High-dose methylprednisolone reduces cytokine-induced adhesion molecules on human brain endothelium

Canadian Journal of Neurological Sciences

Volumn 27, Issue 3, 2000, Pages 241-244

  Gelati, M ^a   Corsini, E ^a   Dufour, A ^a   Massa, G ^a   Giombini, S ^a   Solero, C L ^a   Salmaggi, A ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; METHYLPREDNISOLONE; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ARTICLE; BLOOD BRAIN BARRIER; BRAIN MICROCIRCULATION; CELL MIGRATION; CLINICAL ARTICLE; DOSE RESPONSE; DRUG MEGADOSE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

EID: 0033811281     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0317167100000883     Document Type: Article

References (22)

1. A double-blind controlled trial of high-dose methylprednisolone in patients with multiple sclerosis. 1. Clinical effects
2. Double-blind trial of dexamethasone versus methylprednisolone in multiple sclerosis acute relapses
3. Reduced adhesion of PBMNCs to endothelium in methylprednisolone-treated MS patients: Preliminary results
4. Effects of intravenous methylprednisolone therapy on leukocyte and soluble adhesion molecule expression in MS
5. Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by β-estradiol, progesterone, and dexamethasone
6. Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T-lymphocytes
7. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma
8. Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1
9. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
10. Modulation of adhesion of lymphocytes to routine brain endothelial cells in vitro: Relation to class II major histocompatibility complex expression
11. Effects of interferon-γ on primary cultures of human brain microvessel endothelial cells
12. Up-regulation of intercellular molecule adhesion-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide
13. Expression of vascular cell adhesion-1 molecule-1 (VCAM-1) by human brain microvessel endothelial cells in primary cultures
14. Modulation of ICAM-1, VCAM-1 and HLA-DR by cytokines and steroids on HUVECs and human brain endothelial cells
15. Effects of pulse methylprednisolone on cell adhesion molecules in the synovial membrane in rheumatoid arthritis. Reduced E-selectin and intercellular adhesion molecule-1 expression
16. Methylprednisolone infusion during acute exacerbation of MS: Plasma and CSF concentrations
17. A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leucocyte adhesion to endothelial cells and expression of endothelial-leucocyte adhesion molecule-1 and intercellular adhesion molecule-1
18. Effects of β-IFN-1b treatment in MS patients on adhesion between PBMNCs, HUVECs and MS-HBECs: An in vivo and in vitro study
19. Interferon-beta inhibits activated leukocyte migration through human brain microvascular endothelial cell monolayer
20. Effect of steroids on Gd-enhancing lesions before and during recombinant beta interferon 1a treatment in relapsing-remitting multiple sclerosis
21. Reduction of transendothelial migration of mononuclear cells in β-IFN 1b treated MS patients
22. Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: Relation to bloodbrain barrier injury