancer Biol (2013) 23:391-6. doi:10.1016/j.semcancer.2013.03.001.
    • (2013) Semin Cancer Biol , vol.23 , pp. 391-396
    • Romao, S.1    Gannage, M.2    Munz, C.3
  • 16
    • 84890285799 scopus 로고    scopus 로고
    • Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity
    • doi:10.4161/onci.26260
    • Garg AD, Dudek AM, Agostinis P. Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity. Oncoimmunology (2013) 2:e26260. doi:10.4161/onci.26260.
    • (2013) Oncoimmunology , vol.2
    • Garg, A.D.1    Dudek, A.M.2    Agostinis, P.3
  • 17
    • 84866932320 scopus 로고    scopus 로고
    • ER stress-induced inflammation: does it aid or impede disease progression?
    • doi:10.1016/j.molmed.2012.06.010
    • Garg AD, Kaczmarek A, Krysko O, Vandenabeele P, Krysko DV, Agostinis P. ER stress-induced inflammation: does it aid or impede disease progression? Trends Mol Med (2012) 18:589-98. doi:10.1016/j.molmed.2012.06.010.
    • (2012) Trends Mol Med , vol.18 , pp. 589-598
    • Garg, A.D.1    Kaczmarek, A.2    Krysko, O.3    Vandenabeele, P.4    Krysko, D.V.5    Agostinis, P.6
  • 18
    • 84884311129 scopus 로고    scopus 로고
    • Antigen availability determines CD8(+) T cell-dendritic cell interaction kinetics and memory fate decisions
    • doi:10.1016/j.immuni.2013.08.034
    • Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, et al. Antigen availability determines CD8(+) T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity (2013) 39:496-507. doi:10.1016/j.immuni.2013.08.034.
    • (2013) Immunity , vol.39 , pp. 496-507
    • Henrickson, S.E.1    Perro, M.2    Loughhead, S.M.3    Senman, B.4    Stutte, S.5    Quigley, M.6
  • 19
    • 0742323358 scopus 로고    scopus 로고
    • T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
    • doi:10.1073/pnas.0306407101
    • Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A (2004) 101:998-1003. doi:10.1073/pnas.0306407101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 998-1003
    • Miller, M.J.1    Hejazi, A.S.2    Wei, S.H.3    Cahalan, M.D.4    Parker, I.5
  • 20
    • 0029148878 scopus 로고
    • Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products
    • doi:10.1084/jem.182.2.389
    • Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med (1995) 182:389-400. doi:10.1084/jem.182.2.389.
    • (1995) J Exp Med , vol.182 , pp. 389-400
    • Sallusto, F.1    Cella, M.2    Danieli, C.3    Lanzavecchia, A.4
  • 21
    • 84879780600 scopus 로고    scopus 로고
    • Autophagy: shaping the tumor microenvironment and therapeutic response
    • doi:10.1016/j.molmed.2013.04.005
    • Maes H, Rubio N, Garg AD, Agostinis P. Autophagy: shaping the tumor microenvironment and therapeutic response. Trends Mol Med (2013) 19:428-46. doi:10.1016/j.molmed.2013.04.005.
    • (2013) Trends Mol Med , vol.19 , pp. 428-446
    • Maes, H.1    Rubio, N.2    Garg, A.D.3    Agostinis, P.4
  • 22
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • doi:10.1038/nrc3239
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 12:252-64. doi:10.1038/nrc3239.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 23
    • 84858613590 scopus 로고    scopus 로고
    • Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells
    • doi:10.1016/j.ccr.2012.01.008
    • Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, et al. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell (2012) 21:402-17. doi:10.1016/j.ccr.2012.01.008.
    • (2012) Cancer Cell , vol.21 , pp. 402-417
    • Engelhardt, J.J.1    Boldajipour, B.2    Beemiller, P.3    Pandurangi, P.4    Sorensen, C.5    Werb, Z.6
  • 24
    • 84865422909 scopus 로고    scopus 로고
    • Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
    • doi:10.1038/ni.2376
    • Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol (2012) 13:832-42. doi:10.1038/ni.2376.
    • (2012) Nat Immunol , vol.13 , pp. 832-842
    • Chiba, S.1    Baghdadi, M.2    Akiba, H.3    Yoshiyama, H.4    Kinoshita, I.5    Dosaka-Akita, H.6
  • 25
    • 0036153123 scopus 로고    scopus 로고
    • Tumour escape from immune surveillance through dendritic cell inactivation
    • doi:10.1006/scbi.2001.0400
    • Vicari AP, Caux C, Trinchieri G. Tumour escape from immune surveillance through dendritic cell inactivation. Semin Cancer Biol (2002) 12:33-42. doi:10.1006/scbi.2001.0400.
    • (2002) Semin Cancer Biol , vol.12 , pp. 33-42
    • Vicari, A.P.1    Caux, C.2    Trinchieri, G.3
  • 26
    • 84880922175 scopus 로고    scopus 로고
    • Dendritic cells in the cancer microenvironment
    • doi:10.7150/jca.5046
    • Ma Y, Shurin GV, Peiyuan Z, Shurin MR. Dendritic cells in the cancer microenvironment. J Cancer (2013) 4:36-44. doi:10.7150/jca.5046.
    • (2013) J Cancer , vol.4 , pp. 36-44
    • Ma, Y.1    Shurin, G.V.2    Peiyuan, Z.3    Shurin, M.R.4
  • 28
    • 29144530630 scopus 로고    scopus 로고
    • Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
    • doi:10.1084/jem.20050915
    • Casares N, Pequignot MO, Tesniere A, Ghiringhelli F, Roux S, Chaput N, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 202:1691-701. doi:10.1084/jem.20050915.
    • (2005) J Exp Med , vol.202 , pp. 1691-1701
    • Casares, N.1    Pequignot, M.O.2    Tesniere, A.3    Ghiringhelli, F.4    Roux, S.5    Chaput, N.6
  • 29
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • doi:10.1038/nature02238
    • Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature (2004) 427:154-9. doi:10.1038/nature02238.
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 30
    • 39449094869 scopus 로고    scopus 로고
    • T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
    • doi:10.1038/ni1559
    • Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol (2008) 9:282-91. doi:10.1038/ni1559.
    • (2008) Nat Immunol , vol.9 , pp. 282-291
    • Henrickson, S.E.1    Mempel, T.R.2    Mazo, I.B.3    Liu, B.4    Artyomov, M.N.5    Zheng, H.6
  • 32
    • 0037083571 scopus 로고    scopus 로고
    • Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand
    • Lu G, Janjic BM, Janjic J, Whiteside TL, Storkus WJ, Vujanovic NL. Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand. J Immunol (2002) 168:1831-9.
    • (2002) J Immunol , vol.168 , pp. 1831-1839
    • Lu, G.1    Janjic, B.M.2    Janjic, J.3    Whiteside, T.L.4    Storkus, W.J.5    Vujanovic, N.L.6
  • 33
    • 0037083466 scopus 로고    scopus 로고
    • Innate direct anticancer effector function of human immature dendritic cells. I. Involvement of an apoptosis-inducing pathway
    • Janjic BM, Lu G, Pimenov A, Whiteside TL, Storkus WJ, Vujanovic NL. Innate direct anticancer effector function of human immature dendritic cells. I. Involvement of an apoptosis-inducing pathway. J Immunol (2002) 168:1823-30.
    • (2002) J Immunol , vol.168 , pp. 1823-1830
    • Janjic, B.M.1    Lu, G.2    Pimenov, A.3    Whiteside, T.L.4    Storkus, W.J.5    Vujanovic, N.L.6
  • 34
    • 34047220868 scopus 로고    scopus 로고
    • Cancer immunoediting from immune surveillance to immune escape
    • doi:10.1111/j.1365-2567.2007.02587.x
    • Kim R, Emi M, Tanabe K. Cancer immunoediting from immune surveillance to immune escape. Immunology (2007) 121:1-14. doi:10.1111/j.1365-2567.2007.02587.x.
    • (2007) Immunology , vol.121 , pp. 1-14
    • Kim, R.1    Emi, M.2    Tanabe, K.3
  • 35
    • 84875552922 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer therapy
    • doi:10.1146/annurev-immunol-032712-100008
    • Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Annu Rev Immunol (2013) 31:51-72. doi:10.1146/annurev-immunol-032712-100008.
    • (2013) Annu Rev Immunol , vol.31 , pp. 51-72
    • Kroemer, G.1    Galluzzi, L.2    Kepp, O.3    Zitvogel, L.4
  • 36
    • 79952533264 scopus 로고    scopus 로고
    • Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress
    • doi:10.1038/onc.2010.500
    • Martins I, Kepp O, Schlemmer F, Adjemian S, Tailler M, Shen S, et al. Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress. Oncogene (2011) 30:1147-58. doi:10.1038/onc.2010.500.
    • (2011) Oncogene , vol.30 , pp. 1147-1158
    • Martins, I.1    Kepp, O.2    Schlemmer, F.3    Adjemian, S.4    Tailler, M.5    Shen, S.6
  • 37
    • 84857997683 scopus 로고    scopus 로고
    • A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
    • doi:10.1038/emboj.2011.497
    • Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J (2012) 31:1062-79. doi:10.1038/emboj.2011.497.
    • (2012) EMBO J , vol.31 , pp. 1062-1079
    • Garg, A.D.1    Krysko, D.V.2    Verfaillie, T.3    Kaczmarek, A.4    Ferreira, G.B.5    Marysael, T.6
  • 38
    • 0034161673 scopus 로고    scopus 로고
    • Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines
    • Barratt-Boyes SM, Zimmer MI, Harshyne LA, Meyer EM, Watkins SC, Capuano S III, et al. Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. J Immunol (2000) 164:2487-95.
    • (2000) J Immunol , vol.164 , pp. 2487-2495
    • Barratt-Boyes, S.M.1    Zimmer, M.I.2    Harshyne, L.A.3    Meyer, E.M.4    Watkins, S.C.5    Capuano I.I.I, S.6
  • 39
    • 84863689866 scopus 로고    scopus 로고
    • Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms
    • doi:10.1155/2012/818214
    • Sapoznik S, Hammer O, Ortenberg R, Besser MJ, Ben-Moshe T, Schachter J, et al. Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms. Clin Dev Immunol (2012) 2012:818214. doi:10.1155/2012/818214.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 818214
    • Sapoznik, S.1    Hammer, O.2    Ortenberg, R.3    Besser, M.J.4    Ben-Moshe, T.5    Schachter, J.6
  • 41
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • doi:10.1016/j.cell.2010.01.025
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell (2010) 140:883-99. doi:10.1016/j.cell.2010.01.025.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 42
    • 84866904950 scopus 로고    scopus 로고
    • The emergence of phox-ER stress induced immunogenic apoptosis
    • doi:10.4161/onci.19750
    • Garg AD, Krysko DV, Vandenabeele P, Agostinis P. The emergence of phox-ER stress induced immunogenic apoptosis. Oncoimmunology (2012) 1:786-8. doi:10.4161/onci.19750.
    • (2012) Oncoimmunology , vol.1 , pp. 786-788
    • Garg, A.D.1    Krysko, D.V.2    Vandenabeele, P.3    Agostinis, P.4
  • 43
    • 84878016733 scopus 로고    scopus 로고
    • Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death
    • doi:10.1002/ijc.28070
    • Hodge JW, Garnett CT, Farsaci B, Palena C, Tsang KY, Ferrone S, et al. Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death. Int J Cancer (2013) 133:624-36. doi:10.1002/ijc.28070.
    • (2013) Int J Cancer , vol.133 , pp. 624-636
    • Hodge, J.W.1    Garnett, C.T.2    Farsaci, B.3    Palena, C.4    Tsang, K.Y.5    Ferrone, S.6
  • 44
    • 84874234535 scopus 로고    scopus 로고
    • Human inflammatory dendritic cells induce Th17 cell differentiation
    • doi:10.1016/j.immuni.2012.10.018
    • Segura E, Touzot M, Bohineust A, Cappuccio A, Chiocchia G, Hosmalin A, et al. Human inflammatory dendritic cells induce Th17 cell differentiation. Immunity (2013) 38:336-48. doi:10.1016/j.immuni.2012.10.018.
    • (2013) Immunity , vol.38 , pp. 336-348
    • Segura, E.1    Touzot, M.2    Bohineust, A.3    Cappuccio, A.4    Chiocchia, G.5    Hosmalin, A.6
  • 45
    • 79952716229 scopus 로고    scopus 로고
    • Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy
    • doi:10.1084/jem.20100269
    • Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med (2011) 208:491-503. doi:10.1084/jem.20100269.
    • (2011) J Exp Med , vol.208 , pp. 491-503
    • Ma, Y.1    Aymeric, L.2    Locher, C.3    Mattarollo, S.R.4    Delahaye, N.F.5    Pereira, P.6
  • 46
    • 84870253748 scopus 로고    scopus 로고
    • Controversies on the role of Th17 in cancer: a TGF-beta-dependent immunosuppressive activity?
    • doi:10.1016/j.molmed.2012.09.007
    • Martin F, Apetoh L, Ghiringhelli F. Controversies on the role of Th17 in cancer: a TGF-beta-dependent immunosuppressive activity? Trends Mol Med (2012) 18:742-9. doi:10.1016/j.molmed.2012.09.007.
    • (2012) Trends Mol Med , vol.18 , pp. 742-749
    • Martin, F.1    Apetoh, L.2    Ghiringhelli, F.3
  • 47
    • 77950196277 scopus 로고    scopus 로고
    • T(H)17 cells in tumour immunity and immunotherapy
    • doi:10.1038/nri2742
    • Zou W, Restifo NP. T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 10:248-56. doi:10.1038/nri2742.
    • (2010) Nat Rev Immunol , vol.10 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 48
    • 3042722266 scopus 로고    scopus 로고
    • Immunotherapy: bewitched, bothered, and bewildered no more
    • doi:10.1126/science.1099688
    • Steinman RM, Mellman I. Immunotherapy: bewitched, bothered, and bewildered no more. Science (2004) 305:197-200. doi:10.1126/science.1099688.
    • (2004) Science , vol.305 , pp. 197-200
    • Steinman, R.M.1    Mellman, I.2
  • 49
    • 84887445500 scopus 로고    scopus 로고
    • Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A
    • doi:10.1038/cddis.2013.372
    • Garg AD, Dudek AM, Agostinis P. Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A. Cell Death Dis (2013) 4:e826. doi:10.1038/cddis.2013.372.
    • (2013) Cell Death Dis , vol.4
    • Garg, A.D.1    Dudek, A.M.2    Agostinis, P.3
  • 50
    • 84879783969 scopus 로고    scopus 로고
    • ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
    • doi:10.4161/auto.25399
    • Garg AD, Dudek AM, Ferreira GB, Verfaillie T, Vandenabeele P, Krysko DV, et al. ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. Autophagy (2013) 9:1292-307. doi:10.4161/auto.25399.
    • (2013) Autophagy , vol.9 , pp. 1292-1307
    • Garg, A.D.1    Dudek, A.M.2    Ferreira, G.B.3    Verfaillie, T.4    Vandenabeele, P.5    Krysko, D.V.6
  • 51
    • 84856696459 scopus 로고    scopus 로고
    • Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin
    • doi:10.1007/s00262-011-1184-2
    • Garg AD, Krysko DV, Vandenabeele P, Agostinis P. Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin. Cancer Immunol Immunother (2012) 61:215-21. doi:10.1007/s00262-011-1184-2.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 215-221
    • Garg, A.D.1    Krysko, D.V.2    Vandenabeele, P.3    Agostinis, P.4
  • 52
    • 0035890823 scopus 로고    scopus 로고
    • Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization
    • Kotera Y, Shimizu K, Mule JJ. Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization. Cancer Res (2001) 61:8105-9.
    • (2001) Cancer Res , vol.61 , pp. 8105-8109
    • Kotera, Y.1    Shimizu, K.2    Mule, J.J.3
  • 53
    • 79551523389 scopus 로고    scopus 로고
    • Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
    • doi:10.1158/0008-5472.CAN-10-2788
    • Schiavoni G, Sistigu A, Valentini M, Mattei F, Sestili P, Spadaro F, et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res (2011) 71:768-78. doi:10.1158/0008-5472.CAN-10-2788.
    • (2011) Cancer Res , vol.71 , pp. 768-778
    • Schiavoni, G.1    Sistigu, A.2    Valentini, M.3    Mattei, F.4    Sestili, P.5    Spadaro, F.6
  • 54
    • 77953945438 scopus 로고    scopus 로고
    • Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs
    • doi:10.1182/blood-2009-11-251231
    • Nakahara T, Uchi H, Lesokhin AM, Avogadri F, Rizzuto GA, Hirschhorn-Cymerman D, et al. Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs. Blood (2010) 115:4384-92. doi:10.1182/blood-2009-11-251231.
    • (2010) Blood , vol.115 , pp. 4384-4392
    • Nakahara, T.1    Uchi, H.2    Lesokhin, A.M.3    Avogadri, F.4    Rizzuto, G.A.5    Hirschhorn-Cymerman, D.6
  • 55
    • 36049009999 scopus 로고    scopus 로고
    • Increase of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+ CD25+ T lymphocytes
    • doi:10.1111/j.1365-2249.2007.03521.x
    • Audia S, Nicolas A, Cathelin D, Larmonier N, Ferrand C, Foucher P, et al. Increase of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+ CD25+ T lymphocytes. Clin Exp Immunol (2007) 150:523-30. doi:10.1111/j.1365-2249.2007.03521.x.
    • (2007) Clin Exp Immunol , vol.150 , pp. 523-530
    • Audia, S.1    Nicolas, A.2    Cathelin, D.3    Larmonier, N.4    Ferrand, C.5    Foucher, P.6
  • 56
    • 61449258305 scopus 로고    scopus 로고
    • Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)
    • doi:10.4049/jimmunol.0801829
    • Salem ML, Diaz-Montero CM, Al-Khami AA, El-Naggar SA, Naga O, Montero AJ, et al. Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C). J Immunol (2009) 182:2030-40. doi:10.4049/jimmunol.0801829.
    • (2009) J Immunol , vol.182 , pp. 2030-2040
    • Salem, M.L.1    Diaz-Montero, C.M.2    Al-Khami, A.A.3    El-Naggar, S.A.4    Naga, O.5    Montero, A.J.6
  • 57
    • 33846004208 scopus 로고    scopus 로고
    • Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: creation of a beneficial host microenvironment involving type I IFNs and myeloid cells
    • doi:10.1097/01.cji.0000211311.28739.e3
    • Salem ML, Kadima AN, El-Naggar SA, Rubinstein MP, Chen Y, Gillanders WE, et al. Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: creation of a beneficial host microenvironment involving type I IFNs and myeloid cells. J Immunother (2007) 30:40-53. doi:10.1097/01.cji.0000211311.28739.e3.
    • (2007) J Immunother , vol.30 , pp. 40-53
    • Salem, M.L.1    Kadima, A.N.2    El-Naggar, S.A.3    Rubinstein, M.P.4    Chen, Y.5    Gillanders, W.E.6
  • 58
    • 10844269645 scopus 로고    scopus 로고
    • Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4+CD25+ regulatory T cells
    • Prasad SJ, Farrand KJ, Matthews SA, Chang JH, McHugh RS, Ronchese F. Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4+CD25+ regulatory T cells. J Immunol (2005) 174:90-8.
    • (2005) J Immunol , vol.174 , pp. 90-98
    • Prasad, S.J.1    Farrand, K.J.2    Matthews, S.A.3    Chang, J.H.4    McHugh, R.S.5    Ronchese, F.6
  • 59
    • 84878218095 scopus 로고    scopus 로고
    • Enhanced anti-cancer activity of human dendritic cells sensitized with gamma-irradiation-induced apoptotic colon cancer cells
    • doi:10.1016/j.canlet.2013.02.038
    • Kim SK, Yun CH, Han SH. Enhanced anti-cancer activity of human dendritic cells sensitized with gamma-irradiation-induced apoptotic colon cancer cells. Cancer Lett (2013) 335:278-88. doi:10.1016/j.canlet.2013.02.038.
    • (2013) Cancer Lett , vol.335 , pp. 278-288
    • Kim, S.K.1    Yun, C.H.2    Han, S.H.3
  • 60
    • 34249326159 scopus 로고    scopus 로고
    • Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regression
    • doi:10.1016/j.clim.2007.02.005
    • Huang J, Wang Y, Guo J, Lu H, Lin X, Ma L, et al. Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regression. Clin Immunol (2007) 123:298-310. doi:10.1016/j.clim.2007.02.005.
    • (2007) Clin Immunol , vol.123 , pp. 298-310
    • Huang, J.1    Wang, Y.2    Guo, J.3    Lu, H.4    Lin, X.5    Ma, L.6
  • 61
    • 84863619632 scopus 로고    scopus 로고
    • Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation
    • doi:10.4049/jimmunol.1200563
    • Gupta A, Probst HC, Vuong V, Landshammer A, Muth S, Yagita H, et al. Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J Immunol (2012) 189:558-66. doi:10.4049/jimmunol.1200563.
    • (2012) J Immunol , vol.189 , pp. 558-566
    • Gupta, A.1    Probst, H.C.2    Vuong, V.3    Landshammer, A.4    Muth, S.5    Yagita, H.6
  • 62
    • 0037086079 scopus 로고    scopus 로고
    • Strategies for antigen loading of dendritic cells to enhance the antitumor immune response
    • Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, et al. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res (2002) 62:1884-9.
    • (2002) Cancer Res , vol.62 , pp. 1884-1889
    • Strome, S.E.1    Voss, S.2    Wilcox, R.3    Wakefield, T.L.4    Tamada, K.5    Flies, D.6
  • 63
    • 84862640549 scopus 로고    scopus 로고
    • Maximizing tumor immunity with fractionated radiation
    • doi:10.1016/j.ijrobp.2011.09.049
    • Schaue D, Ratikan JA, Iwamoto KS, McBride WH. Maximizing tumor immunity with fractionated radiation. Int J Radiat Oncol Biol Phys (2012) 83:1306-10. doi:10.1016/j.ijrobp.2011.09.049.
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , pp. 1306-1310
    • Schaue, D.1    Ratikan, J.A.2    Iwamoto, K.S.3    McBride, W.H.4
  • 64
    • 84877817680 scopus 로고    scopus 로고
    • Inhibition of both BRAF and MEK in BRAF(V600E) mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties
    • doi:10.1007/s00262-012-1389-z
    • Ott PA, Henry T, Baranda SJ, Frleta D, Manches O, Bogunovic D, et al. Inhibition of both BRAF and MEK in BRAF(V600E) mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties. Cancer Immunol Immunother (2013) 62:811-22. doi:10.1007/s00262-012-1389-z.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 811-822
    • Ott, P.A.1    Henry, T.2    Baranda, S.J.3    Frleta, D.4    Manches, O.5    Bogunovic, D.6
  • 65
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • doi:10.1158/0008-5472.CAN-10-0118
    • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res (2010) 70:5213-9. doi:10.1158/0008-5472.CAN-10-0118.
    • (2010) Cancer Res , vol.70 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3    Udayakumar, D.4    Njauw, C.N.5    Sloss, C.M.6
  • 66
    • 84866941988 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity
    • doi:10.3109/08820139.2012.676122
    • Harden JL, Egilmez NK. Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity. Immunol Invest (2012) 41:738-64. doi:10.3109/08820139.2012.676122.
    • (2012) Immunol Invest , vol.41 , pp. 738-764
    • Harden, J.L.1    Egilmez, N.K.2
  • 67
    • 33748162638 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells: cytokine modulation comes of age
    • doi:10.1182/blood-2006-03-006403
    • Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood (2006) 108:1435-40. doi:10.1182/blood-2006-03-006403.
    • (2006) Blood , vol.108 , pp. 1435-1440
    • Rutella, S.1    Danese, S.2    Leone, G.3
  • 68
    • 61649125595 scopus 로고    scopus 로고
    • The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
    • doi:10.1016/j.leukres.2008.09.006
    • Yang DH, Park JS, Jin CJ, Kang HK, Nam JH, Rhee JH, et al. The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk Res (2009) 33:665-70. doi:10.1016/j.leukres.2008.09.006.
    • (2009) Leuk Res , vol.33 , pp. 665-670
    • Yang, D.H.1    Park, J.S.2    Jin, C.J.3    Kang, H.K.4    Nam, J.H.5    Rhee, J.H.6
  • 69
    • 79952055852 scopus 로고    scopus 로고
    • Immunological effects of bevacizumab-based treatment in metastatic colorectal cancer
    • doi:10.1159/000320609
    • Manzoni M, Rovati B, Ronzoni M, Loupakis F, Mariucci S, Ricci V, et al. Immunological effects of bevacizumab-based treatment in metastatic colorectal cancer. Oncology (2010) 79:187-96. doi:10.1159/000320609.
    • (2010) Oncology , vol.79 , pp. 187-196
    • Manzoni, M.1    Rovati, B.2    Ronzoni, M.3    Loupakis, F.4    Mariucci, S.5    Ricci, V.6
  • 70
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • doi:10.1158/0008-5472.CAN-10-0153
    • Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res (2010) 70:6171-80. doi:10.1158/0008-5472.CAN-10-0153.
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 71
    • 84856332921 scopus 로고    scopus 로고
    • Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro
    • doi:10.1002/ijc.26181
    • Correale P, Botta C, Cusi MG, Del Vecchio MT, De Santi MM, Gori Savellini G, et al. Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. Int J Cancer (2012) 130:1577-89. doi:10.1002/ijc.26181.
    • (2012) Int J Cancer , vol.130 , pp. 1577-1589
    • Correale, P.1    Botta, C.2    Cusi, M.G.3    Del Vecchio, M.T.4    De Santi, M.M.5    Gori Savellini, G.6
  • 72
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • doi:10.1038/nrc3237
    • Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer (2012) 12:237-51. doi:10.1038/nrc3237.
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 73
    • 82955239884 scopus 로고    scopus 로고
    • Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1
    • doi:10.1186/1471-2407-11-464
    • Moehler M, Sieben M, Roth S, Springsguth F, Leuchs B, Zeidler M, et al. Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1. BMC Cancer (2011) 11:464. doi:10.1186/1471-2407-11-464.
    • (2011) BMC Cancer , vol.11 , pp. 464
    • Moehler, M.1    Sieben, M.2    Roth, S.3    Springsguth, F.4    Leuchs, B.5    Zeidler, M.6
  • 74
    • 79961016549 scopus 로고    scopus 로고
    • Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
    • doi:10.1172/JCI43656
    • Lesterhuis WJ, Punt CJ, Hato SV, Eleveld-Trancikova D, Jansen BJ, Nierkens S, et al. Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest (2011) 121:3100-8. doi:10.1172/JCI43656.
    • (2011) J Clin Invest , vol.121 , pp. 3100-3108
    • Lesterhuis, W.J.1    Punt, C.J.2    Hato, S.V.3    Eleveld-Trancikova, D.4    Jansen, B.J.5    Nierkens, S.6
  • 75
    • 0031890206 scopus 로고    scopus 로고
    • Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
    • doi:10.1038/nm0398-321
    • Rosenberg SA, Yang JC, Schwartzentruber DJ, Hwu P, Marincola FM, Topalian SL, et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med (1998) 4:321-7. doi:10.1038/nm0398-321.
    • (1998) Nat Med , vol.4 , pp. 321-327
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3    Hwu, P.4    Marincola, F.M.5    Topalian, S.L.6
  • 76
    • 41649119810 scopus 로고    scopus 로고
    • Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen
    • doi:10.1073/pnas.0800080105
    • Speiser DE, Baumgaertner P, Voelter V, Devevre E, Barbey C, Rufer N, et al. Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen. Proc Natl Acad Sci U S A (2008) 105:3849-54. doi:10.1073/pnas.0800080105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3849-3854
    • Speiser, D.E.1    Baumgaertner, P.2    Voelter, V.3    Devevre, E.4    Barbey, C.5    Rufer, N.6
  • 77
    • 84858776559 scopus 로고    scopus 로고
    • Experience with synthetic vaccines for cancer and persistent virus infections in nonhuman primates and patients
    • doi:10.1016/B978-0-12-396548-6.00004-4
    • Quakkelaar ED, Melief CJ. Experience with synthetic vaccines for cancer and persistent virus infections in nonhuman primates and patients. Adv Immunol (2012) 114:77-106. doi:10.1016/B978-0-12-396548-6.00004-4.
    • (2012) Adv Immunol , vol.114 , pp. 77-106
    • Quakkelaar, E.D.1    Melief, C.J.2
  • 78
    • 14544288632 scopus 로고    scopus 로고
    • CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    • doi:10.1038/nature03337
    • Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature (2005) 434:88-93. doi:10.1038/nature03337.
    • (2005) Nature , vol.434 , pp. 88-93
    • Janssen, E.M.1    Droin, N.M.2    Lemmens, E.E.3    Pinkoski, M.J.4    Bensinger, S.J.5    Ehst, B.D.6
  • 79
    • 84870333994 scopus 로고    scopus 로고
    • Limited induction of tumor cross-reactive T cells without a measurable clinical benefit in early melanoma patients vaccinated with human leukocyte antigen class I-modified peptides
    • doi:10.1158/1078-0432.CCR-12-1516
    • Filipazzi P, Pilla L, Mariani L, Patuzzo R, Castelli C, Camisaschi C, et al. Limited induction of tumor cross-reactive T cells without a measurable clinical benefit in early melanoma patients vaccinated with human leukocyte antigen class I-modified peptides. Clin Cancer Res (2012) 18:6485-96. doi:10.1158/1078-0432.CCR-12-1516.
    • (2012) Clin Cancer Res , vol.18 , pp. 6485-6496
    • Filipazzi, P.1    Pilla, L.2    Mariani, L.3    Patuzzo, R.4    Castelli, C.5    Camisaschi, C.6
  • 80
    • 70249141312 scopus 로고    scopus 로고
    • Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial
    • doi:10.1002/ijc.24597
    • Leffers N, Lambeck AJ, Gooden MJ, Hoogeboom BN, Wolf R, Hamming IE, et al. Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial. Int J Cancer (2009) 125:2104-13. doi:10.1002/ijc.24597.
    • (2009) Int J Cancer , vol.125 , pp. 2104-2113
    • Leffers, N.1    Lambeck, A.J.2    Gooden, M.J.3    Hoogeboom, B.N.4    Wolf, R.5    Hamming, I.E.6
  • 81
    • 61349184597 scopus 로고    scopus 로고
    • Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer
    • doi:10.1158/1078-0432.CCR-08-2227
    • Speetjens FM, Kuppen PJ, Welters MJ, Essahsah F, Voet van den Brink AM, Lantrua MG, et al. Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer. Clin Cancer Res (2009) 15:1086-95. doi:10.1158/1078-0432.CCR-08-2227.
    • (2009) Clin Cancer Res , vol.15 , pp. 1086-1095
    • Speetjens, F.M.1    Kuppen, P.J.2    Welters, M.J.3    Essahsah, F.4    Voet van den Brink, A.M.5    Lantrua, M.G.6
  • 82
    • 84864662070 scopus 로고    scopus 로고
    • Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    • doi:10.1038/nm.2883
    • Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, et al. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med (2012) 18:1254-61. doi:10.1038/nm.2883.
    • (2012) Nat Med , vol.18 , pp. 1254-1261
    • Walter, S.1    Weinschenk, T.2    Stenzl, A.3    Zdrojowy, R.4    Pluzanska, A.5    Szczylik, C.6
  • 83
    • 84880721353 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic cancer vaccines
    • doi:10.1016/j.immuni.2013.07.004
    • Palucka K, Banchereau J. Dendritic-cell-based therapeutic cancer vaccines. Immunity (2013) 39:38-48. doi:10.1016/j.immuni.2013.07.004.
    • (2013) Immunity , vol.39 , pp. 38-48
    • Palucka, K.1    Banchereau, J.2
  • 84
    • 84880730418 scopus 로고    scopus 로고
    • Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma
    • doi:10.1200/JCO.2012.43.7111
    • Kruit WH, Suciu S, Dreno B, Mortier L, Robert C, Chiarion-Sileni V, et al. Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma. J Clin Oncol (2013) 31:2413-20. doi:10.1200/JCO.2012.43.7111.
    • (2013) J Clin Oncol , vol.31 , pp. 2413-2420
    • Kruit, W.H.1    Suciu, S.2    Dreno, B.3    Mortier, L.4    Robert, C.5    Chiarion-Sileni, V.6
  • 85
    • 77953622301 scopus 로고    scopus 로고
    • Adjuvants for cancer vaccines
    • doi:10.1016/j.smim.2010.04.007
    • Dubensky TW Jr, Reed SG. Adjuvants for cancer vaccines. Semin Immunol (2010) 22:155-61. doi:10.1016/j.smim.2010.04.007.
    • (2010) Semin Immunol , vol.22 , pp. 155-161
    • Dubensky Jr., T.W.1    Reed, S.G.2
  • 86
    • 84878187265 scopus 로고    scopus 로고
    • The lack of predictors for rapid progression in prostate cancer patients receiving sipuleucel-T
    • doi:10.3390/cancers5020511
    • Ng L, Heck W, Lavsa S, Crowther D, Atkinson B, Xiao L, et al. The lack of predictors for rapid progression in prostate cancer patients receiving sipuleucel-T. Cancers (Basel) (2013) 5:511-8. doi:10.3390/cancers5020511.
    • (2013) Cancers (Basel) , vol.5 , pp. 511-518
    • Ng, L.1    Heck, W.2    Lavsa, S.3    Crowther, D.4    Atkinson, B.5    Xiao, L.6
  • 87
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • doi:10.1056/NEJMoa1001294
    • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med (2010) 363:411-22. doi:10.1056/NEJMoa1001294.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3    Berger, E.R.4    Small, E.J.5    Penson, D.F.6
  • 89
    • 84878767645 scopus 로고    scopus 로고
    • Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells
    • doi:10.1371/journal.pone.0065181
    • Bugaut H, Bruchard M, Berger H, Derangere V, Odoul L, Euvrard R, et al. Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells. PLoS One (2013) 8:e65181. doi:10.1371/journal.pone.0065181.
    • (2013) PLoS One , vol.8
    • Bugaut, H.1    Bruchard, M.2    Berger, H.3    Derangere, V.4    Odoul, L.5    Euvrard, R.6
  • 90
    • 77949274559 scopus 로고    scopus 로고
    • Why do cells release vesicles?
    • doi:10.1016/j.thromres.2010.01.037
    • Nieuwland R, Sturk A. Why do cells release vesicles? Thromb Res (2010) 125(Suppl 1):S49-51. doi:10.1016/j.thromres.2010.01.037.
    • (2010) Thromb Res , vol.125 , Issue.SUPPL. 1
    • Nieuwland, R.1    Sturk, A.2
  • 91
    • 83555173384 scopus 로고    scopus 로고
    • Exosomes: small vesicles participating in intercellular communication
    • doi:10.1016/j.biocel.2011.10.005
    • Ludwig A-K, Giebel B. Exosomes: small vesicles participating in intercellular communication. Int J Biochem Cell Biol (2012) 44:11-5. doi:10.1016/j.biocel.2011.10.005.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 11-15
    • Ludwig, A.-K.1    Giebel, B.2
  • 92
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • doi:10.1083/jcb.97.2.329
    • Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol (1983) 97:329-39. doi:10.1083/jcb.97.2.329.
    • (1983) J Cell Biol , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 93
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • doi:10.1083/jcb.101.3.942
    • Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol (1985) 101:942-8. doi:10.1083/jcb.101.3.942.
    • (1985) J Cell Biol , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 94
    • 84881400770 scopus 로고    scopus 로고
    • Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells
    • doi:10.1073/pnas.1221899110
    • Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, et al. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci U S A (2013) 110:13109-13. doi:10.1073/pnas.1221899110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 13109-13113
    • Ramakrishnaiah, V.1    Thumann, C.2    Fofana, I.3    Habersetzer, F.4    Pan, Q.5    de Ruiter, P.E.6
  • 96
    • 67549125238 scopus 로고    scopus 로고
    • Gene expression profiling of the tumor microenvironment during breast cancer progression
    • doi:10.1186/bcr2222
    • Ma XJ, Dahiya S, Richardson E, Erlander M, Sgroi DC. Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res (2009) 11:R7. doi:10.1186/bcr2222.
    • (2009) Breast Cancer Res , vol.11
    • Ma, X.J.1    Dahiya, S.2    Richardson, E.3    Erlander, M.4    Sgroi, D.C.5
  • 98
    • 78651361232 scopus 로고    scopus 로고
    • Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages
    • doi:10.1186/1479-5876-9-9
    • Lasser C, Alikhani VS, Ekstrom K, Eldh M, Paredes PT, Bossios A, et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. J Transl Med (2011) 9:9. doi:10.1186/1479-5876-9-9.
    • (2011) J Transl Med , vol.9 , pp. 9
    • Lasser, C.1    Alikhani, V.S.2    Ekstrom, K.3    Eldh, M.4    Paredes, P.T.5    Bossios, A.6
  • 99
    • 34249792918 scopus 로고    scopus 로고
    • Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    • Yu S, Liu C, Su K, Wang J, Liu Y, Zhang L, et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J Immunol (2007) 178:6867-75.
    • (2007) J Immunol , vol.178 , pp. 6867-6875
    • Yu, S.1    Liu, C.2    Su, K.3    Wang, J.4    Liu, Y.5    Zhang, L.6
  • 100
    • 84871345281 scopus 로고    scopus 로고
    • Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells
    • doi:10.1007/s12094-012-0860-9
    • Ma B, Jiang H, Jia J, Di L, Song G, Yu J, et al. Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells. Clin Transl Oncol (2012) 14:764-73. doi:10.1007/s12094-012-0860-9.
    • (2012) Clin Transl Oncol , vol.14 , pp. 764-773
    • Ma, B.1    Jiang, H.2    Jia, J.3    Di, L.4    Song, G.5    Yu, J.6
  • 101
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • doi:10.1016/S0140-6736(02)09552-1
    • Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, Morice P, et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet (2002) 360:295-305. doi:10.1016/S0140-6736(02)09552-1.
    • (2002) Lancet , vol.360 , pp. 295-305
    • Andre, F.1    Schartz, N.E.2    Movassagh, M.3    Flament, C.4    Pautier, P.5    Morice, P.6
  • 103
    • 79955859969 scopus 로고    scopus 로고
    • Adjuvants for enhancing the immunogenicity of whole tumor cell vaccines
    • doi:10.3109/08830185.2011.572210
    • Chiang CL, Kandalaft LE, Coukos G. Adjuvants for enhancing the immunogenicity of whole tumor cell vaccines. Int Rev Immunol (2011) 30:150-82. doi:10.3109/08830185.2011.572210.
    • (2011) Int Rev Immunol , vol.30 , pp. 150-182
    • Chiang, C.L.1    Kandalaft, L.E.2    Coukos, G.3
  • 105
    • 77955845525 scopus 로고    scopus 로고
    • Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn
    • doi:10.1016/j.yexcr.2010.05.032
    • Zumaquero E, Munoz P, Cobo M, Lucena G, Pavon EJ, Martin A, et al. Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn. Exp Cell Res (2010) 316:2692-706. doi:10.1016/j.yexcr.2010.05.032.
    • (2010) Exp Cell Res , vol.316 , pp. 2692-2706
    • Zumaquero, E.1    Munoz, P.2    Cobo, M.3    Lucena, G.4    Pavon, E.J.5    Martin, A.6
  • 106
    • 84877682356 scopus 로고    scopus 로고
    • Exosomes from CIITA-transfected CT26 cells enhance anti-tumor effects
    • doi:10.7314/APJCP.2013.14.2.987
    • Fan W, Tian XD, Huang E, Zhang JJ. Exosomes from CIITA-transfected CT26 cells enhance anti-tumor effects. Asian Pac J Cancer Prev (2013) 14:987-91. doi:10.7314/APJCP.2013.14.2.987.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 987-991
    • Fan, W.1    Tian, X.D.2    Huang, E.3    Zhang, J.J.4
  • 107
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
    • doi:10.1038/nm0598-594
    • Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, Tenza D, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med (1998) 4:594-600. doi:10.1038/nm0598-594.
    • (1998) Nat Med , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3    Wolfers, J.4    Flament, C.5    Tenza, D.6
  • 108
    • 22044447897 scopus 로고    scopus 로고
    • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
    • doi:10.1182/blood-2005-01-0220
    • Segura E, Nicco C, Lombard B, Veron P, Raposo G, Batteux F, et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood (2005) 106:216-23. doi:10.1182/blood-2005-01-0220.
    • (2005) Blood , vol.106 , pp. 216-223
    • Segura, E.1    Nicco, C.2    Lombard, B.3    Veron, P.4    Raposo, G.5    Batteux, F.6
  • 109
    • 24644485206 scopus 로고    scopus 로고
    • Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    • doi:10.1016/j.bcmd.2005.05.003
    • Segura E, Amigorena S, Thery C. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol Dis (2005) 35:89-93. doi:10.1016/j.bcmd.2005.05.003.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 89-93
    • Segura, E.1    Amigorena, S.2    Thery, C.3
  • 110
    • 63849165317 scopus 로고    scopus 로고
    • Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism
    • doi:10.1182/blood-2008-04-153536
    • Qazi KR, Gehrmann U, Domange Jordo E, Karlsson MC, Gabrielsson S. Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism. Blood (2009) 113:2673-83. doi:10.1182/blood-2008-04-153536.
    • (2009) Blood , vol.113 , pp. 2673-2683
    • Qazi, K.R.1    Gehrmann, U.2    Domange Jordo, E.3    Karlsson, M.C.4    Gabrielsson, S.5
  • 111
    • 84880823162 scopus 로고    scopus 로고
    • Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer
    • doi:10.1371/journal.pone.0070047
    • Gabriel K, Ingram A, Austin R, Kapoor A, Tang D, Majeed F, et al. Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. PLoS One (2013) 8:e70047. doi:10.1371/journal.pone.0070047.
    • (2013) PLoS One , vol.8
    • Gabriel, K.1    Ingram, A.2    Austin, R.3    Kapoor, A.4    Tang, D.5    Majeed, F.6
  • 112
    • 37349012215 scopus 로고    scopus 로고
    • Tumour-released exosomes and their implications in cancer immunity
    • doi:10.1038/sj.cdd.4402237
    • Iero M, Valenti R, Huber V, Filipazzi P, Parmiani G, Fais S, et al. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ (2008) 15:80-8. doi:10.1038/sj.cdd.4402237.
    • (2008) Cell Death Differ , vol.15 , pp. 80-88
    • Iero, M.1    Valenti, R.2    Huber, V.3    Filipazzi, P.4    Parmiani, G.5    Fais, S.6
  • 113
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • doi:10.1172/JCI40483
    • Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest (2010) 120:457-71. doi:10.1172/JCI40483.
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Remy-Martin, J.P.6
  • 114
    • 84859712385 scopus 로고    scopus 로고
    • Immunosuppressive exosomes: a new approach for treating arthritis
    • doi:10.1155/2012/573528
    • Yang C, Robbins PD. Immunosuppressive exosomes: a new approach for treating arthritis. Int J Rheumatol (2012) 2012:573528. doi:10.1155/2012/573528.
    • (2012) Int J Rheumatol , vol.2012 , pp. 573528
    • Yang, C.1    Robbins, P.D.2
  • 115
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • doi:10.1158/0008-5472.CAN-04-3804
    • Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res (2005) 65:5238-47. doi:10.1158/0008-5472.CAN-04-3804.
    • (2005) Cancer Res , vol.65 , pp. 5238-5247
    • Gastpar, R.1    Gehrmann, M.2    Bausero, M.A.3    Asea, A.4    Gross, C.5    Schroeder, J.A.6
  • 116
    • 84867117645 scopus 로고    scopus 로고
    • Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes
    • doi:10.1074/mcp.M111.014845
    • Hosseini-Beheshti E, Pham S, Adomat H, Li N, Tomlinson Guns ES. Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Mol Cell Proteomics (2012) 11:863-85. doi:10.1074/mcp.M111.014845.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 863-885
    • Hosseini-Beheshti, E.1    Pham, S.2    Adomat, H.3    Li, N.4    Tomlinson Guns, E.S.5
  • 117
    • 59649100584 scopus 로고    scopus 로고
    • Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acid
    • doi:10.1177/147323000803600623
    • Guo F, Chang CK, Fan HH, Nie XX, Ren YN, Liu YY, et al. Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acid. J Int Med Res (2008) 36:1342-53. doi:10.1177/147323000803600623.
    • (2008) J Int Med Res , vol.36 , pp. 1342-1353
    • Guo, F.1    Chang, C.K.2    Fan, H.H.3    Nie, X.X.4    Ren, Y.N.5    Liu, Y.Y.6
  • 118
    • 33644531900 scopus 로고    scopus 로고
    • Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines
    • Taieb J, Chaput N, Schartz N, Roux S, Novault S, Menard C, et al. Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines. J Immunol (2006) 176:2722-9.
    • (2006) J Immunol , vol.176 , pp. 2722-2729
    • Taieb, J.1    Chaput, N.2    Schartz, N.3    Roux, S.4    Novault, S.5    Menard, C.6
  • 119
    • 84880049306 scopus 로고    scopus 로고
    • Synergistic induction of adaptive antitumor immunity by codelivery of antigen with alpha-galactosylceramide on exosomes
    • doi:10.1158/0008-5472.CAN-12-3918
    • Gehrmann U, Hiltbrunner S, Georgoudaki AM, Karlsson MC, Naslund TI, Gabrielsson S. Synergistic induction of adaptive antitumor immunity by codelivery of antigen with alpha-galactosylceramide on exosomes. Cancer Res (2013) 73:3865-76. doi:10.1158/0008-5472.CAN-12-3918.
    • (2013) Cancer Res , vol.73 , pp. 3865-3876
    • Gehrmann, U.1    Hiltbrunner, S.2    Georgoudaki, A.M.3    Karlsson, M.C.4    Naslund, T.I.5    Gabrielsson, S.6
  • 120
    • 33751504617 scopus 로고    scopus 로고
    • Dendritic cell derived-exosomes: biology and clinical implementations
    • doi:10.1189/jlb.0206094
    • Chaput N, Flament C, Viaud S, Taieb J, Roux S, Spatz A, et al. Dendritic cell derived-exosomes: biology and clinical implementations. J Leukoc Biol (2006) 80:471-8. doi:10.1189/jlb.0206094.
    • (2006) J Leukoc Biol , vol.80 , pp. 471-478
    • Chaput, N.1    Flament, C.2    Viaud, S.3    Taieb, J.4    Roux, S.5    Spatz, A.6
  • 121
    • 35848941965 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes
    • Hao S, Bai O, Yuan J, Qureshi M, Xiang J. Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes. Cell Mol Immunol (2006) 3:205-11.
    • (2006) Cell Mol Immunol , vol.3 , pp. 205-211
    • Hao, S.1    Bai, O.2    Yuan, J.3    Qureshi, M.4    Xiang, J.5
  • 122
    • 84875069590 scopus 로고    scopus 로고
    • Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands
    • doi:10.4161/onci.20897
    • Munich S, Sobo-Vujanovic A, Buchser WJ, Beer-Stolz D, Vujanovic NL. Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology (2012) 1:1074-83. doi:10.4161/onci.20897.
    • (2012) Oncoimmunology , vol.1 , pp. 1074-1083
    • Munich, S.1    Sobo-Vujanovic, A.2    Buchser, W.J.3    Beer-Stolz, D.4    Vujanovic, N.L.5
  • 123
    • 63449129623 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha
    • doi:10.1371/journal.pone.0004942
    • Viaud S, Terme M, Flament C, Taieb J, Andre F, Novault S, et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha. PLoS One (2009) 4:e4942. doi:10.1371/journal.pone.0004942.
    • (2009) PLoS One , vol.4
    • Viaud, S.1    Terme, M.2    Flament, C.3    Taieb, J.4    Andre, F.5    Novault, S.6
  • 124
    • 39449101177 scopus 로고    scopus 로고
    • Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    • doi:10.1158/0008-5472.CAN-07-3163
    • Zeelenberg IS, Ostrowski M, Krumeich S, Bobrie A, Jancic C, Boissonnas A, et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res (2008) 68:1228-35. doi:10.1158/0008-5472.CAN-07-3163.
    • (2008) Cancer Res , vol.68 , pp. 1228-1235
    • Zeelenberg, I.S.1    Ostrowski, M.2    Krumeich, S.3    Bobrie, A.4    Jancic, C.5    Boissonnas, A.6
  • 125
    • 79959864289 scopus 로고    scopus 로고
    • Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3
    • doi:10.1097/JTO.0b013e31821c421d
    • Schneider T, Hoffmann H, Dienemann H, Schnabel PA, Enk AH, Ring S, et al. Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3. J Thorac Oncol (2011) 6:1162-8. doi:10.1097/JTO.0b013e31821c421d.
    • (2011) J Thorac Oncol , vol.6 , pp. 1162-1168
    • Schneider, T.1    Hoffmann, H.2    Dienemann, H.3    Schnabel, P.A.4    Enk, A.H.5    Ring, S.6
  • 126
    • 84874903268 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity
    • doi:10.4049/jimmunol.1203082
    • Naslund TI, Gehrmann U, Qazi KR, Karlsson MC, Gabrielsson S. Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity. J Immunol (2013) 190:2712-9. doi:10.4049/jimmunol.1203082.
    • (2013) J Immunol , vol.190 , pp. 2712-2719
    • Naslund, T.I.1    Gehrmann, U.2    Qazi, K.R.3    Karlsson, M.C.4    Gabrielsson, S.5
  • 127
    • 61849179182 scopus 로고    scopus 로고
    • Activated T cells recruit exosomes secreted by dendritic cells via LFA-1
    • doi:10.1182/blood-2008-08-174094
    • Nolte-'t Hoen EN, Buschow SI, Anderton SM, Stoorvogel W, Wauben MH. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood (2009) 113:1977-81. doi:10.1182/blood-2008-08-174094.
    • (2009) Blood , vol.113 , pp. 1977-1981
    • Nolte-'t Hoen, E.N.1    Buschow, S.I.2    Anderton, S.M.3    Stoorvogel, W.4    Wauben, M.H.5
  • 128
    • 33846502114 scopus 로고    scopus 로고
    • Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies
    • doi:10.1016/j.biochi.2006.10.014
    • Subra C, Laulagnier K, Perret B, Record M. Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies. Biochimie (2007) 89:205-12. doi:10.1016/j.biochi.2006.10.014.
    • (2007) Biochimie , vol.89 , pp. 205-212
    • Subra, C.1    Laulagnier, K.2    Perret, B.3    Record, M.4
  • 129
    • 32344434352 scopus 로고    scopus 로고
    • Lysophosphatidylcholine is a natural adjuvant that initiates cellular immune responses
    • doi:10.1016/j.vaccine.2005.09.036
    • Perrin-Cocon L, Agaugue S, Coutant F, Saint-Mezard P, Guironnet-Paquet A, Nicolas JF, et al. Lysophosphatidylcholine is a natural adjuvant that initiates cellular immune responses. Vaccine (2006) 24:1254-63. doi:10.1016/j.vaccine.2005.09.036.
    • (2006) Vaccine , vol.24 , pp. 1254-1263
    • Perrin-Cocon, L.1    Agaugue, S.2    Coutant, F.3    Saint-Mezard, P.4    Guironnet-Paquet, A.5    Nicolas, J.F.6
  • 130
    • 79959330841 scopus 로고    scopus 로고
    • Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy
    • doi:10.1016/j.colsurfb.2011.05.013
    • Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, et al. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces (2011) 87:146-50. doi:10.1016/j.colsurfb.2011.05.013.
    • (2011) Colloids Surf B Biointerfaces , vol.87 , pp. 146-150
    • Sokolova, V.1    Ludwig, A.K.2    Hornung, S.3    Rotan, O.4    Horn, P.A.5    Epple, M.6
  • 131
    • 0141962590 scopus 로고    scopus 로고
    • Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid
    • doi:10.1183/09031936.03.00041703
    • Admyre C, Grunewald J, Thyberg J, Gripenback S, Tornling G, Eklund A, et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J (2003) 22:578-83. doi:10.1183/09031936.03.00041703.
    • (2003) Eur Respir J , vol.22 , pp. 578-583
    • Admyre, C.1    Grunewald, J.2    Thyberg, J.3    Gripenback, S.4    Tornling, G.5    Eklund, A.6
  • 132
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • doi:10.1038/nm1523
    • Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2007) 13:54-61. doi:10.1038/nm1523.
    • (2007) Nat Med , vol.13 , pp. 54-61
    • Obeid, M.1    Tesniere, A.2    Ghiringhelli, F.3    Fimia, G.M.4    Apetoh, L.5    Perfettini, J.L.6
  • 133
    • 84862018564 scopus 로고    scopus 로고
    • Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer
    • doi:10.1590/S0100-879X2012007500061
    • Zheng J, Liu Q, Yang J, Ren Q, Cao W, Yu Z, et al. Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer. Braz J Med Biol Res (2012) 45:510-5. doi:10.1590/S0100-879X2012007500061.
    • (2012) Braz J Med Biol Res , vol.45 , pp. 510-515
    • Zheng, J.1    Liu, Q.2    Yang, J.3    Ren, Q.4    Cao, W.5    Yu, Z.6
  • 134
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    • doi:10.1038/nm.2028
    • Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 15:1170-8. doi:10.1038/nm.2028.
    • (2009) Nat Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3    Aymeric, L.4    Ma, Y.5    Ortiz, C.6
  • 135
    • 84857879286 scopus 로고    scopus 로고
    • Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91
    • doi:10.1371/journal.pone.0031732
    • Cirone M, Di Renzo L, Lotti LV, Conte V, Trivedi P, Santarelli R, et al. Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91. PLoS One (2012) 7:e31732. doi:10.1371/journal.pone.0031732.
    • (2012) PLoS One , vol.7
    • Cirone, M.1    Di Renzo, L.2    Lotti, L.V.3    Conte, V.4    Trivedi, P.5    Santarelli, R.6
  • 136
    • 14244262560 scopus 로고    scopus 로고
    • Select forms of tumor cell apoptosis induce dendritic cell maturation
    • doi:10.1189/jlb.0804478
    • Demaria S, Santori FR, Ng B, Liebes L, Formenti SC, Vukmanovic S. Select forms of tumor cell apoptosis induce dendritic cell maturation. J Leukoc Biol (2005) 77:361-8. doi:10.1189/jlb.0804478.
    • (2005) J Leukoc Biol , vol.77 , pp. 361-368
    • Demaria, S.1    Santori, F.R.2    Ng, B.3    Liebes, L.4    Formenti, S.C.5    Vukmanovic, S.6
  • 137
    • 79959277095 scopus 로고    scopus 로고
    • Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines
    • doi:10.1186/1423-0127-18-44
    • Wen CC, Chen HM, Chen SS, Huang LT, Chang WT, Wei WC, et al. Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. J Biomed Sci (2011) 18:44. doi:10.1186/1423-0127-18-44.
    • (2011) J Biomed Sci , vol.18 , pp. 44
    • Wen, C.C.1    Chen, H.M.2    Chen, S.S.3    Huang, L.T.4    Chang, W.T.5    Wei, W.C.6
  • 138
    • 84871985834 scopus 로고    scopus 로고
    • Measles virus causes immunogenic cell death in human melanoma
    • doi:10.1038/gt.2011.205
    • Donnelly OG, Errington-Mais F, Steele L, Hadac E, Jennings V, Scott K, et al. Measles virus causes immunogenic cell death in human melanoma. Gene Ther (2013) 20(1):7-15. doi:10.1038/gt.2011.205.
    • (2013) Gene Ther , vol.20 , Issue.1 , pp. 7-15
    • Donnelly, O.G.1    Errington-Mais, F.2    Steele, L.3    Hadac, E.4    Jennings, V.5    Scott, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.