Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: Comparison with free dexamethasone

Pharmaceutical Research

Volumn 19, Issue 11, 2002, Pages 1730-1735

  Kok, R J ^a   Everts, M ^a   Asgeirsdottir S A ^a   Meijer, D K F ^a   Molema, G ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Activated endothelial cells; Chronic inflammation; Drug targeting; Glucocorticoids; Immunoconjugate; Lysosomal degradation

Indexed keywords

ANTIBODY CONJUGATE; DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOCORTICOID; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; DIFFUSION; DOSE TIME EFFECT RELATION; DRUG BINDING; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG METABOLISM; DRUG TARGETING; DRUG UPTAKE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; PRIORITY JOURNAL; RECEPTOR BINDING;

CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DEXAMETHASONE; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOCONJUGATES;

EID: 0036846648     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020769716288     Document Type: Article

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