Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, Nα-amidino-Tyr-D-Arg-Phe-MeβAla-OH (ADAMB)

Journal of Medicinal Chemistry

Volumn 45, Issue 23, 2002, Pages 5081-5089

  Ogawa, Tadashi ^a   Miyamae, Tetsuhisa ^a   Murayama, Kimie ^b   Okuyama, Kaori ^c   Okayama, Toru ^a   Hagiwara, Masaki ^a   Sakurada, Shinobu ^c   Morikawa, Tadanori ^a  

^a Daiichi Fine Chemical Co Ltd   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; DELTORPHIN; DERMORPHIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MORPHINE; N ALPHA AMIDINOTYROSYL DEXTRO ARGINYLPHENYLALANINE BETA ALANINE METHYL ESTER; N ALPHA AMIDINOTYROSYL DEXTRO ARGINYLPHENYLALANYLGLYCINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONAZINE; NALOXONE; OPIATE; TYROSYL DEXTRO ARGINYLPHENYLALANINE BETA ALANINE; TYROSYL DEXTRO ARGINYLPHENYLALANINE SARCOSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CEREBELLUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUINEA PIGS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MORPHINE; OLIGOPEPTIDES; PAIN MEASUREMENT; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SPINAL CORD; STRUCTURE-ACTIVITY RELATIONSHIP; TAIL;

EID: 0037038319     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010357t     Document Type: Article

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