Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

Tetrahedron

Volumn 62, Issue 36, 2006, Pages 8601-8609

  Sydnes, Magne O ^a   Hayashi, Yoshio ^a   Sharma, Vinay K ^a   Hamada, Takashi ^a   Bacha, Usman ^b   Barrila, Jennifer ^b   Freire, Ernesto ^b   Kiso, Yoshiaki ^a  

^a Center for Frontier Research in Medicinal Science   (Japan)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Protease inhibitors; Severe acute respiratory syndrome coronavirus protease (SARS CoV 3CLpro); Trifluoromethyl ketone

Indexed keywords

4 [N (BENZYLOXYCARBONYL)ALANYLVALYLLEUCYL]AMINO 6,6,6 TIFLUORO 5 OXOHEXANAMIDE; 4 [N (BENZYLOXYCARBONYL)PHENYLALANYLALANYL]AMINO 6,6,6 TIFLUORO 5 OXOHEXANAMIDE; 4 [N (BENZYLOXYCARBONYL)VALYLLEUCYL]AMINO 6,6,6 TIFLUORO 5 OXOHEXANAMIDE; 4 [N (BENZYLOXYCARBONYL)VALYLLEUCYL]AMINO 6,6,6 TIFLUORO 5 OXOHEXANOIC ACID; AMINOALCOHOL; ANTIVIRUS AGENT; BENZYL 4 (2 TERT BUTOXYCARBONYL)ETHYL 5 (TRIFLUOROMETHYL) 5 (TRIMETHYLSILYLOXY)OXAZOLIDINE 3 CARBOXYLATE; GLUTAMIC ACID; GLUTAMINE; KETONE DERIVATIVE; OXAZOLIDINONE DERIVATIVE; PEPTIDE DERIVATIVE; PROTEINASE INHIBITOR; SILANE DERIVATIVE; TERT BUTYL 4 AMINO 6,6,6 TRIFLUORO 5 HYDROXYHEXANOATE; TRIFLUOROMETHYL BETA AMINO ALCOHOL; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; PRIORITY JOURNAL; SARS CORONAVIRUS;

SARS CORONAVIRUS; TETRA; TRIFLUORO;

EID: 33746304862     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.06.052     Document Type: Article

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