Structure-activity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: Rational design of antagonists

Journal of Medicinal Chemistry

Volumn 56, Issue 24, 2013, Pages 10079-10102

  Moreau, Christelle ^a   Kirchberger, Tanja ^b   Swarbrick, Joanna M ^a   Bartlett, Stephen J ^a   Fliegert, Ralf ^b   Yorgan, Timur ^b   Bauche, Andreas ^b   Harneit, Angelika ^b   Guse, Andreas H ^b   Potter, Barry V L ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5' DEOXY 8 PHENYLADENOSINE) 4 (2'',3'' O ISOPROPYLIDENE 5'' O METHYLRIBOSYL) 1,2,3 TRIAZOLE; 2' DEOXYADENOSINE DIPHOSPHORIBOSE; 3 (5' AMINO 5' DEOXYADENOSINE) 4 (5'' AMINO 5'' DEOXY BETA DEXTRO RIBOFURANOSE)CYCLOBUT 3 ENE 1,2 DIONE; 3 (5' AMINO 5' DEOXYADENOSINE) 4 (CYCLOPENTYLAMINO)CYCLOBUT 3 ENE 1,2 DIONE; 3 (5' AMINO 5' DEOXYADENOSINE) 4 (HEXYLAMINO)CYCLOBUT 3 ENE 1,2 DIONE; 3 (5' AMINO 5' DEOXYADENOSINE) 4 BUTYLAMINO CYCLOBUT 3 ENE 1,2 DIONE; 3' DEOXYADENOSINE 5' DIPHOSPHORIBOSE; 6 O METHYLINOSINE DIPHOSPHORIBOSE; 7 DEAZA 8 BROMOADENOSINE DIPHOSPHORIBOSE; 8 (3 ACETYLPHENYL)ADENOSINE DIPHOSPHORIBOSE; 8 (3 THIOPHENYL)ADENOSINE DIPHOSPHORIBOSE; 8 [4 (2 AMINOPROPANOIC ACID)PHENYL]ADENOSINE 5' MONOPHOSPHATE; 8 AMINOADENOSINE DIPHOSPHORIBOSE; 8 PHENYL 2' DEOXY ADENOSINE 5' DIPHOSPHORIBOSE; 8 PHENYLADENOSINE DIPHOSPHORIBOSE; 9 (4 HYDROXYBUTYL)ADENINE 5' DIPHOSPHORIBOSE; ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE TRIPHOSPHORIBOSE; BETA CYCLOPENTYLADENOSINE DIPHOSPHATE; INOSINE 5' DIPHOSPHORIBOSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NEUTROPHIL; PATCH CLAMP TECHNIQUE; STRUCTURE ACTIVITY RELATION;

EID: 84891313988     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401497a     Document Type: Article

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