TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Melzer, Nico ^a   Hicking, Gordon ^a   Göbel, Kerstin ^a   Wiendl, Heinz ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE CENTRAL NERVOUS SYSTEM INFLAMMATION; AUTOIMMUNE DISEASE; CELL ISOLATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD LESION; SPLEEN CELL; T LYMPHOCYTE; WILD TYPE;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CALCIUM; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INFLAMMATION; MICE; NEURONS; OXIDATIVE STRESS; SPLEEN; T-LYMPHOCYTES; TRPM CATION CHANNELS;

EID: 84867423889     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047617     Document Type: Article

References (27)

1. Feske S, (2007) Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol 7: 690-702.
2. Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, et al. (2010) Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. J Immunol 184: 1536-1542.
3. Vig M, Kinet JP, (2009) Calcium signaling in immune cells. Nat Immunol 10: 21-27.
4. Harteneck C, (2005) Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol 371: 307-314.
5. Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, et al. (2004) Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol 286: C129-137.
6. Beck A, Kolisek M, Bagley LA, Fleig A, Penner R, (2006) Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. Faseb J 20: 962-964.
7. Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, et al. (2006) Activation of T cell calcium influx by the second messenger ADP-ribose. J Biol Chem 281: 2489-2496.
8. Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, et al. (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science 293: 1327-1330.
9. Buelow B, Song Y, Scharenberg AM, (2008) The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem 283: 24571-24583.
10. Hill K, Tigue NJ, Kelsell RE, Benham CD, McNulty S, et al. (2006) Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology 50: 89-97.
11. Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, et al. (2006) A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci 101: 66-76.
12. Lipski J, Park TI, Li D, Lee SC, Trevarton AJ, et al. (2006) Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Brain Res 1077: 187-199.
13. Olah ME, Jackson MF, Li H, Perez Y, Sun HS, et al. (2009) Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol 587: 965-979.
14. Smith MA, Herson PS, Lee K, Pinnock RD, Ashford ML, (2003) Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel. J Physiol 547: 417-425.
15. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, et al. (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411: 595-599.
16. Lund FE, (2006) Signaling properties of CD38 in the mouse immune system: enzyme-dependent and-independent roles in immunity. Mol Med 12: 328-333.
17. Malavasi F, Deaglio S, Ferrero E, Funaro A, Sancho J, et al. (2006) CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity. Mol Med 12: 334-341.
18. Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, et al. (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proc Natl Acad Sci U S A 106: 10678-10683.
19. Sumoza-Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, et al. (2011) Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. FASEB J 25: 3529-3542.
20. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, et al. (2008) TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 14: 738-747.
21. Melzer N, Meuth SG, Torres-Salazar D, Bittner S, Zozulya AL, et al. (2008) A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis. PLoS ONE 3: e3149.
22. Bari MR, Akbar S, Eweida M, Kuhn FJ, Gustafsson AJ, et al. (2009) H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. J Cell Mol Med 13: 3260-3267.
23. Kraft R, Grimm C, Frenzel H, Harteneck C, (2006) Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol 148: 264-273.
24. Inada H, Iida T, Tominaga M, (2006) Different expression patterns of TRP genes in murine B and T lymphocytes. Biochem Biophys Res Commun 350: 762-767.
25. Meuth SG, Bittner S, Meuth P, Simon OJ, Budde T, et al. (2008) TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions. J Biol Chem 283: 14559-14570.
26. Bittner S, Meuth SG, Gobel K, Melzer N, Herrmann AM, et al. (2009) TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. Brain 132: 2501-2516.
27. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, et al. (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9: 163-173.