Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4652-4660

  Shao, Yi Ming ^a,b,c   Yang, Wen Bin ^a   Kuo, Tun Hsun ^b   Tsai, Keng Chang ^a   Lin, Chun Hung ^a,b,c   Yang, An Suei ^a   Liang, Po Huang ^a,b,c   Wong, Chi Huey ^a,b,c,d  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Protease inhibitor; SARS; Time dependent inhibition; Trifluoromethyl ketone

Indexed keywords

3 (N LEVO GAMMAGLUTAMINYL LEVO ALANYL) 1,1,1 TRIFLUOROPROPAN 2 ONE; 3 [N (N BENZYLOXYCARBONYL LEVO LEUCYL)] 4 PHENYL 1,1,1 TRIFLUOROBUTAN 2 ONE; 3 [N (N BENZYLOXYCARBONYL LEVO PHENYLALANYL)] 4 PHENYL 1,1,1 TRIFLUOROBUTAN 2 ONE; 3 [N [N BENZYLOXYCARBONYL LEVO ALANYL LEVO VALYL LEVO LEUCYL]] 4 PHENYL 1,1,1 TRIFLUOROBUTAN ONE; 3 [N [N TERT BUTOXYCARBONYL LEVO GAMMAGLUTAMINYL(OTBU0 LEVO ALANYL]] 1,1,1 TRIFLUOROPROPAN 2 ONE; 3 [N N TERT BUTOXYCARBONYL)LEVO LEUCYL] 1,1,1 TRIFLUOROBUTAN 2 ONE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVATION; IN VITRO STUDY; NONHUMAN; SARS CORONAVIRUS;

CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; FLUORINE COMPOUNDS; HYDROGEN BONDING; KETONES; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; SARS VIRUS; VIRAL PROTEINS;

SARS CORONAVIRUS;

EID: 42149094009     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.040     Document Type: Article

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