Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 4, 2007, Pages 1694-1702

  Liu, Hongmei ^a   Zhang, Bangzhi ^a   Liu, Xuefeng ^a   Wang, Changlin ^a   Ni, Jingman ^b   Wang, Rui ^a,c  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

^c Key Laboratory of Preclinical Study for New Drugs of Gansu Province   (China)

Author keywords

Antinociceptive activity; Endomorphin 1; Metabolic stability; Systematic chemical modification

Indexed keywords

17 METHYLNALOXONE; ANALGESIC AGENT; DELTA OPIATE RECEPTOR; ENDOMORPHIN 1; ENDOMORPHIN 1 DERIVATIVE; MU OPIATE RECEPTOR; N ALPHA AMIDINO METHYLTYROSYL DEXTRO PROLYLGLYCYLTRYPTOPHANYL 4 CHLOROPHENYLALANYLAMIDE; N ALPHA AMIDINO METHYLTYROSYL DEXTRO PROLYLGLYCYLTRYPTOPHANYLPHENYLALANYLAMIDE; N ALPHA AMIDINO METHYLTYROSYLPROLYLTRYPTOPHANYL 4 CHLOROPHENYLALANYLAMIDE; N ALPHA AMIDINO METHYLTYROSYLPROLYLTRYPTOPHANYLPHENYLALANYLAMIDE; NALOXONE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; IC 50; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; RAT;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; DRUG DESIGN; DRUG STABILITY; MICE; OLIGOPEPTIDES; PAIN; PHARMACOKINETICS;

EID: 33847789994     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.007     Document Type: Article

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