메뉴 건너뛰기




Volumn 18, Issue 8, 2012, Pages 609-615

Tight junction in blood-brain barrier: An overview of structure, regulation, and regulator substances

Author keywords

Blood brain barrier; Tight junctions; Vascular permeability

Indexed keywords

CLAUDIN 1; CLAUDIN 11; CLAUDIN 2; CLAUDIN 3; CLAUDIN 5; CYCLODEXTRIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JUNCTIONAL ADHESION MOLECULE A; MATRIX METALLOPROTEINASE; OCCLUDIN; PROTEIN ZO1; PROTEIN ZO2;

EID: 84864760434     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2012.00340.x     Document Type: Review
Times cited : (229)

References (105)
  • 1
    • 77956344034 scopus 로고    scopus 로고
    • Looking at the blood-brain barrier: Molecular anatomy and possible investigation approaches
    • Cardoso FL, Brites D, Brito MA. Looking at the blood-brain barrier: Molecular anatomy and possible investigation approaches. Brain Res Rev 2010;64:328-363.
    • (2010) Brain Res Rev , vol.64 , pp. 328-363
    • Cardoso, F.L.1    Brites, D.2    Brito, M.A.3
  • 2
    • 77957007202 scopus 로고    scopus 로고
    • Connecting vascular and nervous system development: Angiogenesis and the blood-brain barrier
    • Tam SJ, Watts RJ. Connecting vascular and nervous system development: Angiogenesis and the blood-brain barrier. Annu Rev Neurosci 2010;33:379-408.
    • (2010) Annu Rev Neurosci , vol.33 , pp. 379-408
    • Tam, S.J.1    Watts, R.J.2
  • 3
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005;57:173-185.
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 4
    • 33845784758 scopus 로고    scopus 로고
    • Blood-brain barrier delivery
    • Pardridge WM. Blood-brain barrier delivery. Drug Discov Today 2007;12:54-61.
    • (2007) Drug Discov Today , vol.12 , pp. 54-61
    • Pardridge, W.M.1
  • 5
    • 0348231898 scopus 로고    scopus 로고
    • Mechanisms of disease: The blood-brain barrier
    • discussion 141-132.
    • Neuwelt EA. Mechanisms of disease: The blood-brain barrier. Neurosurgery 2004;54:131-140; discussion 141-132.
    • (2004) Neurosurgery , vol.54 , pp. 131-140
    • Neuwelt, E.A.1
  • 6
    • 34547645047 scopus 로고    scopus 로고
    • Modelling of the blood-brain barrier in drug discovery and development
    • Cecchelli R, Berezowski V, Lundquist S, et al. Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 2007;6:650-661.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 650-661
    • Cecchelli, R.1    Berezowski, V.2    Lundquist, S.3
  • 7
    • 35748977617 scopus 로고    scopus 로고
    • Challenges for blood-brain barrier (BBB) screening
    • Jeffrey P, Summerfield SG. Challenges for blood-brain barrier (BBB) screening. Xenobiotica 2007;37:1135-1151.
    • (2007) Xenobiotica , vol.37 , pp. 1135-1151
    • Jeffrey, P.1    Summerfield, S.G.2
  • 8
    • 26444528514 scopus 로고    scopus 로고
    • The blood-brain barrier-lessons from moody flies
    • Daneman R, Barres BA. The blood-brain barrier-lessons from moody flies. Cell 2005;123:9-12.
    • (2005) Cell , vol.123 , pp. 9-12
    • Daneman, R.1    Barres, B.A.2
  • 9
    • 0036935830 scopus 로고    scopus 로고
    • Junctional complexes of the blood-brain barrier: Permeability changes in neuroinflammation
    • Petty MA, Lo EH. Junctional complexes of the blood-brain barrier: Permeability changes in neuroinflammation. Prog Neurobiol 2002;68:311-323.
    • (2002) Prog Neurobiol , vol.68 , pp. 311-323
    • Petty, M.A.1    Lo, E.H.2
  • 13
    • 0033973460 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier
    • Kniesel U, Wolburg H. Tight junctions of the blood-brain barrier. Cell Mol Neurobiol 2000;20:57-76.
    • (2000) Cell Mol Neurobiol , vol.20 , pp. 57-76
    • Kniesel, U.1    Wolburg, H.2
  • 14
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou M, Furuse M, Sasaki H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 2000;11:4131-4142.
    • (2000) Mol Biol Cell , vol.11 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3
  • 15
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic B. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008;57:178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.1
  • 16
    • 0035576934 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier
    • Huber JD, Egleton RD, Davis TP. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 2001;24:719-725.
    • (2001) Trends Neurosci , vol.24 , pp. 719-725
    • Huber, J.D.1    Egleton, R.D.2    Davis, T.P.3
  • 17
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • Sandoval KE, Witt KA. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis 2008;32:200-219.
    • (2008) Neurobiol Dis , vol.32 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 18
    • 77954769168 scopus 로고    scopus 로고
    • Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains
    • Romanitan MO, Popescu BO, Spulber S, et al. Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains. J Cell Mol Med 2010;14:1088-1100.
    • (2010) J Cell Mol Med , vol.14 , pp. 1088-1100
    • Romanitan, M.O.1    Popescu, B.O.2    Spulber, S.3
  • 19
    • 34248337945 scopus 로고    scopus 로고
    • Molecular anatomy of the brain endothelial barrier: An overview of the distributional features
    • Ueno M. Molecular anatomy of the brain endothelial barrier: An overview of the distributional features. Curr Med Chem 2007;14:1199-1206.
    • (2007) Curr Med Chem , vol.14 , pp. 1199-1206
    • Ueno, M.1
  • 20
    • 67249126613 scopus 로고    scopus 로고
    • Tight junction proteins as channel formers and barrier builders
    • Amasheh S, Milatz S, Krug SM, et al. Tight junction proteins as channel formers and barrier builders. Ann N Y Acad Sci 2009;1165:211-219.
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 211-219
    • Amasheh, S.1    Milatz, S.2    Krug, S.M.3
  • 21
    • 0037648580 scopus 로고    scopus 로고
    • Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    • Nitta T, Hata M, Gotoh S, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003;161:653-660.
    • (2003) J Cell Biol , vol.161 , pp. 653-660
    • Nitta, T.1    Hata, M.2    Gotoh, S.3
  • 22
    • 33745090582 scopus 로고    scopus 로고
    • Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5
    • Honda M, Nakagawa S, Hayashi K, et al. Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell Mol Neurobiol 2006;26:109-118.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 109-118
    • Honda, M.1    Nakagawa, S.2    Hayashi, K.3
  • 23
    • 76549090463 scopus 로고    scopus 로고
    • Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion
    • Zhang J, Piontek J, Wolburg H, et al. Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proc Natl Acad Sci U S A 2010;107:1425-1430.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1425-1430
    • Zhang, J.1    Piontek, J.2    Wolburg, H.3
  • 24
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview-structure, regulation, and clinical implications
    • Ballabh P, Braun A, Nedergaard M. The blood-brain barrier: An overview-structure, regulation, and clinical implications. Neurobiol Dis 2004;16:1-13.
    • (2004) Neurobiol Dis , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 25
    • 34249650761 scopus 로고    scopus 로고
    • The role of junctional adhesion molecules in vascular inflammation
    • Weber C, Fraemohs L, Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 2007;7:467-477.
    • (2007) Nat Rev Immunol , vol.7 , pp. 467-477
    • Weber, C.1    Fraemohs, L.2    Dejana, E.3
  • 28
    • 33747184013 scopus 로고    scopus 로고
    • ZOning out tight junctions
    • Shin K, Margolis B. ZOning out tight junctions. Cell 2006;126:647-649.
    • (2006) Cell , vol.126 , pp. 647-649
    • Shin, K.1    Margolis, B.2
  • 30
    • 3042590902 scopus 로고    scopus 로고
    • Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis
    • Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis. Physiol Rev 2004;84:869-901.
    • (2004) Physiol Rev , vol.84 , pp. 869-901
    • Bazzoni, G.1    Dejana, E.2
  • 31
    • 33747155076 scopus 로고    scopus 로고
    • ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
    • Umeda K, Ikenouchi J, Katahira-Tayama S, et al. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 2006;126:741-754.
    • (2006) Cell , vol.126 , pp. 741-754
    • Umeda, K.1    Ikenouchi, J.2    Katahira-Tayama, S.3
  • 32
    • 7244219999 scopus 로고    scopus 로고
    • Establishment and characterization of cultured epithelial cells lacking expression of ZO-1
    • Umeda K, Matsui T, Nakayama M, et al. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem 2004;279:44785-44794.
    • (2004) J Biol Chem , vol.279 , pp. 44785-44794
    • Umeda, K.1    Matsui, T.2    Nakayama, M.3
  • 33
    • 40749084863 scopus 로고    scopus 로고
    • Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development
    • Xu J, Kausalya PJ, Phua DC, Ali SM, Hossain Z, Hunziker W. Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol 2008;28:1669-1678.
    • (2008) Mol Cell Biol , vol.28 , pp. 1669-1678
    • Xu, J.1    Kausalya, P.J.2    Phua, D.C.3    Ali, S.M.4    Hossain, Z.5    Hunziker, W.6
  • 34
    • 0242456208 scopus 로고    scopus 로고
    • Expression and distribution of ZO 3, a tight junction MAGUK protein, in mouse tissues
    • Inoko A, Itoh M, Tamura A, Matsuda M, Furuse M, Tsukita S. Expression and distribution of ZO 3, a tight junction MAGUK protein, in mouse tissues. Genes Cells 2003;8:837-845.
    • (2003) Genes Cells , vol.8 , pp. 837-845
    • Inoko, A.1    Itoh, M.2    Tamura, A.3    Matsuda, M.4    Furuse, M.5    Tsukita, S.6
  • 35
    • 0035914113 scopus 로고    scopus 로고
    • Cingulin interacts with F-actin in vitro
    • D'Atri F, Citi S. Cingulin interacts with F-actin in vitro. FEBS Lett 2001;507:21-24.
    • (2001) FEBS Lett , vol.507 , pp. 21-24
    • D'Atri, F.1    Citi, S.2
  • 36
    • 9444239778 scopus 로고    scopus 로고
    • Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression
    • Guillemot L, Hammar E, Kaister C, et al. Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression. J Cell Sci 2004;117:5245-5256.
    • (2004) J Cell Sci , vol.117 , pp. 5245-5256
    • Guillemot, L.1    Hammar, E.2    Kaister, C.3
  • 37
    • 37549007949 scopus 로고    scopus 로고
    • Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression
    • Paschoud S, Citi S. Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression. Mol Membr Biol 2008;25:1-13.
    • (2008) Mol Membr Biol , vol.25 , pp. 1-13
    • Paschoud, S.1    Citi, S.2
  • 38
    • 0035991935 scopus 로고    scopus 로고
    • Molecular complexity of vertebrate tight junctions (Review)
    • D'Atri F, Citi S. Molecular complexity of vertebrate tight junctions (Review). Mol Membr Biol 2002;19:103-112.
    • (2002) Mol Membr Biol , vol.19 , pp. 103-112
    • D'Atri, F.1    Citi, S.2
  • 39
    • 0030027609 scopus 로고    scopus 로고
    • Localization of 7H6 tight junction-associated antigen along the cell border of vascular endothelial cells correlates with paracellular barrier function against ions, large molecules, and cancer cells
    • Satoh H, Zhong Y, Isomura H, et al. Localization of 7H6 tight junction-associated antigen along the cell border of vascular endothelial cells correlates with paracellular barrier function against ions, large molecules, and cancer cells. Exp Cell Res 1996;222:269-274.
    • (1996) Exp Cell Res , vol.222 , pp. 269-274
    • Satoh, H.1    Zhong, Y.2    Isomura, H.3
  • 41
    • 79960357742 scopus 로고    scopus 로고
    • TGF-beta1 Pathway as a new target for neuroprotection in alzheimer's disease
    • Caraci F, Battaglia G, Bruno V, et al. TGF-beta1 Pathway as a new target for neuroprotection in alzheimer's disease. CNS Neurosci Ther 2011;17:237-249.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 237-249
    • Caraci, F.1    Battaglia, G.2    Bruno, V.3
  • 42
    • 34250623663 scopus 로고    scopus 로고
    • Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: Implications for drug therapy
    • Desai BS, Monahan AJ, Carvey PM, Hendey B. Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: Implications for drug therapy. Cell Transplant 2007;16:285-299.
    • (2007) Cell Transplant , vol.16 , pp. 285-299
    • Desai, B.S.1    Monahan, A.J.2    Carvey, P.M.3    Hendey, B.4
  • 43
    • 61349102361 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in Alzheimer's disease: A case-control MRI study
    • Starr JM, Farrall AJ, Armitage P, McGurn B, Wardlaw J. Blood-brain barrier permeability in Alzheimer's disease: A case-control MRI study. Psychiatry Res 2009;171:232-241.
    • (2009) Psychiatry Res , vol.171 , pp. 232-241
    • Starr, J.M.1    Farrall, A.J.2    Armitage, P.3    McGurn, B.4    Wardlaw, J.5
  • 44
    • 34248645424 scopus 로고    scopus 로고
    • The integrity of the blood-brain barrier in Alzheimer's disease
    • Algotsson A, Winblad B. The integrity of the blood-brain barrier in Alzheimer's disease. Acta Neurol Scand 2007;115:403-408.
    • (2007) Acta Neurol Scand , vol.115 , pp. 403-408
    • Algotsson, A.1    Winblad, B.2
  • 46
    • 80053198167 scopus 로고    scopus 로고
    • From hypertension to stroke: Mechanisms and potential prevention strategies
    • Yu JG, Zhou RR, Cai GJ. From hypertension to stroke: Mechanisms and potential prevention strategies. CNS Neurosci Ther 2011;17:577-584.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 577-584
    • Yu, J.G.1    Zhou, R.R.2    Cai, G.J.3
  • 47
    • 72949109548 scopus 로고    scopus 로고
    • Imaging the future of stroke: I. Ischemia
    • Liebeskind DS. Imaging the future of stroke: I. Ischemia. Ann Neurol 2009;66:574-590.
    • (2009) Ann Neurol , vol.66 , pp. 574-590
    • Liebeskind, D.S.1
  • 48
    • 55749101354 scopus 로고    scopus 로고
    • Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment
    • Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood 2008;112:3555-3562.
    • (2008) Blood , vol.112 , pp. 3555-3562
    • Stoll, G.1    Kleinschnitz, C.2    Nieswandt, B.3
  • 49
    • 34247842900 scopus 로고    scopus 로고
    • Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells
    • Koto T, Takubo K, Ishida S, et al. Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells. Am J Pathol 2007;170:1389-1397.
    • (2007) Am J Pathol , vol.170 , pp. 1389-1397
    • Koto, T.1    Takubo, K.2    Ishida, S.3
  • 50
    • 78049452265 scopus 로고    scopus 로고
    • Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation
    • Willis CL, Meske DS, Davis TP. Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation. J Cereb Blood Flow Metab 2010;30:1847-1859.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1847-1859
    • Willis, C.L.1    Meske, D.S.2    Davis, T.P.3
  • 51
    • 70350115239 scopus 로고    scopus 로고
    • Effects of acute hypoxia and hyperthermia on the permeability of the blood-brain barrier in adult rats
    • Natah SS, Srinivasan S, Pittman Q, Zhao Z, Dunn JF. Effects of acute hypoxia and hyperthermia on the permeability of the blood-brain barrier in adult rats. J Appl Physiol 2009;107:1348-1356.
    • (2009) J Appl Physiol , vol.107 , pp. 1348-1356
    • Natah, S.S.1    Srinivasan, S.2    Pittman, Q.3    Zhao, Z.4    Dunn, J.F.5
  • 52
    • 79960741978 scopus 로고    scopus 로고
    • MMP-mediated disruption of Claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia
    • Yang Y, Rosenberg GA. MMP-mediated disruption of Claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia. Methods Mol Biol 2011;762:333-345.
    • (2011) Methods Mol Biol , vol.762 , pp. 333-345
    • Yang, Y.1    Rosenberg, G.A.2
  • 53
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab 2007;27:697-709.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 54
    • 58149326864 scopus 로고    scopus 로고
    • Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia
    • Liu W, Hendren J, Qin XJ, Shen J, Liu KJ. Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem 2009;108:811-820.
    • (2009) J Neurochem , vol.108 , pp. 811-820
    • Liu, W.1    Hendren, J.2    Qin, X.J.3    Shen, J.4    Liu, K.J.5
  • 55
    • 23744445782 scopus 로고    scopus 로고
    • Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations
    • Brooks TA, Hawkins BT, Huber JD, Egleton RD, Davis TP. Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations. Am J Physiol-Heart C 2005;289:H738-743.
    • (2005) Am J Physiol-Heart C , vol.289
    • Brooks, T.A.1    Hawkins, B.T.2    Huber, J.D.3    Egleton, R.D.4    Davis, T.P.5
  • 56
    • 50849106047 scopus 로고    scopus 로고
    • Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia
    • McCaffrey G, Seelbach MJ, Staatz WD, et al. Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia. J Neurochem 2008;106:2395-2409.
    • (2008) J Neurochem , vol.106 , pp. 2395-2409
    • McCaffrey, G.1    Seelbach, M.J.2    Staatz, W.D.3
  • 57
    • 77955919077 scopus 로고    scopus 로고
    • Disruption of the blood-brain barrier in collagen-induced arthritic mice
    • Nishioku T, Yamauchi A, Takata F, et al. Disruption of the blood-brain barrier in collagen-induced arthritic mice. Neurosci Lett 2010;482:208-211.
    • (2010) Neurosci Lett , vol.482 , pp. 208-211
    • Nishioku, T.1    Yamauchi, A.2    Takata, F.3
  • 58
    • 77957955692 scopus 로고    scopus 로고
    • Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA
    • Nakajima A, Inoue E, Tanaka E, et al. Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol 2010;39:360-367.
    • (2010) Scand J Rheumatol , vol.39 , pp. 360-367
    • Nakajima, A.1    Inoue, E.2    Tanaka, E.3
  • 59
    • 78649232339 scopus 로고    scopus 로고
    • The combination of interferon-beta and HMG-CoA reductase inhibition in multiple sclerosis: Enthusiasm lost too soon?
    • Sellner J, Weber MS, Vollmar P, Mattle HP, Hemmer B, Stuve O. The combination of interferon-beta and HMG-CoA reductase inhibition in multiple sclerosis: Enthusiasm lost too soon?CNS Neurosci Ther 2010;16:362-373.
    • (2010) CNS Neurosci Ther , vol.16 , pp. 362-373
    • Sellner, J.1    Weber, M.S.2    Vollmar, P.3    Mattle, H.P.4    Hemmer, B.5    Stuve, O.6
  • 60
    • 27744504478 scopus 로고    scopus 로고
    • Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
    • Vos CM, Geurts JJ, Montagne L, et al. Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiol Dis 2005;20:953-960.
    • (2005) Neurobiol Dis , vol.20 , pp. 953-960
    • Vos, C.M.1    Geurts, J.J.2    Montagne, L.3
  • 61
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • Kirk J, Plumb J, Mirakhur M, McQuaid S. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J Pathol 2003;201:319-327.
    • (2003) J Pathol , vol.201 , pp. 319-327
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 62
    • 77954940188 scopus 로고    scopus 로고
    • Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption
    • Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E. Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption. Drug Metab Dispos 2010;38:1355-1361.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1355-1361
    • Cheng, Z.1    Zhang, J.2    Liu, H.3    Li, Y.4    Zhao, Y.5    Yang, E.6
  • 63
    • 0037237882 scopus 로고    scopus 로고
    • Effect of diabetes on the blood brain barrier
    • Horani MH, Mooradian AD. Effect of diabetes on the blood brain barrier. Curr Pharm Des 2003;9:833-840.
    • (2003) Curr Pharm Des , vol.9 , pp. 833-840
    • Horani, M.H.1    Mooradian, A.D.2
  • 64
    • 3543067962 scopus 로고    scopus 로고
    • Neurodegenerative disorders associated with diabetes mellitus
    • Ristow M. Neurodegenerative disorders associated with diabetes mellitus. J Mol Med (Berl) 2004;82:510-529.
    • (2004) J Mol Med (Berl) , vol.82 , pp. 510-529
    • Ristow, M.1
  • 65
    • 48949117573 scopus 로고    scopus 로고
    • Diabetes, cognitive function, and the blood-brain barrier
    • Huber JD. Diabetes, cognitive function, and the blood-brain barrier. Curr Pharm Des 2008;14:1594-1600.
    • (2008) Curr Pharm Des , vol.14 , pp. 1594-1600
    • Huber, J.D.1
  • 66
    • 33845397903 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats
    • Huber JD, VanGilder RL, Houser KA. Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats. Am J Physiol-Heart C 2006;291:H2660-H2668.
    • (2006) Am J Physiol-Heart C , vol.291
    • Huber, J.D.1    VanGilder, R.L.2    Houser, K.A.3
  • 67
    • 33845915580 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases
    • Hawkins BT, Lundeen TF, Norwood KM, Brooks HL, Egleton RD. Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. Diabetologia 2007;50:202-211.
    • (2007) Diabetologia , vol.50 , pp. 202-211
    • Hawkins, B.T.1    Lundeen, T.F.2    Norwood, K.M.3    Brooks, H.L.4    Egleton, R.D.5
  • 68
    • 79952114546 scopus 로고    scopus 로고
    • Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat
    • Sharma HS, Patnaik R, Sharma A. Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. J Nanosci Nanotechnol 2010;10:7931-7945.
    • (2010) J Nanosci Nanotechnol , vol.10 , pp. 7931-7945
    • Sharma, H.S.1    Patnaik, R.2    Sharma, A.3
  • 69
    • 77954981010 scopus 로고    scopus 로고
    • The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat
    • Kanoski SE, Zhang Y, Zheng W, Davidson TL. The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis 2010;21:207-219.
    • (2010) J Alzheimers Dis , vol.21 , pp. 207-219
    • Kanoski, S.E.1    Zhang, Y.2    Zheng, W.3    Davidson, T.L.4
  • 70
    • 17644380598 scopus 로고    scopus 로고
    • Mechanisms of the blood-brain barrier disruption in HIV-1 infection
    • Toborek M, Lee YW, Flora G, et al. Mechanisms of the blood-brain barrier disruption in HIV-1 infection. Cell Mol Neurobiol 2005;25:181-199.
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 181-199
    • Toborek, M.1    Lee, Y.W.2    Flora, G.3
  • 71
    • 0141816588 scopus 로고    scopus 로고
    • HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells
    • Andras IE, Pu H, Deli MA, Nath A, Hennig B, Toborek M. HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J Neurosci Res 2003;74:255-265.
    • (2003) J Neurosci Res , vol.74 , pp. 255-265
    • Andras, I.E.1    Pu, H.2    Deli, M.A.3    Nath, A.4    Hennig, B.5    Toborek, M.6
  • 72
    • 79960725414 scopus 로고    scopus 로고
    • HIV-1-induced alterations of Claudin-5 expression at the blood-brain barrier level
    • Andras IE, Toborek M. HIV-1-induced alterations of Claudin-5 expression at the blood-brain barrier level. Methods Mol Biol 2011;762:355-370.
    • (2011) Methods Mol Biol , vol.762 , pp. 355-370
    • Andras, I.E.1    Toborek, M.2
  • 73
    • 70349329335 scopus 로고    scopus 로고
    • PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
    • Huang W, Eum SY, Andras IE, Hennig B, Toborek M. PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB J 2009;23:1596-1606.
    • (2009) FASEB J , vol.23 , pp. 1596-1606
    • Huang, W.1    Eum, S.Y.2    Andras, I.E.3    Hennig, B.4    Toborek, M.5
  • 74
    • 33745094734 scopus 로고    scopus 로고
    • Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)
    • Persidsky Y, Heilman D, Haorah J, et al. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 2006;107:4770-4780.
    • (2006) Blood , vol.107 , pp. 4770-4780
    • Persidsky, Y.1    Heilman, D.2    Haorah, J.3
  • 75
    • 24944459847 scopus 로고    scopus 로고
    • Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells
    • Andras IE, Pu H, Tian J, et al. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 2005;25:1159-1170.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1159-1170
    • Andras, I.E.1    Pu, H.2    Tian, J.3
  • 76
    • 41349097097 scopus 로고    scopus 로고
    • STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier
    • Chaudhuri A, Yang B, Gendelman HE, Persidsky Y, Kanmogne GD. STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood 2008;111:2062-2072.
    • (2008) Blood , vol.111 , pp. 2062-2072
    • Chaudhuri, A.1    Yang, B.2    Gendelman, H.E.3    Persidsky, Y.4    Kanmogne, G.D.5
  • 77
    • 36349008783 scopus 로고    scopus 로고
    • Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood-brain barrier
    • Pu H, Hayashi K, Andras IE, Eum SY, Hennig B, Toborek M. Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood-brain barrier. Brain Res 2007;1184:333-344.
    • (2007) Brain Res , vol.1184 , pp. 333-344
    • Pu, H.1    Hayashi, K.2    Andras, I.E.3    Eum, S.Y.4    Hennig, B.5    Toborek, M.6
  • 78
    • 57449112998 scopus 로고    scopus 로고
    • Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: An experimental study using light and electron microscopy
    • Sharma HS, Kiyatkin EA. Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: An experimental study using light and electron microscopy. J Chem Neuroanat 2009;37:18-32.
    • (2009) J Chem Neuroanat , vol.37 , pp. 18-32
    • Sharma, H.S.1    Kiyatkin, E.A.2
  • 79
    • 79551645771 scopus 로고    scopus 로고
    • Brain injury associated with widely abused amphetamines: Neuroinflammation, neurogenesis and blood-brain barrier
    • Silva AP, Martins T, Baptista S, Goncalves J, Agasse F, Malva JO. Brain injury associated with widely abused amphetamines: Neuroinflammation, neurogenesis and blood-brain barrier. Curr Drug Abuse Rev 2010;3:239-254.
    • (2010) Curr Drug Abuse Rev , vol.3 , pp. 239-254
    • Silva, A.P.1    Martins, T.2    Baptista, S.3    Goncalves, J.4    Agasse, F.5    Malva, J.O.6
  • 80
    • 80052037570 scopus 로고    scopus 로고
    • Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9
    • Martins T, Baptista S, Goncalves J, et al. Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9. Brain Res 2011;1411:28-40.
    • (2011) Brain Res , vol.1411 , pp. 28-40
    • Martins, T.1    Baptista, S.2    Goncalves, J.3
  • 81
    • 72049132918 scopus 로고    scopus 로고
    • Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells
    • Ramirez SH, Potula R, Fan S, et al. Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells. J Cereb Blood Flow Metab 2009;29:1933-1945.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1933-1945
    • Ramirez, S.H.1    Potula, R.2    Fan, S.3
  • 82
    • 79952158505 scopus 로고    scopus 로고
    • Cocaine-mediated induction of platelet-derived growth factor: Implication for increased vascular permeability
    • Yao H, Duan M, Buch S. Cocaine-mediated induction of platelet-derived growth factor: Implication for increased vascular permeability. Blood 2011;117:2538-2547.
    • (2011) Blood , vol.117 , pp. 2538-2547
    • Yao, H.1    Duan, M.2    Buch, S.3
  • 83
    • 40949139217 scopus 로고    scopus 로고
    • Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse
    • Mahajan SD, Aalinkeel R, Sykes DE, et al. Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res 2008;1203:133-148.
    • (2008) Brain Res , vol.1203 , pp. 133-148
    • Mahajan, S.D.1    Aalinkeel, R.2    Sykes, D.E.3
  • 84
    • 51349150186 scopus 로고    scopus 로고
    • Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
    • Mahajan SD, Aalinkeel R, Sykes DE, et al. Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability. J Clin Immunol 2008;28:528-541.
    • (2008) J Clin Immunol , vol.28 , pp. 528-541
    • Mahajan, S.D.1    Aalinkeel, R.2    Sykes, D.E.3
  • 85
    • 38949134159 scopus 로고    scopus 로고
    • Cocaine-mediated alteration in tight junction protein expression and modulation of CCL2/CCR2 axis across the blood-brain barrier: Implications for HIV-dementia
    • Dhillon NK, Peng F, Bokhari S, et al. Cocaine-mediated alteration in tight junction protein expression and modulation of CCL2/CCR2 axis across the blood-brain barrier: Implications for HIV-dementia. J Neuroimmune Pharmacol 2008;3:52-56.
    • (2008) J Neuroimmune Pharmacol , vol.3 , pp. 52-56
    • Dhillon, N.K.1    Peng, F.2    Bokhari, S.3
  • 86
    • 41149126601 scopus 로고    scopus 로고
    • Cocaine: A catalyst for human immunodeficiency virus-associated dementia
    • Dhillon NK, Gadgil M, Rahardja A, et al. Cocaine: A catalyst for human immunodeficiency virus-associated dementia. Am J Infectious Dis 2008;4:131-139.
    • (2008) Am J Infectious Dis , vol.4 , pp. 131-139
    • Dhillon, N.K.1    Gadgil, M.2    Rahardja, A.3
  • 87
    • 34447539769 scopus 로고    scopus 로고
    • Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress
    • Colgan OC, Ferguson G, Collins NT, et al. Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress. Am J Physiol-Heart C 2007;292:H3190-H3197.
    • (2007) Am J Physiol-Heart C , vol.292
    • Colgan, O.C.1    Ferguson, G.2    Collins, N.T.3
  • 88
    • 78649646826 scopus 로고    scopus 로고
    • Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth
    • Helms HC, Waagepetersen HS, Nielsen CU, Brodin B. Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth. AAPS J 2010;12:759-770.
    • (2010) AAPS J , vol.12 , pp. 759-770
    • Helms, H.C.1    Waagepetersen, H.S.2    Nielsen, C.U.3    Brodin, B.4
  • 89
    • 55849109629 scopus 로고    scopus 로고
    • Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature
    • Chen L, Yokel RA, Hennig B, Toborek M. Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. J Neuroimmune Pharmacol 2008;3:286-295.
    • (2008) J Neuroimmune Pharmacol , vol.3 , pp. 286-295
    • Chen, L.1    Yokel, R.A.2    Hennig, B.3    Toborek, M.4
  • 90
    • 33646049704 scopus 로고    scopus 로고
    • Brief heat shock affects the permeability and thermotolerance of an in vitro blood-brain barrier model of porcine brain microvascular endothelial cells
    • Jeliazkova-Mecheva VV, Hymer WC, Nicholas NC, Bobilya DJ. Brief heat shock affects the permeability and thermotolerance of an in vitro blood-brain barrier model of porcine brain microvascular endothelial cells. Microvasc Res 2006;71:108-114.
    • (2006) Microvasc Res , vol.71 , pp. 108-114
    • Jeliazkova-Mecheva, V.V.1    Hymer, W.C.2    Nicholas, N.C.3    Bobilya, D.J.4
  • 91
    • 45949097554 scopus 로고    scopus 로고
    • Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
    • Sheikov N, McDannold N, Sharma S, Hynynen K. Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. Ultrasound Med Biol 2008;34:1093-1104.
    • (2008) Ultrasound Med Biol , vol.34 , pp. 1093-1104
    • Sheikov, N.1    McDannold, N.2    Sharma, S.3    Hynynen, K.4
  • 92
    • 79955804758 scopus 로고    scopus 로고
    • Increasing of blood-tumor barrier permeability through paracellular pathway by low-frequency ultrasound irradiation in vitro
    • Fan L, Liu Y, Ying H, et al. Increasing of blood-tumor barrier permeability through paracellular pathway by low-frequency ultrasound irradiation in vitro. J Mol Neurosci 2011;43:541-548.
    • (2011) J Mol Neurosci , vol.43 , pp. 541-548
    • Fan, L.1    Liu, Y.2    Ying, H.3
  • 93
    • 77953293152 scopus 로고    scopus 로고
    • EMP-induced alterations of tight junction protein expression and disruption of the blood-brain barrier
    • Ding GR, Qiu LB, Wang XW, et al. EMP-induced alterations of tight junction protein expression and disruption of the blood-brain barrier. Toxicol Lett 2010;196:154-160.
    • (2010) Toxicol Lett , vol.196 , pp. 154-160
    • Ding, G.R.1    Qiu, L.B.2    Wang, X.W.3
  • 94
    • 0037225649 scopus 로고    scopus 로고
    • Multiple forms of estrogen receptor-alpha in cerebral blood vessels: Regulation by estrogen
    • Stirone C, Duckles SP, Krause DN. Multiple forms of estrogen receptor-alpha in cerebral blood vessels: Regulation by estrogen. Am J Physiol Endocrinol Metab 2003;284:E184-192.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Stirone, C.1    Duckles, S.P.2    Krause, D.N.3
  • 95
    • 9444289385 scopus 로고    scopus 로고
    • 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats
    • Bake S, Sohrabji F. 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats. Endocrinol 2004;145:5471-5475.
    • (2004) Endocrinol , vol.145 , pp. 5471-5475
    • Bake, S.1    Sohrabji, F.2
  • 96
    • 71549122565 scopus 로고    scopus 로고
    • Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins
    • Bake S, Friedman JA, Sohrabji F. Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins. Microvasc Res 2009;78:413-424.
    • (2009) Microvasc Res , vol.78 , pp. 413-424
    • Bake, S.1    Friedman, J.A.2    Sohrabji, F.3
  • 97
    • 79651474491 scopus 로고    scopus 로고
    • Age and 17beta-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovariectomized rats
    • Sandoval KE, Witt KA. Age and 17beta-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovariectomized rats. Microvasc Res 2011;81:198-205.
    • (2011) Microvasc Res , vol.81 , pp. 198-205
    • Sandoval, K.E.1    Witt, K.A.2
  • 98
    • 21144438891 scopus 로고    scopus 로고
    • Occludin as direct target for glucocorticoid-induced improvement of blood-brain barrier properties in a murine in vitro system
    • Forster C, Silwedel C, Golenhofen N, et al. Occludin as direct target for glucocorticoid-induced improvement of blood-brain barrier properties in a murine in vitro system. J Physiol 2005;565:475-486.
    • (2005) J Physiol , vol.565 , pp. 475-486
    • Forster, C.1    Silwedel, C.2    Golenhofen, N.3
  • 99
    • 45549102801 scopus 로고    scopus 로고
    • Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier
    • Forster C, Burek M, Romero IA, Weksler B, Couraud PO, Drenckhahn D. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol 2008;586:1937-1949.
    • (2008) J Physiol , vol.586 , pp. 1937-1949
    • Forster, C.1    Burek, M.2    Romero, I.A.3    Weksler, B.4    Couraud, P.O.5    Drenckhahn, D.6
  • 100
    • 73549104979 scopus 로고    scopus 로고
    • Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep
    • Sadowska GB, Malaeb SN, Stonestreet BS. Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep. Am J Physiol Heart Circ Physiol 2010;298:H179-H188.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Sadowska, G.B.1    Malaeb, S.N.2    Stonestreet, B.S.3
  • 101
    • 0033959607 scopus 로고    scopus 로고
    • Affinity purification and partial characterization of the zonulin/zonula occludens toxin (Zot) receptor from human brain
    • Lu R, Wang W, Uzzau S, Vigorito R, Zielke HR, Fasano A. Affinity purification and partial characterization of the zonulin/zonula occludens toxin (Zot) receptor from human brain. J Neurochem 2000;74:320-326.
    • (2000) J Neurochem , vol.74 , pp. 320-326
    • Lu, R.1    Wang, W.2    Uzzau, S.3    Vigorito, R.4    Zielke, H.R.5    Fasano, A.6
  • 102
    • 11844272009 scopus 로고    scopus 로고
    • The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents
    • Salama NN, Fasano A, Thakar M, Eddington ND. The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents. J Pharmacol Exp Ther 2005;312:199-205.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 199-205
    • Salama, N.N.1    Fasano, A.2    Thakar, M.3    Eddington, N.D.4
  • 103
    • 33646492929 scopus 로고    scopus 로고
    • Tight junction modulation and its relationship to drug delivery
    • Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev 2006;58:15-28.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 15-28
    • Salama, N.N.1    Eddington, N.D.2    Fasano, A.3
  • 104
    • 27844435108 scopus 로고    scopus 로고
    • Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT
    • Menon D, Karyekar CS, Fasano A, Lu R, Eddington ND. Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT. Int J Pharm 2005;306:122-131.
    • (2005) Int J Pharm , vol.306 , pp. 122-131
    • Menon, D.1    Karyekar, C.S.2    Fasano, A.3    Lu, R.4    Eddington, N.D.5
  • 105
    • 63249110007 scopus 로고    scopus 로고
    • Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery
    • Deli MA. Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. Biochim Biophys Acta 2009;1788:892-910.
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 892-910
    • Deli, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.