Divalent copper is a potent extracellular blocker for TRPM2 channel

Biochemical and Biophysical Research Communications

Volumn 424, Issue 2, 2012, Pages 279-284

  Zeng, Bo ^a   Chen, Gui Lan ^a,b   Xu, Shang Zhong ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Calcium channel; Copper; Iron; Lead; Mercury; Selenium; TRPM2 channel

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CALCIUM CHANNEL BLOCKING AGENT; COPPER ION; IRON; LEAD; MERCURY; SELENIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHOLE CELL;

ADENOSINE DIPHOSPHATE RIBOSE; CATIONS, DIVALENT; COPPER; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; IRON; LEAD; MERCURY; PATCH-CLAMP TECHNIQUES; SELENIUM; TRPM CATION CHANNELS;

EID: 84864292111     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.107     Document Type: Article

References (47)

1. Perraud A.L., Fleig A., Dunn C.A., et al. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 2001, 411:595-599.
2. Sumoza-Toledo A., Penner R. TRPM2: a multifunctional ion channel for calcium signalling. J. Physiol. 2011, 589:1515-1525.
3. Uchida K., Dezaki K., Damdindorj B., et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 2011, 60:119-126.
4. Togashi K., Hara Y., Tominaga T., et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J. 2006, 25:1804-1815.
5. Di A., Gao X.P., Qian F., et al. The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat. Immunol. 2011, 13:29-34.
6. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol. Cell 2002, 9:163-173.
7. Knowles H., Heizer J.W., Li Y., et al. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:11578-11583.
8. Xu C., Li P.P., Cooke R.G., et al. TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study. Bipolar Disord. 2009, 11:1-10.
9. Hermosura M.C., Cui A.M., Go R.C., et al. Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:18029-18034.
10. Fonfria E., Marshall I.C., Boyfield I., et al. Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J. Neurochem. 2005, 95:715-723.
11. 2+ influx system mediated by LTRPC2. Science 2001, 293:1327-1330.
12. 2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J. Biol. Chem. 2003, 278:11002-11006.
13. Kolisek M., Beck A., Fleig A., et al. Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol. Cell 2005, 18:61-69.
14. Du J., Xie J., Yue L. Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J. Gen. Physiol. 2009, 134:471-488.
15. Starkus J.G., Fleig A., Penner R. The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification. J. Physiol. 2010, 588:1227-1240.
16. Mathie A., Sutton G.L., Clarke C.E., et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol. Ther. 2006, 111:567-583.
17. Jomova K., Vondrakova D., Lawson M., et al. Metals, oxidative stress and neurodegenerative disorders. Mol. Cell. Biochem. 2010, 345:91-104.
18. Uriu-Adams J.Y., Keen C.L. Copper, oxidative stress, and human health. Mol. Aspects Med. 2005, 26:268-298.
19. Chelly J., Tumer Z., Tonnesen T., et al. Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat. Genet. 1993, 3:14-19.
20. Shahidzadeh R., Sridhar S. Profound copper deficiency in a patient with gastric bypass. Am. J. Gastroenterol. 2008, 103:2660-2662.
21. Brewer G.J. The risks of copper toxicity contributing to cognitive decline in the aging population and to Alzheimer's disease. J. Am. Coll. Nutr. 2009, 28:238-242.
22. Tanzi R.E., Petrukhin K., Chernov I., et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat. Genet. 1993, 5:344-350.
23. Walter R.M., Uriu-Hare J.Y., Olin K.L., et al. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 1991, 14:1050-1056.
24. Lovell M.A., Robertson J.D., Teesdale W.J., et al. Copper, iron and zinc in Alzheimer's disease senile plaques. J. Neurol. Sci. 1998, 158:47-52.
25. Cooper G.J. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease. Drugs 2011, 71:1281-1320.
26. Desai V., Kaler S.G. Role of copper in human neurological disorders. Am. J. Clin. Nutr. 2008, 88:855S-858S.
27. R. Squitti, Copper dysfunction in Alzheimer's disease: From meta-analysis of biochemical studies to new insight into genetics. J. Trace Elem. Med. Biol. (2012) in press.
28. Meloni G., Sonois V., Delaine T., et al. Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity. Nat. Chem. Biol. 2008, 4:366-372.
29. Tougu V., Tiiman A., Palumaa P., et al. Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. Metallomics 2011, 3:250-261.
30. Lin C.J., Huang H.C., Jiang Z.F. Cu(II) interaction with amyloid-beta peptide: a review of neuroactive mechanisms in AD brains. Brain Res. Bull. 2010, 82:235-242.
31. House E., Mold M., Collingwood J., et al. Copper abolishes the beta-sheet secondary structure of preformed amyloid fibrils of amyloid-beta(42). J. Alzheimers Dis. 2009, 18:811-817.
32. Faller P. Copper in Alzheimer disease: too much, too little, or misplaced?. Free Radic. Biol. Med. 2012, 52:747-748.
33. James S.A., Volitakis I., Adlard P.A., et al. Elevated labile Cu is associated with oxidative pathology in Alzheimer disease. Free Radic. Biol. Med. 2012, 52:298-302.
34. Xu S.-Z., Zeng B., Daskoulidou N., et al. Activation of TRPC Cationic Channels by Mercurial Compounds Confers the Cytotoxicity of Mercury Exposure. Toxicol. Sci. 2012, 125:56-68.
35. Xu S.Z., Zhong W., Watson N.M., et al. Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. J. Thromb. Haemost. 2008, 6:692-700.
36. Xu S.Z., Zeng F., Boulay G., et al. Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br. J. Pharmacol. 2005, 145:405-414.
37. Gaggelli E., Kozlowski H., Valensin D., et al. Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis). Chem. Rev. 2006, 106:1995-2044.
38. Alarcon J.M., Brito J.A., Hermosilla T., et al. Ion channel formation by Alzheimer's disease amyloid beta-peptide (Abeta40) in unilamellar liposomes is determined by anionic phospholipids. Peptides 2006, 27:95-104.
39. Zargar A.H., Shah N.A., Masoodi S.R., et al. Copper, zinc, and magnesium levels in non-insulin dependent diabetes mellitus. Post. Grad. Med. J 1998, 74:665-668.
40. Jeong S.W., Park B.G., Park J.Y., et al. Divalent metals differentially block cloned T-type calcium channels. NeuroReport 2003, 14:1537-1540.
41. Gu Q., Lin R.L. Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J. Appl. Physiol. 2010, 108:891-897.
42. Riera C.E., Vogel H., Simon S.A., et al. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 293:R626-634.
43. Yang W., Manna P.T., Zou J., et al. Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore. J. Biol. Chem. 2011, 286:23789-23798.
44. 2+ influx and cell death in rat beta-cell line RIN-5F. Cell Calcium 2006, 39:487-494.
45. Viktorinova A., Toserova E., Krizko M., et al. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism 2009, 58:1477-1482.
46. Canatan H., Bakan I., Akbulut M., et al. Relationship among levels of leptin and zinc, copper, and zinc/copper ratio in plasma of patients with essential hypertension and healthy normotensive subjects. Biol. Trace Elem. Res. 2004, 100:117-123.
47. Miller G.D., Keen C.L., Stern J.S., et al. Copper deficiency and arachidonic acid enhance insulin secretion in isolated pancreatic islets from lean (FaFa) Zucker rats. Pancreas 1998, 17:390-396.