메뉴 건너뛰기




Volumn 306, Issue 1, 2014, Pages

A critical view of the use of genetic tools to unveil neural circuits: The case of leptin action in reproduction

Author keywords

Cre loxP; Leptin; Metabolism; Reproduction; Virus vector

Indexed keywords

CRE RECOMBINASE; LEPTIN; LEPTIN RECEPTOR; RECOMBINASE; VIRUS VECTOR;

EID: 84891552525     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00444.2013     Document Type: Review
Times cited : (9)

References (137)
  • 1
    • 17744375347 scopus 로고    scopus 로고
    • Regulation of neuronal and glial proteins by leptin: Implications for brain development
    • Ahima RS, Bjorbaek C, Osei S, Flier JS. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140: 2755-2762, 1999.
    • (1999) Endocrinology , vol.140 , pp. 2755-2762
    • Ahima, R.S.1    Bjorbaek, C.2    Osei, S.3    Flier, J.S.4
  • 9
    • 0021867688 scopus 로고
    • Ventral premammillary nuclei mediate pheromonal-induced LH release stimuli in the rat
    • Beltramino C, Taleisnik S. Ventral premammillary nuclei mediate pheromonal-induced LH release stimuli in the rat. Neuroendocrinology 41: 119-124, 1985.
    • (1985) Neuroendocrinology , vol.41 , pp. 119-124
    • Beltramino, C.1    Taleisnik, S.2
  • 11
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272: 32686-32695, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    da Silva, B.3    Flier, J.S.4
  • 12
    • 4444255838 scopus 로고    scopus 로고
    • The role of leptin in regulating neuroendocrine function in humans
    • Bluher S, Mantzoros CS. The role of leptin in regulating neuroendocrine function in humans. J Nutr 134: 2469S-2474S, 2004.
    • (2004) J Nutr , vol.134
    • Bluher, S.1    Mantzoros, C.S.2
  • 13
    • 27744573473 scopus 로고    scopus 로고
    • Feedback loops link odor and pheromone signaling with reproduction
    • Boehm U, Zou Z, Buck LB. Feedback loops link odor and pheromone signaling with reproduction. Cell 123: 683-695, 2005.
    • (2005) Cell , vol.123 , pp. 683-695
    • Boehm, U.1    Zou, Z.2    Buck, L.B.3
  • 14
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304: 108-110, 2004.
    • (2004) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 15
    • 0025213598 scopus 로고
    • Effect of food deprivation on the pulsatile LH release in the cycling and ovariectomized female rat
    • Cagampang FR, Maeda K, Yokoyama A, Ota K. Effect of food deprivation on the pulsatile LH release in the cycling and ovariectomized female rat. Horm Metab Res 22: 269-272, 1990.
    • (1990) Horm Metab Res , vol.22 , pp. 269-272
    • Cagampang, F.R.1    Maeda, K.2    Yokoyama, A.3    Ota, K.4
  • 16
    • 0025884362 scopus 로고
    • Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta)
    • Cameron JL, Nosbisch C. Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta). Endocrinology 128: 1532-1540, 1991.
    • (1991) Endocrinology , vol.128 , pp. 1532-1540
    • Cameron, J.L.1    Nosbisch, C.2
  • 18
    • 0028133318 scopus 로고
    • Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris-leucoagglutinin study in the rat
    • Canteras NS, Simerly RB, Swanson LW. Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J Comp Neurol 348: 41-79, 1994.
    • (1994) J Comp Neurol , vol.348 , pp. 41-79
    • Canteras, N.S.1    Simerly, R.B.2    Swanson, L.W.3
  • 19
  • 20
    • 33646929507 scopus 로고    scopus 로고
    • Female odors stimulate CART neurons in the ventral premammillary nucleus of male rats
    • Cavalcante JC, Bittencourt JC, Elias CF. Female odors stimulate CART neurons in the ventral premammillary nucleus of male rats. Physiol Behav 88: 160-166, 2006.
    • (2006) Physiol Behav , vol.88 , pp. 160-166
    • Cavalcante, J.C.1    Bittencourt, J.C.2    Elias, C.F.3
  • 21
    • 0023805013 scopus 로고
    • Neurochemical organization of the hypothalamic projection to the spinal cord in the rat
    • Cechetto DF, Saper CB. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J Comp Neurol 272: 579-604, 1988.
    • (1988) J Comp Neurol , vol.272 , pp. 579-604
    • Cechetto, D.F.1    Saper, C.B.2
  • 22
    • 21844471790 scopus 로고    scopus 로고
    • Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    • Chan JL, Mantzoros CS. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet 366: 74-85, 2005.
    • (2005) Lancet , vol.366 , pp. 74-85
    • Chan, J.L.1    Mantzoros, C.S.2
  • 23
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12: 318-320, 1996.
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 26
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [see comments]
    • Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [see comments]. Science 271: 994-996, 1996.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua Jr., S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.M.5    Tartaglia, L.6    Leibel, R.L.7
  • 29
    • 0020045888 scopus 로고
    • Diabetes-obesity syndromes in mice
    • Coleman DL. Diabetes-obesity syndromes in mice. Diabetes 31: 1-6, 1982.
    • (1982) Diabetes , vol.31 , pp. 1-6
    • Coleman, D.L.1
  • 30
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetesobesity syndromes in mice
    • Coleman DL. Obese and diabetes: two mutant genes causing diabetesobesity syndromes in mice. Diabetologia 14: 141-148, 1978.
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 31
    • 62649100136 scopus 로고    scopus 로고
    • Kisspeptins and GnRH neuronal signalling
    • Colledge WH. Kisspeptins and GnRH neuronal signalling. Trends Endocrinol Metab 20: 115-121, 2009.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 115-121
    • Colledge, W.H.1
  • 32
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8: 571-578, 2005.
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 39
    • 0032919990 scopus 로고    scopus 로고
    • Leptin's actions on the reproductive axis: Perspectives and mechanisms
    • Cunningham MJ, Clifton DK, Steiner RA. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 60: 216-222, 1999.
    • (1999) Biol Reprod , vol.60 , pp. 216-222
    • Cunningham, M.J.1    Clifton, D.K.2    Steiner, R.A.3
  • 42
    • 0141814637 scopus 로고    scopus 로고
    • Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    • de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100: 10972-10976, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10972-10976
    • de Roux, N.1    Genin, E.2    Carel, J.C.3    Matsuda, F.4    Chaussain, J.L.5    Milgrom, E.6
  • 48
    • 84873049395 scopus 로고    scopus 로고
    • The ventral premammillary nucleus links metabolic cues and reproduction
    • Donato J Jr, Elias CF. The ventral premammillary nucleus links metabolic cues and reproduction. Front Endocrinol 2: 57, 2011.
    • (2011) Front Endocrinol , vol.2 , pp. 57
    • Donato Jr., J.1    Elias, C.F.2
  • 49
    • 78049488476 scopus 로고    scopus 로고
    • Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
    • Donato J Jr, Frazao R, Fukuda M, Vianna CR, Elias CF. Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology 151: 5415-5427, 2010.
    • (2010) Endocrinology , vol.151 , pp. 5415-5427
    • Donato Jr., J.1    Frazao, R.2    Fukuda, M.3    Vianna, C.R.4    Elias, C.F.5
  • 50
    • 84876452980 scopus 로고    scopus 로고
    • Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrusestrus transition
    • Donato J Jr, Lee C, Ratra DV, Franci CR, Canteras NS, Elias CF. Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrusestrus transition. Neuroscience 241: 67-79, 2013.
    • (2013) Neuroscience , vol.241 , pp. 67-79
    • Donato Jr., J.1    Lee, C.2    Ratra, D.V.3    Franci, C.R.4    Canteras, N.S.5    Elias, C.F.6
  • 51
    • 2642659482 scopus 로고
    • Physiological differences in uteri of obese stock mice
    • Drasher ML, Dicke MW, Lane PW. Physiological differences in uteri of obese stock mice. J Hered 46: 209-212, 1955.
    • (1955) J Hered , vol.46 , pp. 209-212
    • Drasher, M.L.1    Dicke, M.W.2    Lane, P.W.3
  • 52
    • 84855220278 scopus 로고    scopus 로고
    • Leptin action in pubertal development: Recent advances and unanswered questions
    • Elias CF. Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol Metab 23: 9-15, 2012.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 9-15
    • Elias, C.F.1
  • 53
    • 84873718098 scopus 로고    scopus 로고
    • Leptin signaling and circuits in puberty and fertility
    • Elias CF, Purohit D. Leptin signaling and circuits in puberty and fertility. Cell Molec Life Sci 70: 841-862, 2013.
    • (2013) Cell Molec Life Sci , vol.70 , pp. 841-862
    • Elias, C.F.1    Purohit, D.2
  • 54
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22: 221-232, 1999.
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 55
    • 0036020032 scopus 로고    scopus 로고
    • Leptin and the onset of puberty: Insights from rodent and human genetics
    • Farooqi IS. Leptin and the onset of puberty: insights from rodent and human genetics. Semin Reprod Med 20: 139-144, 2002.
    • (2002) Semin Reprod Med , vol.20 , pp. 139-144
    • Farooqi, I.S.1
  • 56
    • 33845567553 scopus 로고    scopus 로고
    • Genetics of obesity in humans
    • Farooqi IS, O'Rahilly S. Genetics of obesity in humans. Endocr Rev 27: 710-718, 2006.
    • (2006) Endocr Rev , vol.27 , pp. 710-718
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 60
    • 0032065645 scopus 로고    scopus 로고
    • Clinical review 94: What's in a name? In search of leptin's physiologic role
    • Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 83: 1407-1413, 1998.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1407-1413
    • Flier, J.S.1
  • 61
    • 0022071342 scopus 로고
    • Fatness, menarche, and female fertility
    • Frisch RE. Fatness, menarche, and female fertility. Perspect Biol Med 28: 611-633, 1985.
    • (1985) Perspect Biol Med , vol.28 , pp. 611-633
    • Frisch, R.E.1
  • 62
    • 0028390005 scopus 로고
    • The right weight: Body fat, menarche and fertility
    • Frisch RE. The right weight: body fat, menarche and fertility. Proc Nutr Soc 53: 113-129, 1994.
    • (1994) Proc Nutr Soc , vol.53 , pp. 113-129
    • Frisch, R.E.1
  • 63
  • 64
    • 0032586279 scopus 로고    scopus 로고
    • Leptin(116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats
    • Gonzalez LC, Pinilla L, Tena-Sempere M, Aguilar E. Leptin(116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats. Neuroendocrinology 70: 213-220, 1999.
    • (1999) Neuroendocrinology , vol.70 , pp. 213-220
    • Gonzalez, L.C.1    Pinilla, L.2    Tena-Sempere, M.3    Aguilar, E.4
  • 65
    • 84875718677 scopus 로고    scopus 로고
    • Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours
    • Guo M, Huang TY, Garza JC, Chua SC, Lu XY. Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol 16: 857-867, 2013.
    • (2013) Int J Neuropsychopharmacol , vol.16 , pp. 857-867
    • Guo, M.1    Huang, T.Y.2    Garza, J.C.3    Chua, S.C.4    Lu, X.Y.5
  • 66
    • 31044439034 scopus 로고    scopus 로고
    • Leptin in pregnancy: An update
    • Henson MC, Castracane VD. Leptin in pregnancy: an update. Biol Reprod 74: 218-229, 2006.
    • (2006) Biol Reprod , vol.74 , pp. 218-229
    • Henson, M.C.1    Castracane, V.D.2
  • 69
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 41: 317-318, 1950.
    • (1950) J Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 71
    • 49549089117 scopus 로고    scopus 로고
    • Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): Effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats
    • Kalamatianos T, Grimshaw SE, Poorun R, Hahn JD, Coen CW. Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 20: 1089-1097, 2008.
    • (2008) J Neuroendocrinol , vol.20 , pp. 1089-1097
    • Kalamatianos, T.1    Grimshaw, S.E.2    Poorun, R.3    Hahn, J.D.4    Coen, C.W.5
  • 72
    • 75449148131 scopus 로고
    • Body weight and food intake as initiating factors for puberty in the rat
    • Kennedy GC, Mitra J. Body weight and food intake as initiating factors for puberty in the rat. J Physiol 166: 408-418, 1963.
    • (1963) J Physiol , vol.166 , pp. 408-418
    • Kennedy, G.C.1    Mitra, J.2
  • 73
    • 0035145908 scopus 로고    scopus 로고
    • Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene
    • Kowalski TJ, Liu SM, Leibel RL, Chua SC Jr. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 50: 425-435, 2001.
    • (2001) Diabetes , vol.50 , pp. 425-435
    • Kowalski, T.J.1    Liu, S.M.2    Leibel, R.L.3    Chua Jr., S.C.4
  • 74
    • 0010664147 scopus 로고
    • The pituitary-gonad response of genetically obese mice in parabiosis with thin and obese siblings
    • Lane PW. The pituitary-gonad response of genetically obese mice in parabiosis with thin and obese siblings. Endocrinology 65: 863-868, 1959.
    • (1959) Endocrinology , vol.65 , pp. 863-868
    • Lane, P.W.1
  • 75
    • 0002146070 scopus 로고
    • Fertile obese male mice. Relative sterility in obese males corrected by dietary restrictions
    • Lane PW, Dickie MM. Fertile obese male mice. Relative sterility in obese males corrected by dietary restrictions. J Hered 45: 56-58, 1954.
    • (1954) J Hered , vol.45 , pp. 56-58
    • Lane, P.W.1    Dickie, M.M.2
  • 77
    • 0034007139 scopus 로고    scopus 로고
    • Cocaine and amphetamine-regulated-transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro
    • Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Bourguignon JP. Cocaine and amphetamine-regulated-transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro. J Neuroendocrinol 12: 383-385, 2000.
    • (2000) J Neuroendocrinol , vol.12 , pp. 383-385
    • Lebrethon, M.C.1    Vandersmissen, E.2    Gerard, A.3    Parent, A.S.4    Bourguignon, J.P.5
  • 78
    • 0034455630 scopus 로고    scopus 로고
    • In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms
    • Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Junien JL, Bourguignon JP. In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 141: 1464-1469, 2000.
    • (2000) Endocrinology , vol.141 , pp. 1464-1469
    • Lebrethon, M.C.1    Vandersmissen, E.2    Gerard, A.3    Parent, A.S.4    Junien, J.L.5    Bourguignon, J.P.6
  • 79
    • 84860652458 scopus 로고    scopus 로고
    • Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance
    • Leshan RL, Greenwald-Yarnell M, Patterson CM, Gonzalez IE, Myers MG. Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med 18: 820-823, 2012.
    • (2012) Nat Med , vol.18 , pp. 820-823
    • Leshan, R.L.1    Greenwald-Yarnell, M.2    Patterson, C.M.3    Gonzalez, I.E.4    Myers, M.G.5
  • 80
    • 63849216885 scopus 로고    scopus 로고
    • Direct innervation of GnRH neurons by metabolic-and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus
    • Leshan RL, Louis GW, Jo YH, Rhodes CJ, Munzberg H, Myers MG Jr. Direct innervation of GnRH neurons by metabolic-and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci 29: 3138-3147, 2009.
    • (2009) J Neurosci , vol.29 , pp. 3138-3147
    • Leshan, R.L.1    Louis, G.W.2    Jo, Y.H.3    Rhodes, C.J.4    Munzberg, H.5    Myers Jr., M.G.6
  • 84
    • 34548761421 scopus 로고    scopus 로고
    • The role of leptin in the regulation of neuroendocrine function and CNS development
    • Louis GW, Myers MG Jr. The role of leptin in the regulation of neuroendocrine function and CNS development. Rev Endocr Metab Disord 8: 85-94, 2007.
    • (2007) Rev Endocr Metab Disord , vol.8 , pp. 85-94
    • Louis, G.W.1    Myers Jr., M.G.2
  • 85
    • 34748840772 scopus 로고    scopus 로고
    • Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: Analyses using mouse models and a cell line
    • Luque RM, Kineman RD, Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148: 4601-4611, 2007.
    • (2007) Endocrinology , vol.148 , pp. 4601-4611
    • Luque, R.M.1    Kineman, R.D.2    Tena-Sempere, M.3
  • 86
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310: 683-685, 2005.
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 88
    • 0024843726 scopus 로고
    • Effects of prolonged exercise on puberty and luteinizing hormone secretion in female rats
    • Manning JM, Bronson FH. Effects of prolonged exercise on puberty and luteinizing hormone secretion in female rats. Am J Physiol Regul Integr Comp Physiol 257: R1359-R1364, 1989.
    • (1989) Am J Physiol Regul Integr Comp Physiol , vol.257
    • Manning, J.M.1    Bronson, F.H.2
  • 89
    • 79960758876 scopus 로고    scopus 로고
    • Female reproductive maturation in the absence of kisspeptin/GPR54 signaling
    • Mayer C, Boehm U. Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nat Neurosci 14: 704-710, 2011.
    • (2011) Nat Neurosci , vol.14 , pp. 704-710
    • Mayer, C.1    Boehm, U.2
  • 90
    • 67649908458 scopus 로고    scopus 로고
    • A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient
    • Mazen I, El-Gammal M, Abdel-Hamid M, Amr K. A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient. Mol Genet Metab 97: 305-308, 2009.
    • (2009) Mol Genet Metab , vol.97 , pp. 305-308
    • Mazen, I.1    El-Gammal, M.2    Abdel-Hamid, M.3    Amr, K.4
  • 91
    • 79952631516 scopus 로고    scopus 로고
    • Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early-onset obesity
    • Mazen I, El-Gammal M, Abdel-Hamid M, Farooqi IS, Amr K. Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early-onset obesity. Mol Genet Metab 102: 461-464, 2011.
    • (2011) Mol Genet Metab , vol.102 , pp. 461-464
    • Mazen, I.1    El-Gammal, M.2    Abdel-Hamid, M.3    Farooqi, I.S.4    Amr, K.5
  • 93
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination
    • Meyers EN, Lewandoski M, Martin GR. An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination. Nat Genet 18: 136-141, 1998.
    • (1998) Nat Genet , vol.18 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 95
    • 33644665508 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
    • Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab 289: E1051-E1057, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Morrison, C.D.1    Morton, G.J.2    Niswender, K.D.3    Gelling, R.W.4    Schwartz, M.W.5
  • 97
    • 0031051499 scopus 로고    scopus 로고
    • Leptin treatment rescues the sterility of genetically obese ob/ob males
    • Mounzih K, Lu R, Chehab FF. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 138: 1190-1193, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1190-1193
    • Mounzih, K.1    Lu, R.2    Chehab, F.F.3
  • 98
    • 2342444310 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Myers MG Jr. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 59: 287-304, 2004.
    • (2004) Recent Prog Horm Res , vol.59 , pp. 287-304
    • Myers Jr., M.G.1
  • 99
    • 0031813699 scopus 로고    scopus 로고
    • Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting
    • Nagatani S, Guthikonda P, Thompson RC, Tsukamura H, Maeda KI, Foster DL. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 67: 370-376, 1998.
    • (1998) Neuroendocrinology , vol.67 , pp. 370-376
    • Nagatani, S.1    Guthikonda, P.2    Thompson, R.C.3    Tsukamura, H.4    Maeda, K.I.5    Foster, D.L.6
  • 100
    • 4644289298 scopus 로고    scopus 로고
    • Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    • Navarro VM, Castellano JM, Fernandez-Fernandez R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145: 4565-4574, 2004.
    • (2004) Endocrinology , vol.145 , pp. 4565-4574
    • Navarro, V.M.1    Castellano, J.M.2    Fernandez-Fernandez, R.3    Barreiro, M.L.4    Roa, J.5    Sanchez-Criado, J.E.6    Aguilar, E.7    Dieguez, C.8    Pinilla, L.9    Tena-Sempere, M.10
  • 102
    • 0034714039 scopus 로고    scopus 로고
    • Leptin effects on pulsatile gonadotropin-releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y
    • Parent AS, Lebrethon MC, Gerard A, Vandersmissen E, Bourguignon JP. Leptin effects on pulsatile gonadotropin-releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y. Regul Pept 92: 17-24, 2000.
    • (2000) Regul Pept , vol.92 , pp. 17-24
    • Parent, A.S.1    Lebrethon, M.C.2    Gerard, A.3    Vandersmissen, E.4    Bourguignon, J.P.5
  • 103
    • 0026095990 scopus 로고
    • Restoration of pulsatile luteinizing hormone secretion after fasting in rhesus monkeys (Macaca mulatta): Dependence on size of the refeed meal
    • Parfitt DB, Church KR, Cameron JL. Restoration of pulsatile luteinizing hormone secretion after fasting in rhesus monkeys (Macaca mulatta): dependence on size of the refeed meal. Endocrinology 129: 749-756, 1991.
    • (1991) Endocrinology , vol.129 , pp. 749-756
    • Parfitt, D.B.1    Church, K.R.2    Cameron, J.L.3
  • 105
    • 84864067222 scopus 로고    scopus 로고
    • Kisspeptins and reproduction: Physiological roles and regulatory mechanisms
    • Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev 92: 1235-1316, 2012.
    • (2012) Physiol Rev , vol.92 , pp. 1235-1316
    • Pinilla, L.1    Aguilar, E.2    Dieguez, C.3    Millar, R.P.4    Tena-Sempere, M.5
  • 108
    • 1942424812 scopus 로고    scopus 로고
    • Hypothalamic cocaine-and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats
    • Rondini TA, Baddini SP, Sousa LF, Bittencourt JC, Elias CF. Hypothalamic cocaine-and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats. Neuroscience 125: 735-748, 2004.
    • (2004) Neuroscience , vol.125 , pp. 735-748
    • Rondini, T.A.1    Baddini, S.P.2    Sousa, L.F.3    Bittencourt, J.C.4    Elias, C.F.5
  • 109
    • 0021070895 scopus 로고
    • Afferent connections of the median preoptic nucleus in the rat: Anatomical evidence for a cardiovascular integrative mechanism in the anteroventral third ventricular (AV3V) region
    • Saper CB, Levisohn D. Afferent connections of the median preoptic nucleus in the rat: anatomical evidence for a cardiovascular integrative mechanism in the anteroventral third ventricular (AV3V) region. Brain Res 288: 21-31, 1983.
    • (1983) Brain Res , vol.288 , pp. 21-31
    • Saper, C.B.1    Levisohn, D.2
  • 110
    • 0020511166 scopus 로고
    • The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat
    • Sawchenko PE, Swanson LW. The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J Comp Neurol 218: 121-144, 1983.
    • (1983) J Comp Neurol , vol.218 , pp. 121-144
    • Sawchenko, P.E.1    Swanson, L.W.2
  • 113
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest 121: 2413-2421, 2011.
    • (2011) J Clin Invest , vol.121 , pp. 2413-2421
    • Scott, M.M.1    Williams, K.W.2    Rossi, J.3    Lee, C.E.4    Elmquist, J.K.5
  • 116
    • 0023894010 scopus 로고
    • Projections of the medial preoptic nucleus: A Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat
    • Simerly RB, Swanson LW. Projections of the medial preoptic nucleus: a Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat. J Comp Neurol 270: 209-242, 1988.
    • (1988) J Comp Neurol , vol.270 , pp. 209-242
    • Simerly, R.B.1    Swanson, L.W.2
  • 118
    • 0017164596 scopus 로고
    • Reproductive hormonal fFunction in the genetically obese (ob/ob) mouse
    • Swerdloff RS, Batt RA, Bray GA. Reproductive hormonal fFunction in the genetically obese (ob/ob) mouse. Endocrinology 98: 1359-1364, 1976.
    • (1976) Endocrinology , vol.98 , pp. 1359-1364
    • Swerdloff, R.S.1    Batt, R.A.2    Bray, G.A.3
  • 120
    • 0037169830 scopus 로고    scopus 로고
    • Leptin in male reproduction: The testis paradigm
    • Tena-Sempere M, Barreiro ML. Leptin in male reproduction: the testis paradigm. Mol Cell Endocrinol 188: 9-13, 2002.
    • (2002) Mol Cell Endocrinol , vol.188 , pp. 9-13
    • Tena-Sempere, M.1    Barreiro, M.L.2
  • 121
    • 84859415932 scopus 로고    scopus 로고
    • Body weight impact on puberty: Effects of high-calorie diet on puberty onset in female Rhesus monkeys
    • Terasawa E, Kurian JR, Keen KL, Shiel NA, Colman RJ, Capuano SV. Body weight impact on puberty: effects of high-calorie diet on puberty onset in female Rhesus monkeys. Endocrinology 153: 1696-1705, 2012.
    • (2012) Endocrinology , vol.153 , pp. 1696-1705
    • Terasawa, E.1    Kurian, J.R.2    Keen, K.L.3    Shiel, N.A.4    Colman, R.J.5    Capuano, S.V.6
  • 123
    • 80054742593 scopus 로고    scopus 로고
    • Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance
    • True C, Kirigiti MA, Kievit P, Grove KL, Smith MS. Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance. J Neuroendocrinol 23: 1099-1112, 2011.
    • (2011) J Neuroendocrinol , vol.23 , pp. 1099-1112
    • True, C.1    Kirigiti, M.A.2    Kievit, P.3    Grove, K.L.4    Smith, M.S.5
  • 125
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • Vong L, Ye C, Yang Z, Choi B, Chua S Jr, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71: 142-154, 2011.
    • (2011) Neuron , vol.71 , pp. 142-154
    • Vong, L.1    Ye, C.2    Yang, Z.3    Choi, B.4    Chua Jr., S.5    Lowell, B.B.6
  • 127
    • 0033575892 scopus 로고    scopus 로고
    • Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
    • Watanobe H, Suda T, Wikberg JE, Schioth HB. Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats. Biochem Biophys Res Commun 263: 162-165, 1999.
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 162-165
    • Watanobe, H.1    Suda, T.2    Wikberg, J.E.3    Schioth, H.B.4
  • 130
    • 79951990905 scopus 로고    scopus 로고
    • Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network
    • Williams KW, Scott MM, Elmquist JK. Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network. Eur J Pharmacol 660: 2-12, 2011.
    • (2011) Eur J Pharmacol , vol.660 , pp. 2-12
    • Williams, K.W.1    Scott, M.M.2    Elmquist, J.K.3
  • 131
    • 67649984220 scopus 로고    scopus 로고
    • Effect of intracerebroventricular infusion of leptin on the secretory activity of the GnRH/LH axis in fasted prepubertal lambs
    • Wójcik-Gladysz A, Wankowska M, Misztal T, Romanowicz K, Polkowska J. Effect of intracerebroventricular infusion of leptin on the secretory activity of the GnRH/LH axis in fasted prepubertal lambs. Anim Reprod Sci 114: 370-383, 2009.
    • (2009) Anim Reprod Sci , vol.114 , pp. 370-383
    • Wójcik-Gladysz, A.1    Wankowska, M.2    Misztal, T.3    Romanowicz, K.4    Polkowska, J.5
  • 132
    • 84857374972 scopus 로고    scopus 로고
    • Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptindeficient mice restores metabolic functions and fertility
    • Wu Q, Whiddon BB, Palmiter RD. Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptindeficient mice restores metabolic functions and fertility. Proc Natl Acad Sci USA 109: 3155-3160, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 3155-3160
    • Wu, Q.1    Whiddon, B.B.2    Palmiter, R.D.3
  • 133
    • 0033430169 scopus 로고    scopus 로고
    • Female-soiled bedding induced fos immunoreactivity in the ventral part of the premammillary nucleus (PMv) of the male mouse
    • Yokosuka M, Matsuoka M, Ohtani-Kaneko R, Iigo M, Hara M, Hirata K, Ichikawa M. Female-soiled bedding induced fos immunoreactivity in the ventral part of the premammillary nucleus (PMv) of the male mouse. Physiol Behav 68: 257-261, 1999.
    • (1999) Physiol Behav , vol.68 , pp. 257-261
    • Yokosuka, M.1    Matsuoka, M.2    Ohtani-Kaneko, R.3    Iigo, M.4    Hara, M.5    Hirata, K.6    Ichikawa, M.7
  • 134
    • 0031019763 scopus 로고    scopus 로고
    • Role of leptin in hypothalamic-pituitary function [published erratum appears in Proc Natl Acad Sci USA 1997 Sep 30;94(20):11108]
    • Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function [published erratum appears in Proc Natl Acad Sci USA 1997 Sep 30;94(20):11108]. Proc Natl Acad Sci USA 94: 1023-1028, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1023-1028
    • Yu, W.H.1    Kimura, M.2    Walczewska, A.3    Karanth, S.4    McCann, S.M.5
  • 136
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments]
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments]. Nature 372: 425-432, 1994.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 137
    • 0035312367 scopus 로고    scopus 로고
    • Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
    • Zhu Y, Romero MI, Ghosh P, Ye Z, Charnay P, Rushing EJ, Marth JD, Parada LF. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev 15: 859-876, 2001.
    • (2001) Genes Dev , vol.15 , pp. 859-876
    • Zhu, Y.1    Romero, M.I.2    Ghosh, P.3    Ye, Z.4    Charnay, P.5    Rushing, E.J.6    Marth, J.D.7    Parada, L.F.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.