Strategies for antigen loading of dendritic cells to enhance the antitumor immune response

Cancer Research

Volumn 62, Issue 6, 2002, Pages 1884-1889

  Strome, Scott E ^a   Voss, Stephen ^a   Wilcox, Ryan ^a   Wakefield, Tamekia L ^a   Tamada, Koji ^a   Flies, Dallas ^a   Chapoval, Andrei ^a   Lu, Jun ^a   Kasperbauer, Jan L ^a   Padley, Douglas ^a   Vile, Richard ^a   Gastineau, Dennis ^a   Wettstein, Peter ^a   Chen, Lieping ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOLOGY; DENDRITIC CELL; FREEZING; HEATING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; APOPTOSIS; CANCER VACCINES; CARCINOMA, SQUAMOUS CELL; DENDRITIC CELLS; FREEZING; HEATING; HUMANS; IMMUNOTHERAPY, ADOPTIVE; MELANOMA; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NECROSIS; NEOPLASMS, EXPERIMENTAL; OVALBUMIN; T-LYMPHOCYTES, CYTOTOXIC; THYMOMA; TUMOR CELLS, CULTURED;

EID: 0037086079     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Dendritic cells and the control of immunity
2. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
3. Regression of human metastatic renal cell carcinoma after vaccination with tumor cell=dendritic cell hybrids
4. Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumor
5. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
6. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo
7. Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3
8. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
9. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL crosspriming
10. Cancer vaccines
11. Crosspriming of naive CD8 T cells against melanoma antigens
12. Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity
13. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells
14. Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells
15. Human tumor and dendritic cell hybrids generated by electrofusion: Potential for cancer vaccines
16. Eliciting T cell immunity against poorly immunogenic tumors by immunization with dendritic cell=tumor fusion vaccines
17. Fusion induces tumor rejection
18. Adoptive transfer of immature dendritic cells with autologous or allogeneic tumor cells generates systemic antitumor immunity
19. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
20. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
21. Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy
22. Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma
23. Morphological, and biochemical characterization, and analysis of apoptosis
24. Dendritic cell-based immunization for cancer therapy
25. Dendritic cell vaccines for cancer immunotherapy
26. Immunotherapy of cancer with dendritic-cell-based vaccines
27. How does radiation kill cells?
28. Radiation-induced apoptosis: Relevance to radiotherapy
29. Heat shock protein 70 induced during tumor cell killing induce Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake
30. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
31. Natural adjuvants: Endogeous activators of dendritic cells