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Volumn 10, Issue 1, 2014, Pages 2-17

Bioavailability of endomorphins and the blood-brain barrier-a review

Author keywords

Analgesia; Bioavailability; Opioid peptides; Opioid receptors; Passive diffusion; Peptide permeability

Indexed keywords

CELL PENETRATING PEPTIDE; ENDORPHIN; LIPOSOME; OCTANOL; OPIATE; PEPTIDOMIMETIC AGENT;

EID: 84891360918     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/15734064113099990040     Document Type: Review
Times cited : (20)

References (130)
  • 1
    • 0035751792 scopus 로고    scopus 로고
    • Endogenous opiates: 2000
    • Vaccarino, A.L.; Kastin, A.J. Endogenous opiates: 2000. Peptides, 2001, 22, 2257-328.
    • (2001) Peptides , vol.22 , pp. 2257-2328
    • Vaccarino, A.L.1    Kastin, A.J.2
  • 3
    • 2142658722 scopus 로고    scopus 로고
    • New trends in the development of opioid peptide analogues as advanced remedies for pain relief
    • Gentilucci, L. New trends in the development of opioid peptide analogues as advanced remedies for pain relief. Curr. Top. Med. Chem., 2004, 4, 19-38.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 19-38
    • Gentilucci, L.1
  • 5
    • 0030933655 scopus 로고    scopus 로고
    • A potent and selective endogenous agonist for the mu-opiate receptor
    • Zadina, J.E.; Hackler, L.; Ge, L.J.; Kastin, A.J. A potent and selective endogenous agonist for the mu-opiate receptor. Nature, 1997, 386, 499-502.
    • (1997) Nature , vol.386 , pp. 499-502
    • Zadina, J.E.1    Hackler, L.2    Ge, L.J.3    Kastin, A.J.4
  • 6
    • 0031426851 scopus 로고    scopus 로고
    • Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex
    • Hacker, L.; Zadina, J.E.; Ge, L.J.; Kastin, A.J. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides, 1997, 18, 1635-9.
    • (1997) Peptides , vol.18 , pp. 1635-1639
    • Hacker, L.1    Zadina, J.E.2    Ge, L.J.3    Kastin, A.J.4
  • 9
    • 0033835786 scopus 로고    scopus 로고
    • Differential cardiorespiratory effects of endomorphin 1 and endomorphin 2, DAMGO, and morphine
    • Czapla, M.A.; Gozal, D.; Alea, O.A.; Beckerman, R.C.; Zadina, J.E. Differential cardiorespiratory effects of endomorphin 1 and endomorphin 2, DAMGO, and morphine. Am. J. Respir. Crit. Care Med., 2000, 162, 994-9.
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 994-999
    • Czapla, M.A.1    Gozal, D.2    Alea, O.A.3    Beckerman, R.C.4    Zadina, J.E.5
  • 11
    • 84869498477 scopus 로고    scopus 로고
    • Challenges in drug delivery to the brain: Nature is against us
    • Krol, S. Challenges in drug delivery to the brain: Nature is against us. J. Control. Release, 2012, 164, 145-55.
    • (2012) J. Control. Release , vol.164 , pp. 145-155
    • Krol, S.1
  • 12
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
    • Oldendorf, W.H. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol., 1971, 221, 1629-39.
    • (1971) Am. J. Physiol. , vol.221 , pp. 1629-1639
    • Oldendorf, W.H.1
  • 13
    • 0030726198 scopus 로고    scopus 로고
    • Bioavailability and transport of peptides and peptide drugs into the brain
    • Egleton, R.D.; Davis, T.P. Bioavailability and transport of peptides and peptide drugs into the brain. Peptides, 1997, 18, 1431-9.
    • (1997) Peptides , vol.18 , pp. 1431-1439
    • Egleton, R.D.1    Davis, T.P.2
  • 15
    • 0141620181 scopus 로고    scopus 로고
    • Structural and functional aspects of the blood-brain barrier
    • Begley, D.J.; Brightman, M.W. Structural and functional aspects of the blood-brain barrier. Prog. Drug Res., 2003, 61, 39-78.
    • (2003) Prog. Drug Res. , vol.61 , pp. 39-78
    • Begley, D.J.1    Brightman, M.W.2
  • 17
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins, B.T.; Davis, T.P. The bloodbrain barrier/neurovascular unit in health and disease. Pharmacol. Rev., 2005, 57, 173-85.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 19
    • 84864760434 scopus 로고    scopus 로고
    • Tight junction in blood-brain barrier: An overview of structure, regulation, and regulator substances
    • Liu, W.Y.; Wang, Z.B.; Zhang, L.C.; Wei, X.; Li, L. Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances. CNS Neurosci. Ther., 2012, 18, 609-15.
    • (2012) CNS Neurosci. Ther. , vol.18 , pp. 609-615
    • Liu, W.Y.1    Wang, Z.B.2    Zhang, L.C.3    Wei, X.4    Li, L.5
  • 20
    • 0025048342 scopus 로고
    • Electrical resistance across the blood-brain barrier in anaesthetized rats
    • Butt, A.M.; Jones, H.C.; Abbott, N.J. Electrical resistance across the blood-brain barrier in anaesthetized rats. J. Physiol. (London), 1990, 429, 47-62.
    • (1990) J. Physiol. (London) , vol.429 , pp. 47-62
    • Butt, A.M.1    Jones, H.C.2    Abbott, N.J.3
  • 21
    • 84868573143 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier
    • Pardridge, W.M. Drug transport across the blood-brain barrier. J. Cereb. Blood Flow Metab., 2012, 32, 1959-72.
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1959-1972
    • Pardridge, W.M.1
  • 22
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
    • Begley, D.J. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol. Ther., 2004, 104, 29-45.
    • (2004) Pharmacol. Ther. , vol.104 , pp. 29-45
    • Begley, D.J.1
  • 23
    • 35348867323 scopus 로고    scopus 로고
    • Organic anion-transporting polypeptides at the blood-brain and blood-cerebrospinal fluid barriers
    • Westholm, D.E.; Rumbley, J.N.; Salo, D.R.; Rich, T.P.; Anderson, G.W. Organic anion-transporting polypeptides at the blood-brain and blood-cerebrospinal fluid barriers. Curr. Top. Dev. Biol., 2008, 80, 135-70.
    • (2008) Curr. Top. Dev. Biol. , vol.80 , pp. 135-170
    • Westholm, D.E.1    Rumbley, J.N.2    Salo, D.R.3    Rich, T.P.4    Anderson, G.W.5
  • 24
    • 0017487289 scopus 로고
    • The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat
    • Oldendorf, W.H.; Cornford, M.E.; Brown, W.J. The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann. Neurol., 1977, 1, 409-17.
    • (1977) Ann. Neurol. , vol.1 , pp. 409-417
    • Oldendorf, W.H.1    Cornford, M.E.2    Brown, W.J.3
  • 26
    • 17644364388 scopus 로고    scopus 로고
    • Dynamics of CNS barriers: Evolution, differentiation, and modulation
    • Abbott, N.J. Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell. Mol. Neurobiol., 2005, 25, 5-23.
    • (2005) Cell. Mol. Neurobiol. , vol.25 , pp. 5-23
    • Abbott, N.J.1
  • 27
    • 26244456551 scopus 로고    scopus 로고
    • Molecular biology of the blood-brain barrier
    • Pardridge, W.M. Molecular biology of the blood-brain barrier. Mol. Biotechnol., 2005, 30, 57-70.
    • (2005) Mol. Biotechnol. , vol.30 , pp. 57-70
    • Pardridge, W.M.1
  • 28
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge, W.M. The blood-brain barrier: bottleneck in brain drug development. NeuroRx., 2005, 2, 3-14.
    • (2005) NeuroRx. , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 29
    • 84859996647 scopus 로고    scopus 로고
    • Modern methods for delivery of drugs across the blood-brain barrier
    • Chen, Y.; Liu, L. Modern methods for delivery of drugs across the blood-brain barrier. Adv. Drug Deliv. Rev., 2012, 64, 640-65.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 640-665
    • Chen, Y.1    Liu, L.2
  • 30
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott, N.J.; Rönnbäck, L.; Hansson, E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci., 2006, 7, 41-53.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 31
    • 0027404655 scopus 로고
    • Peptidases, peptides, and the mammalian blood-brain barrier
    • Brownlees, J.; Williams, C.H. Peptidases, peptides, and the mammalian blood-brain barrier. J. Neurochem., 1993, 60, 793-803.
    • (1993) J. Neurochem. , vol.60 , pp. 793-803
    • Brownlees, J.1    Williams, C.H.2
  • 32
    • 0035800407 scopus 로고    scopus 로고
    • Regional differences in peptide degradation by rat cerebral microvessels: A potential novel regulatory mechanism for communication between blood and brain
    • Kastin, A.J.; Hahn, K.; Zadina, J.E. Regional differences in peptide degradation by rat cerebral microvessels: a potential novel regulatory mechanism for communication between blood and brain. Life Sci., 2001, 69, 1305-12.
    • (2001) Life Sci. , vol.69 , pp. 1305-1312
    • Kastin, A.J.1    Hahn, K.2    Zadina, J.E.3
  • 33
    • 58149192688 scopus 로고    scopus 로고
    • Delivery of peptides to the brain: Emphasis on therapeutic development
    • Banks, W.A. Delivery of peptides to the brain: emphasis on therapeutic development. Biopolymers, 2008, 90, 589-94.
    • (2008) Biopolymers , vol.90 , pp. 589-594
    • Banks, W.A.1
  • 34
    • 67650033008 scopus 로고    scopus 로고
    • Characteristics of compounds that cross the bloodbrain barrier
    • Banks, W.A. Characteristics of compounds that cross the bloodbrain barrier. BMC Neurol., 2009, 9, 1-5.
    • (2009) BMC Neurol. , vol.9 , pp. 1-5
    • Banks, W.A.1
  • 35
    • 57149110011 scopus 로고    scopus 로고
    • CNS delivery via adsorptive transcytosis
    • Hervé, F.; Ghinea, N.; Scherrmann, J.M. CNS delivery via adsorptive transcytosis. AAPS J., 2008, 10, 455-72.
    • (2008) AAPS J. , vol.10 , pp. 455-472
    • Hervé, F.1    Ghinea, N.2    Scherrmann, J.M.3
  • 37
    • 2442486669 scopus 로고    scopus 로고
    • Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells
    • Somogyvari-Vigh, A.; Kastin, A.J.; Liao, J.; Zadina, J.E.; Pan, W. Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells. Exp. Brain Res., 2004, 156, 224-30.
    • (2004) Exp. Brain Res. , vol.156 , pp. 224-230
    • Somogyvari-Vigh, A.1    Kastin, A.J.2    Liao, J.3    Zadina, J.E.4    Pan, W.5
  • 38
    • 0034194886 scopus 로고    scopus 로고
    • The blood-nerve barrier: Enzymes, transporters and receptors-A comparison with the blood-brain barrier
    • Allt, G.; Lawrenson, J.G. The blood-nerve barrier: enzymes, transporters and receptors-a comparison with the blood-brain barrier. Brain Res. Bull., 2000, 52, 1-12.
    • (2000) Brain Res. Bull. , vol.52 , pp. 1-12
    • Allt, G.1    Lawrenson, J.G.2
  • 39
    • 0016354690 scopus 로고
    • Lipid solubility and drug penetration of the bloodbrain barrier
    • Oldendorf, W.H. Lipid solubility and drug penetration of the bloodbrain barrier. Proc. Soc. Exp. Biol. Med., 1974, 147, 813-16.
    • (1974) Proc. Soc. Exp. Biol. Med. , vol.147 , pp. 813-816
    • Oldendorf, W.H.1
  • 43
    • 0035748363 scopus 로고    scopus 로고
    • Peptide drug modifications to enhance bioavailability and bloodbrain barrier permeability
    • Witt, K.A.; Gillespie, T.J.; Huber, J.D.; Egleton, R.D.; Davis, T.P. Peptide drug modifications to enhance bioavailability and bloodbrain barrier permeability. Peptides, 2001, 22, 2329-43.
    • (2001) Peptides , vol.22 , pp. 2329-2343
    • Witt, K.A.1    Gillespie, T.J.2    Huber, J.D.3    Egleton, R.D.4    Davis, T.P.5
  • 44
    • 48949117592 scopus 로고    scopus 로고
    • Blood-brain barrier and feeding: Regulatory roles of saturable transport systems for ingestive peptides
    • Kastin, A.J.; Pan, W. Blood-brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides. Curr. Pharm. Des., 2008, 14, 1615-9.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1615-1619
    • Kastin, A.J.1    Pan, W.2
  • 45
    • 24144479258 scopus 로고    scopus 로고
    • Glycosylated neuropeptides: A new vista for neuropsychopharmacology?
    • Polt, R.; Dhanasekaran, M.; Keyari, C.M. Glycosylated neuropeptides: a new vista for neuropsychopharmacology? Med. Res. Rev., 2005, 25, 557-85.
    • (2005) Med. Res. Rev. , vol.25 , pp. 557-585
    • Polt, R.1    Dhanasekaran, M.2    Keyari, C.M.3
  • 46
    • 43049097850 scopus 로고    scopus 로고
    • Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: Role of lipophilicity vs structural flexibility
    • Ballet, S.; Misicka, A.; Kosson, P.; Lemieux, C.; Chung, N.N.; Schiller, P.W.; Lipkowski, A.W.; Tourwé, D. Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. J. Med. Chem., 2008, 51, 2571-4.
    • (2008) J. Med. Chem. , vol.51 , pp. 2571-2574
    • Ballet, S.1    Misicka, A.2    Kosson, P.3    Lemieux, C.4    Chung, N.N.5    Schiller, P.W.6    Lipkowski, A.W.7    Tourwé, D.8
  • 47
    • 17844372759 scopus 로고    scopus 로고
    • New prospects for glycopeptide based analgesia: Glycoside-induced penetration of the blood-brain barrier
    • Dhanasekaran, M.; Polt, R. New prospects for glycopeptide based analgesia: glycoside-induced penetration of the blood-brain barrier. Curr. Drug Deliv., 2005, 2, 59-73.
    • (2005) Curr. Drug Deliv. , vol.2 , pp. 59-73
    • Dhanasekaran, M.1    Polt, R.2
  • 48
    • 0029871091 scopus 로고    scopus 로고
    • The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system
    • Begley, D.J. The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system. J. Pharm. Pharmacol., 1996, 48, 136-46.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 136-146
    • Begley, D.J.1
  • 49
    • 7444226830 scopus 로고    scopus 로고
    • Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility
    • Dehring, K.A.; Workman, H.L.; Miller, K.D.; Mandagere, A.; Poole, S.K. Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility. J. Pharm. Biomed. Anal., 2004, 36, 447-56.
    • (2004) J. Pharm. Biomed. Anal. , vol.36 , pp. 447-456
    • Dehring, K.A.1    Workman, H.L.2    Miller, K.D.3    Mandagere, A.4    Poole, S.K.5
  • 50
    • 33646664658 scopus 로고    scopus 로고
    • Transport systems for opioid peptides in mammalian tissues
    • Ganapathy, V.; Miyauchi, S. Transport systems for opioid peptides in mammalian tissues. AAPS J., 2005, 7, E852-6.
    • (2005) AAPS J. , vol.7
    • Ganapathy, V.1    Miyauchi, S.2
  • 51
    • 77952545323 scopus 로고    scopus 로고
    • Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides
    • Van Dorpe, S.; Adriaens, A.; Polis, I.; Peremans, K.; Van Bocxlaer, J.; De Spiegeleer, B. Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides. Peptides, 2010, 31, 1390-9.
    • (2010) Peptides , vol.31 , pp. 1390-1399
    • Van Dorpe, S.1    Adriaens, A.2    Polis, I.3    Peremans, K.4    Van Bocxlaer, J.5    De Spiegeleer, B.6
  • 52
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagonlike peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin, A.J.; Akerstrom, V.; Pan, W.H. Interactions of glucagonlike peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci., 2002, 18, 7-14.
    • (2002) J. Mol. Neurosci. , vol.18 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.H.3
  • 53
    • 0032781654 scopus 로고    scopus 로고
    • Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry
    • Peter, A.; Toth, G.; Tomboly, C.; Laus, G.; Tourwe, D. Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry. J. Chromatogr. A, 1999, 846, 39-48.
    • (1999) J. Chromatogr. A , vol.846 , pp. 39-48
    • Peter, A.1    Toth, G.2    Tomboly, C.3    Laus, G.4    Tourwe, D.5
  • 54
    • 0036711009 scopus 로고    scopus 로고
    • In vitro quantitative study of the degradation of endomorphins
    • Tomboly, C.; Peter, A.; Toth, G. In vitro quantitative study of the degradation of endomorphins. Peptides, 2002, 23, 1573-80.
    • (2002) Peptides , vol.23 , pp. 1573-1580
    • Tomboly, C.1    Peter, A.2    Toth, G.3
  • 56
    • 84857463177 scopus 로고    scopus 로고
    • In vitro blood-brain barrier models: Current and perspective technologies
    • Naik, P.; Cucullo, L. In vitro blood-brain barrier models: current and perspective technologies. J. Pharm. Sci., 2012, 101, 1337-54.
    • (2012) J. Pharm. Sci. , vol.101 , pp. 1337-1354
    • Naik, P.1    Cucullo, L.2
  • 57
    • 84860339691 scopus 로고    scopus 로고
    • Endomorphins: Potential roles and therapeutic indications in the development of opioid peptide analgesic drugs
    • Liu, W.X.; Wang, R. Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs. Med. Res. Rev., 2012, 32, 536-80.
    • (2012) Med. Res. Rev. , vol.32 , pp. 536-580
    • Liu, W.X.1    Wang, R.2
  • 58
    • 34447521097 scopus 로고
    • Correlation of biological activity of phenoxyacetic acids with hammett substituent constants and partition coefficients
    • Hansch, C.; Maloney, P.P.; Fujita, T. Correlation of biological activity of phenoxyacetic acids with hammett substituent constants and partition coefficients. Nature, 1962, 194, 178-80.
    • (1962) Nature , vol.194 , pp. 178-180
    • Hansch, C.1    Maloney, P.P.2    Fujita, T.3
  • 59
    • 0036786475 scopus 로고    scopus 로고
    • Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II
    • Hau, V.; Huber, J.D.; Campos, C.R.; Lipkowski, A.W.; Misicka, A.; Davis, T.P. Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II. J. Pharm. Sci., 2002, 91, 2140-9.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 2140-2149
    • Hau, V.1    Huber, J.D.2    Campos, C.R.3    Lipkowski, A.W.4    Misicka, A.5    Davis, T.P.6
  • 60
    • 33748996832 scopus 로고    scopus 로고
    • Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1
    • Liu, H.; Liu, X.; Yao, J.; Wang, C.; Yu, Y.; Wang, R. Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. J. Pharmacol. Exp. Ther., 2006, 319, 308-16.
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 308-316
    • Liu, H.1    Liu, X.2    Yao, J.3    Wang, C.4    Yu, Y.5    Wang, R.6
  • 61
    • 33847789994 scopus 로고    scopus 로고
    • Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization
    • Liu, H.; Zhang, B.; Liu, X.; Wang, C.; Ni, J.; Wang, R. Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg. Med. Chem., 2007, 15, 1694-702.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 1694-1702
    • Liu, H.1    Zhang, B.2    Liu, X.3    Wang, C.4    Ni, J.5    Wang, R.6
  • 62
    • 0035984809 scopus 로고    scopus 로고
    • Predicting blood-brain barrier permeability of drugs: Evaluation of different in vitro assays
    • Lohmann, C.; Hüwel, S.; Galla, H.J. Predicting blood-brain barrier permeability of drugs: evaluation of different in vitro assays. J. Drug Target., 2002, 10, 263-76.
    • (2002) J. Drug Target. , vol.10 , pp. 263-276
    • Lohmann, C.1    Hüwel, S.2    Galla, H.J.3
  • 65
    • 17644364387 scopus 로고    scopus 로고
    • Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions
    • Roux, F.; Couraud, P.O. Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions. Cell Mol. Neurobiol., 2005, 25, 41-58.
    • (2005) Cell Mol. Neurobiol. , vol.25 , pp. 41-58
    • Roux, F.1    Couraud, P.O.2
  • 66
    • 84865280295 scopus 로고    scopus 로고
    • Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells
    • Hakkarainen, J.J.; Pajander, J.; Laitinen, R.; Suhonen, M.; Forsberg, M.M. Similar molecular descriptors determine the in vitro drug permeability in endothelial and epithelial cells. Int. J. Pharm. 2012, 436, 426-43.
    • (2012) Int. J. Pharm. , vol.436 , pp. 426-443
    • Hakkarainen, J.J.1    Pajander, J.2    Laitinen, R.3    Suhonen, M.4    Forsberg, M.M.5
  • 67
    • 81855206518 scopus 로고    scopus 로고
    • Drug-permeability and transporter assays in Caco-2 and MDCK cell lines
    • Volpe, D.A. Drug-permeability and transporter assays in Caco-2 and MDCK cell lines. Future Med. Chem., 2011, 3, 2063-77.
    • (2011) Future Med. Chem. , vol.3 , pp. 2063-2077
    • Volpe, D.A.1
  • 68
    • 41149178098 scopus 로고    scopus 로고
    • Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migration
    • Man, S.; Ubogu, E.E.; Williams, K.A.; Tucky, B.; Callahan, M.K.; Ransohoff, R.M. Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migration. Clin. Dev. Immunol., 2008, 2008, 384982.
    • (2008) Clin. Dev. Immunol. , vol.2008 , pp. 384982
    • Man, S.1    Ubogu, E.E.2    Williams, K.A.3    Tucky, B.4    Callahan, M.K.5    Ransohoff, R.M.6
  • 69
    • 33847613951 scopus 로고    scopus 로고
    • Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide
    • Koda, Y.; Shiotani, K.; Toth, I.; Tsuda, Y.; Okada, Y.; Blanchfield, J.T. Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide. Bioorg. Med. Chem. Lett., 2007, 17, 2043-6.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2043-2046
    • Koda, Y.1    Shiotani, K.2    Toth, I.3    Tsuda, Y.4    Okada, Y.5    Blanchfield, J.T.6
  • 71
    • 42649132468 scopus 로고    scopus 로고
    • In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue
    • Koda, Y.; Liang, M.T.; Blanchfield, J.T.; Toth, I. In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue. Int. J. Pharm., 2008, 356, 37-43.
    • (2008) Int. J. Pharm. , vol.356 , pp. 37-43
    • Koda, Y.1    Liang, M.T.2    Blanchfield, J.T.3    Toth, I.4
  • 72
    • 43049162813 scopus 로고    scopus 로고
    • Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer
    • Iwan, M.; Jarmolowska, B.; Bielikowicz, K.; Kostyra, E.; Kostyra, H.; Kaczmarski, M. Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Peptides, 2008, 29, 1042-7.
    • (2008) Peptides , vol.29 , pp. 1042-1047
    • Iwan, M.1    Jarmolowska, B.2    Bielikowicz, K.3    Kostyra, E.4    Kostyra, H.5    Kaczmarski, M.6
  • 74
    • 12344322943 scopus 로고    scopus 로고
    • How to measure drug transport across the blood-brain barrier
    • Bickel, U. How to measure drug transport across the blood-brain barrier. NeuroRx., 2005, 2(1), 15-26.
    • (2005) NeuroRx. , vol.2 , Issue.1 , pp. 15-26
    • Bickel, U.1
  • 75
    • 67049114278 scopus 로고    scopus 로고
    • Comparison of blood-brain barrier permeability assays: In situ brain perfusion, MDR1-MDCKII and PAMPA-BBB
    • Di, L.; Kerns, E.H.; Bezar, I.F.; Petusky, S.L.; Huang, Y. Comparison of blood-brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB. J. Pharm. Sci., 2009, 98, 1980-91.
    • (2009) J. Pharm. Sci. , vol.98 , pp. 1980-1991
    • Di, L.1    Kerns, E.H.2    Bezar, I.F.3    Petusky, S.L.4    Huang, Y.5
  • 76
    • 84862846592 scopus 로고    scopus 로고
    • A novel hypothesis of blood-brain barrier (BBB) development and in vitro BBB model: Neural stem cell is the driver of BBB formation and maintenance
    • Lu, J. A novel hypothesis of blood-brain barrier (BBB) development and in vitro BBB model: neural stem cell is the driver of BBB formation and maintenance. J. Exp. Integr. Med., 2012, 2, 39-43.
    • (2012) J. Exp. Integr. Med. , vol.2 , pp. 39-43
    • Lu, J.1
  • 80
    • 17444406065 scopus 로고    scopus 로고
    • Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology
    • Deli, M.A.; Abrahám, C.S.; Kataoka, Y.; Niwa, M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell Mol. Neurobiol., 2005, 25, 59-127.
    • (2005) Cell Mol. Neurobiol. , vol.25 , pp. 59-127
    • Deli, M.A.1    Abrahám, C.S.2    Kataoka, Y.3    Niwa, M.4
  • 81
    • 0030911575 scopus 로고    scopus 로고
    • Structure-activity relationships of a series of [D-Ala2]deltorphin i and II analogues; In vitro blood-brain barrier permeability and stability
    • Thomas, S.A.; Abbruscato, T.J.; Hau, V.S.; Gillespie, T.J.; Zsigo, J.; Hruby, V.J.; Davis, T.P. Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J. Pharmacol. Exp. Ther., 1997, 281, 817-25.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 817-825
    • Thomas, S.A.1    Abbruscato, T.J.2    Hau, V.S.3    Gillespie, T.J.4    Zsigo, J.5    Hruby, V.J.6    Davis, T.P.7
  • 83
    • 79551646674 scopus 로고    scopus 로고
    • A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system
    • Cucullo, L.; Marchi, N.; Hossain, M.; Janigro, D. A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system. J. Cereb. Blood Flow. Metab., 2011, 31, 767-77.
    • (2011) J. Cereb. Blood Flow. Metab. , vol.31 , pp. 767-777
    • Cucullo, L.1    Marchi, N.2    Hossain, M.3    Janigro, D.4
  • 84
    • 33747770301 scopus 로고    scopus 로고
    • Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: A permeability study
    • Santaguida, S.; Janigro, D.; Hossain, M.; Oby, E.; Rapp, E.; Cucullo, L. Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: a permeability study. Brain Res., 2006, 1109, 1-13.
    • (2006) Brain Res. , vol.1109 , pp. 1-13
    • Santaguida, S.1    Janigro, D.2    Hossain, M.3    Oby, E.4    Rapp, E.5    Cucullo, L.6
  • 86
    • 0029689906 scopus 로고    scopus 로고
    • Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system
    • Smith, Q.R. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system. Pharm. Biotechnol., 1996, 8, 285307.
    • (1996) Pharm. Biotechnol. , vol.8 , pp. 285307
    • Smith, Q.R.1
  • 88
    • 33644788804 scopus 로고    scopus 로고
    • CNS drug delivery: Opioid peptides and the blood-brain barrier
    • Witt, K.A.; Davis, T.P. CNS drug delivery: opioid peptides and the blood-brain barrier. AAPS J., 2006, 8, E76-88.
    • (2006) AAPS J. , vol.8
    • Witt, K.A.1    Davis, T.P.2
  • 91
    • 14544294044 scopus 로고    scopus 로고
    • Conformationally restricted peptides as tools in opioid receptor studies
    • Janecka, A.; Kruszynski, R. Conformationally restricted peptides as tools in opioid receptor studies. Curr. Med. Chem., 2005, 12, 471-81.
    • (2005) Curr. Med. Chem. , vol.12 , pp. 471-481
    • Janecka, A.1    Kruszynski, R.2
  • 93
    • 84865095335 scopus 로고    scopus 로고
    • Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation
    • Varamini, P.; Mansfeld, F.M.; Blanchfield, J.T.; Wyse, B.D.; Smith, M.T.; Toth, I. Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 2012, 7, e41909.
    • (2012) PLoS One , vol.7
    • Varamini, P.1    Mansfeld, F.M.2    Blanchfield, J.T.3    Wyse, B.D.4    Smith, M.T.5    Toth, I.6
  • 94
    • 84867580402 scopus 로고    scopus 로고
    • Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives
    • Varamini, P.; Hussein, W.M.; Mansfeld, F.M.; Toth I. Synthesis, biological activity and structure-activity relationship of endomorphin-1/ substance P derivatives. Bioorg. Med. Chem., 2012, 20, 6335-43.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 6335-6343
    • Varamini, P.1    Hussein, W.M.2    Mansfeld, F.M.3    Toth, I.4
  • 95
    • 0023200855 scopus 로고
    • Absorptivemediated endocytosis of cationized albumin and a beta-endorphincationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport
    • Kumagai, A.K.; Eisenberg, J.B.; Pardridge, W.M. Absorptivemediated endocytosis of cationized albumin and a beta-endorphincationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport. J. Biol. Chem., 1987, 262, 15214-9.
    • (1987) J. Biol. Chem. , vol.262 , pp. 15214-15219
    • Kumagai, A.K.1    Eisenberg, J.B.2    Pardridge, W.M.3
  • 96
    • 0037038319 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB)
    • Ogawa, T.; Miyamae, T.; Murayama, K.; Okuyama, K.; Okayama, T.; Hagiwara, M.; Sakurada, S.; Morikawa, T. Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr- D-Arg-Phe-MebetaAla-OH (ADAMB). J. Med. Chem., 2002, 45, 5081-89.
    • (2002) J. Med. Chem. , vol.45 , pp. 5081-5089
    • Ogawa, T.1    Miyamae, T.2    Murayama, K.3    Okuyama, K.4    Okayama, T.5    Hagiwara, M.6    Sakurada, S.7    Morikawa, T.8
  • 97
    • 0027519943 scopus 로고
    • Protein glycosylation. Structural and functional aspects
    • Lis, H.; Sharon N. Protein glycosylation. Structural and functional aspects. Eur. J. Biochem., 1993, 218, 1-27.
    • (1993) Eur. J. Biochem. , vol.218 , pp. 1-27
    • Lis, H.1    Sharon, N.2
  • 100
    • 0034812006 scopus 로고    scopus 로고
    • Glycopeptide analgesics
    • Palian, M.M.; Polt, R.L. Glycopeptide analgesics. Drug. Future, 2001, 26, 561-76.
    • (2001) Drug. Future , vol.26 , pp. 561-576
    • Palian, M.M.1    Polt, R.L.2
  • 103
    • 0032971927 scopus 로고    scopus 로고
    • Dermorphin and deltorphin glycosylated analogues: Synthesis and antinociceptive activity after systemic administration
    • Negri, L.; Lattanzi, R.; Tabacco, F.; Orru, L.; Severini, C.; Scolaro, B.; Rocchi, R. Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration. J. Med. Chem., 1999, 42, 400-4.
    • (1999) J. Med. Chem. , vol.42 , pp. 400-404
    • Negri, L.1    Lattanzi, R.2    Tabacco, F.3    Orru, L.4    Severini, C.5    Scolaro, B.6    Rocchi, R.7
  • 104
    • 37049082387 scopus 로고
    • Synthesis and biological activity of O-glycosylated morphiceptin analogues
    • Bardají, E.; Torres, J.L.; Clapés, P.; Albericio, F.; Barany, G.; Rodríguez, R.E., Sacristán, M.P.; Valencia, G. Synthesis and biological activity of O-glycosylated morphiceptin analogues. J. Chem. Soc. Perkin Trans., 1991, 1, 1755-9.
    • (1991) J. Chem. Soc. Perkin Trans. , vol.1 , pp. 1755-1759
    • Bardají, E.1    Torres, J.L.2    Clapés, P.3    Albericio, F.4    Barany, G.5
  • 107
    • 0033539134 scopus 로고    scopus 로고
    • The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats
    • Schiller, P.W.; Fundytus, M.E.; Merovitz, L.; Weltrowska, G.; Nguyen, T.M.; Lemieux, C.; Chung, N.N.; Coderre, T.J. The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats. J. Med. Chem., 1999, 42, 3520-6.
    • (1999) J. Med. Chem. , vol.42 , pp. 3520-3526
    • Schiller, P.W.1    Fundytus, M.E.2    Merovitz, L.3    Weltrowska, G.4    Nguyen, T.M.5    Lemieux, C.6    Chung, N.N.7    Coderre, T.J.8
  • 108
    • 0033851469 scopus 로고    scopus 로고
    • Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads
    • Hruby, V.J.; Balse, P.M. Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Curr. Med. Chem., 2000, 7, 945-70.
    • (2000) Curr. Med. Chem. , vol.7 , pp. 945-970
    • Hruby, V.J.1    Balse, P.M.2
  • 109
    • 0041475925 scopus 로고    scopus 로고
    • The cyclization of peptides and depsipeptides
    • Davies, J.S. The cyclization of peptides and depsipeptides. J. Peptide Sci., 2003, 9, 471-501.
    • (2003) J. Peptide Sci. , vol.9 , pp. 471-501
    • Davies, J.S.1
  • 110
    • 4744353375 scopus 로고    scopus 로고
    • Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-]
    • Cardillo, G.; Gentilucci, L.; Tolomelli, A.; Spinosa, R.; Calienni, M.; Qasem, A.R.; Spampinato, S. Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-]. J. Med. Chem., 2004, 47, 5198-203.
    • (2004) J. Med. Chem. , vol.47 , pp. 5198-5203
    • Cardillo, G.1    Gentilucci, L.2    Tolomelli, A.3    Spinosa, R.4    Calienni, M.5    Qasem, A.R.6    Spampinato, S.7
  • 112
    • 77957830877 scopus 로고    scopus 로고
    • Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model
    • Bedini, A.; Baiula, M.; Gentilucci, L.; Tolomelli, A.; De Marco, R.; Spampinato, S. Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model. Peptides, 2010, 31, 2135-40.
    • (2010) Peptides , vol.31 , pp. 2135-2140
    • Bedini, A.1    Baiula, M.2    Gentilucci, L.3    Tolomelli, A.4    De Marco, R.5    Spampinato, S.6
  • 116
    • 0036257686 scopus 로고    scopus 로고
    • Converting a peptide into a drug: Strategies to improve stability and bioavailability
    • Adessi, C.; Soto, C. Converting a peptide into a drug: strategies to improve stability and bioavailability. Curr. Med. Chem., 2002, 9, 963-78.
    • (2002) Curr. Med. Chem. , vol.9 , pp. 963-978
    • Adessi, C.1    Soto, C.2
  • 119
    • 84891350619 scopus 로고    scopus 로고
    • Developmental potential for endomorphin opioidmimetic drugs
    • doi:10.1155/2012/715123
    • Okada, Y.; Tsuda, Y.; Salvadori, S.; Lazarus, LH. Developmental potential for endomorphin opioidmimetic drugs. Int. J. Med. Chem., 2012, doi:10.1155/2012/715123.
    • (2012) Int. J. Med. Chem.
    • Okada, Y.1    Tsuda, Y.2    Salvadori, S.3    Lazarus, L.H.4
  • 120
    • 34848892144 scopus 로고    scopus 로고
    • Cell penetrating peptides: Intracellular pathways and pharmaceutical perspectives
    • Patel, L.N.; Zaro, J.L.; Shen, W.C. Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Pharm. Res., 2007, 24, 1977-92.
    • (2007) Pharm. Res. , vol.24 , pp. 1977-1992
    • Patel, L.N.1    Zaro, J.L.2    Shen, W.C.3
  • 121
    • 9644289511 scopus 로고    scopus 로고
    • The use of cell-penetrating peptides for drug delivery
    • Temsamani, J.; Vidal, P. The use of cell-penetrating peptides for drug delivery. Drug Discov. Today, 2004, 9, 1012-9.
    • (2004) Drug Discov. Today , vol.9 , pp. 1012-1019
    • Temsamani, J.1    Vidal, P.2
  • 123
    • 38049054284 scopus 로고    scopus 로고
    • Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus
    • Yu, Y.; Shao, X.; Cui, Y.; Liu, H.M.; Wang, C.L.; Fan, Y.Z.; Liu, J.; Dong, S.L.; Cui, Y.X.; Wang, R. Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus. Chem. Med. Chem., 2007, 2, 309-17.
    • (2007) Chem. Med. Chem. , vol.2 , pp. 309-317
    • Yu, Y.1    Shao, X.2    Cui, Y.3    Liu, H.M.4    Wang, C.L.5    Fan, Y.Z.6    Liu, J.7    Dong, S.L.8    Cui, Y.X.9    Wang, R.10
  • 124
    • 78751645959 scopus 로고    scopus 로고
    • Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine
    • Wang, C.L.; Guo, C.; Wang, Y.Q.; Zhou, Y.; Li, Q.; Ni, J.M.; Wang, R. Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine. Peptides, 2011, 32, 293-9.
    • (2011) Peptides , vol.32 , pp. 293-299
    • Wang, C.L.1    Guo, C.2    Wang, Y.Q.3    Zhou, Y.4    Li, Q.5    Ni, J.M.6    Wang, R.7
  • 125
  • 127
    • 24644453083 scopus 로고    scopus 로고
    • Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery
    • Fahr, A.; Van Hoogevest, P.; May, S.; Bergstrand, N.; Leigh, M.L.S. Transfer of lipophilic drugs between liposomal membranes and biological interfaces: consequences for drug delivery. Eur. J. Pharm. Sci., 2005, 26, 251-65.
    • (2005) Eur. J. Pharm. Sci. , vol.26 , pp. 251-265
    • Fahr, A.1    Van Hoogevest, P.2    May, S.3    Bergstrand, N.4    Leigh, M.L.S.5
  • 128
    • 0032052587 scopus 로고    scopus 로고
    • Liposomes: Quo vadis?
    • Storm, G.; Crommelin, D.J.A. Liposomes: quo vadis? PSTT, 1998, 1, 19-31.
    • (1998) PSTT , vol.1 , pp. 19-31
    • Storm, G.1    Crommelin, D.J.A.2
  • 129
    • 23944455905 scopus 로고    scopus 로고
    • Encapsulation of lipopeptides within liposomes: Effect of number of lipid chains, chain length and method of liposome preparation
    • Liang, M.T.; Davies, N.M.; Toth, I. Encapsulation of lipopeptides within liposomes: effect of number of lipid chains, chain length and method of liposome preparation. Int. J. Pharm., 2005, 301, 247-54.
    • (2005) Int. J. Pharm. , vol.301 , pp. 247-254
    • Liang, M.T.1    Davies, N.M.2    Toth, I.3
  • 130
    • 84864933593 scopus 로고    scopus 로고
    • OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co- glycolic acid) nanoparticles: Synthesis, characterization and evaluation of its brain delivery ability
    • Bao, H.; Jin, X.; Li, L.; Lv, F.; Liu, T. OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co-glycolic acid) nanoparticles: synthesis, characterization and evaluation of its brain delivery ability. J. Mater Sci. Mater Med., 2012, 23, 1891-901.
    • (2012) J. Mater Sci. Mater Med. , vol.23 , pp. 1891-1901
    • Bao, H.1    Jin, X.2    Li, L.3    Lv, F.4    Liu, T.5


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