Glucocorticoid Hormones and Estrogens: Their Interaction with the Endothelial Cells of the Blood-Brain Barrier

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces

Volumn 1, Issue , 2007, Pages 287-312

  Dietrich, Jean Bernard ^a  

^a INSERM   (France)

Author keywords

Adhesion molecules regulated by estrogens in endothelial cells; Brain vessels; Endothelial cells of blood brain barrier; Enzymatic control; Estrogens; Glucocorticoid hormones; Hormonal control

Indexed keywords

ENDOTHELIAL CELLS;

BLOOD-BRAIN BARRIER;

HORMONES;

EID: 84891013124     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527611225.ch13     Document Type: Chapter

References (144)

1. Danielsen, M. 1995, Structure and function of the glucocorticoid receptor, in Nuclear Hormone Receptors, ed. Parker M.G., Academic Press, London, pp. 39-78.
2. Schaaf, M.J. M., Cidlowski, J. A. 2003, Molecular mechanisms of glucocorticoid action and resistance, J. Steroid Biochem. Mol. Biol. 83, 37-48.
3. Sawada, N., Murata, M., Kikuchi, K., Osanai, M., Tobioka, H., Kojima, T., Chiba, H. 2003, Tight junctions and human diseases, Med. Electron. Microsc. 36, 147-156.
4. Ballabh, P., Braun, A., Nedergaard, M. 2004, The blood-brain barrier: an overview. Structure, regulation, and clinical implications, Neurobiol. Dis. 16, 1-13.
5. Green, S., Chambon, P. 1991, The oestrogen receptor: from perception to mechanism, in Nuclear Hormone Receptors, ed. Parker M.G., Academic Press, London, pp. 15-38.
6. Truss, M., Beato, M. 1993, Steroid hormone receptor: interaction with deoxyribonucleic acid and transcription factors, Endocr. Rev. 14, 459-479.
7. De Bosscher, K., Vanden Bergh, W., Haegeman, G. 2000, Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors, J. Neuroimmunol. 109, 16-22.
8. Hayashi, R., Wada, H., Ito, K., Adcock, I.M. 2004, Effects of glucocorticoids on gene transcription, Eur. J. Pharmacol. 500, 51-62.
9. Barnes, P. J. 1998, Anti-inflammatory actions of glucocorticoids: molecular mechanisms, Clin. Sci. 94, 557-572.
10. Pitzalis, C., Pipitone, N., Peretti, M. 2002, Regulation of leukocyte-endothelial interactions by glucocorticoids, Ann. N.Y. Acad. Sci. 966, 101-118.
11. Almawi, W.Y., Melemedjian, O.K. 2002, Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids, J. Mol. Endocrinol. 28, 69-78.
12. Baldwin, A. S. 1996, The NF-κB and IκB proteins: new discoveries and insights, Annu. Rev. Immunol. 14, 74-80.
13. Catron, K. M., Brickwood, J. R., Shang, C., Li, Y., Shannon, M.F., Parks, T. P. 1995, Cooperative binding and synergistic activation by RelA and C/EBPbeta on the intercellular adhesion molecule-1 promoter, Cell Growth Differ. 9, 949-959.
14. Ray, K. P., Farrow, S., Daly, M., Talabot, F., Searle, N. 1997, Induction of the E-selectin promoter by interleukin 1 and tumor necrosis factor alpha, and inhibition by glucocorticoids, Biochem. J. 328, 707-715.
15. Wong, D., Dorovini-Zis, K. 1996, Regulation by cytokines and lipopolysaccharide of E-selectin expression by human brain microvessel endothelial cells in primary culture, J. Neuropathol. Exp. Med. 55, 225-235.
16. Tronche, F., Kellendonk, C., Reichardt, M., Schütz, G. 1998, Genetic dissection of glucocorticoid receptor function in mice, Curr. Opin. Gen. Dev. 8, 532-538.
17. Norman, A., Mizwicki, M.T., Norman, D.P. 2004, Steroid-hormone rapid actions, membrane receptors and a conformation ensemble model, Nat. Rev. Drug Discov. 3, 27-41.
18. Kapajos, J. J., van den Berg, A., Borghuis, T., Banas, B., Huitema, S., Poelstra, K., Bakker, W.W. 2004, Enhanced ecto-pyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticoids in vitro, Eur. J. Pharmacol. 501, 191-198.
19. Solito, E., Mulla, A., Morris, J. F., Christian, H.C., Flower, R. J., Buckingham J. C. 2003, Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase, Endocrinology 144, 1164-1174.
20. Metchnikoff, E. 1892, Leçons sur la Pathologie Comparée de l'Inflammation, Masson, Paris, reissued as.
21. Metchnikoff, E. 1968, Lectures on Comparative Pathology of Inflammation, Dover, New York.
22. Walzog, B., Gaehtgens, P. 2000, Adhesion molecules: the path to the new understanding of acute inflammation, News Physiol. Sci. 15, 107-113.
23. Springer, T.A. 1995, Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration, Annu. Rev. Physiol. 57, 827-872.
24. Zimmerman, G. A., McIntyre, T. M., Mehra, M., Prescott, S.M. 1996, Endothelial cell-associated platelet-activating factor: a novel mechanism for signalling intercellular adhesion, J. Cell. Biol. 110, 529-540.
25. Ulbrich, H., Eriksson, E. E., Lindbom, L. 2003, Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease, Trends Pharmacol. Sci. 24, 640-647.
26. Cato, A. C. B., Wade, E. 1996, Molecular mechanisms of anti-inflammatory response, Bioessays 18, 371-378.
27. Wikström, A. C. 2003, Glucocorticoid action and novel mechanisms of steroid resistance: role of glucocorticoid receptor-interacting proteins for glucocorticoid responsiveness, J. Endocrinol. 178, 331-337.
28. Radomski, M.W., Palmer, R.M. J., Moncada, S. 1990, Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells, Proc. Natl Acad. Sci. USA 87, 10043-10047.
29. MacMicking, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q.W., Sokol, K., Hutchison, N. 1995, Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase, Cell 81, 641-650.
30. Mitchell, J. A., Belvisi, M.G., Akarasereenont, P., Robbins, R. A., Known, O.J., Croxtall, J., Barnes, P. J., Vane, J. R. 1994, Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone, Br. J. Pharmacol. 113, 1008-1014.
31. Muller, W.A. 2002, Leukocyte-endothelial cell interactions in the inflammatory response, Lab. Invest. 82, 521-533.
32. Muller, W.A. 2003, Leukocyte-endothelial cell interactions in leukocyte transmigration and the inflammatory response, Trends Immunol. 24, 326-333.
33. Harlan, J. M., Winn, R. K. 2002, Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy, Crit. Care Med. 30, S214-S219.
34. Campbell, J. J., Butcher, E.C. 1998, Chemokines in tissue-specific and microenvironment specific lymphocyte homing, Curr. Opin. Immunol. 12, 336-341.
35. Muller, W. A., Wigl, S. A., Deng, X., Phillips, D.M. 1993, PECAM-1 is required for transendothelial migration of leukocytes, J. Exp. Med. 178, 449-460.
36. Berman, M.E., Xie, Y., Muller, W.A. 1996, Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1) in natural killer cell transendothelial migration and β2 integrin activation, J. Immunol. 156, 1515-1524.
37. Liao, F., Huynh, H.K., Eiroa, A., Greene, T., Polizzi, E., Muller, W. 1997, Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1, J. Exp. Med. 182, 1337-1343.
38. Cinamon, G., Shinder, V., Alon, R. 2001, Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines, Nat. Immunol. 2, 515-522.
39. Schenkel, A. R., Mahmdouh, Z., Chen, X., Liebman, R. M., Muller, W.M. 2002, CD99 plays a major role in the migration of monocytes through endothelial junctions, Nat. Immunol. 3, 143-150.
40. Ostermann, G., Weber, K.S. G., Zernecke, A., Schroder, A, Weber, C. 2002, JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes, Nat. Immunol. 3, 151-158.
41. Aurrand-Lions, M., Johnson-Leger, C., Imhof, B. A. 2002, The last molecular fortress in leukocyte trans-endothelial migration, Nat. Immunol. 3, 116-118.
42. Brostjan, C., Anrather, J., Csizmadia, V., Natarajan, G., Winkler, H. 1997, Glucocorticoids inhibit E-selectin expression by targeting NF-kappaB and not ATF/c-jun, J. Immunol. 158, 3836-3844.
43. Grober, J. S., Bowden, B. L., Ebling, H., Athey, B., Thompson, C. B., Fox, D.A., Stoolman, L.M. 1993, Monocyte-endothelial adhesion in chronic rheumatoid arthritis: in situ detection of selectin and integrin-dependent interactions, J. Clin. Invest. 91, 2609-2619.
44. Johnson-Tidey, R. R., McGregor, J. L., Taylor, P. R., Poston, R. N. 1994, Increase in the adhesion molecule P-selectin in the endothelium overlying atherosclerotic plaques, Am. J. Pathol. 144, 952-961.
45. Xia, L., Pan, J., Yao, L., McEver, R.P. 1998, A proteasome inhibitor, an antioxydant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-induced expression of P-selectin in human endothelial cells, Blood 91, 162-163.
46. De Coupade, C., Solito, E., Levine, J. D. 2003, Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-397, Br. J. Pharmacol. 140, 133-145.
47. Cronstein, B. N., Kimmel, S. C., Levin, R. I., Martiniuk, F., Weissmann, G. 1992, A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1, Proc. Natl Acad. Sci. USA 89, 9991-9995.
48. Aziz, K. E., Wakefield, D. 1996, Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone and dexamethasone, Cell. Immunol. 167, 79-85.
49. Burke-Gaffney, A., Hellewell, P. 1996, Regulation of ICAM-1 by dexamethasone in a human vascular endothelial cell line EAhy926, Am. J. Physiol. 270, C552-C561.
50. Tan, K. H., Dobbie, M.S., Felix, R. A., Barrand, M.A., Hurst, R. D. 2001, A comparison of the induction of immortalized endothelial cell impermeability by astrocytes, NeuroReport 12, 1329-1334.
51. Dietrich, J. B., Zaepfel, M., Kuchler-Bopp, S. 1999, Dexamethasone represses 3,5,5'-triiodothyronine-stimulated expression of intercellular adhesion molecule-1 in the human cell line ECV 304, Cell. Biol. Toxicol. 15, 269-277.
52. Dufour, A., Corsini, E., Gelati, M., Ciusani, E., Zaffaroni, M., Giombini, S., Massa, G., Salmaggi, A. 1998, Modulation of ICAM-1, VCAM-1 and HLA-DR by cytokines and steroids on HUVECs and human brain endothelial cells, J. Neurol. Sci. 157, 117-121.
53. Gelati, M., Corsini, E., Dufour, A., Massa, G., Giombini, S., Solero, C. L., Salmaggi, A. 2000, High-dose methylprednisolone reduces cytokine-induced adhesion molecules on human brain endothelial cells, Can. J. Neurol. 27, 241-244.
54. Droogan, A. G., Crockard, A. D., McMillan, S. A., Hawkins, S. A. 1998, Effects of intravenous methylprednisolone therapy on leukocyte and soluble adhesion molecule expression, Neurology 50, 224-229.
55. Radi, Z. A., Kehrli Jr, M. R., Ackermann, M.R. 2001, Cell adhesion molecules, leukocyte trafficking, and strategies to reduce leukocyte infiltration, J. Vet. Intern. Med. 15, 516-529.
56. Persidsky, Y. 1999, Model systems for the studies of leukocyte migration across the blood-brain barrier, J. Neurovirol. 5, 579-590.
57. Gaillard, P. J., Voorwinden, L. H., Nielsen, J. L., Ivanov, A., Atsumi, R., Engman, H., Ringbom, C., de Boer, A. G., Breimer, D.D. 2001, Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes, Eur. J. Pharmacol. 12, 215-222.
58. Marshall, D., Haskard, D.O. 2002, Clinical overview of leukocyte adhesion and migration: where are we now? Semin. Immunol. 14, 133-140.
59. Engelhardt, B. 2000, Role of glucocorticoids on T cell recruitment across the blood-brain barrier, Z. Rheumatol. 59 [Suppl. 2], II/18-II/21.
60. Kraus, J., Ochsmann, P., Engelhardt, B., Bauer, R., Kern, A., Traupe, H., Dorndorf, W. 1998, Soluble and cell surface ICAM-3 in blood and cerebrospinal fluid of patients with multiple sclerosis: influence of methylprednisolone treatment and relevance as markers for disease activity, Acta Neurol. Scand. 101, 135-139.
61. Kraus, J., Ochsmann, P., Engelhardt, B., Schiel, C., Hornig, C., Bauer, R., Kern, A., Traupe, H., Dorndorf, W. 2000, Soluble and cell surface ICAM-1 in blood and cerebrospinal fluid as markers for disease activity in multiple sclerosis, Acta Neurol. Scand. 98, 102-109.
62. Reiss, Y., Hoch, G., Deutsch, U., Engelhardt, B. 1998, T cell interaction with ICAM-1 deficient endothelium in vitro: requisite role for ICAM-1 and VCAM-1 in transendothelial migration of T cells, Eur. J. Immunol. 28, 3086-3099.
63. Carpen, O., Pallai, P., Staunton, D.E., Springer T. A. 1992, Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin, J. Cell. Biol. 118, 1223-1234.
64. Vaheri, A., Carpen, O., Heiska, L., Helander, T. S., Jaaskelainen, J., Majander-Nordenswan, P., Sainio, M., Timonen, T., Turunen, O. 1997, The ezrin protein family: membrane-cytoskeleton interactions and diseases association, Curr. Opin. Cell. Biol. 9, 659-666.
65. Helander, T. S., Carpen, O., Turunen, O., Kovanen, P., Vaheri, A., Timonen, T. 1996, ICAM-2 redistributed by ezrin as a target for killer cells, Nature 382, 265-268.
66. Smith, M.D., Ahern, M.J., Brooks, P. M., Roberts-Thomson, P. J. 1988, The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid arthritis. III. Effects on immune and inflammatory indices in synovial fluid, J. Rheumatol. 15, 238-241.
67. Gelati, M., Corsini, E., Dufour, A., Ciusani, E., Massa, G., Frigiero, S., Milanes, C., Nespolo, A., Salmaggi, A. 1997, Reduced adhesion of PBMNCs to endothelium in methylprednisolone-treated MS patients: preliminary results, Acta Neurol. Scand. 96, 283-292.
68. Pitzalis, C., Pipitone, N., Peretti, M. 2002, Regulation of leukocyte-endothelial interactions by glucocorticoids, Ann. N.Y. Acad. Sci. 966, 101-118.
69. Pitzalis, C., Pipitone, N., Bajocchi, G., Hall, N., Goulding, N., Lee, G., Kingsley G., Lanchbury, J., Panayi, G. 1997, Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect, J. Immunol. 158, 5007-5016.
70. Euzger, E., Flower, R. J., Goulding, N. J., Perretti, M. 1999, Differential modulation of annexin I binding sites on monocytes and neutrophils, Med. Inflamm. 8, 53-62.
71. Pitzalis, C., Pipitone, N., Peretti, M. 2001, Glucocorticoids and leukocyte adhesion, in Glucocorticoids, vol. 1, eds. N. J. Goulding, R. J. Flower, Birkhäuser, Basel, pp. 105-118.
72. Goulding, N. J., Ougsbourn, S., Pipitone, N., Biagini, P., Gerli, R., Pitzalis, C. 1999, The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1, Clin. Exp. Immunol. 118, 376-383.
73. Goulding, N. J., Flower, R. J. 2001, Glucocorticoid biology - a molecular maze and clinical challenge, in Glucocorticoids, vol. 1, eds. N. J. Goulding, R. J. Flower, Birkhäuser, Basel, pp. 119-127.
74. Pipitone, N., Sinha, M., Theodoridis, N., Goulding, N., Hall, M., Lanchbury, J., Corrigall, V., Panayi, G., Pitzalis, C. 2001, The glucocorticoid inhibition of LFA-1 and CD2 expression in human mononuclear cells is reversed by IL-1, IL-7 and IL-15, Eur. J. Immunol. 31, 2135-2142.
75. Stanimirovic, D.B., McCarron, R. M., Spatz, M. 1994, Dexamethasone downregulates endothelin receptors in human cerebromicrovascular endothelial cells, Neuropeptides 26, 145-152.
76. Newton, C. J., Ran, G., Xie, Y. X., Bilko, D., Burgoyne, C. H., Adams, I., Abidia, A., McCollum, P.T., Atkins, S. L. 2002, Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone, J. Endocrinol. 174, 7-16.
77. Karlstedt, K., Sallmen, T., Eriksson, K. S., Lintunen, M., Couraud, P. O., Joo, F., Panula, P. 1999, Lack of histamine synthesis and down-regulation of H1 and H2 receptor mRNA levels by dexamethasone in cerebral endothelial cells, J. Cereb. Blood Flow Metab. 9, 321-330.
78. Romero, I. A., Radewicz, K., Jubin, E., Michel, C. C., Greenwood, J., Couraud, P. O., Adamson, P. 2003, Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells, Neurosci. Lett. 344, 112-116.
79. Prat, A., Biernacki, K., Lavoie, J.-F., Poirier, J., Duquette, P., Antel, J. P. 2002, Migration of multiple sclerosis lymphocytes through brain endothelium, Arch. Neurol. 59, 391-397.
80. Simpson, J. E., Newcombe, J., Cuzner, M. L., Woodroofe, M.N. 1998, Expression of beta-chemokines RANTES and MIP-beta by human brain microvessel endothelial cells in primary culture, J. Neuroimmunol. 84, 238-249.
81. Ransohoff, R.M. 1999, Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines, J. Neuroimmunol. 134, 57-68.
82. Seguin, R., Biernacki, K., Rotondo, R. L., Antel, J. P. 2003, Regulation and functional effects of monocyte migration across human brain-derived endothelial cells, J. Neuropathol. Exp. Neurol. 62, 412-419.
83. Andjelkovic, A.V., Pachter, J.S. 2000, Central nervous system endothelium in neuroinflammatory, neuroinfectious and neurodegenerative disease, J. Neurosci. Res. 51, 423-430.
84. Dzenko, K. A., Andjelkovic, A.V., Kuziel, W. A., Pachter, J.S. 2001, The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels, J. Neurosci. 21, 9214-9223.
85. Song, L., Pachter, J.S. 2004, Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells, Microvasc. Res. 67, 78-89.
86. Harkness, K. A., Sussman, J. D., Davies-Jones, G. A., Greenwood, J., Woodroofe, M.N. 2003, Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells, J. Neuroimmunol. 142, 1-9.
87. Harkness, K. A., Adamson, P., Sussman, J. D., Davies-Jones, G. A., Greenwood, J., Woodroofe, M.N. 2000, Dexamethasone regulation of matrix metalloprotease expression in CNS vascular endothelium, Brain 123, 698-709.
88. Rosenberg, G. A., Dencoff, B. S., Correa, N., Reiners, M., Ford, C. C. 1996, Effects of steroids on CSF matrix metalloproteinases in multiple sclerosis:relation to blood-brain barrier injury, Neurology 46, 1626-1632.
89. Gold, R., Buttgereit, F., Toyka, K.V. 2001, Mechanism of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders, J. Neuroimmunol. 117, 1-8.
90. Schmidt, J., Gold, R., Schönrock, L., Zettl, U.K., Hartung, H.P., Toyka, K.V. 2000, T-cell apoptosis in situ in experimental autoimmune encephalomyelitis following methylprednisolone pulse therapy, Brain 123, 1431-1441.
91. Leussink, V., Jung, S., Merschdorf, U., Toyka, K.V., Gold, R. 2001, High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes, Arch. Neurol. 58, 91-97.
92. Corsini, E., Gelati, M., Dufour, A., Massa, G., Nespolo, A., Ciusani, E., Milanese, C., La Mantia, L., Salmaggi, A. 1997, Effects of beta-IFN-1b treatment in MS patients on adhesion between PBMNCs, HUVECs and MS-HBECs: an in vivo and in vitro study, J. Neuroimmunol. 79, 76-83.
93. Schluep, M., Bogousslavsky, J. 1997, Emerging treatments in multiple sclerosis, Eur. Neurol. 38, 216-221.
94. Minagar, A., Long, A., Ma, T., et al. 2003, Interferon (IFN)-beta 1a and IFNbeta 1b block-IFN-gamma-induced disintegration of endothelial junction integrity and barrier. Endothelium 10, 299-307.
95. Kraus, J., Ling, A. K., Hamm, S., Voigt, K., Ochsmann, P., Engelhardt, B. 2004, Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro, Ann. Neurol. 56, 192-205.
96. Gaillard, P. J., van der Meide, P. H., de Boer, A. G., Breiner, D.D. 2001, Glucocorticoid and type I interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis, NeuroReport 12, 2189-2193.
97. Miller, W. L., Blake Tyrrel, J. 1995, The adrenal cortex, in Endocrinology and Metabolism, eds. Felig, P., Baxter J. D., Frohmann, L. A., McGraw-Hill, New York, pp. 555-711.
98. Reichardt, H.M., Tuckermann, J. P., Bauer, A., Schütz, G. 2000, Molecular genetic dissection of glucocorticoid receptor function in vivo, Z. Rheumatol. 59 [Suppl. 2], II/1-II/5.
99. Everts, M., Kok, J., Asgeirsdottir, S. A., Melgert, B. N., Moolenaar, T. J., Koning, G. A., van Luyn, M.J., Meijer, D. K., Molema, G. 2002, Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate, J. Immunol. 168, 883-889.
100. Asgeirsdottir, S. A., Kok, R. J., Everts, M., Meijer, D.K. F., Molema, G. 2003, Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate, Biochem. Pharmacol. 65, 1729-1739.
101. Hall, J. M., Couse, J. F., Korach, K.M. 2001, The multifaced mechanisms of estradiol and estrogen receptor signaling, J. Biol. Chem. 276, 36869-36872.
102. Nadal, A., Diaz, M., Valverde, M.A. 2001, The estrogen trinity: membrane, cytosolic and nuclear effects, News Physiol. Sci. 16, 251-255.
103. Mendelsohn, M.E. 2002, Genomic and nongenomic effects of estrogen in the vasculature, Am. J. Cardiol. 90 [suppl.], 3F-6F.
104. Simoncini, T., Mannella, P., Fornari, L., Caruso, A., Varone, G., Genazzani, A. R. 2004, Genomic and non-genomic effects of estrogens on endothelial cells, Steroids 69, 537-542.
105. Paech, K., Webb, P., Kuiper, G.G. J. M., Nilsson, S., Gustafsson, J.-A., Kushner, P. J., Scanlan, T. S. 1997, Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites, Science 277, 1508-1510.
106. Lee, S. J., McEwen, B. S. 2001, Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications, Annu. Rev. Pharmacol. Toxicol. 41, 569-591.
107. Deecher, D. C., Swiggard, P., Frail, D.E., O'Connor, L.T. 2003, Characterization of a membrane-associated estrogen in a rat hypothalamic cell line (D12), Endocrine 22, 211-223.
108. Gilligan, D.M., Quyyumi, A. A., Cannon III, R. O. 1994, Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women, Circulation 89, 2545-2551.
109. Behl, C. 2002, Oestrogen as neuroprotective hormone, Nat. Rev. Neurosci. 3, 433-442.
110. 2+] increase and cell damage in cultured rat cerebral endothelial cells, Brain Res. 956, 116-125.
111. Shaul, P.W. 2002, Regulation of endothelial nitric oxide synthase: location, location, location, Annu. Rev. Physiol. 64, 749-774.
112. Stirone, C., Chu, Y., Sunday, L., Duckles, S. P., Krause, D.N. 2003, 17-β-estradiol increases endothelial nitric oxide synthase mRNA copy number in cerebral blood vessels: quantification by real-time polymerase chain reaction, Eur. J. Pharmacol. 478, 35-38.
113. Haynes, M.P., Sinha, D., Russell, K. S., Collinge, M., Fulton, D., Morales-Ruiz M., Sessa, W. C., Bender, J.R. 2000, Membrane estrogen receptor engagement activates endothelial nitric oxyde synthase via the PI3-Akt pathway in human endothelial cells, Circ. Res. 87, 677-682.
114. Xu, R., Sowers, J. R., Skafar, D. F., Ram, J. L. 2001, Hydrocortisone modulates the effect of estradiol on endothelial nitric oxide synthase expression in human endothelial cells, Life Sci. 69, 2811-2817.
115. Shi, J., Simpkins, J.W. 1997, 17beta-estradiol modulation of glucose transporter expression in blood-brain barrier, Am. J. Physiol. 272, E1016-E1022.
116. Adamski, J., Ma, Z., Nozell S., Benveniste, E.M. 2004, 17-β-estradiol inhibits class II major histocompatibility complex (MHC) expression: influence on histone modifications and CBP recruitment to the class II MHC promoter, Mol. Endocrinol. 18, 1963-1974.
117. Stirone, C., Duckles, S. P., Krause, D.N. 2003, Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen, Am. J. Physiol. Endocrinol. Metab. 284, E184-E192.
118. Kim-Schulze, S., McGowan, K. A., Hubchak, S. C., Cid, M.B., Kleinman, G. L., Greene, G. L., Schnaper, H.W. 1996, Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells, Circulation 94, 1402-1407.
119. Villablanca, A. C., Lewis, K. A., Rutledge, J. C. 2002, Time-and dose-dependent differential upregulation of three genes by 17beta-estradiol in endothelial cells, J. Appl. Physiol. 92, 1064-1073.
120. Cid, M.C., Kleinman, H.K., Grant, D.S., Schnaper, H.W., Fauci, A. S., Hoffman, G. S. 1994, Estrogens and the vascular endothelium, J. Clin. Invest. 93, 17-25.
121. Caulin-Glaser, T., Watson, C.A., Pardi, R., Bender, J.R. 1996, Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression, J. Clin. Invest. 98, 36-42.
122. Tyree, C. M., Zou, A., Allegretto, E. A. 2002, 17beta-estradiol inhibits cytokine induction of the human E-selectin promoter, J. Steroid Biochem. Mol. Biol. 80, 291-297.
123. Cid, M.C., Esparza, J., Schnaper, W. H., Juan, M., Yague, J., Grant, D. S., Urbano-Marquez, A., Hoffman, G. S., Kleinman, H.K. 1999, Estradiol enhances endothelial cell interactions with extracellular matrix proteins via an increase in integrin expression and function, Angiogenesis 3, 271-280.
124. Galea, E., Santizo, R., Feinstein, D.L., Adamson, P., Greenwood, J., Koenig, H.M., Pelligrino, D.A. 2002, Estrogen inhibits NFkappaB-dependent inflammation in brain endothelium without interfering with IkappaB degradation, NeuroReport 13, 1469-1472.
125. Mori, M., Tsukahara, F., Yoshioka, T., Irie, K., Ohta, H. 2004, Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors, Life Sci. 75, 599-609.
126. Simoncini, T., Maffei, S., Basta, G., Barsacchi, G., Genazzani, A. R., Liao, J. K., De Caterina, R. 2000, Estrogens and glucocorticods inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms, Circ. Res. 87, 19-25.
127. Nakai, K., Itoh, C., Hotta, K., Yoshizumi, M., Hiramori, K. 1994, Estradiol-17beta regulates the induction of VCAM-1 mRNA expression by interleukin-1beta in human umbilical vein endothelial cells, Life Sci. 54, PL221-PL227.
128. Mukherjee, T. K., Nathan, L., Dinh, H., Reddy, S.T., Chaudhuri, G. 2003, 17-Epiestrol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression, J. Biol. Chem. 278, 11746-11752.
129. Offner, H. 2004, Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis, J. Neurosci. Res. 78, 603-624.
130. Jansson, L., Olson, T., Holmdahl, R. 1994, Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collageninduced arthritis in mice, J. Neuroimmunol. 53, 203-207.
131. Bebo, B. F., Fyfe-Johnson, A., Adlard, K., Beam, A. G., Vandenbark, A. A., Offner, H. 2001, Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains, J. Immunol. 166, 2080-2089.
132. Ito, A., Buenafe, A. C., Matejuk, A., Zamora, M., Silverman, M., Dwyer, J., Vandenbark, A. A., Offner, H. 2002, Estrogen treatment down-regulates TNF-alpha production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice, J. Immunol. 167, 542-552.
133. Garridou, L., Laffont, S., Douin-Echinard, V., Coureau, C., Krust, A., Chambon, P., Guery, C. 2004, Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis, J. Immunol. 173, 2345-2342.
134. Polanczyk, M.J., Jones, R. E., Subramanian, S., Afentoulis, M., Rich, C., Zakroczymski, M., Cooke, P., Vandenbark, A. A., Offner, H. 2004, T lymphocytes do not directly mediate the protective effects of estrogen on experimental autoimmune encephalomyelitis, Am. J. Pathol. 165, 2069-2077.
135. Matejuk, A., Dwier, J., Zamora, A., Vandenbark, A. A., Offner, H. 2002, Evaluation of the effects of 17beta-estradiol (17beta-E2) on the gene expression in experimental autoimmune encephalomyelitis using DNA microrrays, Endocrinology 143, 313-319.
136. Kim, S., Liva, S. M., Dalal, M.A., Verity, M. A., Voskuhl, R. R. 1999, Estriol ameliorates autoimmune demyelating disease: implication for multiple sclerosis, Neurology 52, 1230-1238.
137. Sicotte, N. L., Liva, S. M., Klutch, R., Pfeiffer, P., Bouvier, S., Odesa, S., Wu, T. C., Voskuhl, R. R. 2002, Treatment of multiple sclerosis with the pregnancy hormone estriol, Ann. Neurol. 52, 421-428.
138. Soldan, S. S., Alvarez Retuerto, A. I., Sicotte, N.L., Voskuhl, R.R. 2003, Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol, J. Immunol. 171, 6267-6274.
139. Lock, C., Hermans, G., Pedotti, R., et al. 2002, Gene-microarrays analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis, Nat. Med. 8, 500-508.
140. Zavala, F., Abad, S., Ezine, S., Taupin, V., Masson, A., Bach, J. F. 2002, G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine-and cytokine-based immune deviation, J. Immunol. 168, 2001-2019.
141. Rieckmann, P., Martin, S., Weichselbraun, I., et al. 1994, Serial analysis of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood brain damage, Neurology 44, 1523-1526.
142. Tsukada, M., Miyagi, K., Matsuda, M., Yanagisawa, N. 1993, Increased levels of circulating ICAM-1 in multiple sclerosis and human T-lymphotropic virus type 1-associated myelopathy, Ann. Neurol. 33, 591-596.
143. Vayssière, B. M., Dupont, S., Choquart, A., Petit, F., Garcia, T., Marchandeau, H., Gronemeyer, H., Resche-Rigon, M. 1997, Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo, Mol. Endocrinol. 11, 1245-1255.
144. Kok, R. J., Everts, M., Asgeirsdottir, S. A., Meijer, D. K., Molema, G. 2002, Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: comparison with free dexamethasone, Pharm. Res. 19, 1730-1735.