Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells

Toxicological Sciences

Volumn 118, Issue 1, 2010, Pages 160-170

  Trickler, William J ^a   Lantz, Susan M ^a   Murdock, Richard C ^b   Schrand, Amanda M ^b   Robinson, Bonnie L ^a   Newport, Glenn D ^a   Schlager, John J ^b   Oldenburg, Steven J ^c   Paule, Merle G ^a   Slikker Jr , William ^a   Hussain, Saber M ^b   Ali, Syed F ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

^c NanoComposix Inc   (United States)

Author keywords

Blood brain barrier; Neuroinflamation; Neurotoxicity; Rat brain microvessel endothelial cells; Silver nanoparticles

Indexed keywords

FLUORESCEIN; INTERLEUKIN 1BETA; INTERLEUKIN 2; PROSTAGLANDIN E2; SILVER NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN MICROVESSEL ENDOTHELIAL CELL; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENCEPHALITIS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOTOXICITY; IN VITRO STUDY; LASER DOPPLER FLOWMETRY; LIGHT SCATTERING; MEMBRANE PERMEABILITY; MICROVASCULATURE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; INFLAMMATION; INFLAMMATION MEDIATORS; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVESSELS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SCATTERING, RADIATION; SILVER;

RATTUS;

EID: 77958459116     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq244     Document Type: Article

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