-
1
-
-
74949143243
-
Narrative review: The role of leptin in human physiology: Emerging clinical applications
-
Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152:93-100.
-
(2010)
Ann Intern Med
, vol.152
, pp. 93-100
-
-
Kelesidis, T.1
Kelesidis, I.2
Chou, S.3
Mantzoros, C.S.4
-
2
-
-
0031978142
-
Leptin, leptin receptors, and the control of body weight
-
Friedman JM. Leptin, leptin receptors, and the control of body weight. Nutr Rev. 1998;56:s38-46.
-
(1998)
Nutr Rev
, vol.56
-
-
Friedman, J.M.1
-
3
-
-
33744467955
-
The hypothalamic control of feeding and thermogenesis: Implications on the development of obesity
-
Velloso LA. The hypothalamic control of feeding and thermogenesis: implications on the development of obesity. Arq Bras Endocrinol Metabol. 2006;50:165-76.
-
(2006)
Arq Bras Endocrinol Metabol
, vol.50
, pp. 165-176
-
-
Velloso, L.A.1
-
4
-
-
29744445534
-
Adipokine expression profile in adipocytes of different mouse models of obesity
-
Boucher J, Castan-Laurell I, Daviaud D, Guigne C, Buleon M, Carpene C, et al. Adipokine expression profile in adipocytes of different mouse models of obesity. Horm Metab Res. 2005;37:761-7.
-
(2005)
Horm Metab Res
, vol.37
, pp. 761-767
-
-
Boucher, J.1
Castan-Laurell, I.2
Daviaud, D.3
Guigne, C.4
Buleon, M.5
Carpene, C.6
-
5
-
-
34247145563
-
Metabolic profile according to leptin levels in obese patients
-
Feitosa AC, Mancini MC, Cercato C, Villares SM, Halpern A. Metabolic profile according to leptin levels in obese patients. Arq Bras Endocrinol Metabol. 2007;51:59-64.
-
(2007)
Arq Bras Endocrinol Metabol
, vol.51
, pp. 59-64
-
-
Feitosa, A.C.1
Mancini, M.C.2
Cercato, C.3
Villares, S.M.4
Halpern, A.5
-
6
-
-
0033304576
-
Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptinmediated defects
-
Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptinmediated defects. J Clin Endocrinol Metab. 1999;84:3686-95.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 3686-3695
-
-
Ozata, M.1
Ozdemir, I.C.2
Licinio, J.3
-
7
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD, A leptin missense mutation associated with hypogonadism and morbid obesity. Nature Genet. 1998;18:213-5.
-
(1998)
Nature Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
8
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387:903-8.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
-
9
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med. 1999;341:879-84.
-
(1999)
N Engl J Med
, vol.341
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
Lawrence, E.4
Cheetham, C.H.5
Prentice, A.M.6
-
10
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
11
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110:1093-103.
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
Agwu, C.6
-
12
-
-
6344221594
-
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: Report of another case and evaluation of response to four years of leptin therapy
-
Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O'Rahilly S, et al. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab. 2004;89:4821-6.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4821-4826
-
-
Gibson, W.T.1
Farooqi, I.S.2
Moreau, M.3
Depaoli, A.M.4
Lawrence, E.5
O'Rahilly, S.6
-
13
-
-
12144289998
-
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptindeficient adults
-
Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, et al. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptindeficient adults. Proc Natl Acad Sci U S A. 2004;101:4531-6.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4531-4536
-
-
Licinio, J.1
Caglayan, S.2
Ozata, M.3
Yildiz, B.O.4
de Miranda, P.B.5
O'Kirwan, F.6
-
14
-
-
58149240447
-
Leptin replacement improves cognitive development
-
Paz-Filho GJ, Babikian T, Asarnow R, Delibasi T, Esposito K, Erol HK, et al. Leptin replacement improves cognitive development. PLoS One. 2008;3:e3098.
-
(2008)
PLoS One
, vol.3
-
-
Paz-Filho, G.J.1
Babikian, T.2
Asarnow, R.3
Delibasi, T.4
Esposito, K.5
Erol, H.K.6
-
15
-
-
67649908458
-
A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient
-
Mazen I, El-Gammal M, Abdel-Hamid M, Amr K. A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient. Mol Genet Metab. 2009;97:305-8.
-
(2009)
Mol Genet Metab
, vol.97
, pp. 305-308
-
-
Mazen, I.1
El-Gammal, M.2
Abdel-Hamid, M.3
Amr, K.4
-
16
-
-
77954461979
-
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness
-
Fischer-Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth TF, et al. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab. 2010;95:2836-40.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2836-2840
-
-
Fischer-Posovszky, P.1
von Schnurbein, J.2
Moepps, B.3
Lahr, G.4
Strauss, G.5
Barth, T.F.6
-
17
-
-
77955052450
-
Congenital leptin deficiency and thyroid function
-
Paz-Filho G, Delibasi T, Erol HK, Wong ML, Licinio J, Congenital leptin deficiency and thyroid function. Thyroid Res. 2009;2:11.
-
(2009)
Thyroid Res
, vol.2
, pp. 11
-
-
Paz-Filho, G.1
Delibasi, T.2
Erol, H.K.3
Wong, M.L.4
Licinio, J.5
-
18
-
-
16944364768
-
Human leptin levels are pulsatile and inversely related to pituitary- adrenal function
-
Licinio J, Mantzoros C, Negrao AB, Cizza G, Wong ML, Bongiorno PB, et al. Human leptin levels are pulsatile and inversely related to pituitary- adrenal function. Nature Medicine. 1997;3:575-9.
-
(1997)
Nature Medicine
, vol.3
, pp. 575-579
-
-
Licinio, J.1
Mantzoros, C.2
Negrao, A.B.3
Cizza, G.4
Wong, M.L.5
Bongiorno, P.B.6
-
19
-
-
17844366295
-
Synchronicity of frequently sampled TSH and leptin concentrations in healthy adults and leptin deficient subjects: Evidence for possible partial TSH regulation by leptin in humans
-
Mantzoros CS, Ozata M, Negrao AB, Ziotopoulou M, Caglayan S, Suchard M, et al. Synchronicity of frequently sampled TSH and leptin concentrations in healthy adults and leptin deficient subjects: evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab. 2001;86:3284-91.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3284-3291
-
-
Mantzoros, C.S.1
Ozata, M.2
Negrao, A.B.3
Ziotopoulou, M.4
Caglayan, S.5
Suchard, M.6
-
20
-
-
36448938300
-
Effects of leptin replacement on macro- and micronutrient preferences
-
Licinio J, Ribeiro L, Busnello JV, Delibasi T, Thakur S, Elashoff RM, et al. Effects of leptin replacement on macro- and micronutrient preferences. Int J Obes (Lond). 2007;31:1859-63.
-
(2007)
Int J Obes (Lond)
, vol.31
, pp. 1859-1863
-
-
Licinio, J.1
Ribeiro, L.2
Busnello, J.V.3
Delibasi, T.4
Thakur, S.5
Elashoff, R.M.6
-
21
-
-
76149128662
-
Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients
-
Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J, Ravussin E. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. J Clin Endocrinol Metab. 2010;95:851-5.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 851-855
-
-
Galgani, J.E.1
Greenway, F.L.2
Caglayan, S.3
Wong, M.L.4
Licinio, J.5
Ravussin, E.6
-
22
-
-
63649144117
-
Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: Time course of glucose homeostasis in leptin replacement treatment
-
Andreev VP, Paz-Filho G, Wong ML, Licinio J. Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment. Horm Metab Res. 2009;41:142-51.
-
(2009)
Horm Metab Res
, vol.41
, pp. 142-151
-
-
Andreev, V.P.1
Paz-Filho, G.2
Wong, M.L.3
Licinio, J.4
-
23
-
-
57349192938
-
Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
-
Paz-Filho G, Esposito K, Hurwitz B, Sharma A, Dong C, Andreev V, et al. Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. Am J Physiol Endocrinol Metab. 2008;295:E1401-8.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Paz-Filho, G.1
Esposito, K.2
Hurwitz, B.3
Sharma, A.4
Dong, C.5
Andreev, V.6
-
24
-
-
65249108234
-
IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: Implications for metabolic homeostasis
-
Wheatcroft SB, Kearney MT. IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis. Trends Endocrinol Metab. 2009;20:153-62.
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 153-162
-
-
Wheatcroft, S.B.1
Kearney, M.T.2
-
25
-
-
17844366295
-
Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: Evidence for possible partial TSH regulation by leptin in humans
-
Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, et al. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin--deficient subjects: evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab. 2001;86:3284-91.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3284-3291
-
-
Mantzoros, C.S.1
Ozata, M.2
Negrao, A.B.3
Suchard, M.A.4
Ziotopoulou, M.5
Caglayan, S.6
-
26
-
-
22044451057
-
Regulation of thyrotropin synthesis and secretion
-
Moura EG, Moura CC. Regulation of thyrotropin synthesis and secretion. Arq Bras Endocrinol Metabol. 2004;48:40-52.
-
(2004)
Arq Bras Endocrinol Metabol
, vol.48
, pp. 40-52
-
-
Moura, E.G.1
Moura, C.C.2
-
27
-
-
63649161041
-
Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects
-
Paz-Filho GJ, Andrews D, Esposito K, Erol HK, Delibasi T, Wong ML, et al. Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects. Horm Metab Res. 2009;41:164-7.
-
(2009)
Horm Metab Res
, vol.41
, pp. 164-167
-
-
Paz-Filho, G.J.1
Andrews, D.2
Esposito, K.3
Erol, H.K.4
Delibasi, T.5
Wong, M.L.6
-
28
-
-
75749150169
-
Cellular immunity before and after leptin replacement therapy
-
Paz-Filho GJ, Delibasi T, Erol HK, Wong ML, Licinio J. Cellular immunity before and after leptin replacement therapy. J Pediatr Endocrinol Metab. 2009;22:1069-74.
-
(2009)
J Pediatr Endocrinol Metab
, vol.22
, pp. 1069-1074
-
-
Paz-Filho, G.J.1
Delibasi, T.2
Erol, H.K.3
Wong, M.L.4
Licinio, J.5
-
29
-
-
36749097922
-
Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
-
Baicy K, London ED, Monterosso J, Wong ML, Delibasi T, Sharma A, et al. Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci U S A. 2007;104:18276-9.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 18276-18279
-
-
Baicy, K.1
London, E.D.2
Monterosso, J.3
Wong, M.L.4
Delibasi, T.5
Sharma, A.6
-
30
-
-
18844435641
-
Effect of leptin replacement on brain structure in genetically leptin-deficient adults
-
Matochik JA, London ED, Yildiz BO, Ozata M, Caglayan S, De-Paoli AM, et al. Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J Clin Endocrinol Metab. 2005;90:2851-4.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 2851-2854
-
-
Matochik, J.A.1
London, E.D.2
Yildiz, B.O.3
Ozata, M.4
Caglayan, S.5
De-Paoli, A.M.6
-
31
-
-
34548675339
-
Leptin regulates striatal regions and human eating behavior
-
Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC. Leptin regulates striatal regions and human eating behavior. Science. 2007;317:1355.
-
(2007)
Science
, vol.317
, pp. 1355
-
-
Farooqi, I.S.1
Bullmore, E.2
Keogh, J.3
Gillard, J.4
O'Rahilly, S.5
Fletcher, P.C.6
-
32
-
-
72549091935
-
Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging
-
Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA. 2009;302:2565-72.
-
(2009)
JAMA
, vol.302
, pp. 2565-2572
-
-
Lieb, W.1
Beiser, A.S.2
Vasan, R.S.3
Tan, Z.S.4
Au, R.5
Harris, T.B.6
-
33
-
-
77951150172
-
Leptin levels and Alzheimer disease
-
author reply -9
-
Paz-Filho G, Wong ML, Licinio J. Leptin levels and Alzheimer disease. JAMA. 303:1478; author reply -9.
-
JAMA
, vol.303
, pp. 1478
-
-
Paz-Filho, G.1
Wong, M.L.2
Licinio, J.3
-
34
-
-
77149153389
-
Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome
-
da Paz-Filho GJ, Volaco A, Suplicy HL, Radominski RB, Boguszewski CL. Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome. Arq Bras Endocrinol Metabol. 2009;53:1088-95.
-
(2009)
Arq Bras Endocrinol Metabol
, vol.53
, pp. 1088-1095
-
-
da Paz-Filho, G.J.1
Volaco, A.2
Suplicy, H.L.3
Radominski, R.B.4
Boguszewski, C.L.5
-
35
-
-
47249153627
-
Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women
-
Hinuy HM, Hirata MH, Forti N, Diament J, Sampaio MF, Armaganijan D, et al. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arq Bras Endocrinol Metabol. 2008;52:611-6.
-
(2008)
Arq Bras Endocrinol Metabol
, vol.52
, pp. 611-616
-
-
Hinuy, H.M.1
Hirata, M.H.2
Forti, N.3
Diament, J.4
Sampaio, M.F.5
Armaganijan, D.6
-
36
-
-
77953553843
-
Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals
-
Hinuy HM, Hirata MH, Sampaio MF, Armaganijan D, Arazi SS, Salazar LA, et al. Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. Arq Bras Endocrinol Metabol. 54:282-8.
-
Arq Bras Endocrinol Metabol
, vol.54
, pp. 282-288
-
-
Hinuy, H.M.1
Hirata, M.H.2
Sampaio, M.F.3
Armaganijan, D.4
Arazi, S.S.5
Salazar, L.A.6
|