Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 6, 2009, Pages 497-507

  Pantaler, Elena ^a   Lückhoff, Andreas ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

8Br ADP ribose; ACA; DPI; FMLP; Mn2+ quenching; PAF; TRPM2

Indexed keywords

8 BROMO ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; FORMYLMETHIONYLLEUCYLPHENYLALANINE; N (4 AMYLCINNAMOYL)ANTHRANILIC ACID; THAPSIGARGIN; THROMBOCYTE ACTIVATING FACTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; NEUTROPHIL; PHOTOCHEMICAL QUENCHING; RECEPTOR POTENTIAL;

ADENOSINE DIPHOSPHATE RIBOSE; ANILINE COMPOUNDS; ANTHRANILIC ACIDS; CALCIUM; CINNAMATES; FLUORESCENT DYES; HUMANS; MANGANESE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PLATELET ACTIVATING FACTOR; THAPSIGARGIN; TRPM CATION CHANNELS; XANTHENES;

EID: 71349087750     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0464-2     Document Type: Article

References (57)

1. AP Albert SN Saleh WA Large 2008 Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-biphosphate in mesenteric artery myocytes J Physiol 586 3087 3095 10.1113/jphysiol.2008.153676 1:CAS:528: DC%2BD1cXovVSmsbw%3D 18467363 (Pubitemid 351984692)
2. H Ali S Sozzani I Fisher AJ Barr RM Richardson B Haribabu R Snyderman 1998 Differential regulation of formyl peptide and plateletactivating factor receptors J Biol Chem 273 11012 11016 10.1074/jbc.273.18.11012 1:CAS:528:DyaK1cXjtFGktLc%3D 9556582 (Pubitemid 28204943)
3. TT Amatruda 3rd NP Gerard C Gerard MI Simon 1993 Specific interactions of chemoattractant factor receptors with G-proteins J Biol Chem 268 10139 10144 1:CAS:528:DyaK3sXkt1Klt74%3D 8486684
4. N Borregaard OE Sørensen K Theilgaard-Mönch 2007 Neutrophil granules: a library of innate immunity proteins Trends Immunol 28 340 345 10.1016/j.it.2007.06.002 1:CAS:528:DC%2BD2sXotVGqtb0%3D 17627888 (Pubitemid 47077924)
5. S Bréchard EJ Tschirhart 2008 Regulation of superoxide production in neutrophils: role of calcium influx J Leukoc Biol 84 1223 1237 10.1189/jlb.0807553 18519744
6. 2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes Cell Calcium 44 492 506 10.1016/j.ceca.2008. 03.002 18436303
7. SL Brown VR Jala SK Raghuwanshi MW Nasser B Haribabu MR Richardson 2006 Activation and regulation of platelet-activating factor receptor: role of Gi and Gq in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals J Immunol 177 3242 3249 1:CAS:528:DC%2BD28Xot1Cjt74%3D 16920964
8. J Bylund M Samuelsson LV Collins A Karlsson 2003 NADPH-oxidase activation in murine neutrophils via formyl peptide receptors Exp Cell Res 282 70 77 10.1016/S0014-4827(02)00010-1 1:CAS:528:DC%2BD3sXjtFCgtg%3D%3D 12531693 (Pubitemid 36259902)
9. 2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells Biochem J 413 103 113 10.1042/BJ20071471 1:CAS:528:DC%2BD1cXntVWnsbg%3D 18352857 (Pubitemid 351946866)
10. PMC Dang S Rais J Hakim A Perianin 1995 Redistribution of protein kinase C isoforms in human neutrophils stimulated by formyl peptides and phorbol-myristate acetate Biochem Biophys Res Commun 212 664 672 10.1006/bbrc.1995.2020 1:CAS:528:DyaK2MXntFamurc%3D 7626081
11. B Dewald M Thelen M Baggiolini 1988 Two transduction sequences are necessary for neutrophil activation by receptor agonists J Biol Chem 263 16179 16184 1:CAS:528:DyaL1cXlvVymur8%3D 2846536
12. Eisfeld J, Lückhoff A (2007) TRPM2. In: Abramowitz J, Flockerzi V, Nilius B et al (eds) Transient receptor potential (TRP) channels. Handbook of experimental pharmacology, vol 179. Springer, Berlin, pp 237-257
13. 2+ concentrations are essential and synergize with a kinetically distinct second signal Biochem J 322 709 718 1:CAS:528:DyaK2sXit1Ojs7o%3D 9148740
14. H Fu J Karlsson J Bylund C Movitz A Karlsson C Dahlgren 2006 Ligand recognition and activation of formyl peptide receptors in neutrophils J Leukoc Biol 79 247 256 10.1189/jlb.0905498 1:CAS:528:DC%2BD28Xht12rtLs%3D 16365159 (Pubitemid 44831156)
15. - production in neutrophil-like HL-60 cells Eur J Pharmacol 361 293 298 10.1016/S0014- 2999(98)00728-6 1:CAS:528:DyaK1cXnvVSrtb8%3D 9865520 (Pubitemid 29000985)
16. JL Gao PM Murphy 1993 Species and subtype variants of the N-formil peptide chemotactic receptor reveal multiple important functional domains J Biol Chem 268 25395 25401 1:CAS:528:DyaK3sXmt1Ciu7k%3D 8244972
17. 2+ influx in human neutrophil granulocytes. Alterations in chronic granulomatous disease J Biol Chem 272 26471 26478 10.1074/jbc.272.42.26471 1:CAS:528:DyaK2sXmvV2isLc%3D 9334224 (Pubitemid 27458866)
18. Y Gwack S Srikanth S Feske F Cruz-Guilloty M Oh-hora DS Neems PG Hogan A Rao 2007 Biochemical and functional characterization of Orai proteins J Biol Chem 282 16232 16243 10.1074/jbc.M609630200 1:CAS:528:DC%2BD2sXlvVajtrs%3D 17293345 (Pubitemid 47100386)
19. MB Hallett 2003 Holding back neutrophil aggression; the oxidase has potential Clin Exp Immunol 132 181 184 10.1046/j.1365-2249.2003.02158.x 1:CAS:528:DC%2BD3sXktlSrurY%3D 12699403 (Pubitemid 36560610)
20. 2 inhibitor and TRP channel blocker Cardiovasc Drug Rev 25 61 75 1:CAS:528:DC%2BD2sXht12kurrF 17445088
21. 2+ influx in human neutrophils occurs via store-operated mechanisms J Leukoc Biol 69 63 68 1:CAS:528: DC%2BD3MXlvFCiug%3D%3D 11200069
22. I Heiner J Eisfeld CR Halaszovich E Wehage E Jüngling C Zitt A Lückhoff 2003 Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD Biochem J 371 1045 1053 10.1042/BJ20021975 1:CAS:528:DC%2BD3sXjtFKlsLs%3D 12564954 (Pubitemid 36578904)
23. I Heiner N Radukina J Eisfeld F Kühn A Lückhoff 2005 Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target Naunyn Schmiedebergs Arch Pharmacol 371 325 333 10.1007/s00210-005-1033-y 1:CAS:528:DC%2BD2MXltlChsb8%3D 15841395 (Pubitemid 40905087)
24. I Heiner J Eisfeld M Warnstedt N Radukina E Jüngling A Lückhoff 2006 Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes Biochem J 398 Pt 2 225 232 1:CAS:528:DC%2BD28XotV2qs70%3D 16719842
25. T Hofmann AG Obukhov M Schaefer C Harteneck T Gudermann G Schultz 1999 Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol Nature 397 259 263 10.1038/16711 1:CAS:528:DyaK1MXpvVGhsw%3D%3D 9930701 (Pubitemid 29051175)
26. KB Hubbard JR Helper 2006 Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins Cell Signal 18 135 150 10.1016/j.cellsig.2005.08. 004 1:CAS:528:DC%2BD2MXhtFKntr7K 16182515 (Pubitemid 41528793)
27. K Itagaki KB Kannan DH Livingston EA Deitch Z Fekete CJ Hauser 2002 Store-operated calcium entry in human neutrophils reflects multiple contributions from independently regulated pathways J Immunol 168 4063 4069 1:CAS:528:DC%2BD38XivV2isL0%3D 11937565
28. K Itagaki KB Kannan BB Singh CJ Hauser 2004 Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils J Immunol 172 601 607 1:CAS:528: DC%2BD3sXpvFegs7o%3D 14688372
29. A Karlsson C Dahlgren 2002 Assembly and activation of the neutrophil NADPH oxidase in granule membranes Antioxid Redox Signal 14 49 60 10.1089/152308602753625852
30. UH Kim MK Han BH Park HR Kim NH An 1993 Function of NAD glycohydrolase in ADP-ribose uptake from NAD by human erythrocytes Biochim Biophys Acta 1178 121 126 10.1016/0167-4889(93)90001-6 1:CAS:528:DyaK3sXms1OnsLk%3D 8394137
31. FJ Kühn G Knop A Lückhoff 2007 The transmembrane segment S6 determines cation versus anion selectivity of TRPM2 and TRPM8 J Biol Chem 282 27598 27609 10.1074/jbc.M702247200 17604279 (Pubitemid 47529523)
32. FJP Kühn I Heiner A Lückhoff 2005 TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose Pflügers Arch 45 212 219 10.1007/s00424-005-1446-y (Pubitemid 41424925)
33. R Kraft C Grimm H Frenzel C Harteneck 2006 Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid British J Pharmacol 148 264 273 10.1038/sj.bjp.0706739 1:CAS:528:DC%2BD28XltVCjt78%3D (Pubitemid 43801173)
34. P Lacy G Eitzen 2008 Control of granule exocytosis in neutrophils Front Biosci 13 5559 5570 10.2741/3099 1:CAS:528:DC%2BD1cXnsVOju78%3D 18508605
35. I Lange R Penner A Fleig A Beck 2008 Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils Cell Calcium 44 604 615 10.1016/j.ceca.2008.05.001 1:CAS:528:DC%2BD1cXhtlGgs7nK 18572241
36. PD Lew A Monod FA Waldvogel B Dewald M Baggiolini T Pozzan 1986 Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils J Cell Biol 102 2197 2204 10.1083/jcb.102.6.2197 1:CAS:528:DyaL28Xkt1aru7Y%3D 3011810
37. E Ligeti A Mocsai 1999 Exocytosis of neutrophil granulocytes Biochem Pharmacol 57 1209 1214 10.1016/S0006-2952(98)00377-3 1:CAS:528: DyaK1MXivVCjtLk%3D 10230763 (Pubitemid 29185142)
38. PW Marks FR Maxflield 1990 Transient increase in cytosolic free calcium appear to be required for the migration of adherent human neutrophils J Cell Biol 110 43 52 10.1083/jcb.110.1.43 1:CAS:528:DyaK3cXps1yisg%3D%3D 2295684 (Pubitemid 20035876)
39. NJ McLaughlin A Banerjee SY Khan JL Lieber MR Kelher F Gamboni-Robertson FR Sheppard EE Moore GW Mierau DJ Elzi CC Silliman 2008 Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils J Immunol 180 8192 8203 1:CAS:528:DC%2BD1cXntVeltrY%3D 18523285
40. SR McMeekin I Dransfiel AG Rossi C Haslett TR Walker 2006 E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils Blood 107 4938 4945 10.1182/blood-2005-09-3803 1:CAS:528: DC%2BD28XlvFCgtLs%3D 16514053 (Pubitemid 43882648)
41. 2+ Biochem J 269 513 519
42. 2+ rise and migration of human neutrophils J Pharmacol Sci 106 492 504 10.1254/jphs.FP0072083 1:CAS:528:DC%2BD1cXktlWlsLw%3D 18344610
43. JA Nick NJ Avdi SK Young C Knall P Gerwins GL Johnson GS Worthen 1997 Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and fMLP J Clin Invest 99 975 986 10.1172/JCI119263 1:CAS:528:DyaK2sXhs1Kqurg%3D 9062356
44. 2+-induced exocytosis in individual human neutrophils: high- and low-affinity granule populations and submaximal responses EMBO J 17 1279 1288 10.1093/emboj/17.5.1279 9482725 (Pubitemid 28105507)
45. S Partida-Sanchez P Iribarren ME Moreno-Garcia J-L Gao PM Murphy N Oppenheimer JM Wang FE Lund 2004 Chemotaxis and calcium responses of phagocytes to formyl-peptide receptor ligands is differentially regulated by cyclic ADP-ribose J Immunol 172 1896 1906 1:CAS:528:DC%2BD2cXptl2gtg%3D%3D 14734775
46. S Partida-Sanchez A Gasser R Fliegert CC Siebrands W Dammermann G Shi BJ Mousseau A Sumoza-Toledo H Bhagat TF Walseth AH Guse FE Lund 2007 Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-ribose, the major product generated by the CD38 enzyme reaction J Immunol 179 7827 7839 1:CAS:528:DC%2BD2sXhtlajt7nM 18025229
47. AL Perraud A Fleig CA Dunn LA Bagley P Launay C Schmitz AJ Stokes Q Zhu MJ Bessman R Penner JP Kinet AM Scharenberg 2001 ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology Nature 411 595 599 10.1038/35079100 1:CAS:528:DC%2BD3MXksVShsbo%3D 11385575 (Pubitemid 32531407)
48. F Schuber FE Lund 2004 Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites Curr Mol Med 4 249 261 10.2174/1566524043360708 1:CAS:528:DC%2BD2cXjt1Orsr8%3D 15101683 (Pubitemid 38515236)
49. H Sengeløv L Kjeldsen N Borregaard 1993 Control of exocytosis in early neutrophil activation J Immunol 150 1535 1543 8381838
50. Z Shmelzer M Karter M Eisenstein TL Leto N Hadad D Ben-Menahem D Gitler S Banani B Wolach M Rotem R Levy 2008 Cytosolic phospholipase A2α is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain J Biol Chem 238 31898 31908 10.1074/jbc.M804674200
51. J Starkus A Beck A Fleig R Penner 2007 Regulation of TRPM2 by extra- and intracellular calcium J Gen Physiol 130 427 440 10.1085/jgp.200709836 1:CAS:528:DC%2BD2sXht1WmsrjK 17893195 (Pubitemid 47481605)
52. HC Steel R Anderson 2002 Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium Br J Pharmacol 136 81 89 10.1038/sj.bjp.0704685 1:CAS:528:DC%2BD38XjvV2ktrs%3D 11976271
53. Thomas A, Delaville F (1991) The use of fluorescent indicators for measurements of cytosolic-free calcium concentration in cell populations and single cells. In: McCormack JG, Cobbold PH (eds) Cellular calcium: a practical approach. Oxford University Press, New York, pp 1-54
54. 2+ by chemoattractant-activated human neutrophils Biochem Pharmacol 67 2263 2271 10.1016/j.bcp.2004.02.029 1:CAS:528:DC%2BD2cXkt1Skurs%3D 15163557 (Pubitemid 38639934)
55. GR Tintinger AJ Theron HC Steel R Anderson 2001 Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease Clin Exp Immunol 123 254 263 10.1046/j.1365-2249.2001.01447.x 1:CAS:528: DC%2BD3MXhvFertLY%3D 11207656 (Pubitemid 32174777)
56. P Travo H Muller F Schuber 1979 Calf spleen NAD glycohydrolase. Comparison of the catalytic properties of the membrane-bound and the hydrosoluble forms of the enzyme Eur J Biochem 96 141 149 10.1111/j.1432-1033. 1979.tb13023.x 1:CAS:528:DyaE1MXktFGksLc%3D 222585
57. S Yamamoto S Shimizu S Kiyonaka N Takahashi T Wajima Y Hara T Negoro T Hiroi Y Kiuchi T Okada S Kaneko I Lange A Fleig R Penner M Nishi H Takeshima Y Mori 2008 TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration Nat Med 7 738 747 10.1038/nm1758 (Pubitemid 351953041)