Effect of 2′,6′-dimethyl-l-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 6977-6981

  Fichna, Jakub ^a   Perlikowska, Renata ^a   Wyrbska, Anna ^a   Gach, Katarzyna ^a   Piekielna, Justyna ^a   Do Rego, Jean Claude ^b,c   Toth, Geza ^d   Kluczyk, Alicja ^e   Janecki, Tomasz ^f   Janecka, Anna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITÉ DE ROUEN   (France)

^c CNRS   (France)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e UNIVERSITY OF WROC AW   (Poland)

^f LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

and opioid receptors; Antinociception; Binding studies; Hot plate test; Solid phase peptide synthesis

Indexed keywords

2',6' DIMETHYL TYROSINE; 2',6' DIMETHYL TYROSINE C DEXTRO LYSYLPHENYL DEXTRO PROLYLASPARAGINE AMIDE; 2',6' DIMETHYL TYROSINE C DEXTRO LYSYLPHENYLPHENYLASPARAGINE AMIDE; 2',6' DIMETHYL TYROSINE DEXTRO ASPARAGINYLPHENYL DEXTRO PROLYLLYSINE AMIDE; ASPARTIC ACID; BETA FUNALTREXAMINE; CYCLOPEPTIDE; DELTA OPIATE RECEPTOR; DELTORPHIN; ENDOMORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MORPHICEPTIN DERIVATIVE; MU OPIATE RECEPTOR; NALTRINDOLE; NORBINALTORPHIMINE; RESIN; TYROSINE; TYROSINE C DEXTRO ASPARAGINYLPHENYL DEXTRO PROLYLLYSINE AMIDE; TYROSINE C DEXTRO LYSYLPHENYL DEXTRO PROLYLASPARAGINE AMIDE; TYROSINE C DEXTRO LYSYLPHENYLPHENYLASPARAGINE AMIDE; UNCLASSIFIED DRUG; 2',6' DIMETHYLTYROSINE; 2',6'-DIMETHYLTYROSINE; DRUG DERIVATIVE; ENDORPHIN; MORPHICEPTIN; OLIGOPEPTIDE; OPIATE PEPTIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CYCLIZATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME DEGRADATION; HOT PLATE TEST; MALE; MICROWAVE RADIATION; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; SOLID PHASE SYNTHESIS; AMINO ACID SEQUENCE; ANIMAL; DRUG INTERACTION; METABOLISM; STRUCTURE ACTIVITY RELATION; WISTAR RAT;

RATTUS;

AMINO ACID SEQUENCE; ANIMALS; DRUG INTERACTIONS; ENDORPHINS; MALE; MICE; OLIGOPEPTIDES; OPIOID PEPTIDES; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 80655136931     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.040     Document Type: Article

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