2′-deoxy cyclic adenosine 5′-diphosphate ribose derivatives: Importance of the 2′-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives

Journal of Medicinal Chemistry

Volumn 51, Issue 6, 2008, Pages 1623-1636

  Zhang, Bo ^a   Wagner, Gerd K ^a   Weber, Karin ^b   Garnham, Clive ^c   Morgan, Anthony J ^c   Galione, Antony ^c   Guse, Andreas H ^b   Potter, Barry V L ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY CYCLIC ADENOSINE 5' DIPHOSPHATE RIBOSE DERIVATIVE; 8 BROMO 2' DEOXY CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; 8 O METHYL 2' DEOXY CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; 8 PHENYL 2' DEOXY CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; 8 PHENYL CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; 8 PHENYL NICOTINAMIDE ADENINE 5' DINUCLEOTIDE; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; RIBOSE; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CALCIUM; DRUG DERIVATIVE;

APLYSIA; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NONHUMAN; SEA URCHIN; ANIMAL; CHEMISTRY; CONFORMATION; DRUG EFFECT; LYTECHINUS; METABOLISM; OOCYTE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ADP-RIBOSYL CYCLASE; ANIMALS; APLYSIA; CALCIUM; CYCLIC ADP-RIBOSE; HUMANS; JURKAT CELLS; LYTECHINUS; MOLECULAR CONFORMATION; OVUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 41149134471     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7010386     Document Type: Article

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