메뉴 건너뛰기




Volumn 153, Issue 5, 2012, Pages 2408-2419

Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; GONADORELIN; LEPTIN; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; PROTEIN C FOS;

EID: 84860273331     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1822     Document Type: Article
Times cited : (89)

References (76)
  • 1
    • 4444228888 scopus 로고    scopus 로고
    • World Health Organization Fact sheet no. 311. Geneva: World Health Organization Media Centre
    • World Health Organization 2006 Obesity and overweight. In: Fact sheet no. 311. Geneva: World Health Organization Media Centre
    • (2006) Obesity and Overweight
  • 4
    • 73249150146 scopus 로고    scopus 로고
    • Leptin receptor modulationofadiposity and fertility
    • Israel D, Chua Jr S 2010 Leptin receptor modulationofadiposity and fertility. Trends Endocrinol Metab 21:10-16
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 10-16
    • Israel, D.1    Chua Jr., S.2
  • 5
    • 0020066674 scopus 로고
    • Investigation into the hypogonadism of the obese mouse (genotype ob/ob)
    • Batt RA, Everard DM, Gillies G, Wilkinson M, Wilson CA, Yeo TA 1982 Investigation into the hypogonadism of the obese mouse (ge notype ob/ob). J Reprod Fertil 64:363-371 (Pubitemid 12129828)
    • (1982) Journal of Reproduction and Fertility , vol.64 , Issue.2 , pp. 363-371
    • Batt, R.A.L.1    Everard, D.M.2    Gillies, G.3
  • 7
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls AM, Dickie MM, Snell GD 1950 Obese, a new mutation in the house mouse. J Hered 41:317-318
    • (1950) J Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 9
    • 0017164596 scopus 로고
    • Reproductive hormonal function in the genetically obese (ob/ob) mouse
    • Swerdloff RS, Batt RA, Bray GA 1976 Reproductive hormonal function in the genetically obese (ob/ob) mouse. Endocrinology 98: 1359-1364
    • (1976) Endocrinology , vol.98 , pp. 1359-1364
    • Swerdloff, R.S.1    Batt, R.A.2    Bray, G.A.3
  • 10
    • 0018742529 scopus 로고
    • A reproductive endocrine profile in the diabetes (db) mutant mouse
    • DOI 10.1095/biolreprod20.3.552
    • Johnson LM, Sidman RL 1979 A reproductive endocrine profile in the diabetes (db) mutant mouse. Biol Reprod 20:552-559 (Pubitemid 9156427)
    • (1979) Biology of Reproduction , vol.20 , Issue.3 , pp. 552-559
    • Johnson, L.M.1    Sidman, R.L.2
  • 11
    • 24944495425 scopus 로고    scopus 로고
    • Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake
    • DOI 10.1210/en.2005-0492
    • Trevaskis JL, Butler AA 2005 Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. Endocrinology 146:4257-4265 (Pubitemid 41324021)
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4257-4265
    • Trevaskis, J.L.1    Butler, A.A.2
  • 14
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • DOI 10.1038/509
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157 (Pubitemid 28248796)
    • (1998) Nature Genetics , vol.19 , Issue.2 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 15
    • 0036553037 scopus 로고    scopus 로고
    • The melanocortin receptors: Lessons from knockout models
    • Butler AA, Cone RD 2002 The melanocortin receptors: lessons from knockout models. Neuropeptides 36:77-84
    • (2002) Neuropeptides , vol.36 , pp. 77-84
    • Butler, A.A.1    Cone, R.D.2
  • 16
    • 0036123545 scopus 로고    scopus 로고
    • Melanocortins and reproduction
    • DOI 10.1016/S0165-0173(01)00159-X, PII S016501730100159X
    • Schiöth HB, Watanobe H 2002 Melanocortins and reproduction. Brain Res Brain Res Rev 38:340-350 (Pubitemid 34223442)
    • (2002) Brain Research Reviews , vol.38 , Issue.3 , pp. 340-350
    • Schioth, H.B.1    Watanobe, H.2
  • 17
    • 76749171604 scopus 로고    scopus 로고
    • Melanocortins mimic the effects of leptin to restore reproduc tive function in lean hypogonadotropic ewes
    • Backholer K, Bowden M, Gamber K, Bjørbaek C, Iqbal J, Clarke IJ 2010 Melanocortins mimic the effects of leptin to restore reproduc tive function in lean hypogonadotropic ewes. Neuroendocrinology 91:27-40
    • (2010) Neuroendocrinology , vol.91 , pp. 27-40
    • Backholer, K.1    Bowden, M.2    Gamber, K.3    Bjørbaek, C.4    Iqbal, J.5    Clarke, I.J.6
  • 18
    • 71949110404 scopus 로고    scopus 로고
    • Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe
    • Backholer K, Smith J, Clarke IJ 2009 Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. Endocrinology 150:5488-5497
    • (2009) Endocrinology , vol.150 , pp. 5488-5497
    • Backholer, K.1    Smith, J.2    Clarke, I.J.3
  • 19
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein
    • DOI 10.1126/science.278.5335.135
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138 (Pubitemid 27446294)
    • (1997) Science , vol.278 , Issue.5335 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.-K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 20
    • 0035953163 scopus 로고    scopus 로고
    • Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
    • Schioth HB, Kakizaki Y, Kohsaka A, Suda T, Watanobe H 2001 Agouti-related peptide prevents steroid-induced luteinizing hor mone and prolactin surges in female rats. Neuroreport 12:687-690 (Pubitemid 32222698)
    • (2001) NeuroReport , vol.12 , Issue.4 , pp. 687-690
    • Schioth, H.B.1    Kakizaki, Y.2    Kohsaka, A.3    Suda, T.4    Watanobe, H.5
  • 21
    • 12344274258 scopus 로고    scopus 로고
    • Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey
    • DOI 10.1210/en.2004-1093
    • Vulliémoz NR, Xiao E, Xia-Zhang L, Wardlaw SL, Ferin M 2005 Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey. Endocrinology 146:784-789 (Pubitemid 40129835)
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 784-789
    • Vulliemoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Wardlaw, S.L.4    Ferin, M.5
  • 22
    • 0027475201 scopus 로고
    • Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
    • DOI 10.1210/en.132.1.224
    • Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, Rivier JE, Sizonenko PC, Aubert ML 1993 Neuropeptide Yadministered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 132:224-234 (Pubitemid 23019506)
    • (1993) Endocrinology , vol.132 , Issue.1 , pp. 224-234
    • Catzeflis, C.1    Pierroz, D.D.2    Rohner-Jeanrenaud, F.3    Rivier, J.E.4    Sizonenko, P.C.5    Aubert, M.L.6
  • 23
    • 0030041430 scopus 로고    scopus 로고
    • Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats
    • Pierroz DD, Catzeflis C, Aebi AC, Rivier JE, Aubert ML 1996 Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. En docrinology 137:3-12
    • (1996) En Docrinology , vol.137 , pp. 3-12
    • Pierroz, D.D.1    Catzeflis, C.2    Aebi, A.C.3    Rivier, J.E.4    Aubert, M.L.5
  • 24
    • 15544364590 scopus 로고    scopus 로고
    • Maturation of the hypothalamic arcuate agouti-related protein system during postnatal development in the mouse
    • DOI 10.1016/j.devbrainres.2005.01.009
    • Nilsson I, Johansen JE, Schalling M, Hökfelt T, Fetissov SO 2005 Maturation of the hypothalamic arcuate agouti-related protein sys tem during postnatal development in the mouse. Brain Res Dev Brain Res 155:147-154 (Pubitemid 40404068)
    • (2005) Developmental Brain Research , vol.155 , Issue.2 , pp. 147-154
    • Nilsson, I.1    Johansen, J.E.2    Schalling, M.3    Hokfelt, T.4    Fetissov, S.O.5
  • 25
    • 0029153009 scopus 로고
    • Gonadal steroid hormone regulation of proopiomelanocortin gene expression in arcuate neurons that innervate the medial preoptic area of the rat
    • Cheung S, Hammer Jr RP 1995 Gonadal steroid hormone regulation of proopiomelanocortin gene expression in arcuate neurons that innervate the medial preoptic area of the rat. Neuroendocrinology 62:283-292
    • (1995) Neuroendocrinology , vol.62 , pp. 283-292
    • Cheung, S.1    Hammer Jr., R.P.2
  • 26
    • 0023891032 scopus 로고
    • Immunohistochemical evidence for synaptic connections between proopiomelanocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat
    • Leranth C, MacLusky NJ, Shanabrough M, Naftolin F 1988 Immunohistochemical evidence for synaptic connections between proopiomelanocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat. Brain Res 449:167-176
    • (1988) Brain Res , vol.449 , pp. 167-176
    • Leranth, C.1    MacLusky, N.J.2    Shanabrough, M.3    Naftolin, F.4
  • 27
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • DOI 10.1126/science.274.5293.1704
    • Erickson JC, Hollopeter G, Palmiter RD 1996 Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Sci ence 274:1704-1707 (Pubitemid 26414900)
    • (1996) Science , vol.274 , Issue.5293 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 30
    • 0345120956 scopus 로고    scopus 로고
    • The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats
    • DOI 10.1006/bbrc.1999.0547
    • Watanobe H, Schioth HB, Wikberg JE, Suda T 1999 The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats. Biochem Biophys Res Commun 257:860-864 (Pubitemid 29301532)
    • (1999) Biochemical and Biophysical Research Communications , vol.257 , Issue.3 , pp. 860-864
    • Watanobe, H.1    Schioth, H.B.2    Wikberg, J.E.S.3    Suda, T.4
  • 31
    • 33750042605 scopus 로고    scopus 로고
    • Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase
    • DOI 10.1016/j.peptides.2006.05.005, PII S0196978106002403
    • Chai B, Li JY, Zhang W, Newman E, Ammori J, Mulholland MW 2006 Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Peptides 27:2846-2857 (Pubitemid 44584391)
    • (2006) Peptides , vol.27 , Issue.11 , pp. 2846-2857
    • Chai, B.1    Li, J.-Y.2    Zhang, W.3    Newman, E.4    Ammori, J.5    Mulholland, M.W.6
  • 32
    • 0034868336 scopus 로고    scopus 로고
    • Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line
    • DOI 10.1159/000054686
    • Khong K, Kurtz SE, Sykes RL, Cone RD 2001 Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line. Neuroendocrinology 74:193-201 (Pubitemid 32786219)
    • (2001) Neuroendocrinology , vol.74 , Issue.3 , pp. 193-201
    • Khong, K.1    Kurtz, S.E.2    Sykes, R.L.3    Cone, R.D.4
  • 33
    • 0035145908 scopus 로고    scopus 로고
    • Transgenic complementation of leptin-receptor deficiency: I. Rescue of the obesity/diabetes phenotype of lepr-null mice expressing a lepr-b transgene
    • Kowalski TJ, Liu SM, Leibel RL, Chua Jr SC 2001 Transgenic com plementation of leptin-receptor deficiency. I. Rescue of the obesity/ diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 50:425-435 (Pubitemid 32127302)
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 425-435
    • Kowalski, T.J.1    Liu, S.-M.2    Leibel, R.L.3    Chua Jr., S.C.4
  • 35
    • 0033559431 scopus 로고    scopus 로고
    • GABA- and glutamate-activated channels in green fluorescent protein- tagged gonadotropin-releasing hormone neurons in transgenic mice
    • Spergel DJ, Krüth U, Hanley DF, Sprengel R, Seeburg PH 1999 GABA- and glutamate-activated channels in green fluorescent pro tein-tagged gonadotropin-releasing hormone neurons in transgenic mice. J Neurosci 19:2037-2050 (Pubitemid 29133382)
    • (1999) Journal of Neuroscience , vol.19 , Issue.6 , pp. 2037-2050
    • Spergel, D.J.1    Kruth, U.2    Hanley, D.F.3    Sprengel, R.4    Seeburg, P.H.5
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2[- ΔΔC(T)] method. Methods 25:402-408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 40
    • 0014384203 scopus 로고
    • Proposal for a classification of oocytes and follicles in the mouse ovary
    • Pedersen T, Peters H 1968 Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil 17:555-557
    • (1968) J Reprod Fertil , vol.17 , pp. 555-557
    • Pedersen, T.1    Peters, H.2
  • 41
    • 78049518304 scopus 로고    scopus 로고
    • Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition
    • Chun SK, Jo YH 2010 Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition. J Neurophysiol 104: 2321-2328
    • (2010) J Neurophysiol , vol.104 , pp. 2321-2328
    • Chun, S.K.1    Jo, Y.H.2
  • 42
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • DOI 10.1210/en.138.11.5063
    • Thornton JE, Cheung CC, Clifton DK, Steiner RA 1997 Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138:5063-5066 (Pubitemid 27460950)
    • (1997) Endocrinology , vol.138 , Issue.11 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 43
    • 0032915413 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
    • DOI 10.1210/en.140.2.814
    • Mizuno TM, Mobbs CV 1999 Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140:814-817 (Pubitemid 29058217)
    • (1999) Endocrinology , vol.140 , Issue.2 , pp. 814-817
    • Mizuno, T.M.1    Mobbs, C.V.2
  • 44
    • 0027319108 scopus 로고
    • Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse
    • DOI 10.1210/en.132.5.1939
    • Wilding JP, Gilbey SG, Bailey CJ, Batt RA, Williams G, Ghatei MA, Bloom SR 1993 Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothala mus of the obese (ob/ob) mouse. Endocrinology 132:1939-1944 (Pubitemid 23133238)
    • (1993) Endocrinology , vol.132 , Issue.5 , pp. 1939-1944
    • Wilding, J.P.H.1    Gilbey, S.G.2    Bailey, C.J.3    Batt, R.A.L.4    Williams, G.5    Ghatei, M.A.6    Bloom, S.R.7
  • 45
    • 0025917542 scopus 로고
    • Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland
    • Chua Jr SC, Leibel RL, Hirsch J 1991 Food deprivation and age modulate neuropeptide gene expression in the murine hypothala mus and adrenal gland. Brain Res Mol Brain Res 9:95-101 (Pubitemid 20379049)
    • (1991) Molecular Brain Research , vol.9 , Issue.1-2 , pp. 95-101
    • Chua Jr., S.C.1    Leibel, R.L.2    Hirsch, J.3
  • 46
    • 0014004384 scopus 로고
    • Diabetes, a new mu tation in the mouse
    • Hummel KP, Dickie MM, Coleman DL 1966 Diabetes, a new mu tation in the mouse. Science 153:1127-1128
    • (1966) Science , vol.153 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 47
    • 0141864370 scopus 로고    scopus 로고
    • Diabetes (db/db) mutation-induced ovarian involution: Progressive hypercytolipidemia
    • Garris DR, Garris BL 2003 Diabetes (db/db) mutation-induced ovarian involution: progressive hypercytolipidemia. Exp Biol Med (Maywood, NJ) 228:1040-1050 (Pubitemid 37222173)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.9 , pp. 1040-1050
    • Garris, D.R.1    Garris, B.L.2
  • 48
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obe sity
    • Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD 1998 A leptin missense mutation associated with hypogonadism and morbid obe sity. Nat Genet 18:213-215
    • (1998) Nat Genet , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 49
    • 0033303528 scopus 로고    scopus 로고
    • Detection of estrogen re ceptor α and β messenger ribonucleic acids in adult gonadotropinreleasing hormone neurons
    • Skynner MJ, Sim JA, Herbison AE 1999 Detection of estrogen re ceptor α and β messenger ribonucleic acids in adult gonadotropinreleasing hormone neurons. Endocrinology 140:5195-5201
    • (1999) Endocrinology , vol.140 , pp. 5195-5201
    • Skynner, M.J.1    Sim, J.A.2    Herbison, A.E.3
  • 50
    • 0034754656 scopus 로고    scopus 로고
    • A) receptor subunit mRNA expression in postnatal gonadotropin-releasing hormone (GnRH) neurons of the male mouse with single cell RT-PCR
    • DOI 10.1159/000054697
    • Pape JR, Skynner MJ, Sim JA, Herbison AE 2001 Profiling γ-aminobutyric acid [GABA(A)] receptor subunit mRNA expression in postnatal gonadotropin-releasing hormone (Gn RH) neurons of the male mouse with single cell RT-PCR. Neuroendocrinology 74:300-308 (Pubitemid 33033398)
    • (2001) Neuroendocrinology , vol.74 , Issue.5 , pp. 300-308
    • Pape, J.-R.1    Skynner, M.J.2    Sim, J.A.3    Herbison, A.E.4
  • 51
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • DOI 10.1038/ng0396-318
    • Chehab FF, Lim ME, Lu R 1996 Correction of the sterility defect in homozygous obese female mice by treatment with the human re combinant leptin. Nat Genet 12:318-320 (Pubitemid 26080094)
    • (1996) Nature Genetics , vol.12 , Issue.3 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 52
    • 14544272858 scopus 로고    scopus 로고
    • Monogenic obesity in humans
    • DOI 10.1146/annurev.med.56.062904.144924
    • Farooqi IS, O'Rahilly S 2005 Monogenic obesity in humans. Annu Rev Med 56:443-458 (Pubitemid 40299792)
    • (2005) Annual Review of Medicine , vol.56 , pp. 443-458
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 54
    • 1442349754 scopus 로고    scopus 로고
    • Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice
    • Chua Jr SC, Liu SM, Li Q, Sun A, De Nino WF, Heymsfield SB, Guo XE 2004 Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/dia betes and fertility/lactation in lepr-db/db mice. Am J Physiol Endo crinol Metab 286:E384-E392 (Pubitemid 38292688)
    • (2004) American Journal of Physiology - Endocrinology and Metabolism , vol.286 , Issue.3-49
    • Chua Jr., S.C.1    Liu, S.M.2    Li, Q.3    Sun, A.4    DeNino, W.F.5    Heymsfield, S.B.6    Guo, X.E.7
  • 56
    • 77956709758 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling
    • Chai B, Li JY, Zhang W, Wu X, Zhang C, Mulholland MW 2010 Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling. Peptides 31:1888-1893
    • (2010) Peptides , vol.31 , pp. 1888-1893
    • Chai, B.1    Li, J.Y.2    Zhang, W.3    Wu, X.4    Zhang, C.5    Mulholland, M.W.6
  • 57
    • 0010664147 scopus 로고
    • The pituitary-gonad response of genetically obese mice in parabiosis with thin and obese siblings
    • Lane PW 1959 The pituitary-gonad response of genetically obese mice in parabiosis with thin and obese siblings. Endocrinology 65: 863-868
    • (1959) Endocrinology , vol.65 , pp. 863-868
    • Lane, P.W.1
  • 58
    • 3142763087 scopus 로고    scopus 로고
    • Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice
    • DOI 10.1095/biolreprod.104.027292
    • Hamm ML, Bhat GK, Thompson WE, Mann DR 2004 Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice. Biol Reprod 71:66-72 (Pubitemid 38915310)
    • (2004) Biology of Reproduction , vol.71 , Issue.1 , pp. 66-72
    • Hamm, M.L.1    Bhat, G.K.2    Thompson, W.E.3    Mann, D.R.4
  • 59
    • 76949099996 scopus 로고    scopus 로고
    • Increased ovarian follicle atresia in obese Zucker rats is asso ciated with enhanced expression of the forkhead transcription factor FOXO1
    • Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens JJ, Ishihara O 2009 Increased ovarian follicle atresia in obese Zucker rats is asso ciated with enhanced expression of the forkhead transcription factor FOXO1. Med Mol Morphol 42:216-221
    • (2009) Med Mol Morphol , vol.42 , pp. 216-221
    • Kajihara, T.1    Uchino, S.2    Suzuki, M.3    Itakura, A.4    Brosens, J.J.5    Ishihara, O.6
  • 60
    • 0037146224 scopus 로고    scopus 로고
    • Leptin - A growth factor in normal and malignant breast cells and for normal mammary gland development
    • Hu X, Juneja SC, Maihle NJ, Cleary MP 2002 Leptin - a growth factor in normal and malignant breast cells and for normal mam mary gland development. J Natl Cancer Inst 94:1704-1711 (Pubitemid 35446839)
    • (2002) Journal of the National Cancer Institute , vol.94 , Issue.22 , pp. 1704-1711
    • Hu, X.1    Juneja, S.C.2    Maihle, N.J.3    Cleary, M.P.4
  • 62
    • 42549142931 scopus 로고    scopus 로고
    • Mammary development in the embryo and adult: A journey of morphogenesis and commitment
    • DOI 10.1242/dev.005439
    • Watson CJ, Khaled WT 2008 Mammary development in the embryo and adult: a journey of morphogenesis and commitment. Develop ment 135:995-1003 (Pubitemid 351578128)
    • (2008) Development , vol.135 , Issue.6 , pp. 995-1003
    • Watson, C.J.1    Khaled, W.T.2
  • 63
    • 0347416918 scopus 로고    scopus 로고
    • Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats
    • DOI 10.1159/000074886
    • Watanobe H, Yoneda M 2003 Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats. Neuroendocrinology 78:331-338 (Pubitemid 38040071)
    • (2003) Neuroendocrinology , vol.78 , Issue.6 , pp. 331-338
    • Watanobe, H.1    Yoneda, M.2
  • 64
    • 77953936777 scopus 로고    scopus 로고
    • Neuroanatomical evidence for a role of central melanocortin-4 receptors and oxytocin in the efferent control of the rodent clitoris and vagina
    • Gelez H, Poirier S, Facchinetti P, Allers KA, Wayman C, Alexandre L, Giuliano F 2010 Neuroanatomical evidence for a role of central melanocortin-4 receptors and oxytocin in the efferent control of the rodent clitoris and vagina. J Sex Med 7:2056-2067
    • (2010) J Sex Med , vol.7 , pp. 2056-2067
    • Gelez, H.1    Poirier, S.2    Facchinetti, P.3    Allers, K.A.4    Wayman, C.5    Alexandre, L.6    Giuliano, F.7
  • 66
    • 0033779983 scopus 로고    scopus 로고
    • Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Melanotan II
    • Wessells H, Levine N, Hadley ME, Dorr R, Hruby V 2000 Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res 12(Suppl 4):S74-S79
    • (2000) Int J Impot Res , vol.12 , Issue.SUPPL. 4
    • Wessells, H.1    Levine, N.2    Hadley, M.E.3    Dorr, R.4    Hruby, V.5
  • 67
    • 0032566826 scopus 로고    scopus 로고
    • Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats
    • DOI 10.1016/S0167-0115(98)00085-8, PII S0167011598000858
    • Marin-Bivens CL, Kalra SP, Olster DH 1998 Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increasesthe display of sexual behaviors in obese Zucker female rats. Regul Pept 75-76:327-334 (Pubitemid 28477544)
    • (1998) Regulatory Peptides , vol.75-76 , pp. 327-334
    • Marin-Bivens, C.L.1    Kalra, S.P.2    Olster, D.H.3
  • 68
  • 69
    • 0242468477 scopus 로고    scopus 로고
    • Origin of Neuropeptide Y-Containing Afferents to Gonadotropin-Releasing Hormone Neurons in Male Mice
    • DOI 10.1210/en.2003-0470
    • Turi GF, Liposits Z, Moenter SM, Fekete C, Hrabovszky E 2003 Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice. Endocrinology 144:4967-4974 (Pubitemid 37378411)
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4967-4974
    • Turi, G.F.1    Liposits, Z.2    Moenter, S.M.3    Fekete, C.4    Hrabovszky, E.5
  • 70
    • 10444280728 scopus 로고    scopus 로고
    • Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse
    • DOI 10.1016/j.bbrc.2004.11.084, PII S0006291X04026282
    • Irani BG, Xiang Z, Moore MC, Mandel RJ, Haskell-Luevano C 2005 Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse. Biochem Biophys Res Commun 326:638-644 (Pubitemid 39642772)
    • (2005) Biochemical and Biophysical Research Communications , vol.326 , Issue.3 , pp. 638-644
    • Irani, B.G.1    Xiang, Z.2    Moore, M.C.3    Mandel, R.J.4    Haskell-Luevano, C.5
  • 71
    • 0033775888 scopus 로고    scopus 로고
    • Gonadal steroids and energy homeostasis in the leptin era
    • Mystkowski P, Schwartz MW 2000 Gonadal steroids and energy homeostasis in the leptin era. Nutrition 16:937-946
    • (2000) Nutrition , vol.16 , pp. 937-946
    • Mystkowski, P.1    Schwartz, M.W.2
  • 73
    • 0015381515 scopus 로고
    • The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-Ks J and C57BL-6J strains
    • Hummel KP, Coleman DL, Lane PW 1972 The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-Ks J and C57BL-6J strains. Biochem Genet 7:1-13
    • (1972) Biochem Genet , vol.7 , pp. 1-13
    • Hummel, K.P.1    Coleman, D.L.2    Lane, P.W.3
  • 74
    • 0032931966 scopus 로고    scopus 로고
    • Effect of the genetic background on the reproduction of leptin-deficient obese mice
    • DOI 10.1210/en.140.2.732
    • Ewart-Toland A, Mounzih K, Qiu J, Chehab FF 1999 Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology 140:732-738 (Pubitemid 29058207)
    • (1999) Endocrinology , vol.140 , Issue.2 , pp. 732-738
    • Ewart-Toland, A.1    Mounzih, K.2    Qiu, J.3    Chehab, F.F.4
  • 75
    • 0034914282 scopus 로고    scopus 로고
    • Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes
    • DOI 10.1210/en.142.8.3421
    • Qiu J, Ogus S, Mounzih K, Ewart-Toland A, Chehab FF 2001 Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body tempera ture, and severe diabetes. Endocrinology 142:3421-3425 (Pubitemid 32681748)
    • (2001) Endocrinology , vol.142 , Issue.8 , pp. 3421-3425
    • Qiu, J.1    Ogus, S.2    Mounzih, K.3    Ewart-Toland, A.4    Chehab, F.F.5
  • 76
    • 0019037039 scopus 로고
    • A new mutation (db(3J)) at the diabetes locus in strain 129/J mice
    • Leiter EH, Coleman DL, Eisenstein AB, Strack I 1980 A new mu tation (db3J) at the diabetes locus in strain 129/J mice. I. Physio logical and histological characterization. Diabetologia 19:58-65 (Pubitemid 10063102)
    • (1980) Diabetologia , vol.19 , Issue.1 , pp. 58-65
    • Leiter, E.H.1    Coleman, D.L.2    Eisenstein, A.B.3    Strack, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.