Decreased leptin levels in normal weight women with hypothalamic amenorrhea: The effects of body composition and nutritional intake

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 7, 1998, Pages 2309-2312

  Miller, Karen K ^a   Parulekar, Manisha S ^a   Schoenfeld, Elizabeth ^a   Anderson, Ellen ^a   Hubbard, Jane ^a   Klibanski, Anne ^a   Grinspoon, Steven K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AMENORRHEA; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; FAT INTAKE; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; NUTRITIONAL DISORDER; NUTRITIONAL STATUS; PRIORITY JOURNAL;

ADULT; AMENORRHEA; BODY COMPOSITION; BODY WEIGHT; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYPOTHALAMIC DISEASES; LEPTIN; NUTRITIONAL STATUS; OBESITY; OVULATION; PROTEINS; REGRESSION ANALYSIS;

EID: 0031759898     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.7.2309     Document Type: Article

References (31)

1. Considine RV, Sinha MK, Heiman ML, et al. 1996 Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:292-295.
2. Halaas JL, Gajiwala KS, Maffei M, et al. 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
3. Maffei M, Halaas J, Ravussin E, et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nat Med. 1:1155-1161.
4. Stephens TW, Basinski M, Bristow PK, et al. 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-532.
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994 Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
6. Ahima RS, Prabakaran D, Mantzoros C, et al. 1996 Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
7. Grinspoon S, Gulick T, Askari H, et al. 1996 Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab. 81:3861-3863.
8. Laughlin G, Yen S. 1997 Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. J Clin Endocrinol Metab. 82:318-321.
9. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M. 1996 Radioimmunoassay of leptin in human plasma. Clin Chem. 42:942-946.
10. Jordan D, Flood JG, Laposata M, Lewandrowski KB. 1992 Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Normal reference laboratory values. N Engl J Med. 327:718-724.
11. Mazess RB, Barden HS, Bisek JP, Hanson J. 1990 Dual-energy x-ray absorpn'ometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr. 51:1106-1112.
12. Kriska A, Knowler W, LaPorte R, et al. 1990 Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians. Diabetes Care. 13:401-411.
13. Kriska A, Bennett P. 1992 An epidemiological perspective of the relationship between physical activity and NIDDM: from activity assessment to intervention. Diabetes Metab Rev. 8:355-372.
14. Laughlin G, Dominguez C, Yen S. 1998 Nutritional and endocrine-metabolic aberrations in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 83:25-32.
15. Kolaczynski JW, Nyce MR, Considine RV, et al. 1996 Acute and chronic effect of insulin on leptin production in humans. Diabetes. 45:699-701.
16. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. 1996 Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes. 45:695-698.
17. Segal KR, Landt M, Klein S. 1996 Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes. 45:988-991.
18. Bronson F. 1986 Food-restricted, pre-pubertal female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone. Endocrinology. 118:2483-2487.
19. Loucks AB, Heath EM, Law T, Verdun M, Watts JR. 1994 Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women. J Clin Endocrinol Metab. 78:910-915.
20. Boden G, Chen X, Mozzoli M, and Ryan I. 1996 Effects of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab. 81:3419-3423.
21. Grinspoon S, Askari H, Landt M, et al. 1997 Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women. Am J Clin Nutr. 66:1352-1356.
22. Kolaczynski J, Considine R, Ohannesian J, et al. 1996 Responses of leptin to short-term fasting and refeeding in humans. Diabetes. 45:1511-1515.
23. Racette S, Coppack S, Landt M, Klein S. 1997 Leptin production during moderate-intensity aerobic exercise. J Clin Endocrinol Metab. 82:2275-2277.
24. Hickey M, Considine R, Israel R, et al. 1996 Leptin is related to body fat content in male distance runners. Am J Physiol. 271:E938-E940.
25. Hickey M, Houmard J, Considine R, et al. 1997 Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Physiol. 272:E562-E566.
26. Kohrt W, Landt M, Birge S. 1996 Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women. J Clin Endocrinol Metab. 81:3980-3985.
27. Biller B, Federoff H, Koenig J, Klibanski A. 1990 Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea. J Clin Endocrinol Metab. 70:311-317.
28. Suh B, Liu J, Berga S, Quigley M, Laughlin G, Yen S. 1988 Hypercortisolism in patients with functional hypothalamic-amenorrhea. J Clin Endocrinol Metab. 66:733-739.
29. De Vos P, Saladin R, Auwerx J, Staels B. 1995 Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem. 270:15958-15961.
30. Hardie L, Trayhurn P, Abramovich D, Fowler P. 1997 Ciculating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endo. 47:101-106.
31. Barash I, Cheung C, Weigle D, et al. 1996 Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:3144-3147.