Quinidine as an abcb1 probe for testing drug interactions at the blood-brain barrier: An in vitro in vivo correlation study

Journal of Biomolecular Screening

Volumn 16, Issue 8, 2011, Pages 886-894

  Sziráki, István ^a   Erdo, Franciska ^a   Beéry, Erzsébet ^a   Molnár, Petra Magdolna ^b   Fazakas, Csilla ^c   Wilhelm, Imola ^c   Makai, Ildikó ^a   Kis, Emese ^a   Herédi Szabó, Krisztina ^a   Abonyi, Tibor ^a   Krizbai, István ^c   Tóth, Gábor K ^b   Krajcsi, Péter ^a  

^a SOLVO BIOTECHNOLOGY   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

ABCBl P gp; BBB; Microdialysis; PSC 833; Quinidine

Indexed keywords

ABCB1 TRANSPORTER; ADENOSINE TRIPHOSPHATASE; DIGOXIN; MEMBRANE PROTEIN; QUINIDINE; UNCLASSIFIED DRUG; VALSPODAR;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN LEVEL; CELL LINE; DIALYSATE; DRUG BLOOD LEVEL; DRUG POTENCY; EFFUSION; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BIOLOGICAL AGENTS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCULTURE TECHNIQUES; CYCLOSPORINS; DIGOXIN; DOGS; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICRODIALYSIS; P-GLYCOPROTEINS; QUINIDINE; RATS; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 80054720200     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111414896     Document Type: Article

References (28)

1. Schinkel, A. FL; Jonker, J. W. Mammalian Drug Efflux Transporters of the ATP Binding Cassette (ABC) Family: An Overview. Adv. Drug Deliv. Rev. 2003, 55, 3-29. (Pubitemid 36078452)
2. Giacomini, K. M.; Huang, S. M.; Tweedie, D. J.; Benet, L. Z.; Brouwer, K. L.; Chu, X.; Dahlin, A.; Evers, R.; Fischer, V.; Hillgren, K. M.; et al. Membrane Transporters in Drug Development. Nat. Rev. Drug Discov. 2010, 9, 215-236.
3. Zhang, L.; Zhang, Y. D.; Zhao, P.; Huang, S. M. Predicting Drug-Drug Interactions: An FDA Perspective. AAPS J. 2009, 11, 300-306.
4. Ma, J. D.; Tsunoda, S. M.; Bertino, J. S., Jr.; Trivedi, M.; Beale, K. K.; Nafziger, A. N. Evaluation of In Vivo P-glycoprotein Phenotyping Probes: A Need for Validation. Clin. Pharmacokinet. 2010, 49, 223-237.
5. Harashima, H.; Sawada, Y.; Sugiyama, Y.; Iga, T.; Hanano, M. Analysis of Nonlinear Tissue Distribution of Quinidine in Rats by Physiologically Based Pharmacokinetics. J. Pharmacokinet. Biopharm. 1985, 13, 425-440. (Pubitemid 16207488)
6. Kusuhara, H.; Suzuki, H.; Terasaki, T.; Kakee, A.; Lemaire, M.; Sugiyama, Y. P-Glycoprotein Mediates the Efflux of Quinidine across the Blood-Brain Barrier. J. Pharmacol. Exp. Ther. 1997, 283, 574-580. (Pubitemid 27514613)
7. Starling, J. J.; Shepard, R. L.; Cao, J.; Law, K. L.; Norman, B. H.; Kroin, J. S.; Ehlhardt, W. J.; Baughman, T. M.; Winter, M. A.; Bell, M. G.; et al. Pharmacological Characterization of LY335979: A Potent Cyclopropyldibenzosuberane Modulator of P-Glycoprotein. Adv. Enzyme Regul. 1997, 37, 335-347. (Pubitemid 27371567)
8. Sun, H.; Bungay, P. M.; Elmquist, W. F. Effect of Capillary Efflux Transport Inhibition on the Determination of Probe Recovery during In Vivo Microdialysis in the Brain. J. Pharmacol. Exp. Ther. 2001, 297, 991-1000. (Pubitemid 32472496)
9. Eyal, S.; Hsiao, P.; Unadkat, J. D. Drug Interactions at the Blood-Brain Barrier: Fact or Fantasy? Pharmacol. Ther. 2009, 123, 80-104.
10. Advani, R.; Saba, H. I.; Tallman, M. S.; Rowe, J. M.; Wiernik, P. H.; Ramek, J.; Dugan, K.; Lum, B.; Villena, J.; Davis, E.; et al. Treatment of Refractory and Relapsed Acute Myelogenous Leukemia with Combination Chemotherapy Plus the Multidrug Resistance Modulator PSC 833 (Valspodar). Blood 1999, 93, 787-795. (Pubitemid 29067843)
11. O'Brien, M. M.; Lacayo, N. J.; Lum, B. L.; Kshirsagar, S.; Buck, S.; Ravindranath, Y.; Bernstein, M.; Weinstein, H.; Chang, M. N.; Arceci, R. J.; et al. Phase I study of Valspodar (PSC-833) with Mitoxantrone and Etoposide in Refractory and Relapsed Pediatric Acute Leukemia: A Report from the Children's Oncology Group. Pediatr. Blood Cancer 2010, 54, 694-702.
12. Barnett, C. J.; Huff, B.; Kobierski, M. E.; Letourneau, M.; Wilson, T. M. Stereochemistry of C-6 Nucleophilic Displacements on 1, 1- Difluorocyclopropyldibenzosuberanyl Substrates: An Improved Synthesis of Multidrug Resistance Modulator LY335979 Trihydrochloride. J. Org. Chem 2004, 69, 7653-7660. (Pubitemid 39403352)
13. Rajnai, Z.; Mehn, D.; Beery, E.; Okyar, A.; Jani, M.; Toth, G. K.; Fulop, F.; Levi, F.; Krajcsi, P. ABCB1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor. Drug Metab. Dispos. 2010, 38, 2000-2006.
14. Wilhelm, I.; Farkas, A. E.; Nagyoszi, P.; Váró, G.; Bálint, Z.; Végh, G. A.; Couraud, P. O.; Romero, I. A.; Weksler, B.; Krizbai, I. A. Regulation of Cerebral Endothelial Cell Morphology by Extracellular Calcium. Phys. Med. Biol. 2007, 52, 6261-6274. (Pubitemid 350093193)
15. Hutamekalin, P.; Farkas, A. E.; Orbók, A.; Wilhelm, I.; Nagyoszi, P.; Veszelka, S.; Deli, M. A.; Buzás, K.; Hunyadi-Gulyás, E.; Medzihradszky, K. F.; et al. Effect of Nicotine and Polyaromatic Hydrocarbons on Cerebral Endothelial Cells. Cell Biol. Int. 2008, 32, 198-209. (Pubitemid 351291674)
16. Paxinos, G.; Watson, C. The Rat Brain in Stereotaxic Coordinates, 4th Ed.; Academic Press: New York, 1998.
17. Von Richter, O.; Glavinas, H.; Krajcsi, P.; Liehner, S.; siewert, B.; Zech, K. A Novel Screening Strategy to Identify ABCBl Substrates and Inhibitors. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379, 11-26.
18. Polli, J. W.; Wring, S. A.; Humphreys, J. E.; Huang, L.; Morgan, J. B.; Webster, L. O.; serabjit-singh, C. S. Rational Use of In Vitro P-Glycoprotein Assays in Drug Discovery. J. Pharmacol. Exp. Ther. 2001, 299(2), 620-628. (Pubitemid 32979675)
19. Feng, B.; Mills, J. B.; Davidson, R. E.; Mireles, R. J.; Janiszewski, J. S.; Troutman, M. D.; de Morais, S. M. In Vitro P-Glycoprotein Assays to Predict the In Vivo Interactions of P-Glycoprotein with Drugs in the Central Nervous System. Drug Metab. Dispos. 2008, 36, 268-275. (Pubitemid 351185738)
20. Deli, M. A.; Abraham, C. S.; Kataoka, Y.; Niwa, M. Permeability Studies on In Vitro Blood-Brain Barrier Models: Physiology, Pathology, and Pharmacology. Cell Mol. Neurobiol. 2005, 25, 59-127. (Pubitemid 40558585)
21. Nakagawa, S.; Deli, M. A.; Kawaguchi, H.; Shimizudani, T.; Shimono, T.; Kittel, A.; Tanaka, K.; Niwa, M. A New Blood-Brain Barrier Model Using Primary Rat Brain Endothelial Cells, Pericytes and Astrocytes. Neurochem. Int. 2009, 54, 253-263.
22. Dai, H.; Elmquist, W. M. Drug Transport Studies Using Quantitative Microdialysis. In: Methods in Molecular Medicine: Vol. 89. The Blood-Brain Barriers: Biology and Research Protocols; Nag, S., Ed.; Humana: Totowa, NJ, 2003, pp. 249-264.
23. Fellner, S.; Bauer, B.; Miller, D. S.; Schaffrik, M.; Fankhänel, M.; Spruss, T.; Bernhardt, G.; Graeff, C.; Färber, L.; Gschaidmeier, H.; et al. Transport of Paclitaxel (Taxol) across the Blood-Brain Barrier In Vitro and In Vivo. J. Clin. Invest. 2002, 110, 1309-1318. (Pubitemid 35285757)
24. Choo, E. F.; Leake, B.; Wandel, C.; Imamura, H.; Wood, A. J.; Wilkinson, G. R.; Kim, R. B. Pharmacological Inhibition of P-Glycoprotein Transport Enhances the Distribution of HIV-l Protease Inhibitors into Brain and Testes. Drug Metab. Dispos. 2000, 28, 655-660. (Pubitemid 30390404)
25. Dantzig, A. H.; shepard, R. L.; Cao, J.; Law, K. L.; Ehlhardt, W. J.; Baughman, T. M.; Bumol, T. F.; Starling, J. J. Reversal of P-Glycoprotein- Mediated Multidrug Resistance by a Potent Cyclopropyldibenzosuberane Modulator, LY335979. Cancer Res. 1996, 56, 4l7l-4l79. (Pubitemid 26305012)
26. Jain, R.; Majumdar, S.; Nashed, Y.; Mitra, A. K. Circumventing P-Glycoprotein-Mediated Cellular Efflux of Qunidine by Prodrug Derivatization. Mol. Pharm. 2004, 1, 290-299.
27. Hugger, E. D.; Audus, K. L.; Borchardt, R. T. Effects of Poly (Ethylene Glycol) on Efflux Transporter Activity in Caco-2 Cell Monolayers. J. Pharm. Sci. 2002, 91, l980-l990. (Pubitemid 36254934)
28. Werle, M. Polymeric and Low Molecular Mass Efflux Pump Inhibitors for Oral Drug Delivery. J. Pharm. Sci. 2008, 97, 60-70.