Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells

Clinical and Translational Oncology

Volumn 14, Issue 10, 2012, Pages 764-773

  Ma, Bo ^a   Jiang, Hanfang ^a   Jia, Jun ^a   Di, Lijun ^a   Song, Guohong ^a   Yu, Jing ^a   Zhu, Yulin ^a   Lu, Zhihao ^a   Wang, Xiaoli ^a   Zhou, Xinna ^a   Ren, Jun ^a,b  

^a PEKING UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow stromal cells; Exosome; Hepatocellular carcinoma

Indexed keywords

CYCLINE; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW STROMA CELL; CANCER CELL CULTURE; CANCER THERAPY; CELL ACTIVATION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EXOSOME; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC ENGINEERING; HEPATOMA CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STROMA CELL; SUPERNATANT; TUMOR DERIVED EXOSOME; WESTERN BLOTTING;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; EXOSOMES; LIVER NEOPLASMS; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; PHENOTYPE;

EID: 84871345281     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-012-0860-9     Document Type: Article

References (48)

1. Parkin DM, Bray F, Ferlay J et al (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108
2. He J, Gu D, Wu X et al (2005) Major causes of death among men and women in China. N Engl J Med 353:1124-1134
3. Blum HE (2005) Hepatocellular carcinoma: therapy and prevention. World J Gastroenterol 11:7391-7400
4. Said A, Lucey MR (2008) Liver transplantation: an update 2008. Curr Opin Gastroenterol 24:339-345
5. Avila MA, Berasain C, Sangro B et al (2006) New therapies for hepatocellular carcinoma. Oncogene 25:3866-3884
6. Bianco P, Riminucci M, Gronthos S et al (2001) Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180-192
7. Herzog EL, Chai L, Krause DS (2003) Plasticity of marrow-derived stem cells. Blood 102:3483-3493
8. Sato Y, Araki H, Kato J et al (2005) Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 106:756-763
9. Dominici M, Le Blanc K, Mueller I et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315-317
10. Tocci A, Forte L (2003) Mesenchymal stem cell: use and perspectives. Hematol J 4:92-96
11. Nakamura K, Ito Y, Kawano Y et al (2004) Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 11:1155-1164
12. Tropel P, Noel D, Platet N et al (2004) Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow. Exp Cell Res 295:395-406
13. Meirelles L da S, Nardi NB (2003) Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol 123:702-711
14. Duan HF, Wu CT, Wu DL et al (2003) Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor. Mol Ther 8:467-474
15. Mangi AA, Noiseux N, Kong D et al (2003) Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9:1195-1201
16. Parr AM, Tator CH, Keating A (2007) Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 40:609-619
17. Bai L, Caplan A, Lennon D et al (2007) Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochem Res 32:353-362
18. Khakoo AY, Pati S, Anderson SA et al (2006) Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 203:1235-1247
19. Jiang HF, Ren J (2008) Inoculation of murine bone mesenchymal stem cells induces tumor necrosis in mouse with orthotopic hepatocellular carcinoma. J Peking Univ (Health Sci) 40:453-458
20. Studeny M, Marini FC, Champlin RE et al (2002) Bone marrow-derived mesenchymal stem cells as vehicles for interferon-b delivery into tumors. Cancer Res 62:3603-3608
21. Stagg J, Pommey S, Eliopoulos N et al (2006) Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood 107:2570-2577
22. Johnstone RM, Adam M, Hammond JR et al (1987) Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem 262:9412-9420
23. Raposo G, Nijman HW, Stoorvogel W et al (1996) B lymphocytes secrete antigen-presenting vesicles. J Exp Med 183(3):1161-1172
24. Heijnen HF, Schiel AE, Fijnheer R et al (1999) Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 94:3791-3799
25. Skokos D, Botros HG, Demeure C et al (2003) Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J Immunol 170:3037-3045
26. Zitvogel L, Regnault A, Lozier A et al (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 4:594-600
27. Thery C, Duban L, Segura E et al (2002) Indirect activation of naive CD4? T cells by dendritic cell-derived exosomes. Nat Immunol 3:1156-1162
28. Escudier B, Dorval T, Chaput N et al (2005) Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med 3:10-21
29. Morse MA, Garst J, Osada T et al (2005) A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med 3(1):9-19
30. Andre F, Schartz NE, Chaput N et al (2002) Tumor-derived exosomes: a new source of tumor rejection antigens. Vaccine 20:A28-A31
31. Wolfers J, Lozier A, Raposo G et al (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 7:297-303
32. Adams M, Navabi H, Croston D et al (2005) The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 23:2374-2378
33. Lamparski HG, Metha-Damani A, Yao JY et al (2002) Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods 270(2):211-226
34. Andre F, Schartz NE, Movassagh M et al (2002) Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360:295-305
35. Young D, Roman E, Moreno C et al (1993) Molecular chaperones and the immune response. Philos Trans R Soc Lond B Biol Sci 339:363-367
36. Multhoff G, Mizzen L, Winchester CC et al (1999) Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol 27:1627-1636
37. Goldman B (2002) Cancer vaccines: finding the best way to train the immune system. J Natl Cancer Inst 94:1523-1526
38. Udono H, Srivastava PK (1994) Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70. J Immunol 152:5398-5403
39. Tille JC, Pepper MS (2002) Mesenchymal cells potentiate vascular endothelial growth factor-induced angiogenesis in vitro. Exp Cell Res 280:179-191
40. Yu J, Ustach C, Kim HR (2003) Platelet-derived growth factor signaling and human cancer. J Biochem Mol Biol 36:49-59
41. Gastpar R, Gehrmann M, Bausero MA et al (2005) Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res 65:5238-5247
42. Nakamizo A, Marini F, Amano T et al (2005) Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65:3307-3318
43. Karnoub AE, Dash AB, Vo AP et al (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449:557-563
44. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860-867
45. Liotta LA, Kohn EC (2001) The microenvironment of the tumour-host interface. Nature 411:375-379
46. Kang SG, Jeun SS, Lim JY et al (2005) Cytotoxicity of rat marrow stromal cells against malignant glioma cells. Childs Nerv Syst 21:528-538
47. Cha CH, Saif MW, Yamane BH et al (2010) Hepatocellular carcinoma: current management. Curr Probl Surg 47:10-67
48. Hamada H, Kobune M, Nakamura K et al (2005) Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci 96:149-156