TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

British Journal of Pharmacology

Volumn 143, Issue 1, 2004, Pages 186-192

  Fonfria, Elena ^a   Marshall, Ian C B ^a   Benham, Christopher D ^a   Boyfield, Izzy ^a   Brown, Jason D ^a   Hill, Kerstin ^a   Hughes, Jane P ^a   Skaper, Stephen D ^a   McNulty, Shaun ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

CRI G1; DPQ; Hydrogen peroxide; Oxidative stress; PARP; PJ34; SB750139 B; TRPM2

Indexed keywords

3,4 DIHYDRO 5 [4 (1 PIPERIDINYL)BUTOXY] 1[2H]ISOQUINOLINONE; ADENOSINE DIPHOSPHATE RIBOSE; CALCIUM; HYDROGEN PEROXIDE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; SB 750139B; TETRACYCLINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CHANNEL GATING; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INSULINOMA; MELASTIN LIKE TRANSIENT RECEPTOR POTENTIAL 2 CHANNEL; MEMBRANE CURRENT; MEMBRANE DAMAGE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; FLUORESCENT DYES; FLUOROMETRY; HUMANS; HYDROGEN PEROXIDE; INSULINOMA; ION CHANNEL GATING; ION CHANNELS; MEMBRANE PROTEINS; ORGANIC CHEMICALS; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; RATS; TETRAZOLIUM SALTS; THIAZOLES; TRPM CATION CHANNELS;

EID: 4644307600     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705914     Document Type: Article

References (24)

1. BURKART, V., WANG, Z.Q., RADONS, J., HELLER, B., HERCEG, Z., STINGL, L., WAGNER, E.F. & KOLB, H. (1999). Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat. Med., 5, 314-319.
2. COSI, C. (2002). New inhibitors of poly(ADP-ribose) polymerase and their potential therapeutic targets. Expert Opin. Ther. Patents, 12, 1047-1071.
3. DE MURCIA, G. & MENISSIER, D.M. (1994). Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem. Sci., 19, 172-176.
4. ELIASSON, M.J., SAMPEI, K., MANDIR, A.S., HURN, P.D., TRAYSTMAN, R.J., BAO, J., PIEPER, A., WANG, Z.Q., DAWSON, T.M., SNYDER, S.H. & DAWSON, V.L. (1997). Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat. Med., 3, 1089-1095.
5. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol. Cell, 9, 163-173.
6. HEINER, I., EISFELD, J. & LUCKHOFF, A. (2003). Role and regulation of TRP channels in neutrophil granulocytes. Cell Calcium, 33, 533-540.
7. INAMURA, K., SANO, Y., MOCHIZUKI, S., YOKOI, H., MIYAKE, A., NOZAWA, K., KITADA, C., MATSUSHIME, H. & FURUICHI, K. (2003). Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line. J. Membr. Biol., 191, 201-207.
8. KOURIE, J.I. (1998). Interaction of reactive oxygen species with ion transport mechanisms. Am. J. Physiol., 275, C1-C24.
9. KRAFT, R., GRIMM, C., GROSSE, K., HOFFMANN, A., SAUERBRUCH, S., KETTENMANN, H., SCHULTZ, G. & HARTENECK, C. (2004). Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am. J. Physiol. Cell Physiol., 286, C129-C137.
10. LUBISCH, W., GRANDEL, R., KOCK, M., MUELLER, R., HOEGER, T. & SCHULT, S. (2001). New azepinoindole derivatives are PARP inhibitors - useful for the treatment of e.g. stroke, Alzheimer's, Parkinson's or Huntington's disease, epilepsy, kidney damage, acute myocardial infarction, tumors, tumor metastasis, sepsis and ARDS. (DE10039610-A1), Patent.
11. 2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J. Biol. Chem., 278, 11002-11006.
12. 2+ channel protein (Trpc7) highly expressed in brain. Genomics, 54, 124-131.
13. OLIVER, F.J., MENISSIER-DE MURCIA, J., NACCI, C., DECKER, P., ANDRIANTSITOHAINA, R., MULLER, S., DE LA, R.G., STOCLET, J.C. & DE MURCIA, G. (1999). Resistance to endotoxic shock as a consequence of defective NF-kB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J., 18, 4446-4454.
14. PERRAUD, A.L., FLEIG, A., DUNN, C.A., BAGLEY, L.A., LAUNAY, P., SCHMITZ, C., STOKES, A.J., ZHU, Q., BESSMAN, MJ., PENNER, R., KINET, J.P. & SCHARENBERG, A.M. (2001). ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature, 411, 595-599.
15. 2+ influx system mediated by LTRPC2. Science, 293, 1327-1330.
16. SKAPER, S.D. (2003). Poly(ADP-ribosyl)ation enzyme-1 as a target for neuroprotection in acute central nervous system injury. Curr. Drug Target CNS Neurol. Disord., 2, 279-291.
17. SMITH, S. (2001). The world according to PARP. Trends Biochem. Sci., 26, 174-179.
18. SUAREZ-PINZON, W.L., MABLEY, J.G., POWER, R., SZABO, C. & RABINOVITCH, A. (2003). Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes, 52, 1683-1688.
19. TAKAHASHI, K., GREENBERG, J.H., JACKSON, P., MACLIN, K. & ZHANG, J. (1997). Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab., 17, 1137-1142.
20. TANUMA, S., YAGI, T. & JOHNSON, G.S. (1985). Endogenous ADP ribosylation of high mobility group proteins 1 and 2 and histone H1 following DNA damage in intact cells. Arch. Biochem. Biophys., 237, 38-42.
21. 2-mediated cytotoxicity of rat pulmonary endothelial cells. Changes in adenosine triphosphate and purine products and effects of protective interventions. Lab. Invest., 63, 683-689.
22. VIRAG, L. & SZABO, C. (2002). The therapeutic potential of poly(ADP-Ribose) polymerase inhibitors. Pharmacol. Rev., 54, 375-429.
23. WEHAGE, E., EISFELD, J., HEINER, I., JUNGLING, E., ZITT, C. & LUCKHOFF, A. (2002). Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J. Biol. Chem., 277, 23150-23156.
24. ZHANG, W., CHU, X., TONG, Q., CHEUNG, J.Y., CONRAD, K., MASKER, K. & MILLER, B.A. (2003). A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J. Biol. Chem., 278, 16222-16229.