Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters

Journal of Medicinal Chemistry

Volumn 50, Issue 8, 2007, Pages 1850-1864

  Zhang, Jianmin ^a   Pettersson, Hanna I ^a   Huitema, Carly ^b   Niu, Chunying ^a   Yin, Jiang ^a   James, Michael N G ^a,c   Eltis, Lindsay D ^b   Vederas, John C ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Department of Protein Structure and Function ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; CYSTEINE; ESTER DERIVATIVE; HYDRAZIDE DERIVATIVE; KETONE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; PYRIDINE DERIVATIVE; TETRAPEPTIDE;

ACYLATION; ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; IC 50; NONHUMAN; SARS CORONAVIRUS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; BINDING SITES; BIOMIMETICS; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE ENDOPEPTIDASES; ESTERS; KETONES; MODELS, MOLECULAR; OLIGOPEPTIDES; PHTHALAZINES; PYRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 34247274665     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061425k     Document Type: Article

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