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Volumn 660, Issue 1, 2011, Pages 2-12

Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network

Author keywords

Diabetes; Insulin; Leptin; Obesity; Patch clamp; Serotonin

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; BETA INTERMEDIN; INSULIN; INSULIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN; NEUROPEPTIDE Y; PHOSPHATIDYLINOSITOL 3 KINASE; PROOPIOMELANOCORTIN; SEROTONIN; SEROTONIN 2C AGONIST; STEROIDOGENIC FACTOR 1;

EID: 79951990905     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.11.042     Document Type: Review
Times cited : (76)

References (177)
  • 1
    • 0031471301 scopus 로고    scopus 로고
    • Brain melanocortin receptors: From cloning to function
    • DOI 10.1016/S0196-9781(97)00078-8, PII S0196978197000788
    • Adan, R.A., Gispen, W.H., 1997. Brain melanocortin receptors: from cloning to function. Peptides 18, 1279-1287. (Pubitemid 28026902)
    • (1997) Peptides , vol.18 , Issue.8 , pp. 1279-1287
    • Adan, R.A.H.1    Gispen, W.H.2
  • 3
    • 0000828319 scopus 로고
    • Tumeur du corps pituitaire sans acromégalie et avec arrét de développement des organes génitaux
    • Babinski, J.F.F., 1900. Tumeur du corps pituitaire sans acromégalie et avec arrét de développement des organes génitaux. Rev. Neurol. 8, 531-533.
    • (1900) Rev. Neurol. , vol.8 , pp. 531-533
    • Babinski, J.F.F.1
  • 4
    • 0036219070 scopus 로고    scopus 로고
    • Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
    • Bahrenberg, G., Behrmann, I., Barthel, A., Hekerman, P., Heinrich, P.C., Joost, H.G., Becker, W., 2002. Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol. Endocrinol. 16, 859-872.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 859-872
    • Bahrenberg, G.1    Behrmann, I.2    Barthel, A.3    Hekerman, P.4    Heinrich, P.C.5    Joost, H.G.6    Becker, W.7
  • 5
    • 0029099078 scopus 로고
    • Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat
    • Baker, R.A., Herkenham, M., 1995. Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat. J. Comp. Neurol. 358, 518-530.
    • (1995) J. Comp. Neurol. , vol.358 , pp. 518-530
    • Baker, R.A.1    Herkenham, M.2
  • 8
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks, A.S., Davis, S.M., Bates, S.H., Myers Jr., M.G., 2000. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275, 14563-14572.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers Jr., M.G.4
  • 11
    • 0034611681 scopus 로고    scopus 로고
    • Genetics of body-weight regulation
    • Barsh, G.S., Farooqi, I.S., O'Rahilly, S., 2000. Genetics of body-weight regulation. Nature 404, 644-651. (Pubitemid 30205069)
    • (2000) Nature , vol.404 , Issue.6778 , pp. 644-651
    • Barsh, G.S.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 13
    • 42449086900 scopus 로고    scopus 로고
    • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
    • DOI 10.1210/en.2007-1200
    • Bingham, N.C., Anderson, K.K., Reuter, A.L., Stallings, N.R., Parker, K.L., 2008. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149, 2138-2148. (Pubitemid 351574486)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2138-2148
    • Bingham, N.C.1    Anderson, K.K.2    Reuter, A.L.3    Stallings, N.R.4    Parker, K.L.5
  • 14
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E., Flier, J.S., 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1, 619-625. (Pubitemid 128374698)
    • (1998) Molecular Cell , vol.1 , Issue.4 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 16
    • 56449115916 scopus 로고    scopus 로고
    • Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
    • Blouet, C., Ono, H., Schwartz, G.J., 2008. Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab. 8, 459-467.
    • (2008) Cell Metab , vol.8 , pp. 459-467
    • Blouet, C.1    Ono, H.2    Schwartz, G.J.3
  • 18
    • 0000833791 scopus 로고
    • Mechanism of the development of obesity in animals with hypothalamic lesions
    • Brobeck, J.R., 1946. Mechanism of the development of obesity in animals with hypothalamic lesions. Physiol. Rev. 26, 541-559.
    • (1946) Physiol. Rev. , vol.26 , pp. 541-559
    • Brobeck, J.R.1
  • 21
    • 0034981271 scopus 로고    scopus 로고
    • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
    • Butler, A.A., Marks, D.L., Fan, W., Kuhn, C.M., Bartolome, M., Cone, R.D., 2001. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat. Neurosci. 4, 605-611.
    • (2001) Nat. Neurosci. , vol.4 , pp. 605-611
    • Butler, A.A.1    Marks, D.L.2    Fan, W.3    Kuhn, C.M.4    Bartolome, M.5    Cone, R.D.6
  • 22
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., Burn, P., 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Sci. NY N. Y 269, 546-549.
    • (1995) Sci. NY N. , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 23
    • 1542616960 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
    • Carlson, C.J., White, M.F., Rondinone, C.M., 2004. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem. Biophys. Res. Commun. 316, 533-539.
    • (2004) Biochem. Biophys. Res. Commun. , vol.316 , pp. 533-539
    • Carlson, C.J.1    White, M.F.2    Rondinone, C.M.3
  • 26
    • 0026731363 scopus 로고
    • Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA
    • Chhajlani, V., Wikberg, J.E., 1992. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 309, 417-420.
    • (1992) FEBS Lett , vol.309 , pp. 417-420
    • Chhajlani, V.1    Wikberg, J.E.2
  • 29
    • 0027396787 scopus 로고
    • Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor
    • DOI 10.1016/0140-6736(93)90208-X
    • Clark, A.J., McLoughlin, L., Grossman, A., 1993. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet 341, 461-462. (Pubitemid 23054520)
    • (1993) Lancet , vol.341 , Issue.8843 , pp. 461-462
    • Clark, A.J.L.1    McLoughlin, L.2    Grossman, A.3
  • 30
    • 0020318667 scopus 로고
    • Characterization of the structural gene and putative 5'-regulatory sequences for human proopiomelanocortin
    • DOI 10.1038/297335a0
    • Cochet, M., Chang, A.C., Cohen, S.N., 1982. Characterization of the structural gene and putative 5′-regulatory sequences for human proopiomelanocortin. Nature 297, 335-339. (Pubitemid 12025059)
    • (1982) Nature , vol.297 , Issue.5864 , pp. 335-339
    • Cochet, M.1    Chang, A.C.Y.2    Cohen, S.N.3
  • 32
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman, D.L., 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294-298.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 33
    • 0014608866 scopus 로고
    • Effects of parabiosis of normal with genetically diabetic mice
    • Coleman, D.L., Hummel, K.P., 1969. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 217, 1298-1304.
    • (1969) Am. J. Physiol. , vol.217 , pp. 1298-1304
    • Coleman, D.L.1    Hummel, K.P.2
  • 37
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • Cota, D., Matter, E.K., Woods, S.C., Seeley, R.J., 2008. The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J. Neurosci. 28, 7202-7208.
    • (2008) J. Neurosci. , vol.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 38
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • DOI 10.1038/35078085
    • Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J., 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484. (Pubitemid 32494394)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6    Cone, R.D.7    Low, M.J.8
  • 40
    • 15444366416 scopus 로고    scopus 로고
    • Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    • Dunn, S.L., Bjornholm, M., Bates, S.H., Chen, Z., Seifert, M., Myers Jr., M.G., 2005. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol. Endocrinol. 19, 925-938.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 925-938
    • Dunn, S.L.1    Bjornholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers Jr., M.G.6
  • 41
    • 0029020475 scopus 로고
    • An immunocytochemical and morphometric study of the rat pancreatic islets
    • Elayat, A.A., el-Naggar, M.M., Tahir, M., 1995. An immunocytochemical and morphometric study of the rat pancreatic islets. J. Anat. 186 (Pt 3), 629-637.
    • (1995) J. Anat. , vol.186 , Issue.PART 3 , pp. 629-637
    • Elayat, A.A.1    El-Naggar, M.M.2    Tahir, M.3
  • 44
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • DOI 10.1016/S0896-6273(01)80035-0
    • Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B., Elmquist, J.K., 1999. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775-786. (Pubitemid 29411566)
    • (1999) Neuron , vol.23 , Issue.4 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6    Flier, J.S.7    Saper, C.B.8    Elmquist, J.K.9
  • 45
    • 0031906674 scopus 로고    scopus 로고
    • Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    • Elmquist, J.K., Ahima, R.S., Elias, C.F., Flier, J.S., Saper, C.B., 1998a. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl Acad. Sci. USA 95, 741-746.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 741-746
    • Elmquist, J.K.1    Ahima, R.S.2    Elias, C.F.3    Flier, J.S.4    Saper, C.B.5
  • 48
    • 0035930605 scopus 로고    scopus 로고
    • SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
    • Emanuelli, B., Peraldi, P., Filloux, C., Chavey, C., Freidinger, K., Hilton, D.J., Hotamisligil, G.S., Van Obberghen, E., 2001. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J. Biol. Chem. 276, 47944-47949.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47944-47949
    • Emanuelli, B.1    Peraldi, P.2    Filloux, C.3    Chavey, C.4    Freidinger, K.5    Hilton, D.J.6    Hotamisligil, G.S.7    Van Obberghen, E.8
  • 49
    • 0035120192 scopus 로고    scopus 로고
    • Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload
    • Emond, M., Ladenheim, E.E., Schwartz, G.J., Moran, T.H., 2001. Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload. Physiol. Behav. 72, 123-128.
    • (2001) Physiol. Behav. , vol.72 , pp. 123-128
    • Emond, M.1    Ladenheim, E.E.2    Schwartz, G.J.3    Moran, T.H.4
  • 50
    • 0000784915 scopus 로고
    • Über hypophysengangsgeschwulste und hirmcholesteatome
    • Erdheim, J., 1904. Über hypophysengangsgeschwulste und hirmcholesteatome. Sitzungsb Kais Akad Wissen Math Naturw Klin 113, 537.
    • (1904) Sitzungsb Kais Akad Wissen Math Naturw Klin , vol.113 , pp. 537
    • Erdheim, J.1
  • 51
    • 0034548763 scopus 로고    scopus 로고
    • Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
    • Eyckerman, S., Broekaert, D., Verhee, A., Vandekerckhove, J., Tavernier, J., 2000. Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett. 486, 33-37.
    • (2000) FEBS Lett. , vol.486 , pp. 33-37
    • Eyckerman, S.1    Broekaert, D.2    Verhee, A.3    Vandekerckhove, J.4    Tavernier, J.5
  • 52
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortlnergic neurons in feeding and the agouti obesity syndrome
    • DOI 10.1038/385165a0
    • Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J., Cone, R.D., 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168. (Pubitemid 27034218)
    • (1997) Nature , vol.385 , Issue.6612 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 53
    • 1842560331 scopus 로고    scopus 로고
    • Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
    • Fan, W., Ellacott, K.L., Halatchev, I.G., Takahashi, K., Yu, P., Cone, R.D., 2004. Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nat. Neurosci. 7, 335-336.
    • (2004) Nat. Neurosci. , vol.7 , pp. 335-336
    • Fan, W.1    Ellacott, K.L.2    Halatchev, I.G.3    Takahashi, K.4    Yu, P.5    Cone, R.D.6
  • 57
    • 0027277107 scopus 로고
    • Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor
    • Feener, E.P., Backer, J.M., King, G.L., Wilden, P.A., Sun, X.J., Kahn, C.R., White, M.F., 1993. Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J. Biol. Chem. 268, 11256-11264.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11256-11264
    • Feener, E.P.1    Backer, J.M.2    King, G.L.3    Wilden, P.A.4    Sun, X.J.5    Kahn, C.R.6    White, M.F.7
  • 58
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • Flegal, K.M., Carroll, M.D., Ogden, C.L., Curtin, L.R., 2010. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 303, 235-241.
    • (2010) JAMA , vol.303 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 59
    • 0000441640 scopus 로고
    • Ein fall von tumor der hypophysis cerebri ohne akromegalie
    • Fröhlich, A., 1901. Ein fall von tumor der hypophysis cerebri ohne akromegalie. Wien. klinische Rundsch. 15 (833-836), 906-908.
    • (1901) Wien. Klinische Rundsch. , vol.15 , Issue.833-836 , pp. 906-908
    • Fröhlich, A.1
  • 62
    • 70349337472 scopus 로고    scopus 로고
    • Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    • German, J., Kim, F., Schwartz, G.J., Havel, P.J., Rhodes, C.J., Schwartz, M.W., Morton, G.J., 2009. Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 150, 4502-4511.
    • (2009) Endocrinology , vol.150 , pp. 4502-4511
    • German, J.1    Kim, F.2    Schwartz, G.J.3    Havel, P.J.4    Rhodes, C.J.5    Schwartz, M.W.6    Morton, G.J.7
  • 63
    • 0034635374 scopus 로고    scopus 로고
    • Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
    • Goldstein, B.J., Bittner-Kowalczyk, A., White, M.F., Harbeck, M., 2000. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J. Biol. Chem. 275, 4283-4289.
    • (2000) J. Biol. Chem. , vol.275 , pp. 4283-4289
    • Goldstein, B.J.1    Bittner-Kowalczyk, A.2    White, M.F.3    Harbeck, M.4
  • 65
    • 0036142589 scopus 로고    scopus 로고
    • Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake
    • DOI 10.1210/en.143.1.239
    • Grill, H.J., Schwartz, M.W., Kaplan, J.M., Foxhall, J.S., Breininger, J., Baskin, D.G., 2002. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143, 239-246. (Pubitemid 34056425)
    • (2002) Endocrinology , vol.143 , Issue.1 , pp. 239-246
    • Grill, H.J.1    Schwartz, M.W.2    Kaplan, J.M.3    Foxhall, J.S.4    Breininger, J.5    Baskin, D.G.6
  • 66
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • Hahn, T.M., Breininger, J.F., Baskin, D.G., Schwartz, M.W., 1998. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1, 271-272.
    • (1998) Nat. Neurosci. , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 70
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • DOI 10.1038/272827a0
    • Havrankova, J., Roth, J., Brownstein, M., 1978a. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272, 827-829. (Pubitemid 8316991)
    • (1978) Nature , vol.272 , Issue.5656 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 72
    • 72649103549 scopus 로고    scopus 로고
    • Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    • Hayes, M.R., Skibicka, K.P., Leichner, T.M., Guarnieri, D.J., DiLeone, R.J., Bence, K.K., Grill, H.J., 2010. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab 11, 77-83
    • (2010) Cell Metab , vol.11 , pp. 77-83
    • Hayes, M.R.1    Skibicka, K.P.2    Leichner, T.M.3    Guarnieri, D.J.4    DiLeone, R.J.5    Bence, K.K.6    Grill, H.J.7
  • 75
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • Heldin, C.H., 1995. Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223.
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, C.H.1
  • 76
    • 84990756135 scopus 로고
    • Hypothalamic lesions and adiposity in the rat
    • Hetherington, A.W., Ranson, S.W., 1940. Hypothalamic lesions and adiposity in the rat. Anat. Rec. 78, 149-172.
    • (1940) Anat. Rec. , vol.78 , pp. 149-172
    • Hetherington, A.W.1    Ranson, S.W.2
  • 77
    • 31944445046 scopus 로고
    • Effect of early hypophysectomy on hypothalamic obesity
    • Hetherington, A.W., Ranson, S.W., 1942. Effect of early hypophysectomy on hypothalamic obesity. Endocrinology 31, 30-34.
    • (1942) Endocrinology , vol.31 , pp. 30-34
    • Hetherington, A.W.1    Ranson, S.W.2
  • 81
    • 34249785695 scopus 로고    scopus 로고
    • Leptin and the control of food intake: Neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin
    • DOI 10.1210/en.2006-1572
    • Huo, L., Maeng, L., Bjorbaek, C., Grill, H.J., 2007. Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology 148, 2189-2197. (Pubitemid 46997029)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2189-2197
    • Huo, L.1    Maeng, L.2    Bjorbaek, C.3    Grill, H.J.4
  • 82
    • 66049133685 scopus 로고    scopus 로고
    • Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
    • Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X.H., Bjorbaek, C., 2009. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab. 9, 537-547.
    • (2009) Cell Metab. , vol.9 , pp. 537-547
    • Huo, L.1    Gamber, K.2    Greeley, S.3    Silva, J.4    Huntoon, N.5    Leng, X.H.6    Bjorbaek, C.7
  • 84
    • 0027917171 scopus 로고
    • Molecular genetics. Colour-coded switches
    • Jackson, I.J., 1993. Molecular genetics. Colour-coded switches. Nature 362, 587-588.
    • (1993) Nature , vol.362 , pp. 587-588
    • Jackson, I.J.1
  • 87
    • 0029810614 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase1B is a negative regulator of insulin- And insulin-like growth factor-I-stimulated signaling
    • Kenner, K.A., Anyanwu, E., Olefsky, J.M., Kusari, J., 1996. Protein-tyrosine phosphatase1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J. Biol. Chem. 271, 19810-19816.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19810-19816
    • Kenner, K.A.1    Anyanwu, E.2    Olefsky, J.M.3    Kusari, J.4
  • 88
    • 33746537247 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    • DOI 10.1016/j.cmet.2006.06.010, PII S1550413106002427
    • Kievit, P., Howard, J.K., Badman, M.K., Balthasar, N., Coppari, R., Mori, H., Lee, C.E., Elmquist, J.K., Yoshimura, A., Flier, J.S., 2006. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 4, 123-132. (Pubitemid 44138722)
    • (2006) Cell Metabolism , vol.4 , Issue.2 , pp. 123-132
    • Kievit, P.1    Howard, J.K.2    Badman, M.K.3    Balthasar, N.4    Coppari, R.5    Mori, H.6    Lee, C.E.7    Elmquist, J.K.8    Yoshimura, A.9    Flier, J.S.10
  • 89
    • 0021344963 scopus 로고
    • Serotoninergic endings on VIP-neurons in the suprachiasmatic nucleus and on ACTH-neurons in the arcuate nucleus of the rat hypothalamus. A combination of high resolution autoradiography and electron microscopic immunocytochemistry
    • Kiss, J., Leranth, C., Halasz, B., 1984. Serotoninergic endings on VIP-neurons in the suprachiasmatic nucleus and on ACTH-neurons in the arcuate nucleus of the rat hypothalamus. A combination of high resolution autoradiography and electron microscopic immunocytochemistry. Neurosci. Lett. 44, 119-124.
    • (1984) Neurosci. Lett. , vol.44 , pp. 119-124
    • Kiss, J.1    Leranth, C.2    Halasz, B.3
  • 93
    • 40849135860 scopus 로고    scopus 로고
    • 2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors
    • DOI 10.1210/en.2007-1321
    • Lam, D.D., Przydzial, M.J., Ridley, S.H., Yeo, G.S., Rochford, J.J., O'Rahilly, S., Heisler, L.K., 2008. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology 149, 1323-1328. (Pubitemid 351397929)
    • (2008) Endocrinology , vol.149 , Issue.3 , pp. 1323-1328
    • Lam, D.D.1    Przydzial, M.J.2    Ridley, S.H.3    Yeo, G.S.H.4    Rochford, J.J.5    O'Rahilly, S.6    Heisler, L.K.7
  • 94
    • 0028278931 scopus 로고
    • The insulin receptor: Structure, function, and signaling
    • Lee, J., Pilch, P.F., 1994. The insulin receptor: structure, function, and signaling. Am. J. Physiol. 266, C319-C334.
    • (1994) Am. J. Physiol. , vol.266
    • Lee, J.1    Pilch, P.F.2
  • 97
    • 12944261926 scopus 로고    scopus 로고
    • Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
    • Mirshamsi, S., Laidlaw, H.A., Ning, K., Anderson, E., Burgess, L.A., Gray, A., Sutherland, C., Ashford, M.L., 2004. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci. 5, 54.
    • (2004) BMC Neurosci. , vol.5 , pp. 54
    • Mirshamsi, S.1    Laidlaw, H.A.2    Ning, K.3    Anderson, E.4    Burgess, L.A.5    Gray, A.6    Sutherland, C.7    Ashford, M.L.8
  • 98
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno, T.M., Kleopoulos, S.P., Bergen, H.T., Roberts, J.L., Priest, C.A., Mobbs, C.V., 1998. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47, 294-297. (Pubitemid 28079992)
    • (1998) Diabetes , vol.47 , Issue.2 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 99
    • 0242300570 scopus 로고    scopus 로고
    • Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice
    • DOI 10.2337/diabetes.52.11.2675
    • Mizuno, T.M., Kelley, K.A., Pasinetti, G.M., Roberts, J.L., Mobbs, C.V., 2003. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52, 2675-2683. (Pubitemid 37339696)
    • (2003) Diabetes , vol.52 , Issue.11 , pp. 2675-2683
    • Mizuno, T.M.1    Kelley, K.A.2    Pasinetti, G.M.3    Roberts, J.L.4    Mobbs, C.V.5
  • 100
    • 0007818583 scopus 로고
    • Hypertrophie der hypophysis cerebri und dadurchbedingter druck auf die hirngrundflache, insbesndere auf die Schnerven, das chiasma deselben und den linkseitigen
    • Mohr, B., 1840. Hypertrophie der hypophysis cerebri und dadurchbedingter druck auf die hirngrundflache, insbesndere auf die Schnerven, das chiasma deselben und den linkseitigen. Hirnschenkel Wschr. Ges. Heilk 6, 565-571.
    • (1840) Hirnschenkel Wschr. Ges. Heilk , vol.6 , pp. 565-571
    • Mohr, B.1
  • 102
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • Morton, G.J., Gelling, R.W., Niswender, K.D., Morrison, C.D., Rhodes, C.J., Schwartz, M.W., 2005. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2, 411-420.
    • (2005) Cell Metab. , vol.2 , pp. 411-420
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3    Morrison, C.D.4    Rhodes, C.J.5    Schwartz, M.W.6
  • 103
    • 0026800892 scopus 로고
    • The cloning of a family of genes that encode the melanocortin receptors
    • Mountjoy, K.G., Robbins, L.S., Mortrud, M.T., Cone, R.D., 1992. The cloning of a family of genes that encode the melanocortin receptors. Sci. NY N. Y 257, 1248-1251.
    • (1992) Sci. NY N. Y , vol.257 , pp. 1248-1251
    • Mountjoy, K.G.1    Robbins, L.S.2    Mortrud, M.T.3    Cone, R.D.4
  • 104
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy, K.G., Mortrud, M.T., Low, M.J., Simerly, R.B., Cone, R.D., 1994. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8, 1298-1308.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 105
    • 0027212268 scopus 로고
    • The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains
    • Myers Jr., M.G., White, M.F., 1993. The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes 42, 643-650.
    • (1993) Diabetes , vol.42 , pp. 643-650
    • Myers Jr., M.G.1    White, M.F.2
  • 107
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resistance
    • Myers, M.G., Cowley, M.A., Munzberg, H., 2008. Mechanisms of leptin action and leptin resistance. Annu. Rev. Physiol. 70, 537-556.
    • (2008) Annu. Rev. Physiol. , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 108
    • 0018346407 scopus 로고
    • Nucleotide sequence of cloned cDNA for bovine corticotropin-beta- lipoprotein precursor
    • Nakanishi, S., Inoue, A., Kita, T., Nakamura, M., Chang, A.C., Cohen, S.N., Numa, S., 1979. Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278, 423-427. (Pubitemid 9130699)
    • (1979) Nature , vol.278 , Issue.5703 , pp. 423-427
    • Nakanishi, S.1    Inoue, A.2    Kita, T.3
  • 109
    • 0035130843 scopus 로고    scopus 로고
    • AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
    • Nijenhuis, W.A., Oosterom, J., Adan, R.A., 2001. AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol. Endocrinol. 15, 164-171.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 164-171
    • Nijenhuis, W.A.1    Oosterom, J.2    Adan, R.A.3
  • 111
    • 0037315042 scopus 로고    scopus 로고
    • Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
    • DOI 10.2337/diabetes.52.2.227
    • Niswender, K.D., Morrison, C.D., Clegg, D.J., Olson, R., Baskin, D.G., Myers Jr., M.G., Seeley, R.J., Schwartz, M.W., 2003. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52, 227-231. (Pubitemid 36173172)
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 227-231
    • Niswender, K.D.1    Morrison, C.D.2    Clegg, D.J.3    Olson, R.4    Baskin, D.G.5    Myers Jr., M.G.6    Seeley, R.J.7    Schwartz, M.W.8
  • 112
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • Nonogaki, K., Strack, A.M., Dallman, M.F., Tecott, L.H., 1998. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 4, 1152-1156.
    • (1998) Nat. Med. , vol.4 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3    Tecott, L.H.4
  • 113
    • 85019282347 scopus 로고
    • On the relation of chronic interstitial pancreatitis to the islands of langerhans and to diabetes mellitus
    • Opie, E.L., 1900-1901aa. On the relation of chronic interstitial pancreatitis to the islands of langerhans and to diabetes mellitus. J Exper Med 5, 397-428.
    • (1900) J Exper Med , vol.5 , pp. 397-428
    • Opie, E.L.1
  • 114
    • 85025386842 scopus 로고
    • The relation of diabetes mellitus to lesions of the pancreas; hyaline degeneration of the islets of Langerhans
    • Opie, E.L., 1900-1901bb. The relation of diabetes mellitus to lesions of the pancreas; hyaline degeneration of the islets of Langerhans. J Exper Med 5, 527-540.
    • (1900) J Exper Med , vol.5 , pp. 527-540
    • Opie, E.L.1
  • 116
    • 85003201001 scopus 로고
    • The number of islets of Langerhans in the pancreas of the albino rat
    • Overholser, M., 1925. The number of islets of Langerhans in the pancreas of the albino rat. Endocrinology 9, 493-504.
    • (1925) Endocrinology , vol.9 , pp. 493-504
    • Overholser, M.1
  • 117
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes, O.N., Akca, H., Mayo, L.D., Gustin, J.A., Maehama, T., Dixon, J.E., Donner, D.B., 2001. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl Acad. Sci. USA 98, 4640-4645.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6    Donner, D.B.7
  • 119
    • 75349092316 scopus 로고    scopus 로고
    • Leptin excites proopiomelanocortin neurons via activation of TRPC channels
    • Qiu, J., Fang, Y., Ronnekleiv, O.K., Kelly, M.J., 2010. Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J. Neurosci. 30, 1560-1565.
    • (2010) J. Neurosci. , vol.30 , pp. 1560-1565
    • Qiu, J.1    Fang, Y.2    Ronnekleiv, O.K.3    Kelly, M.J.4
  • 120
    • 0027413475 scopus 로고
    • Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
    • DOI 10.1016/0092-8674(93)90572-8
    • Robbins, L.S., Nadeau, J.H., Johnson, K.R., Kelly, M.A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K.G., Cone, R.D., 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827-834. (Pubitemid 23110225)
    • (1993) Cell , vol.72 , Issue.6 , pp. 827-834
    • Robbins, L.S.1    Nadeau, J.H.2    Johnson, K.R.3    Kelly, M.A.4    Roselli-Rehfuss, L.5    Baack, E.6    Mountjoy, K.G.7    Cone, R.D.8
  • 122
    • 0022540417 scopus 로고
    • Neurobiology of an anorectic drug: Fenfluramine
    • Rowland, N.E., Carlton, J., 1986. Neurobiology of an anorectic drug: fenfluramine. Prog. Neurobiol. 27, 13-62.
    • (1986) Prog. Neurobiol. , vol.27 , pp. 13-62
    • Rowland, N.E.1    Carlton, J.2
  • 123
    • 0032803530 scopus 로고    scopus 로고
    • Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
    • DOI 10.1046/j.1365-2443.1999.00263.x
    • Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J.A., Yoshimura, A., 1999. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells 4, 339-351. (Pubitemid 29359449)
    • (1999) Genes to Cells , vol.4 , Issue.6 , pp. 339-351
    • Sasaki, A.1    Yasukawa, H.2    Suzuki, A.3    Kamizono, S.4    Syoda, T.5    Kinjyo, I.6    Sasaki, M.7    Johnston, J.A.8    Yoshimura, A.9
  • 124
    • 0034703097 scopus 로고    scopus 로고
    • CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    • Sasaki, A., Yasukawa, H., Shouda, T., Kitamura, T., Dikic, I., Yoshimura, A., 2000. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29338-29347
    • Sasaki, A.1    Yasukawa, H.2    Shouda, T.3    Kitamura, T.4    Dikic, I.5    Yoshimura, A.6
  • 125
    • 0036773262 scopus 로고    scopus 로고
    • Leptin and neuropeptide Y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: Implications for the control of food intake
    • DOI 10.1210/en.2002-220352
    • Schwartz, G.J., Moran, T.H., 2002. Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake. Endocrinology 143, 3779-3784. (Pubitemid 35244356)
    • (2002) Endocrinology , vol.143 , Issue.10 , pp. 3779-3784
    • Schwartz, G.J.1    Moran, T.H.2
  • 126
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz, M.W., Porte Jr., D., 2005. Diabetes, obesity, and the brain. Sci. NY N. Y 307, 375-379.
    • (2005) Sci. NY N. Y , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr., D.2
  • 129
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz,M.W., Seeley, R.J.,Woods, S.C.,Weigle, D.S., Campfield, L.A., Burn, P., Baskin, D.G., 1997. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119-2123. (Pubitemid 27512108)
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6    Baskin, D.G.7
  • 130
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw, J.E., Sicree, R.A., Zimmet, P.Z., 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diab. Res. Clin. Pract. 87, 4-14.
    • (2010) Diab. Res. Clin. Pract. , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 132
    • 63849112609 scopus 로고    scopus 로고
    • Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
    • Skibicka, K.P., Grill, H.J., 2009a. Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 150, 1705-1711.
    • (2009) Endocrinology , vol.150 , pp. 1705-1711
    • Skibicka, K.P.1    Grill, H.J.2
  • 133
    • 71949093692 scopus 로고    scopus 로고
    • Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins
    • Skibicka, K.P., Grill, H.J., 2009b. Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins. Endocrinology 150, 5351-5361.
    • (2009) Endocrinology , vol.150 , pp. 5351-5361
    • Skibicka, K.P.1    Grill, H.J.2
  • 134
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • DOI 10.1038/37379
    • Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D., Ashford, M.L., 1997. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521-525. (Pubitemid 28013134)
    • (1997) Nature , vol.390 , Issue.6659 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.J.5
  • 135
    • 0033944152 scopus 로고    scopus 로고
    • Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
    • Spanswick, D., Smith, M.A., Mirshamsi, S., Routh, V.H., Ashford, M.L., 2000. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat. Neurosci. 3, 757-758.
    • (2000) Nat. Neurosci. , vol.3 , pp. 757-758
    • Spanswick, D.1    Smith, M.A.2    Mirshamsi, S.3    Routh, V.H.4    Ashford, M.L.5
  • 136
    • 0000555383 scopus 로고
    • Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
    • Stanley, B.G., Leibowitz, S.F., 1985. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl Acad. Sci. USA 82, 3940-3943.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3940-3943
    • Stanley, B.G.1    Leibowitz, S.F.2
  • 138
    • 33645839593 scopus 로고    scopus 로고
    • Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors
    • Sutton, G.M., Trevaskis, J.L., Hulver, M.W., McMillan, R.P., Markward, N.J., Babin, M.J., Meyer, E.A., Butler, A.A., 2006. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147, 2183-2196.
    • (2006) Endocrinology , vol.147 , pp. 2183-2196
    • Sutton, G.M.1    Trevaskis, J.L.2    Hulver, M.W.3    McMillan, R.P.4    Markward, N.J.5    Babin, M.J.6    Meyer, E.A.7    Butler, A.A.8
  • 139
    • 0019313601 scopus 로고
    • A direct projection from the ventromedial nucleus and retrochiasmatic area of the hypothalamus to the medulla and spinal cord of the rat
    • Swanson, L.W., Kuypers, H.G., 1980. A direct projection from the ventromedial nucleus and retrochiasmatic area of the hypothalamus to the medulla and spinal cord of the rat. Neurosci. Lett. 17, 307-312.
    • (1980) Neurosci. Lett. , vol.17 , pp. 307-312
    • Swanson, L.W.1    Kuypers, H.G.2
  • 143
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • DOI 10.1210/en.138.11.5063
    • Thornton, J.E., Cheung, C.C., Clifton, D.K., Steiner, R.A., 1997. Regulation of hypothalamic proopiomelanocortinmRNA by leptin in ob/ob mice. Endocrinology 138, 5063-5066. (Pubitemid 27460950)
    • (1997) Endocrinology , vol.138 , Issue.11 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 146
    • 0027423948 scopus 로고
    • Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene
    • Tsigos, C., Arai, K., Hung, W., Chrousos, G.P., 1993. Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. J. Clin. Investig. 92, 2458-2461.
    • (1993) J. Clin. Investig. , vol.92 , pp. 2458-2461
    • Tsigos, C.1    Arai, K.2    Hung, W.3    Chrousos, G.P.4
  • 147
    • 0024434127 scopus 로고
    • Acetylation alters the feeding response to MSH and beta-endorphin
    • Tsujii, S., Bray, G.A., 1989. Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res. Bull. 23, 165-169.
    • (1989) Brain Res. Bull. , vol.23 , pp. 165-169
    • Tsujii, S.1    Bray, G.A.2
  • 148
    • 0020664262 scopus 로고
    • Complete amino acid sequence of mouse proopiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA
    • Uhler, M., Herbert, E., 1983. Complete amino acid sequence of mouse proopiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA. J. Biol. Chem. 258, 257-261.
    • (1983) J. Biol. Chem. , vol.258 , pp. 257-261
    • Uhler, M.1    Herbert, E.2
  • 149
    • 0021985413 scopus 로고
    • Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
    • DOI 10.1038/313756a0
    • Ullrich, A., Bell, J.R., Chen, E.Y., Herrera, R., Petruzzelli, L.M., Dull, T.J., Gray, A., Coussens, L., Liao, Y.C., Tsubokawa, M., et al., 1985. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313, 756-761. (Pubitemid 15130823)
    • (1985) Nature , vol.313 , Issue.6005 , pp. 756-761
    • Ullrich, A.1    Bell, J.R.2    Chen, E.Y.3
  • 150
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • Vaisse, C., Clement, K., Guy-Grand, B., Froguel, P., 1998. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat. Genet. 20, 113-114.
    • (1998) Nat. Genet. , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3    Froguel, P.4
  • 152
    • 2142758640 scopus 로고    scopus 로고
    • Orexigensensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • van den Top, M., Lee, K., Whyment, A.D., Blanks, A.M., Spanswick, D., 2004. Orexigensensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 7, 493-494.
    • (2004) Nat. Neurosci. , vol.7 , pp. 493-494
    • Van Den Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 153
    • 0032962859 scopus 로고    scopus 로고
    • Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice
    • DOI 10.1007/s002130050952
    • Vickers, S.P., Clifton, P.G., Dourish, C.T., Tecott, L.H., 1999. Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacol. Berl 143, 309-314. (Pubitemid 29204986)
    • (1999) Psychopharmacology , vol.143 , Issue.3 , pp. 309-314
    • Vickers, S.P.1    Clifton, P.G.2    Dourish, C.T.3    Tecott, L.H.4
  • 155
    • 40849116457 scopus 로고    scopus 로고
    • Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors
    • DOI 10.1210/en.2007-0927
    • Wade, J.M., Juneja, P., MacKay, A.W., Graham, J., Havel, P.J., Tecott, L.H., Goulding, E.H., 2008. Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors. Endocrinology 149, 955-961. (Pubitemid 351397943)
    • (2008) Endocrinology , vol.149 , Issue.3 , pp. 955-961
    • Wade, J.M.1    Juneja, P.2    MacKay, A.W.3    Graham, J.4    Havel, P.J.5    Tecott, L.H.6    Goulding, E.H.7
  • 157
    • 0021339433 scopus 로고
    • Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells
    • White, M.F., Haring, H.U., Kasuga, M., Kahn, C.R., 1984. Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. J. Biol. Chem. 259, 255-264.
    • (1984) J. Biol. Chem. , vol.259 , pp. 255-264
    • White, M.F.1    Haring, H.U.2    Kasuga, M.3    Kahn, C.R.4
  • 158
    • 0023834406 scopus 로고
    • A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor
    • White, M.F., Shoelson, S.E., Keutmann, H., Kahn, C.R., 1988. A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J. Biol. Chem. 263, 2969-2980.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2969-2980
    • White, M.F.1    Shoelson, S.E.2    Keutmann, H.3    Kahn, C.R.4
  • 159
    • 0031040793 scopus 로고    scopus 로고
    • Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
    • White, D.W., Kuropatwinski, K.K., Devos, R., Baumann, H., Tartaglia, L.A., 1997. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J. Biol. Chem. 272, 4065-4071.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4065-4071
    • White, D.W.1    Kuropatwinski, K.K.2    Devos, R.3    Baumann, H.4    Tartaglia, L.A.5
  • 160
    • 2342466734 scopus 로고    scopus 로고
    • Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
    • DOI 10.2337/diacare.27.5.1047
    • Wild, S., Roglic, G., Green, A., Sicree, R., King, H., 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diab. Care 27, 1047-1053. (Pubitemid 38579764)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 161
    • 33745034786 scopus 로고    scopus 로고
    • Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive behaviour
    • DOI 10.1113/jphysiol.2006.106336
    • Williams, K.W., Smith, B.N., 2006. Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour. J. Physiol. 573, 395-412. (Pubitemid 43871055)
    • (2006) Journal of Physiology , vol.573 , Issue.2 , pp. 395-412
    • Williams, K.W.1    Smith, B.N.2
  • 162
    • 33947413088 scopus 로고    scopus 로고
    • Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin
    • DOI 10.1210/en.2006-1098
    • Williams, K.W., Zsombok, A., Smith, B.N., 2007. Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin. Endocrinology 148, 1868-1881. (Pubitemid 46457122)
    • (2007) Endocrinology , vol.148 , Issue.4 , pp. 1868-1881
    • Williams, K.W.1    Zsombok, A.2    Smith, B.N.3
  • 163
    • 61449129183 scopus 로고    scopus 로고
    • From observation to experimentation: Leptin action in the mediobasal hypothalamus
    • Williams, K.W., Scott, M.M., Elmquist, J.K., 2009. From observation to experimentation: leptin action in the mediobasal hypothalamus. Am. J. Clin. Nutr. 89, 985S-990S.
    • (2009) Am. J. Clin. Nutr. , vol.89
    • Williams, K.W.1    Scott, M.M.2    Elmquist, J.K.3
  • 164
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • Williams, K.W., Margatho, L.O., Lee, C.E., Choi, M., Lee, S., Scott, M.M., Elias, C.F., Elmquist, J.K., 2010. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J. Neurosci. 30, 2472-2479.
    • (2010) J. Neurosci. , vol.30 , pp. 2472-2479
    • Williams, K.W.1    Margatho, L.O.2    Lee, C.E.3    Choi, M.4    Lee, S.5    Scott, M.M.6    Elias, C.F.7    Elmquist, J.K.8
  • 165
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods, S.C., Lotter, E.C., McKay, L.D., Porte Jr., D., 1979. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282, 503-505. (Pubitemid 10126541)
    • (1979) Nature , vol.282 , Issue.5738 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte Jr., D.4
  • 166
    • 0032577376 scopus 로고    scopus 로고
    • Signals that regulate food intake and energy homeostasis
    • Woods, S.C., Seeley, R.J., Porte Jr., D., Schwartz, M.W., 1998. Signals that regulate food intake and energy homeostasis. Sci. NY N. Y 280, 1378-1383.
    • (1998) Sci. NY N. Y , vol.280 , pp. 1378-1383
    • Woods, S.C.1    Seeley, R.J.2    Porte Jr., D.3    Schwartz, M.W.4
  • 167
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding
    • DOI 10.1210/en.2006-1119
    • Xu, A.W., Ste-Marie, L., Kaelin, C.B., Barsh, G.S., 2007. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148, 72-80. (Pubitemid 46021439)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 170
    • 52949140814 scopus 로고    scopus 로고
    • Making insulin-deficient type 1 diabetic rodents thrive without insulin
    • Yu,X., Park, B.H.,Wang,M.Y.,Wang, Z.V.,Unger, R.H., 2008.Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc. Natl Acad. Sci. USA 105, 14070-14075.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 14070-14075
    • Yu, X.1    Park, B.H.2    Wang, M.Y.3    Wang, Z.V.4    Unger, R.H.5
  • 172
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M., 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432. (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 175
    • 25144451723 scopus 로고    scopus 로고
    • Serotonergic pathways converge upon central melanocortin systems to regulate energy balance
    • DOI 10.1016/j.peptides.2004.12.028, PII S0196978105002238, The Melanocortin Pathway 2005
    • Zhou, L., Williams, T., Lachey, J.L., Kishi, T., Cowley, M.A., Heisler, L.K., 2005. Serotonergic pathways converge upon central melanocortin systems to regulate energy balance. Peptides 26, 1728-1732. (Pubitemid 41354530)
    • (2005) Peptides , vol.26 , Issue.10 , pp. 1728-1732
    • Zhou, L.1    Williams, T.2    Lachey, J.L.3    Kishi, T.4    Cowley, M.A.5    Heisler, L.K.6
  • 177
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • DOI 10.1038/414782a
    • Zimmet, P., Alberti, K.G., Shaw, J., 2001. Global and societal implications of the diabetes epidemic. Nature 414, 782-787. (Pubitemid 34000780)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.M.M.2    Shaw, J.3


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