SCOPUS 정보 검색 플랫폼

Current Medicinal Chemistry

Volumn 9, Issue 9, 2002, Pages 963-978

Converting a peptide into a drug: Strategies to improve stability and bioavailability

(2) Adessi, Céline a Soto, Claudio a

a SERONO PHARMACEUTICAL RES INSTITUTE (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ATAZANAVIR; AZAPEPTIDE; BETA ENDORPHIN; CHYMOTRYPSIN INHIBITOR; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYCLOPEPTIDE; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GONADORELIN; HYPOTHALAMUS HORMONE; INTERMEDIN; LEUCINE ENKEPHALIN; MELANOSTATIN; METENKEPHALIN; NEUROTENSIN; OPIATE; OXYTOCIN; PEPTIDE DERIVATIVE; PEPTIDE HORMONE; PROTEINASE INHIBITOR; PROTIRELIN; PSEUDOPEPTIDE; SERINE PROTEINASE INHIBITOR; SOMATOMEDIN; SOMATOSTATIN; TYROSYLPROLYLLEUCYLGLYCINAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOPRESSIN;

BLOOD BRAIN BARRIER; CHEMICAL MODIFICATION; CHEMICAL PROCEDURES; CHIRALITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; MEMBRANE PERMEABILITY; PROTEIN DEGRADATION; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0036257686 PISSN: 09298673 EISSN: None Source Type: Journal
DOI: 10.2174/0929867024606731 Document Type: Review

Times cited : (576)

References (159)

1
- 0021110888
- (1983) Life Sci , vol.32 , pp. 295
- Kastin, A.J.¹ Banks, W.A.² Zadina, J.E.³ Graf, M.⁴

2
- 0028114088
- (1994) Peptides , vol.15 , pp. 1105
- Ahmed, B.¹ Kastin, A.J.² Banks, W.A.³ Zadina, J.E.⁴

3
- 0027957594
- (1994) Neurosci. Biobehav. Rev , vol.18 , pp. 143
- Maness, L.M.¹ Kastin, A.J.² Weber, J.T.³ Banks, W.A.⁴ Beckman, B.S.⁵ Zadina, J.E.⁶

4
- 0009161935
- Reid, R.E., Ed.; ACS Professional Reference book: New York
- (2000) Peptide and Protein Drug Analysis , vol.17 , pp. 387-422
- Sawyer, T.K.¹

5
- 0001895966
- Strand, F.L., Ed.; The MIT Press: Cambridge
- (1999) Neuropeptides. Regulators of Physiological Process , vol.3 , pp. 43-64
- Strand, F.L.¹

6
- 0000788606
- Weinstein, B., Ed.; Marcel Dekker: New York
- (1983) Chemistry and Biochemistry of Peptides and Proteins , vol.7 , pp. 267-357
- Spatola, A.F.¹

7
- 85037017409
- (1995) Pharmaceutical News , vol.2 , pp. 12
- Shihong, L.¹ Schöneich, C.² Borchardt, R.T.³

8
- 0027404655
- (1993) J. Neurochem , vol.60 , pp. 793
- Brownlees, J.¹ Williams, C.H.²

9
- 0026688157
- (1992) Adv. Drug Res , vol.23 , pp. 127
- Fauchèere, J.-L.¹ Thuriau, C.²

10
- 77956836899
- (1993) Antimicrob. Agents Chemother , vol.28 , pp. 285
- Powell, M.F.¹

11
- 0024388447
- (1989) Peptides , vol.10 , pp. 1063
- Orawski, A.T.¹ Simmons, W.H.²

12
- 0028197169
- (1993) Biochem. Pharmacol , vol.47 , pp. 699
- Kastin, A.J.¹ Hahn, K.² Erchegyi, J.³ Zadina, J.E.⁴ Hackler, L.⁵ Palmgren, M.⁶ Banks, W.A.⁷

13
- 0000466789
- McCubbin, J.A., Kauffman, P.G., and Nemeroff, C.B., Ed.; Academic Press Limited: San Diego
- (1991) Stress, Neuropeptides, and Systemic Disease , vol.8 , pp. 149-177
- Davis, T.P.¹

14
- 0009161936
- Reid, R. E., Ed.; Marcel Decker, Inc: New York
- (2000) Peptide and Protein Drug Analysis , vol.16 , pp. 529-553
- Garner, V.¹

15
- 0031782009
- (1998) Rapid Commun. Mass Spectrom , vol.12 , pp. 1796
- Prokai, L.¹ Zharikova, A.D.²

16
- 0032549755
- (1998) J. Chromatogr. A , vol.800 , pp. 59
- Prokai, L.¹ Kim, H.S.² Zharikova, A.³ Roboz, J.⁴ Ma, L.⁵ Deng, L.⁶ Simonsick W.J., Jr.⁷

17
- 0022917595
- (1986) Drug Metab. Rev , vol.17 , pp. 283
- Humphrey, M.J.¹ Ringrose, P.S.²

18
- 0017210982
- (1976) J. Brain Res. Bull , vol.1 , pp. 591
- Marks, N.¹ Stern, F.² Kastin, A.³

19
- 0017104309
- (1976) Life Sci , vol.19 , pp. 1271
- Benuck, M.¹ Marks, N.²

20
- 0022899739
- (1986) Peptides , vol.7 , pp. 1015
- Heavner, G.A.¹

21
- 0027853643
- (1993) J. Pharmacol. Exp. Ther , vol.266 , pp. 1649
- Weber, S.J.¹ Abbruscato, T.J.² Brownson, E.A.³ Lipkowski, A.W.⁴ Polt, R.⁵ Misicka, A.⁶ Haaseth, R.C.⁷ Bartosz, H.⁸ Hruby, V.J.⁹ Davis, T.P.¹⁰

22
- 0018581732
- (1979) Can. J. Biochem , vol.57 , pp. 548
- Saffran, M.¹ Franco-Saenz, R.² Kong, A.³ Papahadjopoulos, D.⁴ Szoka, F.⁵

23
- 0032827971
- (1999) J. Control Release , vol.62 , pp. 231
- Borchardt, R.T.¹

24
- 0003101732
- Basava, C. and Anantharamaiah, G. M., Ed.; Birkhäusser: Boston
- (1994) Peptides: Design, Synthesis, and Biological Activity , vol.4 , pp. 39-58
- Kates, S.A.¹ Solé, N.A.² Albericio, F.³ Barany, G.⁴

25
- 0027478912
- reviews
- (1993) Med. Res , vol.13 , pp. 327
- Wiley, R.A.¹ Rich, D.H.²

26
- 0000545418
- Wolff M.E. Ed.; John Wiley and Sons, Inc: New York
- (1995) Burger's Medicinal Chemistry and Drug Discovery , vol.20 , pp. 803-861
- Goodman, M.¹ Ro, S.²

27
- 0026357499
- (1991) J. Pharmacol. Exp. Ther , vol.259 , pp. 1109
- Weber, S.J.¹ Greene, D.L.² Sharma, S.D.³ Yamamura, H.I.⁴ Kramer, T.H.⁵ Burks, T.F.⁶ Hruby, V.J.⁷ Hersh, L.B.⁸ Davis, T.P.⁹

29
- 0027005949
- (1992) J. Pharmacol. Exp. Ther , vol.263 , pp. 1308
- Weber, S.J.¹ Greene, D.L.² Hruby, V.J.³ Yamamura, H.I.⁴ Porreca, F.⁵ Davis, T.P.⁶

30
- 0033535525
- (1999) J. Med. Chem , vol.42 , pp. 1170
- Tselios, T.¹ Probert, L.² Daliani, I.³ Matsoukas, E.⁴ Troganis, A.⁵ Gerothanassis, I.P.⁶ Mavromoustakos, T.⁷ Moore, G.J.⁸ Matsoukas, J.M.⁹

31
- 0034684761
- (2000) Bioorg. Med. Chem. Lett , vol.10 , pp. 2713
- Tselios, T.¹ Daliani, I.² Deraos, S.³ Thymianou, S.⁴ Matsoukas, E.⁵ Troganis, A.⁶ Gerothanassis, I.⁷ Mouzaki, A.⁸ Mavromoustakos, T.⁹ Probert, L.¹⁰ Matsoukas, J.¹¹

32
- 0017713371
- (1977) Proc. R. Soc. Lond B Biol. Sci , vol.198 , pp. 249
- Beddell, C.R.¹ Clark, R.B.² Hardy, G.W.³ Lowe, L.A.⁴ Ubatuba, F.B.⁵ Vane, J.R.⁶ Wilkinson, S.⁷

33
- 0019484914
- (1981) FEBS Lett , vol.123 , pp. 291
- Laufer, R.¹ Chorev, M.² Gilon, C.³ Friedman, Z.Y.⁴ Wormser, U.⁵ Selinger, Z.⁶

34
- 0025374744
- (1990) Neuropeptides , vol.16 , pp. 41
- Wormser, U.¹ Laufer, R.² Chorev, M.³ Gilon, C.⁴ Selinger, Z.⁵

35
- 0026643732
- (1992) Mol. Immunol , vol.29 , pp. 1043
- Rozycki, J.¹ Rolka, K.² Wieczorek, Z.³ Zimecki, M.⁴ Kupryszewski, G.⁵

36
- 85037022384
- Rich, D. H. and Gross, E., Ed.; Pierce: Rockford, Illinois
- (1981) Peptides: Synthesis-Structure-Function , pp. 657
- Rioux, F.¹ Quirion, F.² Kerouac, R.³ Pierre, St.S.⁴

37
- 0034012018
- (2000) J. Pharmacol. Exp. Ther , vol.293 , pp. 403
- Taylor, E.M.¹ Otero, D.A.² Banks, W.A.³ O'Brien, J.S.⁴

38
- 0026720252
- (1992) Science , vol.256 , pp. 1798
- Mendel, D.¹ Ellman, J.A.² Chang, Z.³ Veenstra, D.L.⁴ Kollman, P.A.⁵ Schultz, P.G.⁶

39
- 0001210551
- (1992) Curr. Opinion Struct. Biol , vol.2 , pp. 845
- Balaram, P.¹

40
- 0019505301
- (1981) Eur. J. Biochem , vol.114 , pp. 329
- Sandberg, B.E.¹ Lee, C.M.² Hanley, M.R.³ Iversen, L.L.⁴

41
- 0009246298
- Reid, R. E., Ed.; Marcel Decker, Inc: New York
- (2000) Peptide and Protein Drug Analysis , vol.6 , pp. 191-205
- Lesley, S.A.¹

42
- 0026955822
- (1992) Biopolymers , vol.32 , pp. 1461
- Slomczynska, U.¹ Zabrocki, J.² Kaczmarek, K.³ Leplawy, M.T.⁴ Beusen, D.D.⁵ Marshall, G.R.⁶

43
- 0028577295
- (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , pp. 12544
- Chang, T.K.¹ Jackson, D.Y.² Burnier, J.P.³ Wells, J.A.⁴

44
- 0024968835
- (1989) Science , vol.244 , pp. 182
- Noren, C.J.¹ Anthony-Cahill, S.J.² Griffith, M.C.³ Schultz, P.G.⁴

45
- 0018132040
- (1978) FEBS Lett , vol.96 , pp. 273
- Nagaraj, R.¹ Balaram, P.²

46
- 0033044804
- (1999) Mol. Med , vol.77 , pp. 412
- Soto, C.J.¹

47
- 0028994059
- (1995) Pept. Res , vol.8 , pp. 145
- Mutter, M.¹ Nefzi, A.² Sato, T.³ Sun, X.⁴ Wahl, F.⁵ Wohr, T.⁶

48
- 0032054074
- (1998) J. Am. Chem. Soc , vol.120 , pp. 2714
- Keller, M.¹ Sager, C.² Dumy, P.³ Schutkowski, M.⁴ Fischer, G.S.⁵ Mutter, M.⁶

49
- 0001012025
- (1963) Nature , vol.197 , pp. 746
- Gill, T.J.¹ Hanna, J.G.² Doty, P.³

50
- 0013799682
- (1965) Biochem. J , vol.96 , pp. 577
- Borek, F.¹ Stupp, Y.² Fuchs, S.³ Sela, M.⁴

51
- 0028577207
- (1994) Science , vol.266 , pp. 2019
- Dooley, C.T.¹ Chung, N.N.² Wilkes, B.C.³ Schiller, P.W.⁴ Bidlack, J.M.⁵ Pasternak, G.W.⁶ Houghten, R.A.⁷

52
- 0029670478
- (1996) Science , vol.271 , pp. 1854
- Schumacher, T.N.¹ Mayr, L.M.² Minor D.L., Jr.³ Milhollen, M.A.⁴ Burgess, M.W.⁵ Kim, P.S.⁶

53
- 0028875452
- (1995) Trends Biotechnol , vol.13 , pp. 438
- Chorev, M.¹ Goodman, M.²

54
- 0000845126
- (1993) Acc. Chem. Res , vol.26 , pp. 266
- Chorev, M.¹ Goodman, M.²

55
- 0018745671
- (1979) Science , vol.204 , pp. 1210
- Chorev, M.¹ Shavitz, R.² Goodman, M.³ Minick, S.⁴ Guillemin, R.⁵

56
- 0021848338
- (1985) J. Med. Chem , vol.28 , pp. 769
- Salvadori, S.¹ Marastoni, M.² Balboni, G.³ Sarto, G.P.⁴ Tomatis, R.⁵

57
- 0033820739
- (2000) J. Pharmacol. Exp. Ther , vol.295 , pp. 190
- Taylor, E.M.¹ Otero, D.A.² Banks, W.A.³ O'Brien, J.S.⁴

58
- 0031678366
- (1998) Mol. Biotechnol , vol.9 , pp. 205
- al Obeidi, F.¹ Hruby, V.J.² Sawyer, T.K.³

59
- 0018823135
- (1980) Int. J. Pept. Protein Res , vol.15 , pp. 122
- Hudson, D.¹ Sharpe, R.² Szelke, M.³

60
- 0009164005
- (1982) Hypertension , vol.4 , pp. 59
- Szelke, M.¹ Leckie, B.J.² Tree, M.³ Brown, A.⁴ Grant, J.⁵ Hallett, A.⁶ Hughes, M.⁷ Jones, D.M.⁸ Lever, A.F.⁹

61
- 0009163527
- (1979) Pharm. J , pp. 356
- Metcalf, G.¹

62
- 0019395141
- (1981) Eur. J. Pharmacol , vol.70 , pp. 531
- Handa, B.K.¹ Land, A.C.² Lord, J.A.³ Morgan, B.A.⁴ Rance, M.J.⁵ Smith, C.F.⁶

63
- 84985691877
- Rich, D. H. and Gross, E., Ed.; Pierce: Rockford
- (1981) Peptides: Synthesis-Structure-Function , pp. 463
- Natarajan, S.¹ Condon, M.E.² Nakane, M.³ Reid, J.⁴ Gordon, E.M.⁵ Cushman, D.W.⁶ Ondetti, M.A.⁷

64
- 0021833338
- (1985) Peptides , vol.6 , pp. 257
- Benovitz, D.E.¹ Spatola, A.F.²

65
- 0019258064
- (1980) Biochem. Biophys. Res Commun , vol.97 , pp. 1014
- Spatola, A.F.¹ Agarwal, N.S.² Bettag, A.L.³ Yankeelov J.A., Jr.⁴ Bowers, C.Y.⁵ Vale, W.W.⁶

66
- 0026726041
- (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 9367
- Simon, R.J.¹ Kania, R.S.² Zuckermann, R.N.³ Huebner, V.D.⁴ Jewell, D.A.⁵ Banville, S.⁶ Ng, S.⁷ Wang, L.⁸ Rosenberg, S.⁹ Marlowe, C.K.¹⁰

67
- 33749271351
- (1993) Angew. Chem. Int. Ed. Engl , vol.32 , pp. 543
- Kessler, H.¹

68
- 0027934780
- (1994) J. Med. Chem , vol.37 , pp. 2678
- Zuckermann, R.N.¹ Martin, E.J.² Spellmeyer, D.C.³ Stauber, G.B.⁴ Shoemaker, K.R.⁵ Kerr, J.M.⁶ Figliozzi, G.M.⁷ Goff, D.A.⁸ Siani, M.A.⁹ Simon, R.J.¹⁰

69
- 0032837073
- (1999) Bioorg. Med. Chem , vol.7 , pp. 1781
- Ng, S.¹ Goodson, B.² Ehrhardt, A.³ Moos, W.H.⁴ Siani, M.⁵ Winter, J.⁶

70
- 0033027897
- (1999) Antimicrob. Agents Chemother , vol.43 , pp. 1429
- Goodson, B.¹ Ehrhardt, A.² Ng, S.³ Nuss, J.⁴ Johnson, K.⁵ Giedlin, M.⁶ Yamamoto, R.⁷ Moos, W.H.⁸ Krebber, A.⁹ Ladner, M.¹⁰ Giacona, M.B.¹¹ Vitt, C.¹² Winter, J.¹³

71
- 0035952285
- (2001) Bioorg. Med Chem. Lett , vol.11 , pp. 555
- Dasgupta, F.¹ Gangadhar, N.² Bruhaspathy, M.³ Verma, A.K.⁴ Sarin, S.⁵ Mukherjee, A.K.⁶

72
- 0033822654
- (2000) Bioorg. Med. Chem. Lett , vol.10 , pp. 2115
- Pirrung, M.C.¹ Park, K.²

73
- 0026494941
- (1992) J. Med Chem , vol.35 , pp. 4279
- Magrath, J.¹ Abeles, R.H.²

74
- 0033931167
- (2000) Antimicrob. Agents Chemother , vol.44 , pp. 2093
- Robinson, B.S.¹ Riccardi, K.A.² Gong, Y.F.³ Guo, Q.⁴ Stock, D.A.⁵ Blair, W.S.⁶ Terry, B.J.⁷ Deminie, C.A.⁸ Djang, F.⁹ Colonno, R.J.¹⁰ Lin, P.F.¹¹

75
- 0021149796
- (1984) Biochem. Biophys. Res Commun , vol.122 , pp. 791
- Greenlee, W.J.¹ Thorsett, E.D.² Springer, J.P.³ Patchett, A.A.⁴ Ulm, E.H.⁵ Vassil, T.C.⁶

76
- 0021227695
- (1984) J. Biol. Chem , vol.259 , pp. 4288
- Powers, J.C.¹ Boone, R.² Carroll, D.L.³ Gupton, B.F.⁴ Kam, C.M.⁵ Nishino, N.⁶ Sakamoto, M.⁷ Tuhy, P.M.⁸

77
- 0021186126
- (1984) J. Biol. Chem , vol.259 , pp. 4279
- Gupton, B.F.¹ Carroll, D.L.² Tuhy, P.M.³ Kam, C.M.⁴ Powers, J.C.⁵

78
- 0032499279
- (1998) J. Med. Chem , vol.41 , pp. 1344
- Xing, R.¹ Hanzlik, R.P.²

79
- 0003068105
- reid, R. E., Ed.; Marcel Decker, Inc: New York
- (2000) Peptide and Protein Drug Analysis , vol.16 , pp. 81-114
- Sawyer, T.K.¹

80
- 0028293066
- (1994) J. Trends Pharmacol. Sci , vol.15 , pp. 124
- Moore, G.¹

81
- 33947452900
- (2001) J. Am. Chem. Soc , vol.75 , pp. 5329
- Rapoport, H.¹ Lavigne, J.B.²

82
- 0016701344
- (1975) Nature , vol.258 , pp. 577
- Hughes, J.¹ Smith, T.W.² Kosterlitz, H.W.³ Fothergill, L.A.⁴ Morgan, B.A.⁵ Morris, H.R.⁶

83
- 0032133429
- (1998) Curr. Opin. Chem. Biol , vol.2 , pp. 441
- Ripka, A.S.¹ Rich, D.H.²

84
- 0027996724
- (1994) Int. J. Pept. Protein Res , vol.44 , pp. 513
- Nikiforovich, G.V.¹

85
- 0026153696
- (1991) Biopolymers , vol.31 , pp. 725
- Chorev, M.¹ Roubini, E.² Gilon, C.³ Selinger, Z.⁴

86
- 84940139963
- (1990) Blood Vessels , vol.27 , pp. 295
- Timmermans, P.B.¹ Carini, D.J.² Chiu, A.T.³ Duncia, J.V.⁴ Price W.A., Jr.⁵ Wells, G.J.⁶ Wong, P.C.⁷ Wexler, R.R.⁸ Johnson, A.L.⁹

87
- 0030153890
- (1996) Nat. Biotechnol , vol.14 , pp. 709
- Kauvar, L.M.¹

88
- 0030175952
- (1996) Immunopharmacology , vol.33 , pp. 61
- Chakravarty, S.¹ Mavunkel, B.J.² Goehring, R.R.³ Kyle, D.J.⁴

89
- 0003632424
- Cambridge University Press: New York
- (1993) Introduction to the Blood-Brain Barrier
- Pardridge, W.M.¹

90
- 0033391691
- (1999) J. Neurovirol , vol.5 , pp. 556
- Pardridge, W.M.¹

91
- 0009234211
- Pardridge, W.M., Ed.; Cambridge University Press: Cambridge
- (1998) Transport Biology , pp. 165-247
- Pardridge, W.M.¹

92
- 0003020725
- Begley, D.J., Bradbury, M.W., and Kreuter, J., Ed.; Marcel Dekker Inc: New York
- (2000) The Blood-Brain Barrier and Drug Delivery to the CNS , vol.6 , pp. 93-108
- Begley, D.J.¹ Khan, E.U.² Rollinson, C.³ Abbott, J.⁴ Regina, A.⁵ Roux, F.⁶

93
- 0022487852
- Martin, J.B. and Barchas, J.D., Ed.; Raven Press: New York
- (1986) Neuropeptides in Neurologic and Psychiatric Disease , pp. 287-307
- Barchas, J.D.¹ Elliot, G.H.²

94
- 0018188687
- (1978) Science , vol.202 , pp. 18
- Schally, A.V.¹

95
- 0018805142
- (1979) Life Sci , vol.25 , pp. 401
- Kastin, A.J.¹ Olson, R.D.² Schally, A.V.³ Coy, D.H.⁴

96
- 0022414817
- (1985) Psychoneuroendocrinology , vol.10 , pp. 385
- Banks, W.A.¹ Kastin, A.J.²

97
- 0033981738
- (2000) Cell. Mol. Neurobiol , vol.20 , pp. 231
- Habgood, M.D.¹ Begley, D.J.² Abbott, N.J.³

98
- 0000283112
- Taylor, E.M. and Amidon, G.L., Ed.; ACS Professional Reference book: Washington, DC
- (1995) Peptides-Based Drug Design. Controlling transport and Metabolism , pp. 265-337
- Pardridge, W.M.¹

99
- 0030726198
- (1997) Peptides , vol.18 , pp. 1431
- Egleton, R.D.¹ Davis, T.P.²

100
- 0033756459
- (2000) J. Pharm. Sci , vol.89 , pp. 1371
- Tamai, I.¹ Tsuji, A.²

101
- 0035292828
- (2001) Adv. Drug Deliv. Rev , vol.46 , pp. 247
- Bickel, U.¹ Yoshikawa, T.² Pardridge, W.M.³

102
- 0031728078
- (1998) Prog. Drug Res , vol.51 , pp. 95
- Prokai, L.¹

103
- 0033006069
- (1999) Curr. Pharm. Des , vol.5 , pp. 265
- Wang, W.¹ Jiang, J.² Ballard, C.E.³ Wang, B.⁴

104
- 0034192248
- (2000) Pharmaceutical Science and Technology Today , vol.3 , pp. 155
- Temsamani, J.¹ Scherrmann, J.-M.² Rees, A.R.³ Kaczorek, M.⁴

105
- 85037015760
- (1996) Methods Princ. Med. Chem , pp. 355
- Fauchére, J.-L.¹

106
- 0025774429
- (1991) Pharm. Res , vol.8 , pp. 649
- Muranishi, S.¹ Sakai, A.² Yamada, K.³ Murakami, M.⁴ Takada, K.⁵ Kiso, Y.⁶

107
- 0031149919
- (1997) Bioconjug. Chem , vol.8 , pp. 434
- Patel, D.¹ McKinley, B.D.² Davis, T.P.³ Porreca, F.⁴ Yamamura, H.I.⁵ Hruby, V.J.⁶

108
- 0002739535
- Taylor E.M. and Amidon, G.L., Ed.; ACS Professional Reference book: Washington, DC
- (1995) Peptides-Based Drug Design , pp. 317
- Bodor, N.¹ Prokai, L.²

109
- 0030453730
- (1996) Ann. N.Y. Acad. Sci , vol.805 , pp. 270
- Banks, W.A.¹ Uchida, D.² Arimura, A.³ Somogyvari-Vigh, A.⁴ Shioda, S.⁵

110
- 0031596269
- (1998) J. Neural Transm. Suppl , vol.53 , pp. 289
- Windisch, M.¹ Gschanes, A.² Hutter-Paier, B.³

111
- 0028000934
- (1994) Pharm. Res , vol.11 , pp. 1257
- Kang, Y.S.¹ Pardridge, W.M.²

112
- 0025136834
- (1990) Endocrinology , vol.126 , pp. 977
- Pardridge, W.M.¹ Triguero, D.² Buciak, J.L.³

113
- 0032692356
- (1999) J. Neurochem , vol.73 , pp. 2002
- Girod, J.¹ Fenart, L.² Regina, A.³ Dehouck, M.P.⁴ Hong, G.⁵ Scherrmann, J.M.⁶ Cecchelli, R.⁷ Roux, F.⁸

114
- 0025740904
- (1991) J. Pharmacol. Exp. Ther , vol.258 , pp. 186
- Triguero, D.¹ Buciak, J.L.² Pardridge, W.M.³

115
- 0029928170
- (1996) Brain Res. Mol. Brain Res , vol.36 , pp. 280
- Poduslo, J.F.¹ Curran, G.L.²

116
- 0029976387
- (1996) J. Neurochem , vol.66 , pp. 1599
- Poduslo, J.F.¹ Curran, G.L.²

117
- 0033526553
- (1999) J. Neurobiol , vol.39 , pp. 371
- Poduslo, J.F.¹ Curran, G.L.² Kumar, A.³ Frangione, B.⁴ Soto, C.⁵

118
- 0027536084
- (1993) Proc. Natl. Acad. Sci. U.S.A , vol.90 , pp. 2618
- Bickel, U.¹ Yoshikawa, T.² Landaw, E.M.³ Faull, K.F.⁴ Pardridge, W.M.⁵

119
- 0030471676
- (1996) J. Med. Chem , vol.39 , pp. 4775
- Prokai-Tatrai, K.¹ Prokai, L.² Bodor, N.³

120
- 0002952463
- Pardridge W.M., Ed.; Raven Press: New York
- (1993) The Blood Brain Barrier: Cellular and Molecular Biology , pp. 229-248
- Friden, P.M.¹

121
- 0028233389
- (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , pp. 7114
- Polt, R.¹ Porreca, F.² Szabo, L.Z.³ Bilsky, E.J.⁴ Davis, P.⁵ Abbruscato, T.J.⁶ Davis, T.P.⁷ Harvarth, R.⁸ Yamamura, H.I.⁹ Hruby, V.J.¹⁰

122
- 0026545543
- (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 2218
- Poduslo, J.F.¹ Curran, G.L.²

123
- 0034126420
- (2000) Mol. Pharmacol , vol.57 , pp. 679
- Rousselle, C.¹ Clair, P.² Lefauconnier, J.M.³ Kaczorek, M.⁴ Scherrmann, J.M.⁵ Temsamani, J.⁶

124
- 0035196836
- (2001) J. Pharmacol. Exp. Ther , vol.296 , pp. 124
- Rousselle, C.¹ Smirnova, M.² Clair, P.³ Lefauconnier, J.M.⁴ Chavanieu, A.⁵ Calas, B.⁶ Scherrmann, J.M.⁷ Temsamani, J.⁸

125
- 0028062850
- (1994) Pharm. Res , vol.11 , pp. 1681
- Fukuta, M.¹ Okada, H.² Iinuma, S.³ Yanai, S.⁴ Toguchi, H.⁵

126
- 0028301348
- (1994) Proc. Natl. Acad. Sci. U.S. A , vol.91 , pp. 5705
- Poduslo, J.F.¹ Curran, G.L.² Berg, C.T.³

127
- 0344352501
- (1998) Drug Metab. Dispos , vol.26 , pp. 937
- Wu, D.¹ Pardridge, W.M.²

128
- 0028136182
- (1994) Neurosurgery , vol.35 , pp. 294
- Friden, P.M.¹

129
- 0027398553
- (1993) Science , vol.259 , pp. 373
- Friden, P.M.¹ Walus, L.R.² Watson, P.³ Doctrow, S.R.⁴ Kozarich, J.W.⁵ Backman, C.⁶ Bergman, H.⁷ Hoffer, B.⁸ Bloom, F.⁹ Granholm, A.C.¹⁰

130
- 0028558577
- (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , pp. 9077
- Kordower, J.H.¹ Charles, V.² Bayer, R.³ Bartus, R.T.⁴ Putney, S.⁵ Walus, L.R.⁶ Friden, P.M.⁷

131
- 0029265378
- (1995) Bioconjug. Chem , vol.6 , pp. 211
- Bickel, U.¹ Kang, Y.S.² Pardridge, W.M.³

132
- 0031901771
- (1998) Pharm. Res , vol.15 , pp. 576
- Pardridge, W.M.¹ Wu, D.² Sakane, T.³

133
- 13144282770
- (1998) Rev. Neurosci , vol.9 , pp. 31
- Granholm, A.C.¹ Albeck, D.² Backman, C.³ Curtis, M.⁴ Ebendal, T.⁵ Friden, P.⁶ Henry, M.⁷ Hoffer, B.⁸ Kordower, J.⁹ Rose, G.M.¹⁰ Soderstrom, S.¹¹ Bartus, R.T.¹²

134
- 0035910336
- (2001) Brain Res , vol.889 , pp. 49
- Zhang, Y.¹ Pardridge, W.M.²

135
- 0032894155
- (1999) Bioconjug. Chem , vol.10 , pp. 32
- Deguchi, Y.¹ Kurihara, A.² Pardridge, W.M.³

136
- 0033572574
- (1999) Cancer Res , vol.59 , pp. 6159
- Kurihara, A.¹ Pardridge, W.M.²

137
- 0028971069
- (1995) Proc. Natl. Acad. Sci. U.S.A , vol.92 , pp. 10227
- Saito, Y.¹ Buciak, J.² Yang, J.³ Pardridge, W.M.⁴

138
- 0026480374
- (1992) J. Pharmacol. Exp. Ther , vol.263 , pp. 897
- Yoshikawa, T.¹ Pardridge, W.M.²

139
- 0022492783
- (1986) J. Clin. Invest , vol.77 , pp. 977
- Letvin, N.L.¹ Goldmacher, V.S.² Ritz, J.³ Yetz, J.M.⁴ Schlossman, S.F.⁵ Lambert, J.M.⁶

140
- 0026708964
- (1992) J. Pharmacol. Exp. Ther , vol.261 , pp. 1044
- Davis, R.E.¹ Callahan, M.J.² Dickerson, M.³ Downs, D.A.⁴

141
- 0022620942
- (1986) Regul. Pept , vol.14 , pp. 113
- Verhoef, J.C.¹ van den Wildenberg, H.M.²

142
- 0023543618
- (1987) Peptides , vol.8 , pp. 1051
- Mycroft, F.J.¹ Bhargava, H.N.² Wei, E.T.³

143
- 0017663194
- (1977) Arzneimittelforschung , vol.27 , pp. 2286
- Failli, A.¹ Sestanj, K.² Immer, H.U.³ Gotz, M.⁴

144
- 0027995450
- (1994) Peptides , vol.15 , pp. 1567
- Zadina, J.E.¹ Kastin, A.J.² Hackler, L.³ Chang, S.L.⁴

145
- 84867190641
- (1977) Clin. Endocrinol , vol.7 , pp. 1
- Jeffcoate, W.J.¹ Phenekos, C.² Ratcliffe, J.G.³ Williams, S.⁴ Rees, L.⁵ Besser, G.M.⁶

146
- 0017332694
- (1977) Brain Res , vol.126 , pp. 89
- Verhoef, J.¹ Palkovits, M.² Witter, A.³

147
- 0021712174
- (1984) Peptides , vol.5 , pp. 1191
- Akiyama, K.¹ Yamamura, H.I.² Wilkes, B.C.³ Cody, W.L.⁴ Hruby, V.J.⁵ Castrucci, A.M.⁶ Hadley, M.E.⁷

148
- 0025216056
- (1990) Drugs , vol.39 , pp. 523
- Chrisp, P.¹ Goa, K.L.²

149
- 0023726327
- (1988) Horm. Res , vol.29 , pp. 95
- Bolli, G.B.¹ Gottesman, I.S.² Gerich, J.E.³

150
- 0024384374
- (1989) Endocrinology , vol.125 , pp. 217
- Pettibone, D.J.¹ Clineschmidt, B.V.² Anderson, P.S.³ Freidinger, R.M.⁴ Lundell, G.F.⁵ Koupal, L.R.⁶ Schwartz, C.D.⁷ Williamson, J.M.⁸ Goetz, M.A.⁹ Hensens, O.D.¹⁰

151
- 0022478338
- (1986) J. Endocrinol , vol.111 , pp. 125
- Melin, P.¹ Trojnar, J.² Johansson, B.³ Vilhardt, H.⁴ Akerlund, M.⁵

152
- 0026443104
- (1992) J. Med. Chem , vol.35 , pp. 3919
- Evans, B.E.¹ Leighton, J.L.² Rittle, K.E.³ Gilbert, K.F.⁴ Lundell, G.F.⁵ Gould, N.P.⁶ Hobbs, D.W.⁷ DiPardo, R.M.⁸ Veber, D.F.⁹ Pettibone, D.J.¹⁰

153
- 0031704132
- (1998) Adv. Exp. Med. Biol , vol.449 , pp. 473
- Williams, P.D.¹ Bock, M.G.² Evans, B.E.³ Freidinger, R.M.⁴ Pettibone, D.J.⁵

154
- 85037022384
- Rich, H. and Gross, E. Ed.; Pierce: Rockford, Illinois
- (1981) Peptides: Synthesis-Structure-Function , pp. 657
- Rioux, F.¹ Quirion, F.² Pierre, St.S.³

155
- 0026695818
- (1992) J. Med. Chem , vol.35 , pp. 2591
- Lowe J.A. III¹ Drozda, S.E.² Snider, R.M.³ Longo, K.P.⁴ Zorn, S.H.⁵ Morrone, J.⁶ Jackson, E.R.⁷ McLean, S.⁸ Bryce, D.K.⁹ Bordner, J.¹⁰

156
- 0025879914
- (1991) J. Med. Chem , vol.34 , pp. 1514
- Weinstock, J.¹ Keenan, R.M.² Samanen, J.³ Hempel, J.⁴ Finkelstein, J.A.⁵ Franz, R.G.⁶ Gaitanopoulos, D.E.⁷ Girard, G.R.⁸ Gleason, J.G.⁹ Hill, D.T.¹⁰

157
- 0033866867
- (2000) Curr. Opin. Chem. Biol , vol.4 , pp. 401
- Bock, M.G.¹ Longmore, J.²

158
- 0025823301
- (1991) Neuropeptides , vol.19 , Issue.SUPPL. , pp. 57
- Horwell, D.C.¹

159
- 0028509498
- (1994) Bioorg. Med. Chem , vol.2 , pp. 987
- Bock, M.G.¹ DiPardo, R.M.² Newton, R.C.³ Bergman, J.-M.⁴ Veber, D.F.⁵ Freedman, S.B.⁶ Smith, A.J.⁷ Chapman, K.L.⁸ Patel, S.⁹ Kemp, J.A.¹⁰

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.